The efficacy of traditional Chinese medicine （TCM） treatments for Western medicine （WM） diseases relies heavily on the proper classification of patients into TCM syndrome types. The authors developed a data-driven...The efficacy of traditional Chinese medicine （TCM） treatments for Western medicine （WM） diseases relies heavily on the proper classification of patients into TCM syndrome types. The authors developed a data-driven method for solving the classification problem, where syndrome types were identified and quantified based on statistical patterns detected in unlabeled symptom survey data. The new method is a generalization of latent class analysis （LCA）, which has been widely applied in WM research to solve a similar problem, i.e., to identify subtypes of a patient population in the absence of a gold standard. A well-known weakness of LCA is that it makes an unrealistically strong independence assumption. The authors relaxed the assumption by first detecting symptom co-occurrence patterns from survey data and used those statistical patterns instead of the symptoms as features for LCA. This new method consists of six steps： data collection, symptom co-occurrence pattern discovery, statistical pattern interpretation, syndrome identification, syndrome type identification and syndrome type classification. A software package called Lantern has been developed to support the application of the method. The method was illustrated using a data set on vascular mild cognitive impairment.展开更多
Treatment determination based on syndrome differentiation is the key of Chinese medicine. A feasible way of improving the clinical therapy effectiveness is needed to correctly differentiate the syndrome classification...Treatment determination based on syndrome differentiation is the key of Chinese medicine. A feasible way of improving the clinical therapy effectiveness is needed to correctly differentiate the syndrome classifications based on the clinical manifestations. In this paper, a novel data mining method based on manifold ranking （MR） is proposed to explore the relation between syndromes and symptoms for viral hepatitis. Since MR could take the symptom data with expert differentiation and the symptom data without expert differentiation into the task of syndrome classification, the clinical information used for modeling the syndrome features is greatly enlarged so as to improve the precise of syndrome classification. In addition, the proposed method of syndrome classification could also avoid two disadvantages in previous methods： linear relation of the clinical data and mutually exclusive symptoms among different syndromes. And it could help exploit the latent relation between syndromes and symptoms more effectively. Better performance of syndrome classification is able to be achieved according to the experimental results and the clinical experts.展开更多
Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 w...Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 were tracked, summed up and analysized TCM syndromes as stagnation of hepatic qi, deficiency of spleen and pathogenic phlegm reten- tion, blood stasis and toxin stagnation, deficiencies of both blood and qi. Results: (1) For blood stasis and toxin stagnation TCM syndrome, the metastatic rate raised to 45% during 5 years. However, the metastatic rates of other three TCM syn- dromes are 15%, 17.5% and 22.5% respectively. The general distant metastasis rate was 27.5% (P<0.01). (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification (P>0.05). Conclu- sion: (1) TCM syndrome classification has close relation with breast cancer distant metastasis. Distant metastasis have close relationship with blood stasis and toxin stagnation syndrome. (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification, which suggested that metastatic ability has been programmed in the early stage of carcinoma initiation. (3) Significantly enlightening for predict the prognosis under the guide of TCM syn- drome classification and take right therapeutic strategy: attack pathogen and activate blood circulation against cancer.展开更多
OBJECTIVE:To study the features of the distribution and differentiation ofTraditional Chinese Medicine(TCM)syndromes in patients with diabetic peripheral neuropathy(DPN).METHODS:We collected clinical data on illness c...OBJECTIVE:To study the features of the distribution and differentiation ofTraditional Chinese Medicine(TCM)syndromes in patients with diabetic peripheral neuropathy(DPN).METHODS:We collected clinical data on illness course,age,fasting blood glucose,saccharogenic hemoglobin,TCM syndromes,tongue,and pulse of238 DPN patients.Differentiated main syndromes(Yin deficiency and exuberant heat,invasion of spleen by damp-heat,deficiency of both Qi and Yins,and deficiency of both Yin and Yang)and accompanying syndromes(blood stasis and phlegm-dampness)of diabetes were also recorded.The features of DPN syndromes were then analyzed.RESULTS:Among the four main syndromes of diabetes,deficiency of both Yin and Yang was the most common in the 238 DPN patients,of which89%-96%had blood stasis.CONCLUSION:The method of differentiating syndromes of diabetes can be applied to DPN patients.Deficiency of both Yin and Yang,often accompanied by blood stasis,is commonly seen.展开更多
Although ultrasound measurements have been used in previous studies on carpal tunnel syndrome to visualize injury to the median nerve, whether such ultrasound data can indicate the severity of carpal tunnel syndrome r...Although ultrasound measurements have been used in previous studies on carpal tunnel syndrome to visualize injury to the median nerve, whether such ultrasound data can indicate the severity of carpal tunnel syndrome remains controversial. The cross-sectional areas of the median nerve at the tunnel inlet and outlet can show swelling and compression of the nerve at the carpal. We hypothesized that the ratio of the cross-sectional areas of the median nerve at the carpal tunnel inlet to outlet accurately reflects the severity of carpal tunnel syndrome. To test this, high-resolution ultrasound with a linear array transducer at 5–17 MHz was used to assess 77 patients with carpal tunnel syndrome. The results showed that the cut-off point for the inlet-to-outlet ratio was 1.14. Significant differences in the inlet-to-outlet ratio were found among patients with mild, moderate, and severe carpal tunnel syndrome. The cut-off point in the ratio of cross-sectional areas of the median nerve was 1.29 between mild and more severe（moderate and severe） carpal tunnel syndrome patients with 64.7% sensitivity and 72.7% specificity. The cut-off point in the ratio of cross-sectional areas of the median nerve was 1.52 between the moderate and severe carpal tunnel syndrome patients with 80.0% sensitivity and 64.7% specificity. These results suggest that the inlet-to-outlet ratio reflected the severity of carpal tunnel syndrome.展开更多
