An actual control demand of rotary kiln is taken as background. By analyzing and improving approach of MPC （synthesizing model predictive control）, an effective strategy which applies complex S-MPC in actual industr...An actual control demand of rotary kiln is taken as background. By analyzing and improving approach of MPC （synthesizing model predictive control）, an effective strategy which applies complex S-MPC in actual industrial process is designed. Firstly, after analyzing the main components technology and calcination reaction mechanism in detail, the calcining belt state-space model of rotary kiln is built using PO-Moesp （past-output multivariable output error state space model identification） method. Then, calcining belt temperature predictive control system is de signed. The control system combines time-delay gain scheduled, output-tracking, recursive subspace adaptive and other methods, and forms the off-line/on-line predictive controller of rotary kiln. At last, MATLAB is applied for simulation, experiments run in constant value tracking and servo tracking situation. Simulation results show its ef- fectiveness and feasibility.展开更多
The magnesia -hercynite bricks offer a new lining to rotary cement kiln. They are well adopted and widely used in the high temperature zone of cement kiln, and have obtained good performance at rigorous and severe wor...The magnesia -hercynite bricks offer a new lining to rotary cement kiln. They are well adopted and widely used in the high temperature zone of cement kiln, and have obtained good performance at rigorous and severe working conditions. The synthesis of hercynite requires a suitable atmosphere with proper O2 partial pressures which makes sure FeO can stably exist at the synthesizing temperature. Current industrial production of hercynite mainly adopts fused method. The other method, sinte- ring method, is not mature and needs further research. The magnesia - hercynite brick shows high hot toughhess, high adhesion strength to kiln crust, and good corrosion resistance to alkali salt in cement kilns. The mismatching of thermal expansion between magnesia and hercynite can improve the thermal shock resistance of the bricks, but the oxidation of partial Fe^2＋ , the high temperature solution, and low temperature exsolution of transgranular secondary spinel lead to cubical expansion, .formation of more cracks, and poor thermal shock resistance of the bricks.展开更多
4,4-Dialkyl-2-oxazolin-5-ones are prepared by one step reaction of 2-oxazolin-5-one with the magnesium methyl carbonate(MMC)and alkyIhalides.It is a novel and convenient method for synthesis of α, Υ-disubstitutcd α...4,4-Dialkyl-2-oxazolin-5-ones are prepared by one step reaction of 2-oxazolin-5-one with the magnesium methyl carbonate(MMC)and alkyIhalides.It is a novel and convenient method for synthesis of α, Υ-disubstitutcd α-amino acid by hydrolysis of 4,4-dialkyl-2-oxazolin-5-ones.展开更多
The whole performance of the networked control system （NCSs） depends on two interaction factors, namely the quality of control performance （QoP） and quality of network service （QoS）. So, to optimize the whole pe...The whole performance of the networked control system （NCSs） depends on two interaction factors, namely the quality of control performance （QoP） and quality of network service （QoS）. So, to optimize the whole perfor-mance of NCSs, the problem of guaranteeing QoP and QoS plays an important role in the design of NCSs. However, up to now, little work has been done in this field. In this paper, a synthesizing control model of NCSs to guarantee QoP and QoS is proposed, and a feasible condition of optimizing whole performance of NCSs is also suggested. Finally, the simulation results show that the proposed model is effective.展开更多
A head-related transfer function （HRTF） model for fast and real-time synthesizing multiple virtual sound sources is proposed. A head-related impulse response （HRIR, time- domain version of HRTF） is first decompose...A head-related transfer function （HRTF） model for fast and real-time synthesizing multiple virtual sound sources is proposed. A head-related impulse response （HRIR, time- domain version of HRTF） is first decomposed by a two-level wavelet packet and then represented by a model composed of subband filters and reconstruction filters. The coefficients of the subband filters are the zero interpolation of the wavelet coefficients of the HRIR. The coefficients of the reconstruction filters can be calculated from the wavelet function. The model is simplified by applying a threshold method to reduce the wavelet coefficients. The calculated results indicate that for a model with 30 wavelet coefficients, the error of reconstructed HRIR is about 1%. And the result of a psychoacoustic test shows that a model with 35 wavelet coefficients is perceptually indistinguishable from the original HRIR. When multiple virtual sound sources are synthesized simultaneously, the computational cost of the proposed model is much less than the traditional HRTF filters.展开更多
