Systemic sclerosis（SSc） is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the anti...Systemic sclerosis（SSc） is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the antigen-specific immune system and the non-specific Immune system, resulting in autoantibody production, vascular endothelial activation of small blood vessels, and tissue fibrosis as a result of fibroblast dysfunction. Given the heterogeneity of clinical presentation of the disease, a lack of universal models has impeded adequate testing of potential therapies for SSc. Regardless, recent research has elucidated the roles of various ubiquitous molecular mechanisms that contribute to the clinical manifestation of the disease. Transforming growth factor β（TGF-β） has been identified as a regulator of pathological fibrogenesis in SSc. Various processes, including cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis are regulated by TGF-β,a type of cytokine secreted by macrophages and many other cell types. Understanding the essential role TGF-β pathways play in the pathology of systemic sclerosis could provide a potential outlet for treatment and a better understanding of this severe disease.展开更多
The development and wide application of genetic transformation for cotton improvement are restrained by the unresolved problem of genotype dependence in regeneration in vitro.High embryogenic and regenerative potentia...The development and wide application of genetic transformation for cotton improvement are restrained by the unresolved problem of genotype dependence in regeneration in vitro.High embryogenic and regenerative potential have been obtained for limited number of Coker type genotypes。展开更多
This paper describes a person identifcation method for a mobile robot which performs specifc person following under dynamic complicated environments like a school canteen where many persons exist.We propose a distance...This paper describes a person identifcation method for a mobile robot which performs specifc person following under dynamic complicated environments like a school canteen where many persons exist.We propose a distance-dependent appearance model which is based on scale-invariant feature transform（SIFT） feature.SIFT is a powerful image feature that is invariant to scale and rotation in the image plane and also robust to changes of lighting condition.However,the feature is weak against afne transformations and the identifcation power will thus be degraded when the pose of a person changes largely.We therefore use a set of images taken from various directions to cope with pose changes.Moreover,the number of SIFT feature matches between the model and an input image will decrease as the person becomes farther away from the camera.Therefore,we also use a distance-dependent threshold.The person following experiment was conducted using an actual mobile robot,and the quality assessment of person identifcation was performed.展开更多
1 Introduction The transformation of agrifood systems represents one of the most critical challenges of our time,particularly for regions supporting large populations while facing complex environmental,social and econ...1 Introduction The transformation of agrifood systems represents one of the most critical challenges of our time,particularly for regions supporting large populations while facing complex environmental,social and economic pressures.China and Africa,collectively home to over 2.9 billion people,exemplify both the urgency and the diversity of approaches needed to build resilient,sustainable and inclusive food systems.While both regions have achieved significant progress through various agricultural and food policy initiatives over recent decades,they now confront a new generation of complex,interconnected challenges.展开更多
1 Introduction The explosive growth of the global commercial space industry has brought low-Earth orbit(LEO)satellite constellation programs,such as Starlink and Qianfan,to a pivotal stage in the evolution of space de...1 Introduction The explosive growth of the global commercial space industry has brought low-Earth orbit(LEO)satellite constellation programs,such as Starlink and Qianfan,to a pivotal stage in the evolution of space development toward commercialization.1 Traditional space missions have stringent requirements for mission risk and payload mass,while commercial satellite design emphasizes economic viability.2 This systemic transformation has not only redefined the operational framework of aerospace engineering but also opened critical pathways for the spatial application of emerging photovoltaic technologies.Perovskite solar cells(PSCs),endowed with high specific power and cost-effectiveness,have demonstrated competitive potential against silicon-based counterparts in terrestrial applications.3 Crucially,their application prospects are particularly promising in the space domain,where device mass,power density,and cost efficiency are critical design constraints.展开更多
