Microorganisms constitute an essential component in the indoor environment,which is closely related to hu-man health.However,there is limited evidence regarding the associations between indoor airborne microbiome and ...Microorganisms constitute an essential component in the indoor environment,which is closely related to hu-man health.However,there is limited evidence regarding the associations between indoor airborne microbiome and systemic inflammation,as well as whether this association is modified by indoor particulate matter and the underlying mechanisms.In this prospective repeated-measure study among 66 participants,indoor airborne mi-crobiome was characterized using amplicon sequencing and qPCR.Indoor fine particulate matter(PM_(2.5))and inhalable particulate matter(PM10)were measured.Systemic inflammatory biomarkers were assessed,including white blood cell(WBC),neutrophil(NEUT),monocyte,eosinophil counts,and their proportions.Targeted serum amino acid metabolomics were conducted to explore the underlying mechanisms.Linear mixed-effect models re-vealed that bacterial and fungal Simpson diversity were significantly associated with decreased WBC and NEUT.For example,for each interquartile range increase in the bacterial Simpson diversity,WBC and NEUT changed by-4.53%(95%CI:-8.25%,-0.66%)and-5.95%(95%CI:-11.3%,-0.27%),respectively.Notably,increased inflammatory risks of airborne microbial exposure were observed when indoor PM_(2.5) and PM10 levels were below the WHO air quality guidelines.Mediation analyses indicated that dopamine metabolism partially mediated the anti-inflammatory effects of fungal diversity exposure.Overall,our study indicated protection from a diverse indoor microbial environment on cardiovascular health and proposed an underlying mechanism through amino acid metabolism.Additionally,health risks associated with microbial exposure deserve more attention in con-texts of low indoor particulate matter pollution.Further research is necessary to fully disentangle the complex relationships between indoor microbiome,air pollutants,and human health.展开更多
Prostate cancer is a significant global health issue with inflammation emerging as a critical driver of progression.The prostate tumor microenvironment(TME)is comprised of tumor cells,mesenchymal stem cells,immune cel...Prostate cancer is a significant global health issue with inflammation emerging as a critical driver of progression.The prostate tumor microenvironment(TME)is comprised of tumor cells,mesenchymal stem cells,immune cells,cancer-associated fibroblasts,adipocytes,and the extracellular matrix.All of these TME components interact via soluble factors,such as growth factors,cytokines,and chemokines.These interactions remodel the TME and drive inflammation and tumor progression.Prolonged inflammation leads to dysregulated activation and infiltration of immune cells in the TME.This process maintains an immunosuppressive environment and facilitates epithelial-to-mesenchymal transition,migration,and invasion.Chronic inflammation causes inflammatory mediators to enter the circulation over time,as evidenced by systemic biomarkers,such as the systemic immune-inflammation index,which links inflammation to disease severity.Interactions between the prostate gland and adipose tissues further exacerbate systemic inflammation.Inflammation in the prostate gland confers resistance to therapy,primes distant metastatic niches,and promotes metastatic spread,resulting in poor clinical outcomes.Therapeutic strategies,such as anti-inflammatory agents and immunotherapies,hold promise in mitigating disease burden.This review explored the immune landscape of systemic inflammation in prostate cancer,discussed the role of the immune landscape in resistance to therapy and metastasis,and offered insights into potential interventions for targeting inflammation to limit prostate cancer burden.展开更多
BACKGROUND Gastric cancer(GC)has a relatively high incidence and mortality rate.Surgery is the primary treatment;however,the survival rate of patients remains low.Therefore,there is an urgent need to identify simple a...BACKGROUND Gastric cancer(GC)has a relatively high incidence and mortality rate.Surgery is the primary treatment;however,the survival rate of patients remains low.Therefore,there is an urgent need to identify simple and feasible prognostic indicators for GC.As an inflammation-related biomarker,the systemic inflammation response index(SIRI),platelet-to-lymphocyte ratio(PLR),and SIRI-PLR can be obtained from routine blood tests.Compared with existing prognostic indicators,which are expensive and rely on complex analyses,SIRI-PLR offers extremely high convenience and cost-effectiveness.AIM To explore the impact of SIRI-PLR on the prognosis of patients with stage I–III GC after surgery and construct a nomogram.METHODS We retrospectively analyzed the clinical and pathological data of patients with GC who underwent radical surgery at The First Affiliated Hospital of Anhui Medical University between January 2014 and December 2017.A total of 1071 patients with clear clinical prognoses were selected.Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors associated with overall survival in patients with GC,and a nomogram prediction model was constructed.RESULTS Multivariate Cox regression analysis revealed that age,tumor size,T stage,N stage,SIRI-PLR,and carcinoembryonic antigen were independent prognostic factors.The areas under the curve of the nomogram for training and validation sets were 0.821 and 0.848,respectively.Calibration plots and decision curve analyses demonstrated that the nomogram exhibited good predictive performance and clinical utility in training and validation cohorts.CONCLUSION Preoperative SIRI-PLR was significantly associated with the prognosis of patients with stage I–III GC following radical gastrectomy.Our nomogram could serve as an essential tool for clinicians to predict the postoperative prognosis of patients with stage I–III GC.展开更多
Objective Venous thromboembolism is a highly prevalent condition after polytrauma,and recognized as an important factor contributing to poor prognosis.The aim of this study was to investigate the risk factors for lowe...Objective Venous thromboembolism is a highly prevalent condition after polytrauma,and recognized as an important factor contributing to poor prognosis.The aim of this study was to investigate the risk factors for lower extremity deep venous thrombosis(LEDVT)in a severely traumatized population and to evaluate their predictive value for LEDVT.Methods This was a retrospective,single-center observational study.All subjects were severely traumatized patients who were admitted to the Traumatic Intensive Care Unit from January 2021 to May 2024.Based on Doppler ultrasound findings of both lower extremities from the time of injury to 30 days post-injury,patients who developed LEDVT were enrolled in the LEDVT group,and those who did not develop LEDVT were enrolled in the NLEDVT group.Demographic,clinical,and laboratory data were collected upon admission.Multivariable logistic regression analysis was performed to identify risk factors for LEDVT.Receiver operating characteristic(ROC)curve was used to evaluate the overall fit of the final model.Results There were 56 patients enrolled in the LEDVT group and 81 patients in the NLEDVT group.Age,Aggregate Index of Systemic Inflammation(AISI),Systemic Inflammation Response Index(SIRI),ICU length of stay,and albumin were identified as independent risk factors for LEDVT(all P<0.05).The area under their ROC curves were 0.604,0.657,0.694,0.668,and 0.405,respectively.Combined model for early clinical prediction of LEDVT in severely traumatized patients by age,SIRI,AISI,and albumin resulted in an area under the ROC curve of 0.805(95%CI:0.73-0.88,SE=0.037).Conclusion The combination of age,SIRI,AISI,and albumin has a predictive value for LEDVT in severely traumatized patients.展开更多