Ribosomally synthesized and post-translationally modified peptides(RiPPs)constitute a vast and diverse family of bioactive peptides.These peptides,synthesized by ribosomes and subsequently modified by various tailorin...Ribosomally synthesized and post-translationally modified peptides(RiPPs)constitute a vast and diverse family of bioactive peptides.These peptides,synthesized by ribosomes and subsequently modified by various tailoring enzymes,possess a wide chemical space.Among these modifications,radical S-adenosylmethionine(rSAM)enzymes employ unique radical chemistry to introduce a variety of novel peptide structures,which are crucial for their activity.This review examines the major types of modifications in RiPPs catalyzed by rSAM enzymes,incorporating recent advancements in protein structure analysis techniques and computational methods.Additionally,it elucidates the diverse catalytic mechanisms and substrate selectivity of these enzymes through an analysis of the latest crystal structures.展开更多
In this study,we demonstrate the direct in-situ synthesis of NiTi alloys with tunable chemical com-position(Ni/Ti atomic ratio)and corresponding thermomechanical response.This synthesis is achieved by regulating the f...In this study,we demonstrate the direct in-situ synthesis of NiTi alloys with tunable chemical com-position(Ni/Ti atomic ratio)and corresponding thermomechanical response.This synthesis is achieved by regulating the feeding speed ratio of pure Ni and Ti wires during the additive manufacturing pro-cess based on dual-wire-feed electron beam directed energy deposition(EB-DED)technology.Under ap-propriate process conditions,the resulting NiTi alloys exhibit a controllable evolution around the near-equiatomic composition and display a typical columnar grain morphology characteristic of additively manufactured NiTi alloys.With an increase in Ni content(shifting from Ti-rich to Ni-rich),the second phase particles present in the samples change from Ti-rich phase(Ti_(2) Ni)to Ni-rich phases(such as Ni4 Ti3 and Ni3 Ti_(2)).The phase transformation temperatures gradually decrease with increasing Ni content,and the predominant matrix phase transitions from martensite to austenite.The as-built NiTi alloy exhibits a typical tensile curve with a good tensile elongation of 11%,fabricated under suitable composition and microstructure conditions.This result surpasses values reported in current in-situ synthesized NiTi alloys through additive manufacturing methods.Moreover,it almost reaches the levels achieved by additively manufactured NiTi alloys using pre-alloyed raw materials.Furthermore,this study reports,for the first time in the field of in-situ synthesized NiTi alloys,a good tensile shape memory effect,achieving an im-pressive recovery rate of up to 70%under a tensile strain of 6%.This investigation provides a meaningful theoretical perspective and technical strategy for the integrated customization of NiTi alloy components in structure,composition,and function.This low-cost and high-efficiency approach is particularly attrac-tive for the preparation of functional graded,large-scale and disposable NiTi components.展开更多
针对具有多维状态变量、多种工作模式和故障模式的复杂工程系统,提出一种基于综合健康指数(synthesized health index,SHI)与相关向量机(relevance vector machine,RVM)的系统级失效预测方法。在离线训练阶段,先根据有限失效历史数据建...针对具有多维状态变量、多种工作模式和故障模式的复杂工程系统,提出一种基于综合健康指数(synthesized health index,SHI)与相关向量机(relevance vector machine,RVM)的系统级失效预测方法。在离线训练阶段,先根据有限失效历史数据建立各工作模式下的健康评估模型,并据此获得各历史退化轨迹的SHI序列;然后再使用RVM对这些序列进行回归处理,进而辨识出与回归曲线最为匹配的函数模型。在线预测阶段,先运用健康评估模型计算当前设备的SHI序列并进行RVM回归,再拟合出离线阶段确定的函数模型并添加时变噪声;最后,外推预测出系统剩余使用寿命的概率密度分布。该方法成功应用到涡轮发动机的失效预测案例。展开更多
