Autism spectrum disorder(AsD)is a highly heterogeneous neurodevelopmental disorder.Early diagnosis and intervention are crucial for improving outcomes.Traditional single-modality diagnostic methods are subjective,limi...Autism spectrum disorder(AsD)is a highly heterogeneous neurodevelopmental disorder.Early diagnosis and intervention are crucial for improving outcomes.Traditional single-modality diagnostic methods are subjective,limited,and struggle to reveal the underlying pathological mechanisms.In contrast,multimodal data analysis integrates behavioral,physiological,and neuroimaging information with advanced machine-learning and deeplearning algorithms to overcome these limitations.In this review,we surveyed the recent pediatric AsD literature,highlighting artificial intelligence-driven diagnostic techniques,multimodal data fusion strategies,and emerging trends in ASD assessment.We surveyed studies that integrated two or more modalities and summarized the fusion levels,learning paradigms,tasks,datasets,and metrics.Multimodal approaches outperform singlemodality baselines in classification,severity estimation,and subtyping by leveraging complementary information and reducing modality-specific biases.Multimodal approaches significantly enhance diagnostic accuracy and comprehensiveness,enabling early screening of AsD,symptom subtyping,severity assessment,and personalized interventions.Advances in multimodal fusion techniques have promoted progress in precision medicine for the treatment of ASD.展开更多
基金supported by the National Key Research and Development Program of China(Research Grant Number:2023YFC3603600).
文摘Autism spectrum disorder(AsD)is a highly heterogeneous neurodevelopmental disorder.Early diagnosis and intervention are crucial for improving outcomes.Traditional single-modality diagnostic methods are subjective,limited,and struggle to reveal the underlying pathological mechanisms.In contrast,multimodal data analysis integrates behavioral,physiological,and neuroimaging information with advanced machine-learning and deeplearning algorithms to overcome these limitations.In this review,we surveyed the recent pediatric AsD literature,highlighting artificial intelligence-driven diagnostic techniques,multimodal data fusion strategies,and emerging trends in ASD assessment.We surveyed studies that integrated two or more modalities and summarized the fusion levels,learning paradigms,tasks,datasets,and metrics.Multimodal approaches outperform singlemodality baselines in classification,severity estimation,and subtyping by leveraging complementary information and reducing modality-specific biases.Multimodal approaches significantly enhance diagnostic accuracy and comprehensiveness,enabling early screening of AsD,symptom subtyping,severity assessment,and personalized interventions.Advances in multimodal fusion techniques have promoted progress in precision medicine for the treatment of ASD.
