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Optimal Planning of Multiple PV-DG in Radial Distribution Systems Using Loss Sensitivity Analysis and Genetic Algorithm
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作者 A. Elkholy 《Journal of Power and Energy Engineering》 2025年第2期1-22,共22页
This paper introduces an optimized planning approach for integrating photovoltaic as distributed generation (PV-DG) into the radial distribution power systems, utilizing exhaustive load flow (ELF), loss sensitivity fa... This paper introduces an optimized planning approach for integrating photovoltaic as distributed generation (PV-DG) into the radial distribution power systems, utilizing exhaustive load flow (ELF), loss sensitivity factor (LSF), genetic algorithms (GA) methods, and numerical method based on LSF. The methodology aims to determine the optimal allocation and sizing of multiple PV-DG to minimize power loss through time series power flow analysis. An approach utilizing continuous sensitivity analysis is developed and inherently leverages power flow and loss equations to compute LSF of all buses in the system towards employing a dynamic PV-DG model for more accurate results. The algorithm uses a numerical grid search method to optimize PV-DG placement in a power distribution system, focusing on minimizing system losses. It combines iterative analysis, sensitivity assessment, and comprehensive visualization to identify and present the optimal PV-DG configurations. The present-ed algorithms are verified through co-simulation framework combining MATLAB and OpenDSS to carry out analysis for 12-bus radial distribution test system. The proposed numerical method is compared with other algorithms, such as ELF, LSF methods, and Genetic Algorithms (GA). Results show that the proposed numerical method performs well in comparison with LSF and ELF solutions. 展开更多
关键词 Photovoltaic systems Distributed Generation Multiple Allocation and Sizing Power Losses Radial Distribution system Genetic Algorithm
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Reinforcement Learning in Mechatronic Systems: A Case Study on DC Motor Control
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作者 Alexander Nüßgen Alexander Lerch +5 位作者 René Degen Marcus Irmer Martin de Fries Fabian Richter Cecilia Boström Margot Ruschitzka 《Circuits and Systems》 2025年第1期1-24,共24页
The integration of artificial intelligence into the development and production of mechatronic products offers a substantial opportunity to enhance efficiency, adaptability, and system performance. This paper examines ... The integration of artificial intelligence into the development and production of mechatronic products offers a substantial opportunity to enhance efficiency, adaptability, and system performance. This paper examines the utilization of reinforcement learning as a control strategy, with a particular focus on its deployment in pivotal stages of the product development lifecycle, specifically between system architecture and system integration and verification. A controller based on reinforcement learning was developed and evaluated in comparison to traditional proportional-integral controllers in dynamic and fault-prone environments. The results illustrate the superior adaptability, stability, and optimization potential of the reinforcement learning approach, particularly in addressing dynamic disturbances and ensuring robust performance. The study illustrates how reinforcement learning can facilitate the transition from conceptual design to implementation by automating optimization processes, enabling interface automation, and enhancing system-level testing. Based on the aforementioned findings, this paper presents future directions for research, which include the integration of domain-specific knowledge into the reinforcement learning process and the validation of this process in real-world environments. The results underscore the potential of artificial intelligence-driven methodologies to revolutionize the design and deployment of intelligent mechatronic systems. 展开更多
关键词 Artificial Intelligence in Product Development Mechatronic systems Reinforcement Learning for Control system Integration and Verification Adaptive Optimization Processes Knowledge-Based Engineering
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基于L-System与遗传算法的光线仿生采集在建筑设计中的应用研究
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作者 闵睿熙 张永 刘力 《贵阳学院学报(自然科学版)》 2025年第2期75-78,共4页