An optimized method is presented to design the down scalers in a GHz frequency synthesizer. The down scalers are comprised of dual modulus prescaler （DMP） and programmable ＆ pulse swallow divider,different methods ...An optimized method is presented to design the down scalers in a GHz frequency synthesizer. The down scalers are comprised of dual modulus prescaler （DMP） and programmable ＆ pulse swallow divider,different methods of high frequency analog circuit and digital logical synthesis are adopted respectively. Using a DMP high speed, lower jitter and lower power dissipation are obtained,and output frequency of 133.0MHz of the DMP working at divide-by-8 shows an RMS jitter less than 2ps. The flexibility and reusability of the progrs, mmable divider is high;its use could be extended to many complicated frequency synthesizers. By comparison,it is a better design on performance of high-frequency circuit and good design flexibility.展开更多
A programmable multi-modulus frequency divider is designed and implemented in a 0. 35μm CMOS process. The multi-modulus frequency divider is a single chip with two dividers in series,which are divided by 4 or 5 presc...A programmable multi-modulus frequency divider is designed and implemented in a 0. 35μm CMOS process. The multi-modulus frequency divider is a single chip with two dividers in series,which are divided by 4 or 5 prescaler and by 128-255 multi-modulus frequency divider. In the circuit design, power and speed trade-offs are analyzed for the prescaler, and power optimization techniques are used according to the input frequency of each divider cell for the 128-255 multimodulus frequency divider. The chip is designed with ESD protected I/O PAD. The dividers chain can work as high as 2.4GHz with a single ended input signal and beyond 2.6GHz with differential input signals. The dual-modulus prescaler consumes 11mA of current while the 128-255 multi-modulus frequency divider consumes 17mA of current with a 3.3V power supply. The core area of the die without PAD is 0.65mm × 0.3mm. This programmable multi-modulus frequency divider can be used for 2.4GHz ISM band PLL-based frequency synthesizers. To our knowledge, this is the first reported multi-modulus frequency divider with this structure in China.展开更多
A complete closed-loop third order s-domain model is analyzed for a frequency synthesizer. Based on the model and root-locus technique, the procedure for parameters design is described, and the relationship between th...A complete closed-loop third order s-domain model is analyzed for a frequency synthesizer. Based on the model and root-locus technique, the procedure for parameters design is described, and the relationship between the process,voltage,and temperature variation of parameters and the loop stability is quantitatively analyzed. A variation margin is proposed for stability compensation. Furthermore,a simple adjustable current cell in the charge pump is proposed for additional stability compensation and a novel VCO with linear gain is adopted to limit the total variation. A fully integrated frequency synthesizer from 1 to 1.05GHz with 250kHz channel resolution is implemented to verify the methods.展开更多
A design and implementation for a 2.4GHz quadrature output frequency synthesizer intended for bluetooth in 0. 35μm CMOS technology are presented. A differentially controlled quadrature voltage-controlled oscillator ...A design and implementation for a 2.4GHz quadrature output frequency synthesizer intended for bluetooth in 0. 35μm CMOS technology are presented. A differentially controlled quadrature voltage-controlled oscillator （QVCO） is employed to generate quadrature （I/Q） signals. A second-order loop filter, with a unit gain transconductance amplifier having the performance of a third-order loop filter,is exploited for low cost. The measured spot phase noise is -106.15dBc/Hz@ 1MHz. Close-in phase noise is less than -70dBc/Hz. The synthesizer consumes 13.5mA under a 3.3V voltage supply. The core size is 1.3mm×0. 8mm.展开更多
A new FM transmitter is reported. It adopts a fractional-N PLL synthesizer to realize the FM modulator. An extra offset current has also been applied to eliminate the effects of the mismatch in CP. The chip is fabrica...A new FM transmitter is reported. It adopts a fractional-N PLL synthesizer to realize the FM modulator. An extra offset current has also been applied to eliminate the effects of the mismatch in CP. The chip is fabricated with CSMC 0.5μm DPTM CMOS technology. Experiments show that it achieves THD≤0.08% and SNR≤ 82dB,and the maximum outband emission energy ≤ 90dBc/Hz. Furthermore,it also uses an auto frequency adjusting method to avoid tuning up the external inductances. All these merits are very suitable for FM transmission.展开更多