The natural history of cirrhosis can be divided into an initial stage, known as compensated cirrhosis, and an advanced stage which encompasses both decompensated cirrhosis and acute-on-chronic liver failure(ACLF). The...The natural history of cirrhosis can be divided into an initial stage, known as compensated cirrhosis, and an advanced stage which encompasses both decompensated cirrhosis and acute-on-chronic liver failure(ACLF). The latter syndrome has been recently described as an acute deterioration of liver function in patients with cirrhosis, which is usually triggered by a precipitating event and results in the failure of one or more organs and high short-term mortality rates. Each stage is characterized by distinctive clinical manifestations and prognoses. One of the key elements involved in cirrhosis physiopathology is systemic inflammation, recently described as one of the components in the cirrhosis-associated immune dysfunction syndrome. This syndrome refers to the combination of immune deficiency and exacerbated inflammation that coexist during the course of cirrhosis and relates to the appearance of clinical complications. Since systemic inflammation is often difficult to assess in cirrhosis patients, new objective, reproducible and readily-available markers are needed in order to optimize prognosis and lengthen survival. Thus, surrogate serum markers and clinical parameters of systemic inflammation have been sought to improve disease follow-up and management, especially in decompensated cirrhosis and ACLF. Leukocyte counts(evaluated as total leukocytes, total eosinophils or neutrophil:lymphocyte ratio) and plasma levels of procalcitonin or C-reactive protein have been proposed as prognostic markers, each with advantages and shortcomings. Research and prospective randomized studies that validate these and other markers are clearly warranted.展开更多
Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal...Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes.展开更多
Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and cancers.While it is known that chromium accumulation in the liver ...Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and cancers.While it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly understood.To address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic inflammation.Platelet(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic inflammation.In the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,respectively.Furthermore,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,respectively.In addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or ALT.These findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.展开更多
Objective:To evaluate the effect of the modified systemic inflammation score(mSIS)on prognosis in patients diagnosed with COVID-19.Methods:In this retrospective cross-sectional study,181 patients were selected and div...Objective:To evaluate the effect of the modified systemic inflammation score(mSIS)on prognosis in patients diagnosed with COVID-19.Methods:In this retrospective cross-sectional study,181 patients were selected and divided into two groups:patients with and without admission to the intensive care unit(ICU).An albumin level of≥4.0 g/dL and lymphocyte-to-monocyte ratio(LMR)of≥3.4 was scored 0,an albumin level of<4.0 g/dL or LMR of<3.4 was scored 1,and an albumin level of<4.0 g/dL and LMR of<3.4 was scored 2.Results:A total of 242 COVID-19 positive patients were initially included in this study.Of these patients,61 were excluded and 181 patients remained.Among the 181 participants,94(51.9%)were female,and the median age was 61(51,75)years.The mSIS scale ranged from 0 to 2.After analysis,the median score was 0(0,0)in the non-ICU group and 2(0,2)in the ICU group(P<0.001).The median white blood cell,lymphocyte counts,and albumin levels were lower in the ICU group(P<0.001,P<0.001,and P<0.001,respectively).In logistic regression analysis lymphocytopenia(OR=5.158,95%CI=1.249-21.304,P=0.023),hypoalbuminemia(OR=49.921,95%CI=1.843-1352.114,P=0.020),AST elevation(OR=3.939,95%CI=1.017-15.261,P=0.047),and mSIS=2(OR=5.853,95%CI=1.338-25.604,P=0.019)were identified as independent predictors of ICU admission.Conclusion:The mSIS can be used as an independent parameter for establishing the intensive care needs of patients with COVID-19.展开更多
Serum markers of systemic inflammation （SAA （serum amyloid protein A）, CRP （C-reactive protein）, cq-AT （ct l-antitripsin）, Hp （haptoglobin） and F （fibrinogen）） have been studied in 317 patients with pulmon...Serum markers of systemic inflammation （SAA （serum amyloid protein A）, CRP （C-reactive protein）, cq-AT （ct l-antitripsin）, Hp （haptoglobin） and F （fibrinogen）） have been studied in 317 patients with pulmonary tuberculosis. It was established that sensitivity of SAA as an activity marker was higher than of other acute phase reactants, because its levels were increased in 98.8% patients, whereas the level of CRP exceeded the norm in 80.8%, α1-AT--in 59.3%, Hp----in 43.5% and F--in 63.1% cases. The degree of increase of acute phase reactants directly related to the expressiveness of tuberculosis intoxication, the extent of the process in the lung and the quantity of MTB （M. tuberculosis） in sputum. We concluded that SAA was a useful marker of the process activity in patients with pulmonary tuberculosis and its sensitivity was higher than that of other acute phase reactants.展开更多
Objective: To research the effectiveness of ulinastatin in combination with continuous renal replacement therapy in treating sepsis acute kidney injury and its effect on systemic inflammation, immune function and miRA...Objective: To research the effectiveness of ulinastatin in combination with continuous renal replacement therapy in treating sepsis acute kidney injury and its effect on systemic inflammation, immune function and miRAN expression. Methods: The 84 patients who were diagnosed with sepsis complicated by acute kidney injury in our hospital between May 2020 and June 2022 were chosen and randomly assigned to the study group (n = 42) and the control group (n = 42). Ulinastatin in combination with continuous renal replacement therapy was administered to the study group, whereas the control group was administered with continuous renal replacement therapy alone. Both groups’ clinical effects were observed. The levels of blood urea nitrogen (BUN), serum creatinine (SCr), tumor necrosis factor-α (TNF-α), high sensitivity Creactive protein (hs-CRP), vascular cell adhesion molecule-1 (VCAM-1), IgG, IgA, IgM, expression levels of miR-233 and miR-10a were compared among both the groups, pre-, and post-treatment. Results: The study group’s overall effectiveness rate was higher that is 95.24%, in comparison to the control group’s 78.57%, and this difference was statistically significant (P α, hs-CRP, VCAM-1, and miR-233 and miR-10a expression levels in both the study and control groups were decreased, however, the study group had reduced levels in comparison to the control group, with statistically significant differences (P P Conclusion: Ulinastatin in combination with continuous renal replacement therapy for treating sepsis acute kidney injury exhibits a positive effect and can significantly improve the systemic inflammation and immune function in patients.展开更多
Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(S...Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI),novel indices,reflect the body’s chronic immune-inflammatory state.This study aimed to investigate the associations between the SII or SIRI and GDM.Methods:A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020,recruiting participants in their first trimester of pregnancy.Baseline SII and SIRI values were derived from routine clinical blood results,calculated as follows:SII=neutrophil(Neut)count×platelet(PLT)count/lymphocyte(Lymph)count,SIRI=Neut count×monocyte(Mono)count/Lymph count,with participants being grouped by quartiles of their SII or SIRI values.Participants were followed up for GDM with a 75-g,2-h oral glucose tolerance test(OGTT)at 24-28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups(IADPSG).Logistic regression was used to analyze the odds ratios(ORs)(95%confidence intervals[CIs])for the the associations between SII,SIRI,and the risk of GDM.Results:Among the 28,124 women included in the study,the average age was 31.8±3.8 years,and 15.76%(4432/28,124)developed GDM.Higher SII and SIRI quartiles were correlated with increased GDM rates,with rates ranging from 12.26%(862/7031)in the lowest quartile to 20.10%(1413/7031)in the highest quartile for the SII(P_(trend)<0.001)and 11.92-19.31%for the SIRI(P_(trend)<0.001).The ORs(95%CIs)of the second,third,and fourth SII quartiles were 1.09(0.98-1.21),1.21(1.09-1.34),and 1.39(1.26-1.54),respectively.The SIRI findings paralleled the SII outcomes.For the second through fourth quartiles,the ORs(95%CIs)were 1.24(1.12-1.38),1.41(1.27-1.57),and 1.64(1.48-1.82),respectively.These associations were maintained in subgroup and sensitivity analyses.Conclusion:The SII and SIRI are potential independent risk factors contributing to the onset of GDM.展开更多