基于林登麦伊尔系统与遗传算法的光线仿生采集模型,通过模拟自然界中生物对光的利用方式,以此模拟采光效果。结果显示,所提模型可以看出不同时间段和不同测点的采光强度变化。晴天采光时14∶00至16∶00期间,5个测点的采光强度较高。阴... 基于林登麦伊尔系统与遗传算法的光线仿生采集模型,通过模拟自然界中生物对光的利用方式,以此模拟采光效果。结果显示,所提模型可以看出不同时间段和不同测点的采光强度变化。晴天采光时14∶00至16∶00期间,5个测点的采光强度较高。阴天的采光强度集中于12∶00至14∶00,其余时间采集的太阳强度相对较少,不利于采光。这说明,所提模型能够有效地预测建筑内不同区域的采光强度,并针对不同天气对光照条件进行合理利用。 展开更多
关键词 L-system 遗传算法 光线仿生采集 建筑光照优化
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System Xc-/GSH/GPX4通路介导铁死亡在消化道肿瘤耐药中的研究进展 被引量:1
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作者 李星霓 王潇 赵贵君 《河北医药》 2025年第4期663-667,共5页
获得性耐药是降低消化道肿瘤治疗疗效,引起肿瘤复发甚至死亡的主要原因,也是消化道肿瘤治疗的主要挑战。System Xc-/GSH/GPX4通路介导铁死亡与消化道肿瘤耐药性密切相关。了解System Xc/GSH/GPX4的结构和功能,探讨System Xc-/GSH/GPX4... 获得性耐药是降低消化道肿瘤治疗疗效,引起肿瘤复发甚至死亡的主要原因,也是消化道肿瘤治疗的主要挑战。System Xc-/GSH/GPX4通路介导铁死亡与消化道肿瘤耐药性密切相关。了解System Xc/GSH/GPX4的结构和功能,探讨System Xc-/GSH/GPX4通路在消化道肿瘤耐药中的作用,对于靶向System Xc-/GSH/GPX4通路及其相关调控因子,诱导铁死亡,克服肿瘤耐药性,提高肿瘤治疗疗效具有重要意义。本文通过阐述system Xc/GSH/GPX4的结构和功能,探讨System Xc-/GSH/GPX4通路在消化道肿瘤耐药中的作用,为进一步深入消化道肿瘤治疗提供新的思路及方向。 展开更多
关键词 system Xc-/GSH/GPX4 活性氧 铁死亡 消化道肿瘤 耐药
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Architecture to Secure Electrical Control System in Cyber-Physical System
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作者 Depeng Li 《Journal of Information Security》 2025年第1期149-157,共9页
It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle acc... It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle access, or human drivers. To mitigate potential risks, this paper provides the inauguration study by proposing a theoretical framework in the physical, human and cyber triad. Its goal is to, at each time point, detect adversary control behaviors and protect control systems against malicious operations via integrating a variety of methods. This paper only proposes a theoretical framework which tries to indicate possible threats. With the support of the framework, the security system can lightly reduce the risk. The development and implementation of the system are out of scope. 展开更多
关键词 ARCHITECTURE Control system FRAMEWORK
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Construction and Application of University Welcome System under the Background of Informatization
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作者 Rong Su 《Journal of Software Engineering and Applications》 2025年第2期67-75,共9页
The rapid advancement of information technology has promoted the development of informatization in universities. The freshmen welcome information system of universities is the first important system to showcase the di... The rapid advancement of information technology has promoted the development of informatization in universities. The freshmen welcome information system of universities is the first important system to showcase the digital level of the university to new students. With the expansion of the enrollment scale of universities, improving the efficiency of welcoming work has become an urgent problem to be solved. This article analyzes the characteristics and existing problems of the welcoming work, combined with the main technical methods of information system construction, and based on the comprehensive situation of information systems in our university, proposes the construction goals and ideas of the welcoming information system, summarizes the construction process and operation results of the welcome system, and explores possible directions for future optimization. 展开更多
关键词 Welcome system INFORMATIZATION UNIVERSITY Digital Campus REGISTRATION
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Multi-Factor Authentication for Keyless Entry Systems: An Innovative Approach to Automotive Security
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作者 Danilo Brito Shakour Abuzneid 《Journal of Information Security》 2025年第1期78-100,共23页
Car manufacturers aim to enhance the use of two-factor authentication (2FA) to protect keyless entry systems in contemporary cars. Despite providing significant ease for users, keyless entry systems have become more s... Car manufacturers aim to enhance the use of two-factor authentication (2FA) to protect keyless entry systems in contemporary cars. Despite providing significant ease for users, keyless entry systems have become more susceptible to appealing attacks like relay attacks and critical fob hacking. These weaknesses present considerable security threats, resulting in unauthorized entry and car theft. The suggested approach combines a conventional keyless entry feature with an extra security measure. Implementing multi-factor authentication significantly improves the security of systems that allow keyless entry by reducing the likelihood of unauthorized access. Research shows that the benefits of using two-factor authentication, such as a substantial increase in security, far outweigh any minor drawbacks. 展开更多