By analyzing hundreds of capillary pressure curves, the controlling factors of shape and type of capillary pressure curves are found and a novel method is presented to construct capillary pressure curves by using rese...By analyzing hundreds of capillary pressure curves, the controlling factors of shape and type of capillary pressure curves are found and a novel method is presented to construct capillary pressure curves by using reservoir permeability and a synthesized index. The accuracy of this new method is verified by mercury-injection experiments. Considering the limited quantity of capillary pressure data, a new method is developed to extract the Swanson parameter from the NMR T2 distribution and estimate reservoir permeability. Integrating with NMR total porosity, reservoir capillary pressure curves can be constructed to evaluate reservoir pore structure in the intervals with NMR log data. An in-situ example of evaluating reservoir pore structure using the capillary pressure curves by this new method is presented. The result shows that it accurately detects the change in reservoir pore structure as a function of depth.展开更多
A cordierite was synthesized from calcined bauxite, talcum, and quartz. The properties and microstructure of the cordierite sintered samples were characterized by Archimedes＇ method, thermal dilatometry, X-ray diffra...A cordierite was synthesized from calcined bauxite, talcum, and quartz. The properties and microstructure of the cordierite sintered samples were characterized by Archimedes＇ method, thermal dilatometry, X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and so on. The experimental results showed that calcined bauxite could broaden the range of synthesizing temperature from 1300 ℃ to 1420 ℃ and get pure cordierite. The bulk density and linear thermal expansion coefficient of the sample synthesized at 1420 ℃ for 2 h were 1.97 g·cm^-3 and 2.1×10^-6 ℃^-1, respectively. The XRD analysis showed that the major crystalline phase was a-cordierite with almost no glassy matters, the SEM images illustrated a small vent hole and the size were 5 -100 μm, the well-grown hexagonal and granular cordierite grains had the sizes distributed among 0.1-8 ;xm, and providing high mechanical strength and lower linear thermal expansion coefficient.展开更多
A series of （4-（2,4,5-trifluorophenyl）piperazin-1-yl） methanone derivatives 9a–k as potential dipeptidyl peptidase-4 （DPP-4） inhibitors were synthesized by microwave assisted nucleophilic substitution of 1,2,4,...A series of （4-（2,4,5-trifluorophenyl）piperazin-1-yl） methanone derivatives 9a–k as potential dipeptidyl peptidase-4 （DPP-4） inhibitors were synthesized by microwave assisted nucleophilic substitution of 1,2,4,5-tetrafluorobenzene with piperazine, followed by carbamoylation and condensation. The inhibitory activities of these new compounds on DPP-4 were evaluated in vitro, and compounds 9d and 9g showed moderate inhibitory activities.展开更多
A new stationary phase for iodide ion analysis has been developed. The cationic polymerepichlorohydrin-dimethylamine（PEPI-DMA） was served as modifier in synthesizing polyelectrolyte sorbents and the macroporous poly...A new stationary phase for iodide ion analysis has been developed. The cationic polymerepichlorohydrin-dimethylamine（PEPI-DMA） was served as modifier in synthesizing polyelectrolyte sorbents and the macroporous polystyrene-divinylbenzene（PS-DVB） resin was used as support. The positively charged polymer（PEPI-DMA） was electrostatically bonded to a negatively charged particle（PS-DVB sulfonated）. The new stationary phase was characterized by scanning electron microscopy（SEM）, Fourier transform infrared（FTIR）, elemental analysis, chemical adsorption and desorption measurements. The chromatographic evaluation of the new stationary phase was performed using various anions with a conductivity detector. The new stationary phase was also applied to the determination of iodide directly with a DC amperometric detector using a platinum working electrode and an Ag/Ag Cl reference electrode. The chromatographic conditions were optimized and the eluent solution contained 5 mmol/L HNO3 and 15 mmol/L Na NO3 at a flow rate of 1.0 m L/min and column temperature of 30 8C. The applied voltage of the DC amperometric detector was 0.9 V. Under the optimum conditions, the linear range of the method was 0.2–50 mg/L for iodide ion with a correlation coefficient of 0.9990. The detection limit was 0.05 mg/L（calculated at S/N = 3） and the relative standard deviations（RSD, n = 6） were all less than 1% for retention time, peak area and peak height. This method was also utilized for the determination of iodide ions in samples of povidone iodine solution and kelp samples with satisfactory results.展开更多
Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and pred...Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly expressed in steroid-synthesizing tissues including the central nervous system（CNS）.However,展开更多
基金Item Sponsored by National Natural Science Foundation of China(61034005)
文摘An actual control demand of rotary kiln is taken as background. By analyzing and improving approach of MPC （synthesizing model predictive control）, an effective strategy which applies complex S-MPC in actual industrial process is designed. Firstly, after analyzing the main components technology and calcination reaction mechanism in detail, the calcining belt state-space model of rotary kiln is built using PO-Moesp （past-output multivariable output error state space model identification） method. Then, calcining belt temperature predictive control system is de signed. The control system combines time-delay gain scheduled, output-tracking, recursive subspace adaptive and other methods, and forms the off-line/on-line predictive controller of rotary kiln. At last, MATLAB is applied for simulation, experiments run in constant value tracking and servo tracking situation. Simulation results show its ef- fectiveness and feasibility.
文摘The magnesia -hercynite bricks offer a new lining to rotary cement kiln. They are well adopted and widely used in the high temperature zone of cement kiln, and have obtained good performance at rigorous and severe working conditions. The synthesis of hercynite requires a suitable atmosphere with proper O2 partial pressures which makes sure FeO can stably exist at the synthesizing temperature. Current industrial production of hercynite mainly adopts fused method. The other method, sinte- ring method, is not mature and needs further research. The magnesia - hercynite brick shows high hot toughhess, high adhesion strength to kiln crust, and good corrosion resistance to alkali salt in cement kilns. The mismatching of thermal expansion between magnesia and hercynite can improve the thermal shock resistance of the bricks, but the oxidation of partial Fe^2＋ , the high temperature solution, and low temperature exsolution of transgranular secondary spinel lead to cubical expansion, .formation of more cracks, and poor thermal shock resistance of the bricks.
文摘4,4-Dialkyl-2-oxazolin-5-ones are prepared by one step reaction of 2-oxazolin-5-one with the magnesium methyl carbonate(MMC)and alkyIhalides.It is a novel and convenient method for synthesis of α, Υ-disubstitutcd α-amino acid by hydrolysis of 4,4-dialkyl-2-oxazolin-5-ones.
文摘The whole performance of the networked control system （NCSs） depends on two interaction factors, namely the quality of control performance （QoP） and quality of network service （QoS）. So, to optimize the whole perfor-mance of NCSs, the problem of guaranteeing QoP and QoS plays an important role in the design of NCSs. However, up to now, little work has been done in this field. In this paper, a synthesizing control model of NCSs to guarantee QoP and QoS is proposed, and a feasible condition of optimizing whole performance of NCSs is also suggested. Finally, the simulation results show that the proposed model is effective.
基金supported by the National Nature Science Fund of China(50938003,10774049)State Key Lab of Subtropical Building Science,South China University of Technology
文摘A head-related transfer function （HRTF） model for fast and real-time synthesizing multiple virtual sound sources is proposed. A head-related impulse response （HRIR, time- domain version of HRTF） is first decomposed by a two-level wavelet packet and then represented by a model composed of subband filters and reconstruction filters. The coefficients of the subband filters are the zero interpolation of the wavelet coefficients of the HRIR. The coefficients of the reconstruction filters can be calculated from the wavelet function. The model is simplified by applying a threshold method to reduce the wavelet coefficients. The calculated results indicate that for a model with 30 wavelet coefficients, the error of reconstructed HRIR is about 1%. And the result of a psychoacoustic test shows that a model with 35 wavelet coefficients is perceptually indistinguishable from the original HRIR. When multiple virtual sound sources are synthesized simultaneously, the computational cost of the proposed model is much less than the traditional HRTF filters.