Objective To realize the characteristics of "zheng" differentiation-treatment for hand, foot and mouth disease(HFMD), a new methodology of syndrome differentiation for different stages of HFMD has been explo...Objective To realize the characteristics of "zheng" differentiation-treatment for hand, foot and mouth disease(HFMD), a new methodology of syndrome differentiation for different stages of HFMD has been explored. Methods Total of 2 325 cases with HFMD were recorded by distributing them into exterior syndrome stage, interior syndrome stage, severe syndrome stage and recovered syndrome stage, respectively, and the main symptoms and subsidiary symptoms of different stages of HFMD have been observed. The major and minor pathogenesis of HFMD in different stages were obtained, and compared with the "2010 Guideline for the Diagnosis and Treatment of HFMD". Results It was found that the major pathogenesis of exterior stage was defined as "the invation of the wenevil to the defender of the body with the collaterals got involved ", and the minor as "qi deficiency"; in interior stage, "the fury of Gan-Yang" was the main pathogenesis, and "qi in chaos and qi deficiency" was the minor; in severe syndrome stage, "the damage of heart, liver and lung" was the main pathogenesis, and "qi in chaos" was the minor; and the pathogenesis of recovered stage was "qi-yin deficiency". Compared with the "2010 Guideline for the Diagnosis and Treatment of HFMD", it showed that "the obstruction of the fei-pi qi by the mixture of shi-re evil" and "the mixture of shi-re" in vivo was quite difficult to be explained in completely different context in the general situation; in the severe stage, the TCM clinical characteristics of syndrome differentiation might lose; in the early acute severe cases, the phenomenon that xin-yang and fei-qi almost ran out was difficult to be observed, then, the line between the severe and the acute severe became vague.Conclusions The theory of syndrome differentiation by stages of HFMD was reasonable in the actual situation of clinical description on HFMD which was expected to be further tested and widely applied in the "zheng" differentiation-treatment of HFMD in the future.展开更多
BACKGROUND： Poly-criteria pathogenesis of patients with stroke causes diversity of syndrome types of traditional Chinese medicine （TCM）; meanwhile, complexity and diversity of pathological mechanism also play a key...BACKGROUND： Poly-criteria pathogenesis of patients with stroke causes diversity of syndrome types of traditional Chinese medicine （TCM）; meanwhile, complexity and diversity of pathological mechanism also play a key role in determining severity so as to induce effects on nervous function and manifestation of mental psychology in patients with post-stroke depression （PSD）. OBJECTIVE： To analyze the syndrome types of TCM with nervous function and manifestations of mental psychology in PSD patients so as to provide evidence for the treatment based on the syndrome differentiation. DESIGN： Contrast observation. SETTING： Departments of Neurology and Traditional Chinese Medicine, General Hospital of Fuxin Mining Industry Group. PARTICIPANTS： A total of 469 outpatients or inpatients with stroke were selected from the Department of Neurology, General Hospital of Fuxin Mining Industry Group from April 2002 to July 2005. All subjects met the diagnostic criteria of stroke established by the Fourth National Cerebrovascular Disease Academic Meeting in 1995 and were finally diagnosed with CT and MRI. Totally, 177 PSD patients were involved in the final analysis and provided the confirmed consent. There were 121 males and 56 females aged from 46 to 79 years. METHODS： （1） All the enrolled subjects were diagnosed for syndrome differentiation by senior TCM physicians within 1 week before discharge based on Diagnostics of Traditional Chinese Medicine, which was classified into 5 types, including sputum-stasis stagnation syndrome, qi stagnation and blood stasis, kidney-essence deficiency, deficiency of the spleen and stomach and phlegm-fire disturbing the heart. In addition, they were also assessed by neurologic deficit scale （NDS; 45 points in total; the higher the scores were, the severer the deficit was）, Fugl-Meyer assessment, （FMA; 100 points in total, including 66 points of upper limbs and 34 points of lower limbs; the higher the scores were, the stronger the motor function was）, modified Barthel index [BI; 100 points in total; the higher the scores were, the better the activity of daily life （ADL） was], symptom checklist-90 （SCL-90; including total scores, positive scores, mean and average scores of positive items）, Hamilton depression rating scale （HAMD） and Hamilton anxiety rating scale （HAMA, the higher the scores were, the severer the degree was）. （2） Patients were divided into one symptom type, two symptom types and ≥ 3 symptom types; meanwhile, they were also divided into deficiency symptom, excess symptom and deficiency-excess symptom. Scores among various groups were compared simultaneously. MAIN OUTCOME MEASURES： Comparison of nervous function and mental psychology of PSD patients with various symptoms. RESULTS： （1） Differences of various symptoms： Among 177 patients, there were 43 subjects in the types of sputum-stasis stagnation, 64 in qi stagnation and blood stasis, 21 in kidney-essence deficiency, 33 in deficiency of the spleen and stomach, and 16 in phlegm-fire disturbing the heart. In the comparison of the scores of nervous function and psychological tests among different syndrome types, the scores of most motor functions of upper and lower limbs, total scores of FMA and ADL in PSD patients of sputum-stasis stagnation, qi stagnation and blood stasis, kidney-essence deficiency were obviously lower than those of the total samples and PSD patients of deficiency of the spleen and stomach and phlegm-fire disturbing the heart, whereas the total scores of NDS, HAMD, HAMA, SCL-90 and SCL-90 positive items, average number of SCL-90 positive items and average