关键词 MFA Keyless Entry systems Automotive Security Biometric Authentication
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Analysis of Two Irrigation Water Pumping Systems on the Taddis Valley Site: Solar Kit and Motor Pump Unit (GMP) in Tahoua (Niger)
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作者 Yerima Bako Djibo Aboubacar Guero Yadji Bori Haoua 《World Journal of Engineering and Technology》 2025年第1期39-48,共10页
The study was carried out in the Tahoua region at the market gardening sites of the Taddis 1 and 2 valley. Small-scale pumping irrigation is one of the most interesting uses of solar energy. The objective of this stud... The study was carried out in the Tahoua region at the market gardening sites of the Taddis 1 and 2 valley. Small-scale pumping irrigation is one of the most interesting uses of solar energy. The objective of this study is to carry out a comparative analysis of two dewatering pumping systems (Solar Kit and GMP) for water mobilization on a certain number of criteria such as sustainable use, economic aspect and performance. To achieve this, the adapted methodology consisted first of all in the development of a data collection tool in the field. Then flow measurements, estimation of fuel consumption, pressure height, etc., were carried out. Thus, the data collection involved a sample of 120 irrigators who had to use the two (2) types of pumping systems. The collected data were analyzed and processed with appropriate software. The results of the study show that the two pumping systems studied have strengths and constraints. Thus, the solar pumping system has a significant investment cost, very low maintenance and a low operating cost. On the other hand, the system with a generator has a relatively low investment cost (25 to 30 times less than solar), but a relatively high operating, upkeep and maintenance cost. He adds that these assets and constraints must be taken into consideration when an investment is made. This study shows that 74% of producers use GMP compared to 26% who use the Solar Kit. But in practice, the Solar Kit is more reliable for producers from the point of view of planted area, environmental management and investment costs, supply of fuel and lubricant. These results indicate better performance of the solar pumping system compared to GMP at the study sites. 展开更多
关键词 Market Gardening Sites Pumping systems Solar Kit GMP Taddis and Tahoua Valley
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Effectiveness of Logistics Management Information System (LMIS) in Improving the Availability of Essential Medicines and Medical Supplies in Public Hospitals in Zambia: A Cross-Sectional Study
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作者 Aubrey Kanyika Steward Mudenda +4 位作者 Victor Daka Nayuda Kaonga Chitundu Mbao Diana K. Mwaba Scott Kaba Matafwali 《Pharmacology & Pharmacy》 2025年第2期61-72,共12页
Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for manag... Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for managing the supply chain of these commodities. This study aimed to evaluate the effectiveness of LMIS in ensuring the availability of essential medicines and medical supplies in public hospitals in the Copperbelt Province of Zambia. Materials and Methods: From February to April 2022, a cross-sectional study was conducted in 12 public hospitals across the Copperbelt Province. Data were collected using structured questionnaires, checklists, and stock control cards. The study assessed LMIS availability, training, and knowledge among pharmacy personnel, as well as data accuracy, product availability, and order fill rates. Descriptive statistics were used to analyse the data. Results: All surveyed hospitals had LMIS implemented and were using eLMIS as the primary LMIS. Only 47% and 48% of pharmacy personnel received training in eLMIS and Essential Medicines Logistics Improvement Program (EMLIP), respectively. Most personnel demonstrated good knowledge of LMIS, with 77.7% able to log in to eLMIS Facility Edition, 76.6% able to locate stock control cards in the system, and 78.7% able to perform transactions. However, data accuracy from physical and electronic records varied from 0% to 60%, and product availability ranged from 50% to 80%. Order fill rates from Zambia Medicines and Medical Supplies Agency (ZAMMSA) were consistently below 30%. Discrepancies were observed between physical stock counts and eLMIS records. Conclusion: This study found that most hospitals in the Copperbelt Province of Zambia have implemented LMIS use. While LMIS implementation is high in the Copperbelt Province of Zambia, challenges such as low training levels, data inaccuracies, low product availability, and order fill rates persist. Addressing these issues requires a comprehensive approach, including capacity building, data quality improvement, supply chain coordination, and investment in infrastructure and human resources. Strengthening LMIS effectiveness is crucial for improving healthcare delivery and patient outcomes in Zambia. 展开更多