Both overall and abdominal obesity are well-established risk factors for various cancer types,including colorectal cancer(CRC)[1].However,how adiposity impacts CRC development has been insufficiently investigated.Thre...Both overall and abdominal obesity are well-established risk factors for various cancer types,including colorectal cancer(CRC)[1].However,how adiposity impacts CRC development has been insufficiently investigated.Three primary hypotheses have been suggested to elucidate the biological pathways that link adiposity and CRC:alterations in insulin signaling,dysregulation of adipose tissue-derived inflammation,and sex hormone metabolism[2,3].展开更多
Purpose Systemic inflammation has been increasingly implicated in the pathogenesis of polycystic ovary syndrome(PCOS),but the causal nature and direction of this relationship remain uncertain.This study aimed to evalu...Purpose Systemic inflammation has been increasingly implicated in the pathogenesis of polycystic ovary syndrome(PCOS),but the causal nature and direction of this relationship remain uncertain.This study aimed to evaluate the potential causal associations between circulating inflammatory cytokines and the risk of PCOS using a Mendelian randomisation(MR)approach.Methods We conducted a two-sample MR analysis using summary-level data from large-scale genome-wide association studies involving 91 systemic inflammatory markers(n=14824)and PCOS(10074 cases and 103164 controls)among individuals of European ancestry.Genetic variants associated with cytokines at genome-wide significance(p<5×10^(-8))were selected as instrumental variables.The inverse-variance weighted method was used as the primary analytical strategy,supplemented by sensitivity analyses and correction for multiple testing.Results Genetically predicted higher circulating levels of C-X-C motif chemokine ligand 11(CXCL11)were significantly associated with a reduced risk of PCOS(OR=0.740,95%CI 0.625 to 0.871,p<0.001),and this association remained statistically significant after multiple testing correction(adjusted p=0.030).Nominal associations with decreased PCOS risk were also observed for interleukin-13(IL-13),IL-10 and adenosine deaminase(ADA),but these did not withstand correction for multiple comparisons.No evidence of horizontal pleiotropy was detected,and leave-one-out sensitivity analyses supported the robustness of the findings.Conclusion These results support a potential causal role of systemic inflammation in the development of PCOS,with CXCL11 emerging as a promising inflammatory marker and potential therapeutic target.Further studies are needed to validate these findings and explore their clinical relevance in PCOS management.展开更多
Background:Systemic inflammatory markers are associated with cardiovascular disease.This study aimed to assess the relationship between systemic inflammatory markers and abdominal aortic calcification(AAC).Methods:Dat...Background:Systemic inflammatory markers are associated with cardiovascular disease.This study aimed to assess the relationship between systemic inflammatory markers and abdominal aortic calcification(AAC).Methods:Data were collected from the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey(NHANES).AAC was quantified using the Kauppila scoring system,which is based on dual-energy X-ray absorptiometry.Severe abdominal aortic calcifi-cation(sAAC)was defined as a total AAC score≥6.Multivariate regression models were used to determine the relationships between sys-temic inflammation indicators,AAC scores,and sAAC.Results:Data from 3047 participants were analyzed.After adjusting for multiple covariates,AAC scores increased slightly for every one-unit increase in standardized systemic immune-inflammation index(SII;β=0.13;95%confidence interval[CI]:0.01–0.25,P=0.030).Neutrophil-to-lymphocyte ratio(NLR)was positively correlated with higher AAC scores(β=0.15;95%CI:0.06–0.24,P=0.001)and sAAC(odds ratio[OR]:1.10;95%CI:1.01–1.19,P=0.025).There was no significant correlation between platelet-to-lymphocyte ratio(PLR)and AAC scores(β=−0.0006;95%CI:−0.0018 to 0.0030).Conversely,lymphocyte-to-monocyte ratio(LMR)was positively associated with lower AAC scores(β=−0.14;95%CI:−0.22 to−0.05,P=0.001),with a 12%decrease in the odds of sAAC for every one-unit increase in LMR(OR:0.88;95%CI:0.79–0.97,P=0.013).Conclusion:Correlations between different systemic inflammation markers and AAC varied among the adult population of the United States.NLR was associated with higher AAC scores and an increased incidence of sAAC,whereas LMR had the opposite effect.NLR and LMR have emerged as potential biomarkers forAACrisk,highlighting theirimportance in understanding the inflammatory processes associated withAAC.展开更多
Atrial fibrillation(Afib)is a common arrhythmia with significant public health implications,affecting millions of individuals worldwide.Catheter ablation(CA)is an established treatment for drug-resistant Afib,yet recu...Atrial fibrillation(Afib)is a common arrhythmia with significant public health implications,affecting millions of individuals worldwide.Catheter ablation(CA)is an established treatment for drug-resistant Afib,yet recurrence remains a major concern,impacting quality of life in a significant portion of patients.Inflammation plays a critical role in the recurrence of Afib after ablation,with systemic inflammatory markers such as C-reactive protein being linked to higher recurrence rates.In this editorial,we discuss the study by Wang et al,published in the latest issue,which investigates the predictive role of the systemic immune inflammation index(SII)in Afib recurrence following radiofrequency CA.Elevated pre-ablation SII levels are identified as an independent predictor of recurrence,significantly enhancing the predictive power of the APPLE score.Integration of SII improved the APPLE score’s predictive performance,as shown by enhanced area under the curve,net reclassification improvement,and integrated discrimination improvement.This combined model highlights the importance of both structural and inflammatory factors in Afib recurrence,offering a more personalized approach to patient management.Additionally,the affordability and accessibility of SII enhance its practicality in clinical workflows.The study by Wang et al underscores the potential of integrating SII with existing scoring systems to refine risk stratification and optimize treatment strategies.Future research should validate these findings across diverse populations,explore limitations such as the potential influence of comorbidities on SII reliability,and investigate additional biomarkers to enhance predictive accuracy.展开更多
The recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly elucidated.There are many factors associat...The recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly elucidated.There are many factors associated with AF recurrence,such as duration of AF,male sex,concomitant heart failure,hemodynamic parameters,chronic obstructive pulmonary disease,hypertension,obstructive sleep apnea,hyperthyroidism,smoking and obesity.However,the inflammatory changes are strongly associated with electrical and structural cardiac remodeling,cardiac damage,myocardial fibrotic changes,microvascular dysfunction and altered reparative response.In this context,biomarkers reflecting the different stages of AF pathogenesis deserve thorough investigation.The authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation(SII)index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the APPLE.Furthermore,the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment approach.In conclusion,the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.展开更多