score of SCL-90 positive items in the former three groups were all obviously higher than those in the latter three groups （P 〈 0.05 - 0.01）. （2） Different number of syndrome types： In the comparison of the scores of nervous function and psychological tests among the PSD patients with different number of syndrome types, the scores of most motor functions of upper and lower limbs, total scores of FMA and ADL in PSD patients with one or two syndrome types were obviously higher than those of the total samples and the PSD patients with three or more syndrome types, whereas the total scores of NDS, HAMD, HAMA, SCL-90 and SCL-90 positive items, average number of SCL-90 positive items and average score of SCL-90 positive items were all obviously lower in the former two than in the latter two （P 〈 0.05 - 0.01）. （3） There were no obvious differences in the scores of most items of nervous function and psychological tests among the PSD patients of deficiency syndrome, excess syndrome and the deficiency-excess syndrome （P 〉 0.05）. CONCLUSION： The damages of nervous function and mental psychology are more serious in PSD patients with the syndrome types of sputum-stasis stagnation, qi stagnation and blood stasis, kidney-essence deficiency, as well as those with several （three or more） syndrome types, and the conditions may be improved by the treatment based on TCM syndrome differentiation.展开更多
Summary： Thirty-three cases of nerve tinnitus were treated mainly by needling acupoints Baihui（GV 20）, Tinggong（SI 19）, Tinghui（GB 2）, Yifeng（TE 17） and Zhongzhu（TE 3）. In the presence of kidney deficiency,...Summary： Thirty-three cases of nerve tinnitus were treated mainly by needling acupoints Baihui（GV 20）, Tinggong（SI 19）, Tinghui（GB 2）, Yifeng（TE 17） and Zhongzhu（TE 3）. In the presence of kidney deficiency, Shenshu（BL 23） and Mingmen（GV 4） were added; in the presence of liver-gallbladder fire preponderance, Taichong（LR 3） and Qiuxu（GB 40） were added; in the presence of exogenous wind heat, Waiguan（TE 5） and Hegu（LI 4） were added. After 6-course treatments, 6 cases were cured, 22 cases improved and 2 cases failed, with the total effective rate of 93.9%.展开更多
Objective： To observe the therapeutic effect of treating postoperative gastrointestinal syndrome with combined needles and herbs. Method： Altogether 117 in-patients were randomly allocated into the treatment group o...Objective： To observe the therapeutic effect of treating postoperative gastrointestinal syndrome with combined needles and herbs. Method： Altogether 117 in-patients were randomly allocated into the treatment group of 86 cases and control group of 31 cases. Point injection was mainly adopted in the treatment group plus Chinese herbal decoction, while Western medicine was adopted in the control group. And then the therapeutic effect of the two groups was compared. Result： The total effective rate of the treatment group and control group were 96.5% and 80.6% respectively, and the treatment course of the treatment group was significantly shorter than the control group （P 〈 0.01）. Conclusion： Combined needles and herbs have excellent effect in treating postoperative gastrointestinal syndrome and were superior to Western medicine.展开更多
The 6 point behavioral rating scale and Stead＇s grading method of diagnostic scale were applied to evaluate objectively the therapeutic effects of Tuina on 150 patients with tension-type headache in the experimental ...The 6 point behavioral rating scale and Stead＇s grading method of diagnostic scale were applied to evaluate objectively the therapeutic effects of Tuina on 150 patients with tension-type headache in the experimental and controlled groups in this study. The results indicated that abdominal Tuina method of invigorating blood circulation and regulating qi had better effect than the routine Tuina method in treating tension-type headache. Meantime, it is considered that eliminating the immoderate defensive response caused by the process of headache-muscular contraction headache is the academic basis of the marked effect.展开更多
According to differentiation of traditional Chinese medicine, Irritable Bowel Syndrome was classified into two types, disharmony of the liver and spleen and deficiency of the heart and spleen, which were treated with ...According to differentiation of traditional Chinese medicine, Irritable Bowel Syndrome was classified into two types, disharmony of the liver and spleen and deficiency of the heart and spleen, which were treated with acupuncture respectivdy. As a result, of 31 cases, 25 cases had marked effectiveness, 5 cases had effectiveness and 1 case had ineffectiveness.展开更多
Objective：To analyze the diagnostic consistency of Chinese medicine（CM） specialists in patients with cardiovascular disease and to study syndrome classification and identification based on the multi-label learning ...Objective：To analyze the diagnostic consistency of Chinese medicine（CM） specialists in patients with cardiovascular disease and to study syndrome classification and identification based on the multi-label learning method.Methods：Using self-developed CM clinical scales to collect cases,inquiry information,complexity,tongue manifestation and pulse manifestation were assessed.The number of cases collected was 2,218.Firstly,each case was differentiated by two CM specialists according to the same diagnostic criteria.The consistency of the diagnosis based on Cohen’s Kappa coefficient was analyzed.Secondly,take the same diagnosis syndromes of two specialists as the results of the cases.According to injury information in the CM scale ＂yes＂ or ＂no＂ was assigned ＂1＂ or ＂0＂,and according to the syndrome type in each case ＂yes＂ or ＂no＂ was assigned ＂1＂ or ＂0＂.CM information data on cardiovascular disease cases were established.We studied CM syndrome classification and identification based on the relevant feature for each label（REAL） leaming method,and the diagnostic rate of the syndrome was studied using the REAL method when the number of features selected was 5,10,15,20,30,50,70,and 100,respectively.Results：The syndromes with good diagnostic consistency were Heart（Xin）-qi deficiency,Heart-yang deficiency,Heart-yin deficiency,phlegm,stagnation of blood and stagnation of qi.Syndromes with poor diagnostic consistency were heartblood deficiency and blood deficiency of Heart and Liver（Gan）.The highest diagnostic rates using the REAL method were Heart-yang deficiency followed by Heart-qi deficiency.A different number of features,such as 5,10,15,20,30,40,50,70,and 100,respectively,were selected and the diagnostic accuracy based on five features showed the highest diagnostic accuracy.The top five features which had a strong correlation with the syndromes were in accordance with the CM theory.Conclnsions：CM syndrome differentiation is strongly subjective and it is difficult to obtain good diagnostic consistency.The REAL method fully considers the relationship between syndrome types and injury symptoms,and is suitable for the establishment of models for CM syndrome classification and identification.This method can probably provide the prerequisite for objectivity and standardization of CM differentiation.展开更多