基金supported by the National Key Research and Development Program of China(No.2023YFA0916000)the National Natural Science Foundation of China(No.32371324)the High-level Talent Startup Fund provided by China Pharmaceutical University.
文摘Ribosomally synthesized and post-translationally modified peptides(RiPPs)constitute a vast and diverse family of bioactive peptides.These peptides,synthesized by ribosomes and subsequently modified by various tailoring enzymes,possess a wide chemical space.Among these modifications,radical S-adenosylmethionine(rSAM)enzymes employ unique radical chemistry to introduce a variety of novel peptide structures,which are crucial for their activity.This review examines the major types of modifications in RiPPs catalyzed by rSAM enzymes,incorporating recent advancements in protein structure analysis techniques and computational methods.Additionally,it elucidates the diverse catalytic mechanisms and substrate selectivity of these enzymes through an analysis of the latest crystal structures.
基金the State Key Laboratory of Tribology in Advanced Equipment(Project code:SKLT2022C20)Postdoc Matching Fund Scheme of The Hong Kong Polytechnic University(Project code:1-W283)+3 种基金Research Institute of Advanced Manufacturing at The Hong Kong Polytechnic University(PolyU)(Project code:CD9E,CD8Y)PolyU Research and Inno-vation Office(Project code:BBR5)Departmental General Research Fund of the Department of Industrial and Systems Engineering of The Hong Kong Polytechnic University(Project code:G-UAKX)the funding support for the State Key Laboratories in Hong Kong from the Innovation and Technology Commission of the Govern-ment of the Hong Kong Special Administrative Region,China.
文摘In this study,we demonstrate the direct in-situ synthesis of NiTi alloys with tunable chemical com-position(Ni/Ti atomic ratio)and corresponding thermomechanical response.This synthesis is achieved by regulating the feeding speed ratio of pure Ni and Ti wires during the additive manufacturing pro-cess based on dual-wire-feed electron beam directed energy deposition(EB-DED)technology.Under ap-propriate process conditions,the resulting NiTi alloys exhibit a controllable evolution around the near-equiatomic composition and display a typical columnar grain morphology characteristic of additively manufactured NiTi alloys.With an increase in Ni content(shifting from Ti-rich to Ni-rich),the second phase particles present in the samples change from Ti-rich phase(Ti_(2) Ni)to Ni-rich phases(such as Ni4 Ti3 and Ni3 Ti_(2)).The phase transformation temperatures gradually decrease with increasing Ni content,and the predominant matrix phase transitions from martensite to austenite.The as-built NiTi alloy exhibits a typical tensile curve with a good tensile elongation of 11%,fabricated under suitable composition and microstructure conditions.This result surpasses values reported in current in-situ synthesized NiTi alloys through additive manufacturing methods.Moreover,it almost reaches the levels achieved by additively manufactured NiTi alloys using pre-alloyed raw materials.Furthermore,this study reports,for the first time in the field of in-situ synthesized NiTi alloys,a good tensile shape memory effect,achieving an im-pressive recovery rate of up to 70%under a tensile strain of 6%.This investigation provides a meaningful theoretical perspective and technical strategy for the integrated customization of NiTi alloy components in structure,composition,and function.This low-cost and high-efficiency approach is particularly attrac-tive for the preparation of functional graded,large-scale and disposable NiTi components.