关键词 Logistics Management Information system Essential Medicines Medical Supplies Supply Chain Management Zambia
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Weighted Voting Ensemble Model Integrated with IoT for Detecting Security Threats in Satellite Systems and Aerial Vehicles
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作者 Raed Alharthi 《Journal of Computer and Communications》 2025年第2期250-281,共32页
Small-drone technology has opened a range of new applications for aerial transportation. These drones leverage the Internet of Things (IoT) to offer cross-location services for navigation. However, they are susceptibl... Small-drone technology has opened a range of new applications for aerial transportation. These drones leverage the Internet of Things (IoT) to offer cross-location services for navigation. However, they are susceptible to security and privacy threats due to hardware and architectural issues. Although small drones hold promise for expansion in both civil and defense sectors, they have safety, security, and privacy threats. Addressing these challenges is crucial to maintaining the security and uninterrupted operations of these drones. In this regard, this study investigates security, and preservation concerning both the drones and Internet of Drones (IoD), emphasizing the significance of creating drone networks that are secure and can robustly withstand interceptions and intrusions. The proposed framework incorporates a weighted voting ensemble model comprising three convolutional neural network (CNN) models to enhance intrusion detection within the network. The employed CNNs are customized 1D models optimized to obtain better performance. The output from these CNNs is voted using a weighted criterion using a 0.4, 0.3, and 0.3 ratio for three CNNs, respectively. Experiments involve using multiple benchmark datasets, achieving an impressive accuracy of up to 99.89% on drone data. The proposed model shows promising results concerning precision, recall, and F1 as indicated by their obtained values of 99.92%, 99.98%, and 99.97%, respectively. Furthermore, cross-validation and performance comparison with existing works is also carried out. Findings indicate that the proposed approach offers a prospective solution for detecting security threats for aerial systems and satellite systems with high accuracy. 展开更多
关键词 Intrusion Detection Cyber-Physical systems Drone Security Weighted Ensemble Voting Unmanned Vehicles Security Strategies
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Exploring Cyber Threat Intelligence into Land Administration Systems for Enhanced Cyber Resilience
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作者 Pierre-François Blin Trias Aditya +1 位作者 Purnama Budi Santosa Christophe Claramunt 《Journal of Geographic Information System》 2025年第1期45-65,共21页
The current global cybersecurity landscape, characterized by the increasing scale and sophistication of cyberattacks, underscores the importance of integrating Cyber Threat Intelligence (CTI) into Land Administration ... The current global cybersecurity landscape, characterized by the increasing scale and sophistication of cyberattacks, underscores the importance of integrating Cyber Threat Intelligence (CTI) into Land Administration Systems (LAS). LAS services involve requests and responses concerning public and private cadastral data, including credentials of parties, ownership, and spatial parcels. This study explores the integration of CTI in LAS to enhance cyber resilience, focusing on the unique vulnerabilities of LAS, such as sensitive data management and interconnection with other critical systems related to spatial data uses and changes. The approach employs a case study of a typical country-specific LAS to analyse structured vulnerabilities and their attributes to determine the degree of vulnerability of LAS through a quantitative inductive approach. The analysis results indicate significant improvements in identifying and mitigating potential threats through CTI integration, thus enhancing cyber resilience. These findings are crucial for policymakers and practitioners to develop robust cybersecurity strategies for LAS. 展开更多