To observe the acupuncture treatment of 38 patients with menopausal syndrome.The main acupoints were Fengchi(GB 20),Taiyang(Ex-HN 5),Hegu(L14),Neiguan(PC 6),Qihai(CV 6),Yanglingquan(GB 34),Taichong(LR 3)and Taixi(KI 3...To observe the acupuncture treatment of 38 patients with menopausal syndrome.The main acupoints were Fengchi(GB 20),Taiyang(Ex-HN 5),Hegu(L14),Neiguan(PC 6),Qihai(CV 6),Yanglingquan(GB 34),Taichong(LR 3)and Taixi(KI 3).The adjunct acupoints were added under differentiation.After one to three therapeutic courses clinical recovery occurred in 26 cases,effectiveness in 10 cases,and ineffectiveness in 2 cases.展开更多
102 cases of Tourette＇s syndrome were divided into three types of the liver and kidney yin deficiency, phlegm and damp blockage and spleen and stomach deficiency. Acupuncture, auricular-plaster therapy, cupping thera...102 cases of Tourette＇s syndrome were divided into three types of the liver and kidney yin deficiency, phlegm and damp blockage and spleen and stomach deficiency. Acupuncture, auricular-plaster therapy, cupping therapy and herbal medicine were combined to treat this syndrome. As a result, 30 cases were satisfactorily effective, 61 cases were improved and 11 cases were ineffective with a total effective rate of 98.2% and no side effects were noticed during treatment.展开更多
Better therapeutfc effects have been achieved in the treatment of 112 simple obesity cases,mainly with acupuncture therapy plus auxiliary treatment of acupuncture weight loss apparatus.The results showed that the effe...Better therapeutfc effects have been achieved in the treatment of 112 simple obesity cases,mainly with acupuncture therapy plus auxiliary treatment of acupuncture weight loss apparatus.The results showed that the effective rate was 85%in 112 cases by one course of the treatments,92%in 84 cases by two courses of the treatments,and 98%in 43 cases by three courses of the treatments.The therapeutic effect in combination with acupuncture apparatus was better in long courses of the treatment than in the short courses of the treatments,in male than in female.in young age than in old age,in mild case than in severe condition,in short duration than in long duration,in excessive pattern than in deficient pattern,in those without complications than in those with complications,and in those without family history than in those with family history,indicating that carly treatment and prolonged treatment can enhance the therapeutic effects in weight loss by acupuncture.展开更多
Objective:To observe the therapeutic effect of acupuncture therapy for treatment of chronic atrophic gastritis.Methods:According to the theory of TCM,36 cases of chronic atrophic gastritis were differentiated and trea...Objective:To observe the therapeutic effect of acupuncture therapy for treatment of chronic atrophic gastritis.Methods:According to the theory of TCM,36 cases of chronic atrophic gastritis were differentiated and treated by acupuncture.Gastroscopy and electrogastrograph(EGG)of the body surface,gastric acid and pepsin,blood gastrin,blood prostaglandin E(PGE),gastric mucosal cells and G cells are recorded.Results:Acupuncture therapy had a better effect in improving clinical symptoms,the markedly effective rate was 97.2%and the disappearing rate of clinical manifestations 97.02%;after acupuncture treatment,blood PGE concentration increased;gastric acid secretion increased;gastric dynamics was enhanced and the amplitude of EGG rose;acupuncture could significantly facilitate secretion of gastrin.Conclusion:Acupuncture is a convenient treatment method for atrophic gastritis with quick effect and without side effects.展开更多
The main acupoints of Zhongwan(CV 12),Tianshu(ST 25),Zusanli(ST 36),Shangjuxu(ST37),Dachangshu(BL 25)and Shenque(CV 8),in combination with the corresponding acupoints based on the syndrome differentiation,were selecte...The main acupoints of Zhongwan(CV 12),Tianshu(ST 25),Zusanli(ST 36),Shangjuxu(ST37),Dachangshu(BL 25)and Shenque(CV 8),in combination with the corresponding acupoints based on the syndrome differentiation,were selected to treat 28 cases of chronic nonspecific ulcerative colitis,the result showed clinical cure in 18 cases,clinical effect in 15 cases,failure in 5 cases.The most treatment times were 46,and the least 25.展开更多
Objective： To compare the therapeutic effects between the needling method by identification of deficient and excessive patterns and the needling method by routine meridian differentiation in the treatment of soft tis...Objective： To compare the therapeutic effects between the needling method by identification of deficient and excessive patterns and the needling method by routine meridian differentiation in the treatment of soft tissue injuries. Methods. 380 cases of the patients with soft tissue injuries were randomly divided into pattern identification group （200 cases, with the needling method by identification of deficient and excessive patterns） and meridian identification group （180 cases, with the needling method by routine meridian differentiation）, to observe and compare the therapeutic effects in the two groups. Results： The curative effect was 86% in the pattern identification group and 31.11% in the meridian identification group, with a significant difference （P〈 0.01）. In comparison with the total average treatment times in the cured and improved cases, the pattern identification group was 8.8 days and the meridian identification group was 15.6 days, with a remarkable significant difference （P〈 0.01）. The pattern identification group was better than the meridian identification group. Conclusion： In the treatment of soft tissue injuries, the needling method by identification of deficient and excessive patterns was better than the needling method by routine meridian differentiation.展开更多