Atrial fibrillation(AF)is the most common arrhythmia in humans,affecting more than 40 million people worldwide.Radiofrequency catheter ablation(RFCA)was first introduced as a treatment for AF by Haïssaguerre M in...Atrial fibrillation(AF)is the most common arrhythmia in humans,affecting more than 40 million people worldwide.Radiofrequency catheter ablation(RFCA)was first introduced as a treatment for AF by Haïssaguerre M in the late 1990s.This procedure quickly became the treatment of choice,especially for symptomatic patients with AF refractory to medication.However,up to 45%of patients may experience AF recurrence within 12 months after RFCA.In this setting,AF recurrence is likely multifactorial,including atrial remodeling,local fibrosis or incomplete ablation due to failure in locating the trigger.Additionally,patients with obesity,sleep apnea,hypertension,or diabetes are at an increased risk of AF recurrence after RFCA.Inflammation is increasingly recognized as a potential key factor in AF recurrence and may arise both from the healing response of heart tissue post-ablation or from chronic low-grade inflammation,as observed in many risk factors.Here,we present an original study by Wang et al,which investigated the combination of the systemic immune-inflammation index-a marker developed to assess overall inflammatory status-and the APPLE score,designed to predict AF recurrence following RFCA.The study found that using both indicators together improved the accuracy of AF recurrence prediction.These findings underscore the significant role of inflammation in cardiovascular disease and demonstrated its impact on AF recurrence after RFCA.Further research is warranted to validate the combined use of these two scores in clinical settings for predicting AF recurrence following catheter ablation.展开更多
BACKGROUND Systemic immune-inflammation index(SII)combined with serum lactoferrin(LF)level can provide a reference for predicting the postoperative survival and prognosis of older patients with colon cancer.AIM To eva...BACKGROUND Systemic immune-inflammation index(SII)combined with serum lactoferrin(LF)level can provide a reference for predicting the postoperative survival and prognosis of older patients with colon cancer.AIM To evaluate the predictive value of SII combined with serum LF for postoperative survival in older patients with colon cancer.METHODS This prospective study included 62 older patients[range,65-85 years;average age(72.46±6.02)years]with colon cancer who underwent radical surgery at our hospital between January 2023 and September 2024.Colon cancer was confirmed on postoperative pathology.All patients underwent peripheral blood,LF,and tumor marker tests and imaging examinations preoperatively.The ability to predict overall survival(OS)and disease-free survival(DFS)by dynamically monitoring the SII[platelet(PLT)count×neutrophil(NEU)count/lymphocyte(LYM)count]and LF levels in combination with postoperative follow-up data was assessed.SII,LF levels,and postoperative data were analyzed using receiver operating characteristic curves,univariate,and multivariate Cox regression analyses to assess OS and DFS.RESULTS All patients were followed up conventionally postoperatively.There were no significant differences in the patients’baseline data.From 3 months preoperatively until after surgery,the values of routine blood indices(NEUs,LYMs,and PLTs)and SII tended to decrease,but the difference was not statistically significant.The LF level gradually decreased,and there were significant differences at 1 week,1 month and 3 months postoperatively(P<0.05).Liver and kidney functions significantly increased 1 week postoperatively and gradually recovered(P<0.05).The C-reactive protein level significantly increased 1 week postoperatively,whereas the prealbumin level significantly decreased then recovered 3 months postoperatively(P<0.05).The levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)significantly increased 6 months postoperatively,suggesting an increased risk of recurrence(P<0.05).Both the OS and DFS showed significant changes over time.Preoperative SII and LF levels had significant predictive values for OS and DFS.In logistics regression analysis,a SII of 585 or greater and LF level less than 185 ng/mL(determined by maximizing the Youden index)correlated with postoperative survival(P<0.05).Further Cox regression analysis showed that the SII and LF,CA19-9,and CEA levels were independent predictors of postoperative OS(P<0.05),whereas the tumor,node,metastasis stage;LF level;and SII were independent predictors of DFS.CONCLUSION This preliminary analysis suggests that the SII and LF levels may predict the survival and prognosis of older patients with colon cancer postoperatively,when assessing the risk of postoperative recurrence and complications.These two categories of indicators have good prognostic evaluation potential in clinical practice and can provide strong support for the development of individualized treatment strategies.展开更多
Obstructive sleep apnea syndrome （OSAS） and hypertension commonly coexist. Clinical studies indicate that OSAS plays a key role in increasing the risk of prevalent hypertension. Chronic intermittent hypoxia （CIH） ...Obstructive sleep apnea syndrome （OSAS） and hypertension commonly coexist. Clinical studies indicate that OSAS plays a key role in increasing the risk of prevalent hypertension. Chronic intermittent hypoxia （CIH） is the core pathological mechanism of OSAS, and has a close relationship with systemic inflammation. Growing evidence shows that CIH and hypertension are strongly related, involving markers or pathways indicative of systemic inflammation, such as high-sensitivity C-reactive protein （hs-CRP）, interteukin-6, nuclear factor-kappa B, tumor necrosis factor-α, interleukin-8 and p38 mitogen-activated protein kinase （MAPK）dependent pathways. Oxidative stress also plays an important role in this process, including in the activation of polymorphonuclear neutrophils. However, the pathophysiological and clinical significance of systemic inflammation in CIH and hypertension is not proven. This review article highlights the relationship between CIH and hypertension through systemic inflammation and the current interventions available in Chinese medicine, to offer a background for the future treatment of OSAS-related hypertension with integrative medicine.展开更多
The objectives of this study were to determine the effects of dietary supplementation with citrus flavonoid extracts(CFE)on milk performance,serum biochemistry parameters,fecal volatile fatty acids,fecal microbial com...The objectives of this study were to determine the effects of dietary supplementation with citrus flavonoid extracts(CFE)on milk performance,serum biochemistry parameters,fecal volatile fatty acids,fecal microbial community,and fecal metabolites in dairy cows.Eight multiparous lactating Holstein cows were used in a replicated 4×4 Latin square design(21-day period).Cows were fed a basal diet without addition(CON)or basal diet with added CFE at 50(CFE50),100(CFE10),and 150 g/d(CFE150).Feeding CFE up to 150 g/d increased milk yield and milk lactose percentage.Supplementary CFE linearly decreased milk somatic cell count.Serum cytokines interleukin-1β(IL-1β),IL-2,IL-6,and tumor necrosis factor-α(TNF-α)concentrations decreased linearly as the levels of CFE increased.Cows in CFE150 had lower serum lipopolysaccharide and lipopolysaccharide binding protein compared with CON.These results indicate feeding CFE decreased systemic inflammation and endotoxin levels in dairy cows.Furthermore,feeding CFE linearly increased the concentrations of total volatile fatty acids,acetate,and butyrate in feces.The relative abundances of beneficial bacteria Bifidobacterium spp.,Clostridium coccoides-Eubacterium rectale group,and Faecalibacterium prausnitzii in feces increased linearly with increasing CFE supplementation.The diversity and community structure of fecal microbiota were un-affected by CFE supplementation.However,supplementing CFE reduced the relative abundances of genera Ruminococcus_torques_group,Roseburia,and Lachnospira,but increased genera Bacteroides and Phascolarctobacterium.Metabolomics analysis showed that supplementary CFE resulted in a significant modification in the fecal metabolites profile.Compared with CON,fecal naringenin,hesperetin,hippuric acid,and sphingosine concentrations were greater in CFE150 cows,while fecal GlcCer(d18:1/20:0),Cer(d18:0/24:0),Cer(d18:0/22:0),sphinganine,and deoxycholic acid concentrations were less in CFE150 cows.Predicted pathway analysis suggested that"sphingolipid metabolism"was significantly enriched.Overall,these results indicate that citrus flavonoids could exert health-promoting effects by modulating hindgut microbiome and metabolism in lactating cows.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFC3702704)the National Natural Science Foundation of China(Nos.22376005,22076006 and 82073506).