关键词 Cyber Threat Intelligence Common Vulnerabilities and Exposures Geodata Land Administration systems Risk Assessment Spatial Cadastral Data
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Reviewing Stability Criteria for Positive Homogeneous Systems and Adding One for Discrete-Time Cases with Degree Less Than One
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作者 Nguyen Quang Tuan 《Circuits and Systems》 2024年第1期1-11,共11页
The article synthesizes and presents the results regarding the stability of positive homogeneous systems that have been researched and published in recent years. Next, we provide a sufficient condition for global expo... The article synthesizes and presents the results regarding the stability of positive homogeneous systems that have been researched and published in recent years. Next, we provide a sufficient condition for global exponential stability in the case of discrete-time positive homogeneous systems with an order less than one with time-varying delays. 展开更多
关键词 Exponential Stability Homogeneous systems Positive systems Positive Homogeneous systems
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Model-Based Systems Engineering Approach to Design a Human Settlement to Better Serve Displaced People
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作者 Anicet Adjahossou 《Open Journal of Applied Sciences》 2024年第4期865-880,共16页
The challenge of transitioning from temporary humanitarian settlements to more sustainable human settlements is due to a significant increase in the number of forcibly displaced people over recent decades, difficultie... The challenge of transitioning from temporary humanitarian settlements to more sustainable human settlements is due to a significant increase in the number of forcibly displaced people over recent decades, difficulties in providing social services that meet the required standards, and the prolongation of emergencies. Despite this challenging context, short-term considerations continue to guide their planning and management rather than more integrated, longer-term perspectives, thus preventing viable, sustainable development. Over the years, the design of humanitarian settlements has not been adapted to local contexts and perspectives, nor to the dynamics of urbanization and population growth and data. In addition, the current approach to temporary settlement harms the environment and can strain limited resources. Inefficient land use and ad hoc development models have compounded difficulties and generated new challenges. As a result, living conditions in settlements have deteriorated over the last few decades and continue to pose new challenges. The stakes are such that major shortcomings have emerged along the way, leading to disruption, budget overruns in a context marked by a steady decline in funding. However, some attempts have been made to shift towards more sustainable approaches, but these have mainly focused on vague, sector-oriented themes, failing to consider systematic and integration views. This study is a contribution in addressing these shortcomings by designing a model-driving solution, emphasizing an integrated system conceptualized as a system of systems. This paper proposes a new methodology for designing an integrated and sustainable human settlement model, based on Model-Based Systems Engineering and a Systems Modeling Language to provide valuable insights toward sustainable solutions for displaced populations aligning with the United Nations 2030 agenda for sustainable development. 展开更多
关键词 Humanitarian Settlement Human Settlement Sustainability systems Engineering Model-Based systems Engineering systems Modeling Language
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Telematics as a Transformative Agent for the Zimbabwean Auto Insurance Ecosystem
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作者 Prosper Tafadzwa Denhere Joyce Denhere +4 位作者 Gracious Mutipforo Chipo Katsande Allan Muzenda Nelson Matanana Gibson Muridzi 《Journal of Computer and Communications》 2024年第7期39-58,共20页