Purpose:To observe the therapeutic effect of acupuncture treatment for diabetes.Method:Based upon proper diet,100 cases of patients with diabetes were treated with Pishu(BL 20),Shenshu(BL 23),Feishu(BL 13),Weiwanxiash...Purpose:To observe the therapeutic effect of acupuncture treatment for diabetes.Method:Based upon proper diet,100 cases of patients with diabetes were treated with Pishu(BL 20),Shenshu(BL 23),Feishu(BL 13),Weiwanxiashu(Extra),Zusanli(ST 36),Sanyinjiao(SP 6),Hegu(LI 4),and Xuehai(SP 10)by electric acupuncture,with acupoints added or deducted upon syndrome differentiation.Results:Fasting blood sugar decreased in the patients after the treatments,with a significant difference(P<0.05)in comparison with before treatment.And the patients with obvious symptoms decreased from 85%before the treatment to 4%after the treatment.Conclusions:Acupuncture treatment can reduce fasting blood sugar in the patients with diabetes and is also remarkably effective in improving the clinical symptoms.展开更多
基金supported by Hong Kong Research Grants Council under grants No.16202515 and16212516Guangzhou HKUST Fok Ying Tung Research Institute,China Ministry of Science and Technology TCM Special Research Projects Program under grants No.200807011,No.201007002 and No.201407001-8+2 种基金Beijing Science and Technology Program under grant No.Z111107056811040Beijing New Medical Discipline Development Program under grant No.XK100270569Beijing University of Chinese Medicine under grant No.2011-CXTD-23
文摘The efficacy of traditional Chinese medicine （TCM） treatments for Western medicine （WM） diseases relies heavily on the proper classification of patients into TCM syndrome types. The authors developed a data-driven method for solving the classification problem, where syndrome types were identified and quantified based on statistical patterns detected in unlabeled symptom survey data. The new method is a generalization of latent class analysis （LCA）, which has been widely applied in WM research to solve a similar problem, i.e., to identify subtypes of a patient population in the absence of a gold standard. A well-known weakness of LCA is that it makes an unrealistically strong independence assumption. The authors relaxed the assumption by first detecting symptom co-occurrence patterns from survey data and used those statistical patterns instead of the symptoms as features for LCA. This new method consists of six steps： data collection, symptom co-occurrence pattern discovery, statistical pattern interpretation, syndrome identification, syndrome type identification and syndrome type classification. A software package called Lantern has been developed to support the application of the method. The method was illustrated using a data set on vascular mild cognitive impairment.
基金Supported by National Natural Science Foundation of China(No.81202858)National Key Technology Support Program(No.2012BAI25B02)+1 种基金Self-selected Subject of China Academyof Chinese Medical Sciences(No.ZZ05003,No.ZZ03090,No.Z0217)the Beijing Key Laboratory of Advanced Information Science and Network Technology(No.XDXX1306)
文摘Treatment determination based on syndrome differentiation is the key of Chinese medicine. A feasible way of improving the clinical therapy effectiveness is needed to correctly differentiate the syndrome classifications based on the clinical manifestations. In this paper, a novel data mining method based on manifold ranking （MR） is proposed to explore the relation between syndromes and symptoms for viral hepatitis. Since MR could take the symptom data with expert differentiation and the symptom data without expert differentiation into the task of syndrome classification, the clinical information used for modeling the syndrome features is greatly enlarged so as to improve the precise of syndrome classification. In addition, the proposed method of syndrome classification could also avoid two disadvantages in previous methods： linear relation of the clinical data and mutually exclusive symptoms among different syndromes. And it could help exploit the latent relation between syndromes and symptoms more effectively. Better performance of syndrome classification is able to be achieved according to the experimental results and the clinical experts.
文摘Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 were tracked, summed up and analysized TCM syndromes as stagnation of hepatic qi, deficiency of spleen and pathogenic phlegm reten- tion, blood stasis and toxin stagnation, deficiencies of both blood and qi. Results: (1) For blood stasis and toxin stagnation TCM syndrome, the metastatic rate raised to 45% during 5 years. However, the metastatic rates of other three TCM syn- dromes are 15%, 17.5% and 22.5% respectively. The general distant metastasis rate was 27.5% (P<0.01). (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification (P>0.05). Conclu- sion: (1) TCM syndrome classification has close relation with breast cancer distant metastasis. Distant metastasis have close relationship with blood stasis and toxin stagnation syndrome. (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification, which suggested that metastatic ability has been programmed in the early stage of carcinoma initiation. (3) Significantly enlightening for predict the prognosis under the guide of TCM syn- drome classification and take right therapeutic strategy: attack pathogen and activate blood circulation against cancer.
基金Supported by the National Fund of Natural Sciences(No.81173445)
文摘OBJECTIVE:To study the features of the distribution and differentiation ofTraditional Chinese Medicine(TCM)syndromes in patients with diabetic peripheral neuropathy(DPN).METHODS:We collected clinical data on illness course,age,fasting blood glucose,saccharogenic hemoglobin,TCM syndromes,tongue,and pulse of238 DPN patients.Differentiated main syndromes(Yin deficiency and exuberant heat,invasion of spleen by damp-heat,deficiency of both Qi and Yins,and deficiency of both Yin and Yang)and accompanying syndromes(blood stasis and phlegm-dampness)of diabetes were also recorded.The features of DPN syndromes were then analyzed.RESULTS:Among the four main syndromes of diabetes,deficiency of both Yin and Yang was the most common in the 238 DPN patients,of which89%-96%had blood stasis.CONCLUSION:The method of differentiating syndromes of diabetes can be applied to DPN patients.Deficiency of both Yin and Yang,often accompanied by blood stasis,is commonly seen.