文摘Microorganisms constitute an essential component in the indoor environment,which is closely related to hu-man health.However,there is limited evidence regarding the associations between indoor airborne microbiome and systemic inflammation,as well as whether this association is modified by indoor particulate matter and the underlying mechanisms.In this prospective repeated-measure study among 66 participants,indoor airborne mi-crobiome was characterized using amplicon sequencing and qPCR.Indoor fine particulate matter(PM_(2.5))and inhalable particulate matter(PM10)were measured.Systemic inflammatory biomarkers were assessed,including white blood cell(WBC),neutrophil(NEUT),monocyte,eosinophil counts,and their proportions.Targeted serum amino acid metabolomics were conducted to explore the underlying mechanisms.Linear mixed-effect models re-vealed that bacterial and fungal Simpson diversity were significantly associated with decreased WBC and NEUT.For example,for each interquartile range increase in the bacterial Simpson diversity,WBC and NEUT changed by-4.53%(95%CI:-8.25%,-0.66%)and-5.95%(95%CI:-11.3%,-0.27%),respectively.Notably,increased inflammatory risks of airborne microbial exposure were observed when indoor PM_(2.5) and PM10 levels were below the WHO air quality guidelines.Mediation analyses indicated that dopamine metabolism partially mediated the anti-inflammatory effects of fungal diversity exposure.Overall,our study indicated protection from a diverse indoor microbial environment on cardiovascular health and proposed an underlying mechanism through amino acid metabolism.Additionally,health risks associated with microbial exposure deserve more attention in con-texts of low indoor particulate matter pollution.Further research is necessary to fully disentangle the complex relationships between indoor microbiome,air pollutants,and human health.
文摘Prostate cancer is a significant global health issue with inflammation emerging as a critical driver of progression.The prostate tumor microenvironment(TME)is comprised of tumor cells,mesenchymal stem cells,immune cells,cancer-associated fibroblasts,adipocytes,and the extracellular matrix.All of these TME components interact via soluble factors,such as growth factors,cytokines,and chemokines.These interactions remodel the TME and drive inflammation and tumor progression.Prolonged inflammation leads to dysregulated activation and infiltration of immune cells in the TME.This process maintains an immunosuppressive environment and facilitates epithelial-to-mesenchymal transition,migration,and invasion.Chronic inflammation causes inflammatory mediators to enter the circulation over time,as evidenced by systemic biomarkers,such as the systemic immune-inflammation index,which links inflammation to disease severity.Interactions between the prostate gland and adipose tissues further exacerbate systemic inflammation.Inflammation in the prostate gland confers resistance to therapy,primes distant metastatic niches,and promotes metastatic spread,resulting in poor clinical outcomes.Therapeutic strategies,such as anti-inflammatory agents and immunotherapies,hold promise in mitigating disease burden.This review explored the immune landscape of systemic inflammation in prostate cancer,discussed the role of the immune landscape in resistance to therapy and metastasis,and offered insights into potential interventions for targeting inflammation to limit prostate cancer burden.
基金Supported by Key Projects of Anhui Provincial Department of Education,No.2023AH053330.
文摘BACKGROUND Gastric cancer(GC)has a relatively high incidence and mortality rate.Surgery is the primary treatment;however,the survival rate of patients remains low.Therefore,there is an urgent need to identify simple and feasible prognostic indicators for GC.As an inflammation-related biomarker,the systemic inflammation response index(SIRI),platelet-to-lymphocyte ratio(PLR),and SIRI-PLR can be obtained from routine blood tests.Compared with existing prognostic indicators,which are expensive and rely on complex analyses,SIRI-PLR offers extremely high convenience and cost-effectiveness.AIM To explore the impact of SIRI-PLR on the prognosis of patients with stage I–III GC after surgery and construct a nomogram.METHODS We retrospectively analyzed the clinical and pathological data of patients with GC who underwent radical surgery at The First Affiliated Hospital of Anhui Medical University between January 2014 and December 2017.A total of 1071 patients with clear clinical prognoses were selected.Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors associated with overall survival in patients with GC,and a nomogram prediction model was constructed.RESULTS Multivariate Cox regression analysis revealed that age,tumor size,T stage,N stage,SIRI-PLR,and carcinoembryonic antigen were independent prognostic factors.The areas under the curve of the nomogram for training and validation sets were 0.821 and 0.848,respectively.Calibration plots and decision curve analyses demonstrated that the nomogram exhibited good predictive performance and clinical utility in training and validation cohorts.CONCLUSION Preoperative SIRI-PLR was significantly associated with the prognosis of patients with stage I–III GC following radical gastrectomy.Our nomogram could serve as an essential tool for clinicians to predict the postoperative prognosis of patients with stage I–III GC.
基金Basic Research Spe-cial Project of Suzhou Science and Technology Bureau(SSD2024050).
文摘Objective Venous thromboembolism is a highly prevalent condition after polytrauma,and recognized as an important factor contributing to poor prognosis.The aim of this study was to investigate the risk factors for lower extremity deep venous thrombosis(LEDVT)in a severely traumatized population and to evaluate their predictive value for LEDVT.Methods This was a retrospective,single-center observational study.All subjects were severely traumatized patients who were admitted to the Traumatic Intensive Care Unit from January 2021 to May 2024.Based on Doppler ultrasound findings of both lower extremities from the time of injury to 30 days post-injury,patients who developed LEDVT were enrolled in the LEDVT group,and those who did not develop LEDVT were enrolled in the NLEDVT group.Demographic,clinical,and laboratory data were collected upon admission.Multivariable logistic regression analysis was performed to identify risk factors for LEDVT.Receiver operating characteristic(ROC)curve was used to evaluate the overall fit of the final model.Results There were 56 patients enrolled in the LEDVT group and 81 patients in the NLEDVT group.Age,Aggregate Index of Systemic Inflammation(AISI),Systemic Inflammation Response Index(SIRI),ICU length of stay,and albumin were identified as independent risk factors for LEDVT(all P<0.05).The area under their ROC curves were 0.604,0.657,0.694,0.668,and 0.405,respectively.Combined model for early clinical prediction of LEDVT in severely traumatized patients by age,SIRI,AISI,and albumin resulted in an area under the ROC curve of 0.805(95%CI:0.73-0.88,SE=0.037).Conclusion The combination of age,SIRI,AISI,and albumin has a predictive value for LEDVT in severely traumatized patients.