文摘针对具有多维状态变量、多种工作模式和故障模式的复杂工程系统,提出一种基于综合健康指数(synthesized health index,SHI)与相关向量机(relevance vector machine,RVM)的系统级失效预测方法。在离线训练阶段,先根据有限失效历史数据建立各工作模式下的健康评估模型,并据此获得各历史退化轨迹的SHI序列;然后再使用RVM对这些序列进行回归处理,进而辨识出与回归曲线最为匹配的函数模型。在线预测阶段,先运用健康评估模型计算当前设备的SHI序列并进行RVM回归,再拟合出离线阶段确定的函数模型并添加时变噪声;最后,外推预测出系统剩余使用寿命的概率密度分布。该方法成功应用到涡轮发动机的失效预测案例。
文摘An optimized method is presented to design the down scalers in a GHz frequency synthesizer. The down scalers are comprised of dual modulus prescaler （DMP） and programmable ＆ pulse swallow divider,different methods of high frequency analog circuit and digital logical synthesis are adopted respectively. Using a DMP high speed, lower jitter and lower power dissipation are obtained,and output frequency of 133.0MHz of the DMP working at divide-by-8 shows an RMS jitter less than 2ps. The flexibility and reusability of the progrs, mmable divider is high;its use could be extended to many complicated frequency synthesizers. By comparison,it is a better design on performance of high-frequency circuit and good design flexibility.
文摘A programmable multi-modulus frequency divider is designed and implemented in a 0. 35μm CMOS process. The multi-modulus frequency divider is a single chip with two dividers in series,which are divided by 4 or 5 prescaler and by 128-255 multi-modulus frequency divider. In the circuit design, power and speed trade-offs are analyzed for the prescaler, and power optimization techniques are used according to the input frequency of each divider cell for the 128-255 multimodulus frequency divider. The chip is designed with ESD protected I/O PAD. The dividers chain can work as high as 2.4GHz with a single ended input signal and beyond 2.6GHz with differential input signals. The dual-modulus prescaler consumes 11mA of current while the 128-255 multi-modulus frequency divider consumes 17mA of current with a 3.3V power supply. The core area of the die without PAD is 0.65mm × 0.3mm. This programmable multi-modulus frequency divider can be used for 2.4GHz ISM band PLL-based frequency synthesizers. To our knowledge, this is the first reported multi-modulus frequency divider with this structure in China.
文摘A complete closed-loop third order s-domain model is analyzed for a frequency synthesizer. Based on the model and root-locus technique, the procedure for parameters design is described, and the relationship between the process,voltage,and temperature variation of parameters and the loop stability is quantitatively analyzed. A variation margin is proposed for stability compensation. Furthermore,a simple adjustable current cell in the charge pump is proposed for additional stability compensation and a novel VCO with linear gain is adopted to limit the total variation. A fully integrated frequency synthesizer from 1 to 1.05GHz with 250kHz channel resolution is implemented to verify the methods.
文摘A design and implementation for a 2.4GHz quadrature output frequency synthesizer intended for bluetooth in 0. 35μm CMOS technology are presented. A differentially controlled quadrature voltage-controlled oscillator （QVCO） is employed to generate quadrature （I/Q） signals. A second-order loop filter, with a unit gain transconductance amplifier having the performance of a third-order loop filter,is exploited for low cost. The measured spot phase noise is -106.15dBc/Hz@ 1MHz. Close-in phase noise is less than -70dBc/Hz. The synthesizer consumes 13.5mA under a 3.3V voltage supply. The core size is 1.3mm×0. 8mm.
文摘A new FM transmitter is reported. It adopts a fractional-N PLL synthesizer to realize the FM modulator. An extra offset current has also been applied to eliminate the effects of the mismatch in CP. The chip is fabricated with CSMC 0.5μm DPTM CMOS technology. Experiments show that it achieves THD≤0.08% and SNR≤ 82dB,and the maximum outband emission energy ≤ 90dBc/Hz. Furthermore,it also uses an auto frequency adjusting method to avoid tuning up the external inductances. All these merits are very suitable for FM transmission.