基金supported by a grant from the Shanghai Key Laboratory of Peripheral Nerve and Microsurgery in China,No.14DZ2273300the Natural Science Foundation of Shanghai in China,No.13ZR1404600a grant from the National Key Basic Research Program of China(973 Program),No.2014CB542201
文摘Although ultrasound measurements have been used in previous studies on carpal tunnel syndrome to visualize injury to the median nerve, whether such ultrasound data can indicate the severity of carpal tunnel syndrome remains controversial. The cross-sectional areas of the median nerve at the tunnel inlet and outlet can show swelling and compression of the nerve at the carpal. We hypothesized that the ratio of the cross-sectional areas of the median nerve at the carpal tunnel inlet to outlet accurately reflects the severity of carpal tunnel syndrome. To test this, high-resolution ultrasound with a linear array transducer at 5–17 MHz was used to assess 77 patients with carpal tunnel syndrome. The results showed that the cut-off point for the inlet-to-outlet ratio was 1.14. Significant differences in the inlet-to-outlet ratio were found among patients with mild, moderate, and severe carpal tunnel syndrome. The cut-off point in the ratio of cross-sectional areas of the median nerve was 1.29 between mild and more severe（moderate and severe） carpal tunnel syndrome patients with 64.7% sensitivity and 72.7% specificity. The cut-off point in the ratio of cross-sectional areas of the median nerve was 1.52 between the moderate and severe carpal tunnel syndrome patients with 80.0% sensitivity and 64.7% specificity. These results suggest that the inlet-to-outlet ratio reflected the severity of carpal tunnel syndrome.
基金supported by the development and construction project of State Administration of l Traditional Chinese Medicine (200907001-3)the key science and technology project of Shenzhen (201003134, 201002110)
文摘Objective To realize the characteristics of "zheng" differentiation-treatment for hand, foot and mouth disease(HFMD), a new methodology of syndrome differentiation for different stages of HFMD has been explored. Methods Total of 2 325 cases with HFMD were recorded by distributing them into exterior syndrome stage, interior syndrome stage, severe syndrome stage and recovered syndrome stage, respectively, and the main symptoms and subsidiary symptoms of different stages of HFMD have been observed. The major and minor pathogenesis of HFMD in different stages were obtained, and compared with the "2010 Guideline for the Diagnosis and Treatment of HFMD". Results It was found that the major pathogenesis of exterior stage was defined as "the invation of the wenevil to the defender of the body with the collaterals got involved ", and the minor as "qi deficiency"; in interior stage, "the fury of Gan-Yang" was the main pathogenesis, and "qi in chaos and qi deficiency" was the minor; in severe syndrome stage, "the damage of heart, liver and lung" was the main pathogenesis, and "qi in chaos" was the minor; and the pathogenesis of recovered stage was "qi-yin deficiency". Compared with the "2010 Guideline for the Diagnosis and Treatment of HFMD", it showed that "the obstruction of the fei-pi qi by the mixture of shi-re evil" and "the mixture of shi-re" in vivo was quite difficult to be explained in completely different context in the general situation; in the severe stage, the TCM clinical characteristics of syndrome differentiation might lose; in the early acute severe cases, the phenomenon that xin-yang and fei-qi almost ran out was difficult to be observed, then, the line between the severe and the acute severe became vague.Conclusions The theory of syndrome differentiation by stages of HFMD was reasonable in the actual situation of clinical description on HFMD which was expected to be further tested and widely applied in the "zheng" differentiation-treatment of HFMD in the future.
文摘BACKGROUND： Poly-criteria pathogenesis of patients with stroke causes diversity of syndrome types of traditional Chinese medicine （TCM）; meanwhile, complexity and diversity of pathological mechanism also play a key role in determining severity so as to induce effects on nervous function and manifestation of mental psychology in patients with post-stroke depression （PSD）. OBJECTIVE： To analyze the syndrome types of TCM with nervous function and manifestations of mental psychology in PSD patients so as to provide evidence for the treatment based on the syndrome differentiation. DESIGN： Contrast observation. SETTING： Departments of Neurology and Traditional Chinese Medicine, General Hospital of Fuxin Mining Industry Group. PARTICIPANTS： A total of 469 outpatients or inpatients with stroke were selected from the Department of Neurology, General Hospital of Fuxin Mining Industry Group from April 2002 to July 2005. All subjects met the diagnostic criteria of stroke established by the Fourth National Cerebrovascular Disease Academic Meeting in 1995 and were finally diagnosed with CT and MRI. Totally, 177 PSD patients were involved in the final analysis and provided the confirmed consent. There were 121 males and 56 females aged from 46 to 79 years. METHODS： （1） All the enrolled subjects were diagnosed for syndrome differentiation by senior TCM physicians within 1 week before discharge based on Diagnostics of Traditional Chinese Medicine, which was classified into 5 types, including sputum-stasis stagnation syndrome, qi stagnation and blood stasis, kidney-essence deficiency, deficiency of the spleen and stomach and phlegm-fire disturbing the heart. In addition, they were also assessed by neurologic deficit scale （NDS; 45 points in total; the higher the scores were, the severer the deficit was）, Fugl-Meyer assessment, （FMA; 100 points in total, including 66 points of upper limbs and 34 points of lower limbs; the higher the scores were, the stronger the motor function was）, modified Barthel index [BI; 100 points in total; the higher the scores were, the better the activity of daily life （ADL） was], symptom checklist-90 （SCL-90; including total scores, positive scores, mean and average scores of positive items）, Hamilton depression rating scale （HAMD） and Hamilton anxiety rating scale （HAMA, the higher the scores were, the severer the degree was）. （2） Patients were divided into one symptom type, two symptom types and ≥ 3 symptom types; meanwhile, they were also divided into deficiency symptom, excess symptom and deficiency-excess symptom. Scores among various groups were compared simultaneously. MAIN OUTCOME MEASURES： Comparison of nervous function and mental psychology of PSD patients with various symptoms. RESULTS： （1） Differences of various symptoms： Among 177 patients, there were 43 subjects in the types of sputum-stasis stagnation, 64 in qi stagnation and blood stasis, 21 in kidney-essence deficiency, 