This paper investigates the stability analysis and H_∞ control for a class of nonlinear timedelay systems,and proposes a number of new results.Firstly,an equivalent form is given for this class of systems by means of...This paper investigates the stability analysis and H_∞ control for a class of nonlinear timedelay systems,and proposes a number of new results.Firstly,an equivalent form is given for this class of systems by means of coordinate transformation and orthogonal decomposition of vector fields.Then,based on the equivalent form,some delay-dependent results are derived for the stability analysis of the systems by constructing a novel Lyapunov functional.Thirdly,the authors use the equivalent form and the obtained stability results to investigate the H_∞ control problem for a class of nonhnear time-delay control systems,and present a control design procedure.Finally,an illustrative example is given to show the effectiveness of the results obtained in this paper.It is shown that the main results of this paper are easier to check than some existing ones,and have less conservatism.展开更多
Background The development of modern agriculture has significantly contributed to improving global food security and safety,alleviating poverty,and enhancing human health and livelihoods.However,the rapid advancement ...Background The development of modern agriculture has significantly contributed to improving global food security and safety,alleviating poverty,and enhancing human health and livelihoods.However,the rapid advancement of modern agriculture has also brought about various challenges that limit its sustainable development.This commentary aims to discuss these issues through the One Health lens,and provide valuable insights for balancing modern agricultural activities with the need to protect and promote the health of all the sectors.Main text This commentary explores the multifaceted impacts of modern agriculture on social development,as well as the associated various health challenges and environmental impacts within the One Health framework.Key issues include ecosystem degradation,increased risk of interspecies disease transmission like zoonoses,reverse zoonoses,and vector-borne diseases,and the escalated threat of antimicrobial resistance due to intensified agricultural production and increased antimicrobial use.To address these challenges,this commentary outlines potential solutions anchored in the development and implementation of modern technologies and good agricultural practices,such as precision farming,integrated pest management,biosecurity measures,vaccination programs,as well as surveillance and early detection of health risks.Conclusions Good agricultural practices supported by scientific and technological advancements are essential for aligning productivity with the One Health vision,ensuring the health and resilience of all the sectors.Enhancing stakeholder education,strengthening regulatory frameworks,and providing supportive policies and infrastructure for farmers to adopt sustainable practices are crucial for the long-term viability of agrifood systems.The Food and Agriculture Organization of the United Nations plays a pivotal role in guiding this sustainable transformation through the One Health approach.展开更多
文摘Systemic sclerosis（SSc） is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the antigen-specific immune system and the non-specific Immune system, resulting in autoantibody production, vascular endothelial activation of small blood vessels, and tissue fibrosis as a result of fibroblast dysfunction. Given the heterogeneity of clinical presentation of the disease, a lack of universal models has impeded adequate testing of potential therapies for SSc. Regardless, recent research has elucidated the roles of various ubiquitous molecular mechanisms that contribute to the clinical manifestation of the disease. Transforming growth factor β（TGF-β） has been identified as a regulator of pathological fibrogenesis in SSc. Various processes, including cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis are regulated by TGF-β,a type of cytokine secreted by macrophages and many other cell types. Understanding the essential role TGF-β pathways play in the pathology of systemic sclerosis could provide a potential outlet for treatment and a better understanding of this severe disease.
文摘The development and wide application of genetic transformation for cotton improvement are restrained by the unresolved problem of genotype dependence in regeneration in vitro.High embryogenic and regenerative potential have been obtained for limited number of Coker type genotypes。
基金supported by JSPS KAKENHI (No.23700203) and NEDO Intelligent RT Software Project
文摘This paper describes a person identifcation method for a mobile robot which performs specifc person following under dynamic complicated environments like a school canteen where many persons exist.We propose a distance-dependent appearance model which is based on scale-invariant feature transform（SIFT） feature.SIFT is a powerful image feature that is invariant to scale and rotation in the image plane and also robust to changes of lighting condition.However,the feature is weak against afne transformations and the identifcation power will thus be degraded when the pose of a person changes largely.We therefore use a set of images taken from various directions to cope with pose changes.Moreover,the number of SIFT feature matches between the model and an input image will decrease as the person becomes farther away from the camera.Therefore,we also use a distance-dependent threshold.The person following experiment was conducted using an actual mobile robot,and the quality assessment of person identifcation was performed.