Zimbabwe has witnessed the evolution of Information Communication Technology (ICT). The vehicle population soared to above 1.2 million hence rendering the Transport and Insurance domains complex. Therefore, there is a... Zimbabwe has witnessed the evolution of Information Communication Technology (ICT). The vehicle population soared to above 1.2 million hence rendering the Transport and Insurance domains complex. Therefore, there is a need to look at ways that can augment conventional Vehicular Management Information Systems (VMIS) in transforming business processes through Telematics. This paper aims to contextualise the role that telematics can play in transforming the Insurance Ecosystem in Zimbabwe. The main objective was to investigate the integration of Usage-Based Insurance (UBI) with vehicle tracking solutions provided by technology companies like Econet Wireless in Zimbabwe, aiming to align customer billing with individual risk profiles and enhance the synergy between technology and insurance service providers in the motor insurance ecosystem. A triangulation through structured interviews, questionnaires, and literature review, supported by Information Systems Analysis and Design techniques was conducted. The study adopted a case study approach, qualitatively analyzing the complexities of the Telematics insurance ecosystem in Zimbabwe, informed by the TOGAF framework. A case-study approach was applied to derive themes whilst applying within and cross-case analysis. Data was collected using questionnaires, and interviews. The findings of the research clearly show the importance of Telematics in modern-day insurance and the positive relationship between technology and insurance business performance. The study, therefore revealed how UBI can incentivize positive driver behavior, potentially reducing insurance premiums for safe drivers and lowering the incidence of claims against insurance companies. Future work can be done on studying the role of Telematics in combating highway crime and corruption. 展开更多
关键词 TELEMATICS Vehicle Tracking systems Usage Based Insurance Digital Insurance Vehicle Management Information systems Intelligent Transportation systems
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A Systems Approach to Assessing Sustainability Capacity in Kalobeyei Refugee Settlement in Turkana County, Kenya
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作者 Anicet Adjahossou 《Open Journal of Applied Sciences》 2024年第4期833-848,共16页
Refugee settlements face several challenges in transitioning from a temporary planning approach to more sustainable settlements. This is mainly due to an increase in the number of forcibly displaced people over the la... Refugee settlements face several challenges in transitioning from a temporary planning approach to more sustainable settlements. This is mainly due to an increase in the number of forcibly displaced people over the last few decades, and the difficulties of sustainably providing social services that meet the required standards. The development of refugee settlements assumed that forcibly displaced people would return to their places or countries of origin. Unfortunately, displacement situations are prolonged indefinitely, forcing these people to spend most of their lives in conditions that are often deplorable and substandard, and therefore unsustainable. In most cases, the establishment of refugee settlements is triggered by an emergency caused by an influx of forcibly displaced people, who need to be accommodated urgently and provided with some form of international assistance and protection. This leaves little or no time for proper planning for long-term development as required. In addition, the current approach to temporary settlement harms the environment and can strain limited resources with ad hoc development models that have exacerbated difficulties. As a result, living conditions in refugee settlements have deteriorated over the last few decades and continue to pose challenges as to how best to design, plan, and sustain settlements over time. To contribute to addressing these challenges, this study proposes a new methodology supported by Model-Based Systems Engineering (MBSE) and a Systems Modeling Language (SysML) to develop a typical sustainable human settlement system model, which has functionally and operationally executed using a Systems Engineering (SE) approach. To assess the sustainability capacity of the proposed system, this work applies a matrix of crossed impact multiplication through a case study by conducting a system capacity interdependence analysis (SCIA) using the MICMAC methodology (Cross-impact matrix multiplication applied to classification) to assess the interdependency that exist between the sub-systems categories to deliver services at the system level. The sustainability analysis results based on capacity variables influence and dependency models shows that development activities in the settlement are unstable and, therefore, unsustainable since there is no apparent difference between the influential and dependent data used for the assessment. These results illustrate that an integrated system could improve human settlements’ sustainability and that capacity building in service delivery is beneficial and necessary. 展开更多