33 in deficiency of the spleen and stomach, and 16 in phlegm-fire disturbing the heart. In the comparison of the scores of nervous function and psychological tests among different syndrome types, the scores of most motor functions of upper and lower limbs, total scores of FMA and ADL in PSD patients of sputum-stasis stagnation, qi stagnation and blood stasis, kidney-essence deficiency were obviously lower than those of the total samples and PSD patients of deficiency of the spleen and stomach and phlegm-fire disturbing the heart, whereas the total scores of NDS, HAMD, HAMA, SCL-90 and SCL-90 positive items, average number of SCL-90 positive items and average score of SCL-90 positive items in the former three groups were all obviously higher than those in the latter three groups （P 〈 0.05 - 0.01）. （2） Different number of syndrome types： In the comparison of the scores of nervous function and psychological tests among the PSD patients with different number of syndrome types, the scores of most motor functions of upper and lower limbs, total scores of FMA and ADL in PSD patients with one or two syndrome types were obviously higher than those of the total samples and the PSD patients with three or more syndrome types, whereas the total scores of NDS, HAMD, HAMA, SCL-90 and SCL-90 positive items, average number of SCL-90 positive items and average score of SCL-90 positive items were all obviously lower in the former two than in the latter two （P 〈 0.05 - 0.01）. （3） There were no obvious differences in the scores of most items of nervous function and psychological tests among the PSD patients of deficiency syndrome, excess syndrome and the deficiency-excess syndrome （P 〉 0.05）. CONCLUSION： The damages of nervous function and mental psychology are more serious in PSD patients with the syndrome types of sputum-stasis stagnation, qi stagnation and blood stasis, kidney-essence deficiency, as well as those with several （three or more） syndrome types, and the conditions may be improved by the treatment based on TCM syndrome differentiation.
文摘Summary： Thirty-three cases of nerve tinnitus were treated mainly by needling acupoints Baihui（GV 20）, Tinggong（SI 19）, Tinghui（GB 2）, Yifeng（TE 17） and Zhongzhu（TE 3）. In the presence of kidney deficiency, Shenshu（BL 23） and Mingmen（GV 4） were added; in the presence of liver-gallbladder fire preponderance, Taichong（LR 3） and Qiuxu（GB 40） were added; in the presence of exogenous wind heat, Waiguan（TE 5） and Hegu（LI 4） were added. After 6-course treatments, 6 cases were cured, 22 cases improved and 2 cases failed, with the total effective rate of 93.9%.
文摘Objective： To observe the therapeutic effect of treating postoperative gastrointestinal syndrome with combined needles and herbs. Method： Altogether 117 in-patients were randomly allocated into the treatment group of 86 cases and control group of 31 cases. Point injection was mainly adopted in the treatment group plus Chinese herbal decoction, while Western medicine was adopted in the control group. And then the therapeutic effect of the two groups was compared. Result： The total effective rate of the treatment group and control group were 96.5% and 80.6% respectively, and the treatment course of the treatment group was significantly shorter than the control group （P 〈 0.01）. Conclusion： Combined needles and herbs have excellent effect in treating postoperative gastrointestinal syndrome and were superior to Western medicine.
文摘The 6 point behavioral rating scale and Stead＇s grading method of diagnostic scale were applied to evaluate objectively the therapeutic effects of Tuina on 150 patients with tension-type headache in the experimental and controlled groups in this study. The results indicated that abdominal Tuina method of invigorating blood circulation and regulating qi had better effect than the routine Tuina method in treating tension-type headache. Meantime, it is considered that eliminating the immoderate defensive response caused by the process of headache-muscular contraction headache is the academic basis of the marked effect.
文摘According to differentiation of traditional Chinese medicine, Irritable Bowel Syndrome was classified into two types, disharmony of the liver and spleen and deficiency of the heart and spleen, which were treated with acupuncture respectivdy. As a result, of 31 cases, 25 cases had marked effectiveness, 5 cases had effectiveness and 1 case had ineffectiveness.
基金Supported by the National Natural Science Foundation of China(No.81173199)
文摘Objective：To analyze the diagnostic consistency of Chinese medicine（CM） specialists in patients with cardiovascular disease and to study syndrome classification and identification based on the multi-label learning method.Methods：Using self-developed CM clinical scales to collect cases,inquiry information,complexity,tongue manifestation and pulse manifestation were assessed.The number of cases collected was 2,218.Firstly,each case was differentiated by two CM specialists according to the same diagnostic criteria.The consistency of the diagnosis based on Cohen’s Kappa coefficient was analyzed.Secondly,take the same diagnosis syndromes of two specialists as the results of the cases.According to injury information in the CM scale ＂yes＂ or ＂no＂ was assigned ＂1＂ or ＂0＂,and according to the syndrome type in each case ＂yes＂ or ＂no＂ was assigned ＂1＂ or ＂0＂.CM information data on cardiovascular disease cases were established.We studied CM syndrome classification and identification based on the relevant feature for each label（REAL） leaming method,and the diagnostic rate of the syndrome was studied using the REAL method when the number of features selected was 5,10,15,20,30,50,70,and 100,respectively.Results：The syndromes with good diagnostic consistency were Heart（Xin）-qi deficiency,Heart-yang deficiency,Heart-yin deficiency,phlegm,stagnation of blood and stagnation of qi.Syndromes with poor diagnostic consistency were heartblood deficiency and blood deficiency of Heart and Liver（Gan）.The highest diagnostic rates using the REAL method were Heart-yang deficiency followed by Heart-qi deficiency.A different number of features,such as 5,10,15,20,30,40,50,70,and 100,respectively,were selected and the diagnostic accuracy based on five features showed the highest diagnostic accuracy.The top five features which had a strong correlation with the syndromes were in accordance with the CM theory.Conclnsions：CM syndrome differentiation is strongly subjective and it is difficult to obtain good diagnostic consistency.The REAL method fully considers the relationship between syndrome types and injury symptoms,and is suitable for the establishment of models for CM syndrome classification and identification.This method can probably provide the prerequisite for objectivity and standardization of CM differentiation.