文摘By analyzing hundreds of capillary pressure curves, the controlling factors of shape and type of capillary pressure curves are found and a novel method is presented to construct capillary pressure curves by using reservoir permeability and a synthesized index. The accuracy of this new method is verified by mercury-injection experiments. Considering the limited quantity of capillary pressure data, a new method is developed to extract the Swanson parameter from the NMR T2 distribution and estimate reservoir permeability. Integrating with NMR total porosity, reservoir capillary pressure curves can be constructed to evaluate reservoir pore structure in the intervals with NMR log data. An in-situ example of evaluating reservoir pore structure using the capillary pressure curves by this new method is presented. The result shows that it accurately detects the change in reservoir pore structure as a function of depth.
基金Funded by the National Basic Research Program ("973"Program)(2010CB227105)
文摘A cordierite was synthesized from calcined bauxite, talcum, and quartz. The properties and microstructure of the cordierite sintered samples were characterized by Archimedes＇ method, thermal dilatometry, X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and so on. The experimental results showed that calcined bauxite could broaden the range of synthesizing temperature from 1300 ℃ to 1420 ℃ and get pure cordierite. The bulk density and linear thermal expansion coefficient of the sample synthesized at 1420 ℃ for 2 h were 1.97 g·cm^-3 and 2.1×10^-6 ℃^-1, respectively. The XRD analysis showed that the major crystalline phase was a-cordierite with almost no glassy matters, the SEM images illustrated a small vent hole and the size were 5 -100 μm, the well-grown hexagonal and granular cordierite grains had the sizes distributed among 0.1-8 ;xm, and providing high mechanical strength and lower linear thermal expansion coefficient.
基金supported by Nationa l973 Projects from the Ministry of Science and Technology of China(Grant No.2010CB735601 and 2012CB724501)
文摘A series of （4-（2,4,5-trifluorophenyl）piperazin-1-yl） methanone derivatives 9a–k as potential dipeptidyl peptidase-4 （DPP-4） inhibitors were synthesized by microwave assisted nucleophilic substitution of 1,2,4,5-tetrafluorobenzene with piperazine, followed by carbamoylation and condensation. The inhibitory activities of these new compounds on DPP-4 were evaluated in vitro, and compounds 9d and 9g showed moderate inhibitory activities.
基金financially supported by Natural Science Foundation of Zhejiang Province(Nos.Y4110532,LQ13B050001,LY12B05003)Professional Development Program for Visiting Scholars from Colleges and Universities in Zhejiang Province(No.FX2013148)+1 种基金Major National Scientific Instrument and Equipment Development Special of China(No.2012YQ09022903)Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang Province
文摘A new stationary phase for iodide ion analysis has been developed. The cationic polymerepichlorohydrin-dimethylamine（PEPI-DMA） was served as modifier in synthesizing polyelectrolyte sorbents and the macroporous polystyrene-divinylbenzene（PS-DVB） resin was used as support. The positively charged polymer（PEPI-DMA） was electrostatically bonded to a negatively charged particle（PS-DVB sulfonated）. The new stationary phase was characterized by scanning electron microscopy（SEM）, Fourier transform infrared（FTIR）, elemental analysis, chemical adsorption and desorption measurements. The chromatographic evaluation of the new stationary phase was performed using various anions with a conductivity detector. The new stationary phase was also applied to the determination of iodide directly with a DC amperometric detector using a platinum working electrode and an Ag/Ag Cl reference electrode. The chromatographic conditions were optimized and the eluent solution contained 5 mmol/L HNO3 and 15 mmol/L Na NO3 at a flow rate of 1.0 m L/min and column temperature of 30 8C. The applied voltage of the DC amperometric detector was 0.9 V. Under the optimum conditions, the linear range of the method was 0.2–50 mg/L for iodide ion with a correlation coefficient of 0.9990. The detection limit was 0.05 mg/L（calculated at S/N = 3） and the relative standard deviations（RSD, n = 6） were all less than 1% for retention time, peak area and peak height. This method was also utilized for the determination of iodide ions in samples of povidone iodine solution and kelp samples with satisfactory results.
基金part supported by grants from the National Institutes of Health[R01NS061983,R01ES015988 and R01HD087566)]Shriners Hospitals for Children to WD
文摘Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly expressed in steroid-synthesizing tissues including the central nervous system（CNS）.However,