文摘The natural history of cirrhosis can be divided into an initial stage, known as compensated cirrhosis, and an advanced stage which encompasses both decompensated cirrhosis and acute-on-chronic liver failure(ACLF). The latter syndrome has been recently described as an acute deterioration of liver function in patients with cirrhosis, which is usually triggered by a precipitating event and results in the failure of one or more organs and high short-term mortality rates. Each stage is characterized by distinctive clinical manifestations and prognoses. One of the key elements involved in cirrhosis physiopathology is systemic inflammation, recently described as one of the components in the cirrhosis-associated immune dysfunction syndrome. This syndrome refers to the combination of immune deficiency and exacerbated inflammation that coexist during the course of cirrhosis and relates to the appearance of clinical complications. Since systemic inflammation is often difficult to assess in cirrhosis patients, new objective, reproducible and readily-available markers are needed in order to optimize prognosis and lengthen survival. Thus, surrogate serum markers and clinical parameters of systemic inflammation have been sought to improve disease follow-up and management, especially in decompensated cirrhosis and ACLF. Leukocyte counts(evaluated as total leukocytes, total eosinophils or neutrophil:lymphocyte ratio) and plasma levels of procalcitonin or C-reactive protein have been proposed as prognostic markers, each with advantages and shortcomings. Research and prospective randomized studies that validate these and other markers are clearly warranted.
基金supported by the National Major Research and the Innovation Program of China(Grant No.2016YFC1303200)the National Key R&D Program of China(Grant No.2017YFC0908300)the National Natural Science Foundation of China(Grant No.81972761)。
文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes.
基金supported by the National Natural Science Foundation of China(Nos.82273603,82003427,U2004202)。
文摘Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and cancers.While it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly understood.To address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic inflammation.Platelet(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic inflammation.In the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,respectively.Furthermore,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,respectively.In addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or ALT.These findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.
文摘Objective:To evaluate the effect of the modified systemic inflammation score(mSIS)on prognosis in patients diagnosed with COVID-19.Methods:In this retrospective cross-sectional study,181 patients were selected and divided into two groups:patients with and without admission to the intensive care unit(ICU).An albumin level of≥4.0 g/dL and lymphocyte-to-monocyte ratio(LMR)of≥3.4 was scored 0,an albumin level of<4.0 g/dL or LMR of<3.4 was scored 1,and an albumin level of<4.0 g/dL and LMR of<3.4 was scored 2.Results:A total of 242 COVID-19 positive patients were initially included in this study.Of these patients,61 were excluded and 181 patients remained.Among the 181 participants,94(51.9%)were female,and the median age was 61(51,75)years.The mSIS scale ranged from 0 to 2.After analysis,the median score was 0(0,0)in the non-ICU group and 2(0,2)in the ICU group(P<0.001).The median white blood cell,lymphocyte counts,and albumin levels were lower in the ICU group(P<0.001,P<0.001,and P<0.001,respectively).In logistic regression analysis lymphocytopenia(OR=5.158,95%CI=1.249-21.304,P=0.023),hypoalbuminemia(OR=49.921,95%CI=1.843-1352.114,P=0.020),AST elevation(OR=3.939,95%CI=1.017-15.261,P=0.047),and mSIS=2(OR=5.853,95%CI=1.338-25.604,P=0.019)were identified as independent predictors of ICU admission.Conclusion:The mSIS can be used as an independent parameter for establishing the intensive care needs of patients with COVID-19.
文摘Serum markers of systemic inflammation （SAA （serum amyloid protein A）, CRP （C-reactive protein）, cq-AT （ct l-antitripsin）, Hp （haptoglobin） and F （fibrinogen）） have been studied in 317 patients with pulmonary tuberculosis. It was established that sensitivity of SAA as an activity marker was higher than of other acute phase reactants, because its levels were increased in 98.8% patients, whereas the level of CRP exceeded the norm in 80.8%, α1-AT--in 59.3%, Hp----in 43.5% and F--in 63.1% cases. The degree of increase of acute phase reactants directly related to the expressiveness of tuberculosis intoxication, the extent of the process in the lung and the quantity of MTB （M. tuberculosis） in sputum. We concluded that SAA was a useful marker of the process activity in patients with pulmonary tuberculosis and its sensitivity was higher than that of other acute phase reactants.
文摘Objective: To research the effectiveness of ulinastatin in combination with continuous renal replacement therapy in treating sepsis acute kidney injury and its effect on systemic inflammation, immune function and miRAN expression. Methods: The 84 patients who were diagnosed with sepsis complicated by acute kidney injury in our hospital between May 2020 and June 2022 were chosen and randomly assigned to the study group (n = 42) and the control group (n = 42). Ulinastatin in combination with continuous renal replacement therapy was administered to the study group, whereas the control group was administered with continuous renal replacement therapy alone. Both groups’ clinical effects were observed. The levels of blood urea nitrogen (BUN), serum creatinine (SCr), tumor necrosis factor-α (TNF-α), high sensitivity Creactive protein (hs-CRP), vascular cell adhesion molecule-1 (VCAM-1), IgG, IgA, IgM, expression levels of miR-233 and miR-10a were compared among both the groups, pre-, and post-treatment. Results: The study group’s overall effectiveness rate was higher that is 95.24%, in comparison to the control group’s 78.57%, and this difference was statistically significant (P α, hs-CRP, VCAM-1, and miR-233 and miR-10a expression levels in both the study and control groups were decreased, however, the study group had reduced levels in comparison to the control group, with statistically significant differences (P P Conclusion: Ulinastatin in combination with continuous renal replacement therapy for treating sepsis acute kidney injury exhibits a positive effect and can significantly improve the systemic inflammation and immune function in patients.
基金supported by the Capital’s Funds for Health Improvement and Research(No.2024-2G-2118)the National Key Research and Development Program of China(No.2016YFC1000100)+2 种基金the Leading Talents in the Construction Project of High Level Public Health Technical Talents in Beijing(No.20221003)the“Green Seedling”Youth Program by the Beijing Hospitals Authority(No.QML20231402)the Young Elite Scientist Sponsorship Program by the Beijing Association for Science and Technology(No.BYESS2022200).
文摘Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI),novel indices,reflect the body’s chronic immune-inflammatory state.This study aimed to investigate the associations between the SII or SIRI and GDM.Methods:A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020,recruiting participants in their first trimester of pregnancy.Baseline SII and SIRI values were derived from routine clinical blood results,calculated as follows:SII=neutrophil(Neut)count×platelet(PLT)count/lymphocyte(Lymph)count,SIRI=Neut count×monocyte(Mono)count/Lymph count,with participants being grouped by quartiles of their SII or SIRI values.Participants were followed up for GDM with a 75-g,2-h oral glucose tolerance test(OGTT)at 24-28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups(IADPSG).Logistic regression was used to analyze the odds ratios(ORs)(95%confidence intervals[CIs])for the the associations between SII,SIRI,and the risk of GDM.Results:Among the 28,124 women included in the study,the average age was 31.8±3.8 years,and 15.76%(4432/28,124)developed GDM.Higher SII and SIRI quartiles were correlated with increased GDM rates,with rates ranging from 12.26%(862/7031)in the lowest quartile to 20.10%(1413/7031)in the highest quartile for the SII(P_(trend)<0.001)and 11.92-19.31%for the SIRI(P_(trend)<0.001).The ORs(95%CIs)of the second,third,and fourth SII quartiles were 1.09(0.98-1.21),1.21(1.09-1.34),and 1.39(1.26-1.54),respectively.The SIRI findings paralleled the SII outcomes.For the second through fourth quartiles,the ORs(95%CIs)were 1.24(1.12-1.38),1.41(1.27-1.57),and 1.64(1.48-1.82),respectively.These associations were maintained in subgroup and sensitivity analyses.Conclusion:The SII and SIRI are potential independent risk factors contributing to the onset of GDM.