文摘1 Introduction The transformation of agrifood systems represents one of the most critical challenges of our time,particularly for regions supporting large populations while facing complex environmental,social and economic pressures.China and Africa,collectively home to over 2.9 billion people,exemplify both the urgency and the diversity of approaches needed to build resilient,sustainable and inclusive food systems.While both regions have achieved significant progress through various agricultural and food policy initiatives over recent decades,they now confront a new generation of complex,interconnected challenges.
文摘1 Introduction The explosive growth of the global commercial space industry has brought low-Earth orbit(LEO)satellite constellation programs,such as Starlink and Qianfan,to a pivotal stage in the evolution of space development toward commercialization.1 Traditional space missions have stringent requirements for mission risk and payload mass,while commercial satellite design emphasizes economic viability.2 This systemic transformation has not only redefined the operational framework of aerospace engineering but also opened critical pathways for the spatial application of emerging photovoltaic technologies.Perovskite solar cells(PSCs),endowed with high specific power and cost-effectiveness,have demonstrated competitive potential against silicon-based counterparts in terrestrial applications.3 Crucially,their application prospects are particularly promising in the space domain,where device mass,power density,and cost efficiency are critical design constraints.
基金supported by the National Natural Science Foundation of China under Grant Nos.G60774009,61074068,61034007,61374065,and 61304033the Research Fund for the Doctoral Program of Chinese Higher Education under Grant No.200804220028+1 种基金the Natural Science Foundation of Shandong Province under Grant Nos.ZR2013ZEM006,ZR2011EL021,BS2011ZZ012,2013ZRB01873Colleges and Universities in Shandong Province Science and Technology Project under Grant Nos.J13LN37 and J12LN29
文摘This paper investigates the stability analysis and H_∞ control for a class of nonlinear timedelay systems,and proposes a number of new results.Firstly,an equivalent form is given for this class of systems by means of coordinate transformation and orthogonal decomposition of vector fields.Then,based on the equivalent form,some delay-dependent results are derived for the stability analysis of the systems by constructing a novel Lyapunov functional.Thirdly,the authors use the equivalent form and the obtained stability results to investigate the H_∞ control problem for a class of nonhnear time-delay control systems,and present a control design procedure.Finally,an illustrative example is given to show the effectiveness of the results obtained in this paper.It is shown that the main results of this paper are easier to check than some existing ones,and have less conservatism.
基金National Key Research and Development Program of China(No.2022YFD1301105)FAO regular fund to implement the Programme Priority Area on One Health(GF.CJWZD.RY10300000000)。
文摘Background The development of modern agriculture has significantly contributed to improving global food security and safety,alleviating poverty,and enhancing human health and livelihoods.However,the rapid advancement of modern agriculture has also brought about various challenges that limit its sustainable development.This commentary aims to discuss these issues through the One Health lens,and provide valuable insights for balancing modern agricultural activities with the need to protect and promote the health of all the sectors.Main text This commentary explores the multifaceted impacts of modern agriculture on social development,as well as the associated various health challenges and environmental impacts within the One Health framework.Key issues include ecosystem degradation,increased risk of interspecies disease transmission like zoonoses,reverse zoonoses,and vector-borne diseases,and the escalated threat of antimicrobial resistance due to intensified agricultural production and increased antimicrobial use.To address these challenges,this commentary outlines potential solutions anchored in the development and implementation of modern technologies and good agricultural practices,such as precision farming,integrated pest management,biosecurity measures,vaccination programs,as well as surveillance and early detection of health risks.Conclusions Good agricultural practices supported by scientific and technological advancements are essential for aligning productivity with the One Health vision,ensuring the health and resilience of all the sectors.Enhancing stakeholder education,strengthening regulatory frameworks,and providing supportive policies and infrastructure for farmers to adopt sustainable practices are crucial for the long-term viability of agrifood systems.The Food and Agriculture Organization of the United Nations plays a pivotal role in guiding this sustainable transformation through the One Health approach.
