北京,2015年11月17日人机交互解决方案的领先开发商S y n a p t i c s公司（NASDAQ：SYNA）今天宣布,将凭借全面和专用的汽车解决方案组合,广泛开拓汽车市场。这些汽车专用解决方案将与消费电子领域的人机交互技术齐头并进。Synaptics...北京,2015年11月17日人机交互解决方案的领先开发商S y n a p t i c s公司（NASDAQ：SYNA）今天宣布,将凭借全面和专用的汽车解决方案组合,广泛开拓汽车市场。这些汽车专用解决方案将与消费电子领域的人机交互技术齐头并进。Synaptics拥有业界领先的触摸控制器、显示驱动器、生物识别传感器,这些都将迎合汽车行业的需求,并将遍布于汽车的许多地方。展开更多
全球领先的人机界面解决方案开发商Synaptics近日宣布,开始提供其全新6x6mm Natural ID FS4500指纹传感器解决方案的样品。该解决方案可透过玻璃或陶瓷按键（覆盖玻璃厚度可高达300微米）,提供安全的生物识别功能。随着智能手机越来越...全球领先的人机界面解决方案开发商Synaptics近日宣布,开始提供其全新6x6mm Natural ID FS4500指纹传感器解决方案的样品。该解决方案可透过玻璃或陶瓷按键（覆盖玻璃厚度可高达300微米）,提供安全的生物识别功能。随着智能手机越来越多地采用耐用型玻璃按键,Synaptics将凭借行业领先的安全特性,提供具备多种形状、尺寸和支持不同表面材质的产品,来满足OEM厂商多样化的需求。展开更多
人机交互解决方案的领先开发商Synaptics公司近日宣布,面向市场全面提供Clear Pad Clear Force压力感知触控解决方案的样品。Clear Force为客户提供了新的人机交互方式,例如,通过用手指或触控笔施加不同的力度,调整滚动速度和缩放比例...人机交互解决方案的领先开发商Synaptics公司近日宣布,面向市场全面提供Clear Pad Clear Force压力感知触控解决方案的样品。Clear Force为客户提供了新的人机交互方式,例如,通过用手指或触控笔施加不同的力度,调整滚动速度和缩放比例、实现连续可变的游戏控制以及不同的文本或照片编辑方式,因此可使设备制造商实现智能手机差异化。展开更多
Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience...Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.展开更多
Alzheimer’s disease(AD)is the most common cause of dementia,characterized by progressive cognitive decline,and affects over 55 million people worldwide.AD is pathological featured by the aberrant accumulation of amyl...Alzheimer’s disease(AD)is the most common cause of dementia,characterized by progressive cognitive decline,and affects over 55 million people worldwide.AD is pathological featured by the aberrant accumulation of amyloid-βplaques,neurofibrillary tangles formed by hyperphosphorylated tau,synaptic loss,and dysfunction of neurotransmitter systems.Evidence from in vivo and autopsy studies has consistently shown that synaptic dysfunction and loss are strongly correlated with cognitive decline in AD,particularly in brain regions such as the hippocampus and cortex,which are critical for memory formation and processing.This perspective highlights recent histopathological findings related to synaptic dysfunction in AD,advancements in the development of imaging and fluid-based biomarkers for synaptic loss,and future studies.展开更多
文摘北京,2015年11月17日人机交互解决方案的领先开发商S y n a p t i c s公司（NASDAQ：SYNA）今天宣布,将凭借全面和专用的汽车解决方案组合,广泛开拓汽车市场。这些汽车专用解决方案将与消费电子领域的人机交互技术齐头并进。Synaptics拥有业界领先的触摸控制器、显示驱动器、生物识别传感器,这些都将迎合汽车行业的需求,并将遍布于汽车的许多地方。
文摘全球领先的人机界面解决方案开发商Synaptics近日宣布,开始提供其全新6x6mm Natural ID FS4500指纹传感器解决方案的样品。该解决方案可透过玻璃或陶瓷按键（覆盖玻璃厚度可高达300微米）,提供安全的生物识别功能。随着智能手机越来越多地采用耐用型玻璃按键,Synaptics将凭借行业领先的安全特性,提供具备多种形状、尺寸和支持不同表面材质的产品,来满足OEM厂商多样化的需求。
文摘人机交互解决方案的领先开发商Synaptics公司近日宣布,面向市场全面提供Clear Pad Clear Force压力感知触控解决方案的样品。Clear Force为客户提供了新的人机交互方式,例如,通过用手指或触控笔施加不同的力度,调整滚动速度和缩放比例、实现连续可变的游戏控制以及不同的文本或照片编辑方式,因此可使设备制造商实现智能手机差异化。
基金supported by the National Natural Science Foundation of China,No.31760290,82160688the Key Development Areas Project of Ganzhou Science and Technology,No.2022B-SF9554(all to XL)。
文摘Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.
基金supported by Swiss Center for Applied Human Toxicology(SCAHT AP22-01)(to RN).
文摘Alzheimer’s disease(AD)is the most common cause of dementia,characterized by progressive cognitive decline,and affects over 55 million people worldwide.AD is pathological featured by the aberrant accumulation of amyloid-βplaques,neurofibrillary tangles formed by hyperphosphorylated tau,synaptic loss,and dysfunction of neurotransmitter systems.Evidence from in vivo and autopsy studies has consistently shown that synaptic dysfunction and loss are strongly correlated with cognitive decline in AD,particularly in brain regions such as the hippocampus and cortex,which are critical for memory formation and processing.This perspective highlights recent histopathological findings related to synaptic dysfunction in AD,advancements in the development of imaging and fluid-based biomarkers for synaptic loss,and future studies.