基金funding from British Heart Foundation,Cancer Research UK,Diabetes UK,and National Institute for Health Research(NIHR)supported by the National Health Service(NHS).
文摘Both overall and abdominal obesity are well-established risk factors for various cancer types,including colorectal cancer(CRC)[1].However,how adiposity impacts CRC development has been insufficiently investigated.Three primary hypotheses have been suggested to elucidate the biological pathways that link adiposity and CRC:alterations in insulin signaling,dysregulation of adipose tissue-derived inflammation,and sex hormone metabolism[2,3].
基金supported by the Multidisciplinary Clinical Research Innovation Team Project of Beijing Chao-Yang Hospital(grant no.CYDXK202203)。
文摘Purpose Systemic inflammation has been increasingly implicated in the pathogenesis of polycystic ovary syndrome(PCOS),but the causal nature and direction of this relationship remain uncertain.This study aimed to evaluate the potential causal associations between circulating inflammatory cytokines and the risk of PCOS using a Mendelian randomisation(MR)approach.Methods We conducted a two-sample MR analysis using summary-level data from large-scale genome-wide association studies involving 91 systemic inflammatory markers(n=14824)and PCOS(10074 cases and 103164 controls)among individuals of European ancestry.Genetic variants associated with cytokines at genome-wide significance(p<5×10^(-8))were selected as instrumental variables.The inverse-variance weighted method was used as the primary analytical strategy,supplemented by sensitivity analyses and correction for multiple testing.Results Genetically predicted higher circulating levels of C-X-C motif chemokine ligand 11(CXCL11)were significantly associated with a reduced risk of PCOS(OR=0.740,95%CI 0.625 to 0.871,p<0.001),and this association remained statistically significant after multiple testing correction(adjusted p=0.030).Nominal associations with decreased PCOS risk were also observed for interleukin-13(IL-13),IL-10 and adenosine deaminase(ADA),but these did not withstand correction for multiple comparisons.No evidence of horizontal pleiotropy was detected,and leave-one-out sensitivity analyses supported the robustness of the findings.Conclusion These results support a potential causal role of systemic inflammation in the development of PCOS,with CXCL11 emerging as a promising inflammatory marker and potential therapeutic target.Further studies are needed to validate these findings and explore their clinical relevance in PCOS management.
基金supported by the Taishan Young Scholar Program of Shandong Province(grant number tsqn202306349)ECCM Program of Clinical Research Center of Shandong University(grant number 2021SDUCRCA001).
文摘Background:Systemic inflammatory markers are associated with cardiovascular disease.This study aimed to assess the relationship between systemic inflammatory markers and abdominal aortic calcification(AAC).Methods:Data were collected from the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey(NHANES).AAC was quantified using the Kauppila scoring system,which is based on dual-energy X-ray absorptiometry.Severe abdominal aortic calcifi-cation(sAAC)was defined as a total AAC score≥6.Multivariate regression models were used to determine the relationships between sys-temic inflammation indicators,AAC scores,and sAAC.Results:Data from 3047 participants were analyzed.After adjusting for multiple covariates,AAC scores increased slightly for every one-unit increase in standardized systemic immune-inflammation index(SII;β=0.13;95%confidence interval[CI]:0.01–0.25,P=0.030).Neutrophil-to-lymphocyte ratio(NLR)was positively correlated with higher AAC scores(β=0.15;95%CI:0.06–0.24,P=0.001)and sAAC(odds ratio[OR]:1.10;95%CI:1.01–1.19,P=0.025).There was no significant correlation between platelet-to-lymphocyte ratio(PLR)and AAC scores(β=−0.0006;95%CI:−0.0018 to 0.0030).Conversely,lymphocyte-to-monocyte ratio(LMR)was positively associated with lower AAC scores(β=−0.14;95%CI:−0.22 to−0.05,P=0.001),with a 12%decrease in the odds of sAAC for every one-unit increase in LMR(OR:0.88;95%CI:0.79–0.97,P=0.013).Conclusion:Correlations between different systemic inflammation markers and AAC varied among the adult population of the United States.NLR was associated with higher AAC scores and an increased incidence of sAAC,whereas LMR had the opposite effect.NLR and LMR have emerged as potential biomarkers forAACrisk,highlighting theirimportance in understanding the inflammatory processes associated withAAC.
文摘Atrial fibrillation(Afib)is a common arrhythmia with significant public health implications,affecting millions of individuals worldwide.Catheter ablation(CA)is an established treatment for drug-resistant Afib,yet recurrence remains a major concern,impacting quality of life in a significant portion of patients.Inflammation plays a critical role in the recurrence of Afib after ablation,with systemic inflammatory markers such as C-reactive protein being linked to higher recurrence rates.In this editorial,we discuss the study by Wang et al,published in the latest issue,which investigates the predictive role of the systemic immune inflammation index(SII)in Afib recurrence following radiofrequency CA.Elevated pre-ablation SII levels are identified as an independent predictor of recurrence,significantly enhancing the predictive power of the APPLE score.Integration of SII improved the APPLE score’s predictive performance,as shown by enhanced area under the curve,net reclassification improvement,and integrated discrimination improvement.This combined model highlights the importance of both structural and inflammatory factors in Afib recurrence,offering a more personalized approach to patient management.Additionally,the affordability and accessibility of SII enhance its practicality in clinical workflows.The study by Wang et al underscores the potential of integrating SII with existing scoring systems to refine risk stratification and optimize treatment strategies.Future research should validate these findings across diverse populations,explore limitations such as the potential influence of comorbidities on SII reliability,and investigate additional biomarkers to enhance predictive accuracy.
文摘The recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly elucidated.There are many factors associated with AF recurrence,such as duration of AF,male sex,concomitant heart failure,hemodynamic parameters,chronic obstructive pulmonary disease,hypertension,obstructive sleep apnea,hyperthyroidism,smoking and obesity.However,the inflammatory changes are strongly associated with electrical and structural cardiac remodeling,cardiac damage,myocardial fibrotic changes,microvascular dysfunction and altered reparative response.In this context,biomarkers reflecting the different stages of AF pathogenesis deserve thorough investigation.The authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation(SII)index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the APPLE.Furthermore,the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment approach.In conclusion,the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.