关键词 Humanitarian Settlement systems Engineering (SE) SUSTAINABILITY Capacity Assessment Model-Based systems Engineering (MBSE) systems Modeling Language (SysML)
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System Xc-/GPX4/Nrf2介导的铁死亡对脓毒症大鼠肠道机械屏障的影响 被引量:5
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作者 马涛 黄玮玮 于湘友 《中华实用诊断与治疗杂志》 2024年第1期12-18,共7页
目的 探讨System Xc-/GPX4/Nrf2通路介导的铁死亡对脓毒症大鼠肠道机械屏障损伤程度及炎症状态的影响。方法 24只SPF级雄性大鼠随机分为假手术组、脓毒症组、铁死亡组、治疗组各6只。脓毒症组、铁死亡组、治疗组采用盲肠结扎穿孔法制备... 目的 探讨System Xc-/GPX4/Nrf2通路介导的铁死亡对脓毒症大鼠肠道机械屏障损伤程度及炎症状态的影响。方法 24只SPF级雄性大鼠随机分为假手术组、脓毒症组、铁死亡组、治疗组各6只。脓毒症组、铁死亡组、治疗组采用盲肠结扎穿孔法制备脓毒症大鼠模型,假手术组开腹游离盲肠后还纳关腹。造模即刻,治疗组皮下注射去铁胺20 mg/kg,铁死亡组腹腔注射铁死亡激活剂Erastin 20 mg/kg,假手术组和脓毒症组腹腔注射等量生理盐水,注射后4组均皮下注射37℃生理盐水50 mg/kg液体复苏。造模24 h大鼠麻醉后开腹,取十二指肠(空肠),机械法组织匀浆后收集细胞悬液,应用荧光探针法检测小肠平滑肌细胞活性氧(ROS);透射电镜下观察小肠上皮组织中线粒体形态。然后腹主动脉采血离心取血清,采用比色法检测Fe^(3+)、D-乳酸脱氢酶(D-LDH)水平,采用硫代巴比妥酸缩合法检测丙二醛(MDA)水平,采用ELISA法检测肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6水平。采血后处死大鼠,取小肠组织,采用HE染色观察组织病理学改变,采用免疫组织化学ABC法检测GPX4、Nrf2、Claudin-1阳性面积百分比,采用Western blot法检测GPX4、Nrf2、Claudin-1蛋白相对表达量。结果 (1)治疗组[(56 528±182)×10~5/mL]、脓毒症组[(67 964±844)×10~5/mL]、铁死亡组[(71 958±1 306)×10~5/mL]小肠平滑肌细胞ROS荧光强度均高于假手术组[(52 551±438)×10~5/mL](P<0.05),脓毒症组、铁死亡组高于治疗组(P<0.05),铁死亡组高于脓毒症组(P<0.05)。(2)假手术组小肠上皮组织线粒体形态完整、嵴丰富整齐、双膜结构存在且体积较大;脓毒症组线粒体体积变小,膜信号变强,线粒体嵴松散并发生溶解现象;治疗组线粒体体积较脓毒症组略有恢复,双膜结构部分存在,线粒体嵴少量溶解;铁死亡组线粒体体积较脓毒症组进一步缩小,膜密度增高,线粒体嵴发生溶解及消失。(3)脓毒症组、治疗组、铁死亡组血清Fe^(3+)含量低于假手术组(P<0.05),MDA、D-LDH水平均高于假手术组(P<0.05);脓毒症组、铁死亡组血清Fe^(3+)含量低于治疗组,MDA、D-LDH水平高于治疗组(P<0.05);铁死亡组血清Fe^(3+)含量低于脓毒症组,MDA、D-LDH水平高于脓毒症组(P<0.05)。(4)脓毒症组、治疗组、铁死亡组血清IL-1β、TNF-α、IL-6水平均高于假手术组(P<0.05),脓毒症组、铁死亡组高于治疗组(P<0.05),铁死亡组高于脓毒症组(P<0.05)。(5)假手术组小肠绒毛丰富规整、未见基底层分离及毛细血管充血;脓毒症组绒毛顶端出现溶解、破碎,炎症细胞浸润明显,毛细血管充血;治疗组绒毛顶端部分破裂情况略有好转,但仍有毛细血管充血、炎症细胞浸润;铁死亡组小肠绒毛已出现崩解、脱落,炎症组织浸润明显,部分延伸到绒毛两侧,黏膜与黏膜下层出现分离。(6)脓毒症组、治疗组、铁死亡组Nrf2阳性面积百分比大于假手术组(P<0.05),GPX4、Claudin-1阳性面积百分比小于假手术组(P<0.05);脓毒症组、铁死亡组Nrf2阳性面积百分比大于治疗组,GPX4、Claudin-1阳性面积百分比小于治疗组(P<0.05);铁死亡组Nrf2阳性面积百分比大于脓毒症组,GPX4、Claudin-1阳性面积百分比小于脓毒症组(P<0.05)。(7)脓毒症组、铁死亡组Nrf2蛋白相对表达量高于治疗组,GPX4、Claudin-1蛋白相对表达量均低于治疗组(P<0.05);铁死亡组Nrf2蛋白相对表达量高于脓毒症组,GPX4、Claudin-1蛋白相对表达量均低于脓毒症组(P<0.05)。结论 脓毒症大鼠模型肠道损伤中存在铁死亡现象;抑制System Xc-/GPX4/Nrf2通路介导的铁死亡,可改善脓毒症大鼠肠道机械屏障的损伤程度及炎症状态。 展开更多
关键词 脓毒症 肠道损伤 system Xc-/GPX4/Nrf2 铁死亡 大鼠
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Robust H_∞ Stabilization of Uncertain Linear Time-Delay System with Delayed/Undelayed State Feedback Controllers
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作者 陈万义 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2001年第4期71-76,共6页
This paper focuses on the H∞ controller design for linear systems with time-varying delays and norm-bounded parameter perturbations in the system state and control/disturbance. On the existence of delayed/undelayed f... This paper focuses on the H∞ controller design for linear systems with time-varying delays and norm-bounded parameter perturbations in the system state and control/disturbance. On the existence of delayed/undelayed full state feedback controllers, we present a sufficient condition and give a design method in the form of Riccati equation. The controller can not only stabilize the time-delay system, but also make the H∞ norm of the closed-loop system be less than a given bound. This result practically generalizes the related results in current literature. 展开更多
关键词 Closed loop control systems Feedback control Linear control systems Perturbation techniques Riccati equations Robustness (control systems) State feedback system stability Time varying control systems Uncertain systems
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Conventional Geothermal Systems and Unconventional Geothermal Developments: An Overview 被引量:1
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作者 Maryam Khodayar Sveinbjörn Björnsson 《Open Journal of Geology》 CAS 2024年第2期196-246,共51页