文摘To observe the acupuncture treatment of 38 patients with menopausal syndrome.The main acupoints were Fengchi(GB 20),Taiyang(Ex-HN 5),Hegu(L14),Neiguan(PC 6),Qihai(CV 6),Yanglingquan(GB 34),Taichong(LR 3)and Taixi(KI 3).The adjunct acupoints were added under differentiation.After one to three therapeutic courses clinical recovery occurred in 26 cases,effectiveness in 10 cases,and ineffectiveness in 2 cases.
文摘102 cases of Tourette＇s syndrome were divided into three types of the liver and kidney yin deficiency, phlegm and damp blockage and spleen and stomach deficiency. Acupuncture, auricular-plaster therapy, cupping therapy and herbal medicine were combined to treat this syndrome. As a result, 30 cases were satisfactorily effective, 61 cases were improved and 11 cases were ineffective with a total effective rate of 98.2% and no side effects were noticed during treatment.
文摘Better therapeutfc effects have been achieved in the treatment of 112 simple obesity cases,mainly with acupuncture therapy plus auxiliary treatment of acupuncture weight loss apparatus.The results showed that the effective rate was 85%in 112 cases by one course of the treatments,92%in 84 cases by two courses of the treatments,and 98%in 43 cases by three courses of the treatments.The therapeutic effect in combination with acupuncture apparatus was better in long courses of the treatment than in the short courses of the treatments,in male than in female.in young age than in old age,in mild case than in severe condition,in short duration than in long duration,in excessive pattern than in deficient pattern,in those without complications than in those with complications,and in those without family history than in those with family history,indicating that carly treatment and prolonged treatment can enhance the therapeutic effects in weight loss by acupuncture.
文摘Objective:To observe the therapeutic effect of acupuncture therapy for treatment of chronic atrophic gastritis.Methods:According to the theory of TCM,36 cases of chronic atrophic gastritis were differentiated and treated by acupuncture.Gastroscopy and electrogastrograph(EGG)of the body surface,gastric acid and pepsin,blood gastrin,blood prostaglandin E(PGE),gastric mucosal cells and G cells are recorded.Results:Acupuncture therapy had a better effect in improving clinical symptoms,the markedly effective rate was 97.2%and the disappearing rate of clinical manifestations 97.02%;after acupuncture treatment,blood PGE concentration increased;gastric acid secretion increased;gastric dynamics was enhanced and the amplitude of EGG rose;acupuncture could significantly facilitate secretion of gastrin.Conclusion:Acupuncture is a convenient treatment method for atrophic gastritis with quick effect and without side effects.
文摘The main acupoints of Zhongwan(CV 12),Tianshu(ST 25),Zusanli(ST 36),Shangjuxu(ST37),Dachangshu(BL 25)and Shenque(CV 8),in combination with the corresponding acupoints based on the syndrome differentiation,were selected to treat 28 cases of chronic nonspecific ulcerative colitis,the result showed clinical cure in 18 cases,clinical effect in 15 cases,failure in 5 cases.The most treatment times were 46,and the least 25.
文摘Objective： To compare the therapeutic effects between the needling method by identification of deficient and excessive patterns and the needling method by routine meridian differentiation in the treatment of soft tissue injuries. Methods. 380 cases of the patients with soft tissue injuries were randomly divided into pattern identification group （200 cases, with the needling method by identification of deficient and excessive patterns） and meridian identification group （180 cases, with the needling method by routine meridian differentiation）, to observe and compare the therapeutic effects in the two groups. Results： The curative effect was 86% in the pattern identification group and 31.11% in the meridian identification group, with a significant difference （P〈 0.01）. In comparison with the total average treatment times in the cured and improved cases, the pattern identification group was 8.8 days and the meridian identification group was 15.6 days, with a remarkable significant difference （P〈 0.01）. The pattern identification group was better than the meridian identification group. Conclusion： In the treatment of soft tissue injuries, the needling method by identification of deficient and excessive patterns was better than the needling method by routine meridian differentiation.
文摘Purpose:To observe the therapeutic effect of acupuncture treatment for diabetes.Method:Based upon proper diet,100 cases of patients with diabetes were treated with Pishu(BL 20),Shenshu(BL 23),Feishu(BL 13),Weiwanxiashu(Extra),Zusanli(ST 36),Sanyinjiao(SP 6),Hegu(LI 4),and Xuehai(SP 10)by electric acupuncture,with acupoints added or deducted upon syndrome differentiation.Results:Fasting blood sugar decreased in the patients after the treatments,with a significant difference(P<0.05)in comparison with before treatment.And the patients with obvious symptoms decreased from 85%before the treatment to 4%after the treatment.Conclusions:Acupuncture treatment can reduce fasting blood sugar in the patients with diabetes and is also remarkably effective in improving the clinical symptoms.