文摘Atrial fibrillation(AF)is the most common arrhythmia in humans,affecting more than 40 million people worldwide.Radiofrequency catheter ablation(RFCA)was first introduced as a treatment for AF by Haïssaguerre M in the late 1990s.This procedure quickly became the treatment of choice,especially for symptomatic patients with AF refractory to medication.However,up to 45%of patients may experience AF recurrence within 12 months after RFCA.In this setting,AF recurrence is likely multifactorial,including atrial remodeling,local fibrosis or incomplete ablation due to failure in locating the trigger.Additionally,patients with obesity,sleep apnea,hypertension,or diabetes are at an increased risk of AF recurrence after RFCA.Inflammation is increasingly recognized as a potential key factor in AF recurrence and may arise both from the healing response of heart tissue post-ablation or from chronic low-grade inflammation,as observed in many risk factors.Here,we present an original study by Wang et al,which investigated the combination of the systemic immune-inflammation index-a marker developed to assess overall inflammatory status-and the APPLE score,designed to predict AF recurrence following RFCA.The study found that using both indicators together improved the accuracy of AF recurrence prediction.These findings underscore the significant role of inflammation in cardiovascular disease and demonstrated its impact on AF recurrence after RFCA.Further research is warranted to validate the combined use of these two scores in clinical settings for predicting AF recurrence following catheter ablation.
基金Supported by Rugao Science and Technology Research and Development Program(Agriculture and Social Development)Project,No.SRGS(24)061.
文摘BACKGROUND Systemic immune-inflammation index(SII)combined with serum lactoferrin(LF)level can provide a reference for predicting the postoperative survival and prognosis of older patients with colon cancer.AIM To evaluate the predictive value of SII combined with serum LF for postoperative survival in older patients with colon cancer.METHODS This prospective study included 62 older patients[range,65-85 years;average age(72.46±6.02)years]with colon cancer who underwent radical surgery at our hospital between January 2023 and September 2024.Colon cancer was confirmed on postoperative pathology.All patients underwent peripheral blood,LF,and tumor marker tests and imaging examinations preoperatively.The ability to predict overall survival(OS)and disease-free survival(DFS)by dynamically monitoring the SII[platelet(PLT)count×neutrophil(NEU)count/lymphocyte(LYM)count]and LF levels in combination with postoperative follow-up data was assessed.SII,LF levels,and postoperative data were analyzed using receiver operating characteristic curves,univariate,and multivariate Cox regression analyses to assess OS and DFS.RESULTS All patients were followed up conventionally postoperatively.There were no significant differences in the patients’baseline data.From 3 months preoperatively until after surgery,the values of routine blood indices(NEUs,LYMs,and PLTs)and SII tended to decrease,but the difference was not statistically significant.The LF level gradually decreased,and there were significant differences at 1 week,1 month and 3 months postoperatively(P<0.05).Liver and kidney functions significantly increased 1 week postoperatively and gradually recovered(P<0.05).The C-reactive protein level significantly increased 1 week postoperatively,whereas the prealbumin level significantly decreased then recovered 3 months postoperatively(P<0.05).The levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)significantly increased 6 months postoperatively,suggesting an increased risk of recurrence(P<0.05).Both the OS and DFS showed significant changes over time.Preoperative SII and LF levels had significant predictive values for OS and DFS.In logistics regression analysis,a SII of 585 or greater and LF level less than 185 ng/mL(determined by maximizing the Youden index)correlated with postoperative survival(P<0.05).Further Cox regression analysis showed that the SII and LF,CA19-9,and CEA levels were independent predictors of postoperative OS(P<0.05),whereas the tumor,node,metastasis stage;LF level;and SII were independent predictors of DFS.CONCLUSION This preliminary analysis suggests that the SII and LF levels may predict the survival and prognosis of older patients with colon cancer postoperatively,when assessing the risk of postoperative recurrence and complications.These two categories of indicators have good prognostic evaluation potential in clinical practice and can provide strong support for the development of individualized treatment strategies.
基金Supported by the Special Research Foundation of National Clinical Research Facility of Traditional Chinese Medicine (No.JDZX2012108)China Postdoctoral Foundation(No. 200902187)+1 种基金Famous Doctor Inheritance Research Foundation of China Academy of Chinese Medical Sciences(CM20121018) "3+3" Famous Doctor Inheritance Program of Beijing Administration of Traditional Chinese Medicine
文摘Obstructive sleep apnea syndrome （OSAS） and hypertension commonly coexist. Clinical studies indicate that OSAS plays a key role in increasing the risk of prevalent hypertension. Chronic intermittent hypoxia （CIH） is the core pathological mechanism of OSAS, and has a close relationship with systemic inflammation. Growing evidence shows that CIH and hypertension are strongly related, involving markers or pathways indicative of systemic inflammation, such as high-sensitivity C-reactive protein （hs-CRP）, interteukin-6, nuclear factor-kappa B, tumor necrosis factor-α, interleukin-8 and p38 mitogen-activated protein kinase （MAPK）dependent pathways. Oxidative stress also plays an important role in this process, including in the activation of polymorphonuclear neutrophils. However, the pathophysiological and clinical significance of systemic inflammation in CIH and hypertension is not proven. This review article highlights the relationship between CIH and hypertension through systemic inflammation and the current interventions available in Chinese medicine, to offer a background for the future treatment of OSAS-related hypertension with integrative medicine.
基金funded by the Categorized Development Project 2022(Start-up Foundation for Talent Introduction,Beijing University of Agriculture5066516004/003)the China Postdoctoral Science Foundation(2022M710181).
文摘The objectives of this study were to determine the effects of dietary supplementation with citrus flavonoid extracts(CFE)on milk performance,serum biochemistry parameters,fecal volatile fatty acids,fecal microbial community,and fecal metabolites in dairy cows.Eight multiparous lactating Holstein cows were used in a replicated 4×4 Latin square design(21-day period).Cows were fed a basal diet without addition(CON)or basal diet with added CFE at 50(CFE50),100(CFE10),and 150 g/d(CFE150).Feeding CFE up to 150 g/d increased milk yield and milk lactose percentage.Supplementary CFE linearly decreased milk somatic cell count.Serum cytokines interleukin-1β(IL-1β),IL-2,IL-6,and tumor necrosis factor-α(TNF-α)concentrations decreased linearly as the levels of CFE increased.Cows in CFE150 had lower serum lipopolysaccharide and lipopolysaccharide binding protein compared with CON.These results indicate feeding CFE decreased systemic inflammation and endotoxin levels in dairy cows.Furthermore,feeding CFE linearly increased the concentrations of total volatile fatty acids,acetate,and butyrate in feces.The relative abundances of beneficial bacteria Bifidobacterium spp.,Clostridium coccoides-Eubacterium rectale group,and Faecalibacterium prausnitzii in feces increased linearly with increasing CFE supplementation.The diversity and community structure of fecal microbiota were un-affected by CFE supplementation.However,supplementing CFE reduced the relative abundances of genera Ruminococcus_torques_group,Roseburia,and Lachnospira,but increased genera Bacteroides and Phascolarctobacterium.Metabolomics analysis showed that supplementary CFE resulted in a significant modification in the fecal metabolites profile.Compared with CON,fecal naringenin,hesperetin,hippuric acid,and sphingosine concentrations were greater in CFE150 cows,while fecal GlcCer(d18:1/20:0),Cer(d18:0/24:0),Cer(d18:0/22:0),sphinganine,and deoxycholic acid concentrations were less in CFE150 cows.Predicted pathway analysis suggested that"sphingolipid metabolism"was significantly enriched.Overall,these results indicate that citrus flavonoids could exert health-promoting effects by modulating hindgut microbiome and metabolism in lactating cows.