This paper provides an overview of conventional geothermal systems and unconventional geothermal developments as a common reference is needed for discussions between energy professionals. Conventional geothermal syste... This paper provides an overview of conventional geothermal systems and unconventional geothermal developments as a common reference is needed for discussions between energy professionals. Conventional geothermal systems have the heat, permeability and fluid, requiring only drilling down to °C, normal heat flow or decaying radiogenic granite as heat sources, and used in district heating. Medium-temperature (MT) 100°C - 190°C, and high-temperature (HT) 190°C - 374°C resources are mostly at plate boundaries, with volcanic intrusive heat source, used mostly for electricity generation. Single well capacities are °C - 500°C) and a range of depths (1 m to 20 Km), but lack permeability or fluid, thus requiring stimulations for heat extraction by conduction. HVAC is 1 - 2 m deep and shallow geothermal down to 500 m in wells, both capturing °C, with °C are either advanced by geothermal developers at <7 Km depth (Enhanced Geothermal Systems (EGS), drilling below brittle-ductile transition zones and under geothermal fields), or by the Oil & Gas industry (Advanced Geothermal Systems, heat recovery from hydrocarbon wells or reservoirs, Superhot Rock Geothermal, and millimeter-wave drilling down to 20 Km). Their primary aim is electricity generation, relying on closed-loops, but EGS uses fractures for heat exchange with earthquake risks during fracking. Unconventional approaches could be everywhere, with shallow geothermal already functional. The deeper and hotter unconventional alternatives are still experimental, overcoming costs and technological challenges to become fully commercial. Meanwhile, the conventional geothermal resources remain the most proven opportunities for investments and development. 展开更多
关键词 Conventional Geothermal systems Unconventional Geothermal Developments Shallow and Deep Closed-Loops Enhanced Geothermal systems Supercritical and Millimeter-Wave Drilling
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A PID Tuning Approach for Inertial Systems Performance Optimization
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作者 Irina Cojuhari 《Applied Mathematics》 2024年第1期96-107,共12页
In the practice of control the industrial processes, proportional-integral-derivative controller remains pivotal due to its simple structure and system performance-oriented tuning process. In this paper are presented ... In the practice of control the industrial processes, proportional-integral-derivative controller remains pivotal due to its simple structure and system performance-oriented tuning process. In this paper are presented two approaches for synthesis the proportional-integral-derivative controller to the models of objects with inertia, that offer the procedure of system performance optimization based on maximum stability degree criterion. The proposed algorithms of system performance optimization were elaborated for model of objects with inertia second and third order and offer simple analytical expressions for tuning the PID controller. Validation and verification are conducted through computer simulations using MATLAB, demonstrating successful performance optimization and showcasing the effectiveness PID controllers’ tuning. The proposed approaches contribute insights to the field of control, offering a pathway for optimizing the performance of second and third-order inertial systems through robust controller synthesis. 展开更多
关键词 PID Control Algorithm Inertial systems system Performance Optimization Maximum Stability Degree
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基于System xc(-)-GSH-GPX4抗氧化功能轴探讨眼针改善脑缺血再灌注损伤大鼠神经元铁死亡的作用机制 被引量:10
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作者 曹亚荣 马贤德 +6 位作者 樊程程 张新宇 王奡 王圣澎 孙梦月 王哲 张威 《针刺研究》 CAS CSCD 北大核心 2024年第12期1239-1247,共9页
目的:观察眼针对急性脑缺血再灌注损伤(CIRI)大鼠脑缺血半暗带皮质组织中抗氧化功能轴系统XC[System xc(-)]-谷胱甘肽(GSH)-谷胱甘肽过氧化物酶4(GPX4)的影响,探讨眼针改善CIRI大鼠神经元铁死亡的作用机制。方法:SD大鼠随机分为假手术... 目的:观察眼针对急性脑缺血再灌注损伤(CIRI)大鼠脑缺血半暗带皮质组织中抗氧化功能轴系统XC[System xc(-)]-谷胱甘肽(GSH)-谷胱甘肽过氧化物酶4(GPX4)的影响,探讨眼针改善CIRI大鼠神经元铁死亡的作用机制。方法:SD大鼠随机分为假手术组、模型组、眼针组和抑制剂组,每组15只。改良线栓法复制CIRI大鼠模型;眼针组和抑制剂组针刺双侧“上焦区”“肝区”“下焦区”“肾区”,留针30 min,于脑缺血再灌注后30 min、12 h、24 h各施针1次。抑制剂组每次针刺前30 min腹腔注射GPX4抑制剂RSL3(10 mg/kg),共3次。改良Garcia JH评分法评估大鼠神经功能损伤程度;TTC染色观察脑组织梗死灶面积;HE染色观察缺血区脑组织形态;透射电子显微镜观察缺血区脑组织神经元线粒体结构;比色法检测缺血区脑组织丙二醛(MDA)、GSH、亚铁离子(Fe2+)含量;ELISA法检测活性氧(ROS)的活性;Western blot法检测缺血区脑组织溶质载体家族7成员11(SLC7A11)、溶质载体家族3成员2(SLC3A2)和GPX4的蛋白表达;实时荧光定量PCR法检测缺血区脑组织SLC7A11、GPX4的mRNA表达。结果:与假手术组比较,模型组大鼠改良Garcia JH神经功能损伤评分降低(P<0.01),缺血侧脑组织可见明显的灰白色梗死灶,HE染色示出现多个较大面积的典型脑梗死改变,线粒体超微结构呈典型铁死亡改变,缺血区脑组织Fe2+、MDA含量及ROS活性显著升高(P<0.01);GSH含量,SLC7A11、SLC3A2、GPX4蛋白及GPX4、SLC7A11mRNA表达显著降低(P<0.01)。与模型组比较,眼针组治疗后改良Garcia JH神经功能损伤评分升高(P<0.01),脑组织的梗死灶面积缩小,脑组织细胞损伤程度明显减轻,线粒体损伤减轻,缺血区脑组织Fe2+、MDA含量及ROS活性显著降低(P<0.01);GSH含量,SLC7A11、SLC3A2、GPX4蛋白及GPX4、SLC7A11 mRNA表达升高(P<0.01,P<0.05)。与眼针组比较,抑制剂组神经功能损伤评分降低(P<0.01),梗死灶面积增大,细胞损伤程度加重,线粒体损伤加重,缺血区脑组织Fe2+、MDA含量及ROS活性显著升高(P<0.01,P<0.05);GSH含量,SLC7A11、SLC3A2、GPX4蛋白及GPX4、SLC7A11 mRNA表达降低(P<0.01,P<0.05)。结论:眼针可通过调控System xc(-)-GSH-GPX4抗氧化功能轴改善CIRI大鼠神经元铁死亡。 展开更多
关键词 眼针 脑缺血再灌注损伤 铁死亡 system xc(-)-GSH-GPX4 抗氧化功能轴 缺血半暗带
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