D-π hybridization is a key structural feature that may significantly affect the intrinsic electronic properties of metallopolymers.Herein,we present the electrosynthesis and memristive properties of metallopolymers u...D-π hybridization is a key structural feature that may significantly affect the intrinsic electronic properties of metallopolymers.Herein,we present the electrosynthesis and memristive properties of metallopolymers using the distinct d-π hybridization monomers R_(1) and R_(2).R_(1)(Ru^(Ⅱ)-(tpz)Cl_(2))features tetradentate ligands(tpz,6,6'-di(1H-pyrazol-1-yl)-2,2'-bipyridine)enforcing quasi-octahedral geometry;R_(2)(Ru^(Ⅱ)-(bpp)_(2))incorporates tridentate ligands(bpp,2,6-di(1H-pyrazol-1-yl)pyridine)inducing pronounced geometric distortion.The planar ligand(tpz)in R_(1) facilitates ordered molecular assembly through high conformational rigidity and extensive π-π stacking,resulting in increased molecular densities and enhanced morphological uniformity compared to R_(2) metallopolymers.Due to pyrazole’s weaker π-acceptance and strongerσ-donation compared to pyridine,R_(1) exhibits a 119 nm red-shift in metal-to-ligand charge transfer(MLCT)band and a 30 mV anodic shift in Ru^(+2/+3)redox potential relative to R_(2).Coupled with a reduced HOMO-LUMO gap,the uniform and ordered structure leads to a lower conductance decay constant in R_(1).Additionally,R_(2) metallopolymers exhibit superior memristive performance(characterized by lower switching voltage and higher switching ratio)via redox-induced aromatic transitions in axial ligands enhancing electronic delocalization.This work compares two metallopolymers with different ligand geometries,revealing how this difference leads to distinct charge transport and memristive behaviors.展开更多
High-entropy oxides(HEOs)have emerged as a promising class of memristive materials,characterized by entropy-stabilized crystal structures,multivalent cation coordination,and tunable defect landscapes.These intrinsic f...High-entropy oxides(HEOs)have emerged as a promising class of memristive materials,characterized by entropy-stabilized crystal structures,multivalent cation coordination,and tunable defect landscapes.These intrinsic features enable forming-free resistive switching,multilevel conductance modulation,and synaptic plasticity,making HEOs attractive for neuromorphic computing.This review outlines recent progress in HEO-based memristors across materials engineering,switching mechanisms,and synaptic emulation.Particular attention is given to vacancy migration,phase transitions,and valence-state dynamics—mechanisms that underlie the switching behaviors observed in both amorphous and crystalline systems.Their relevance to neuromorphic functions such as short-term plasticity and spike-timing-dependent learning is also examined.While encouraging results have been achieved at the device level,challenges remain in conductance precision,variability control,and scalable integration.Addressing these demands a concerted effort across materials design,interface optimization,and task-aware modeling.With such integration,HEO memristors offer a compelling pathway toward energy-efficient and adaptable brain-inspired electronics.展开更多
Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has...Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has been verified to evaluate the performance of FENTs,but until recently,the response time,another crucial indicator,has been ignored.Employing finite-element method,we investigated the relationship among gate charge,switching ratio and response time by divisionally manipulating gate charge,including entrance surface and the surface of confinement space,for ion transport to optimize switching capability.The dual-split gate charge on FENTs exhibits synergistic effect on switching response.Based on the two regional gate charge on FENTs,multivalence ions in lower concentration,high aspect ratio and single channel show higher switching ratio but longer response time compared to monovalent ions.The findings highlight the necessity of balancing these two signals in FENTs and offer insights for optimizing their design and expanding applications to dual-signal-detection iontronics.展开更多
BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic mal...BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic malignancies.CASE SUMMARY We herein report a rare case of a 59-year-old female who presented with acute left upper quadrant abdominal pain without any history of trauma.Abdominal imaging demonstrated a heterogeneous splenic lesion with hemoperitoneum,raising clinical suspicion of SSR.Emergency laparotomy revealed a pancreatic tumor invading the spleen and left kidney,with associated splenic rupture and dense adhesions,necessitating en bloc resection of the distal pancreas,spleen,and left kidney.Histopathology revealed a biphasic malignancy composed of moderately differentiated pancreatic ductal adenocarcinoma and an undifferentiated carcinoma with rhabdoid morphology and loss of SMARCB1 expression.Immunohistochemical analysis confirmed complete loss of SMARCB1/INI1 in the undifferentiated component,along with a high Ki-67 index(approximately 80%)and CD10 positivity.The ductal adenocarcinoma component retained SMARCB1/INI1 expression and was positive for CK7 and CK-pan.Transitional zones between the two tumor components suggested progressive dedifferentiation and underlying genomic instability.The patient received adjuvant chemotherapy with gemcitabine and nab-paclitaxel and maintained a satisfactory quality of life at the 6-month follow-up.CONCLUSION This study reports a rare case of SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma of the pancreas combined with ductal adenocarcinoma,presenting as SSR-an exceptionally uncommon initial manifestation of pancreatic malignancy.展开更多
As investigated by 3GPP,support of UPF(user plane function)onboard satellite can reduce the latency of communications via satellite,and then it becomes a key enhancement in 5G network integrating with satellite commun...As investigated by 3GPP,support of UPF(user plane function)onboard satellite can reduce the latency of communications via satellite,and then it becomes a key enhancement in 5G network integrating with satellite communication.However,current 5G system cannot support UPF onboard LEO(low earth orbit)satellites,as it would face challenges like UPF mobility handling,synchronization between mobile network and satellite network,and condition of activating local data switching.To solve such challenges,this paper proposes a solution to support UPF onboard LEO satellite,which consists of enhanced network architecture,I-UPF(intermediate UPF)based local data switching scheme and communication latency based data path selection.We subsequently develop analytic models for performance evaluation and conduct simulations using the constellation configuration of iridium II.The simulation results show that the data switching via I-UPF onboard LEO satellite can reduce E2E(end to end)packet delivery latency and E2E packet loss ratio significantly compared with that of routing the data back to 5GC on the ground.The proposed scheme yet has increased signaling cost for handling UPF mobility.els,compared with existing similar companding algorithms.展开更多
Coherent perfect absorption(CPA)and coherent perfect transmission(CPT)are two extreme states arising from the manipulation of optical fields.Generally,CPA and CPT occur under different input-field phases.Therefore,we ...Coherent perfect absorption(CPA)and coherent perfect transmission(CPT)are two extreme states arising from the manipulation of optical fields.Generally,CPA and CPT occur under different input-field phases.Therefore,we propose a scheme to realize an all-optical switch based on phase-dependent CPA–CPT conversion.In our proposal,the CPT state and the CPA state are treated as the on state and the off state,respectively.Consequently,the efficiency of this all-optical switch can reach the maximum value of 1.With the introduction of an incoherent pump field,the CPA state can be achieved under a weaker input probe field or can be converted into a CPT state.The results show that the optical switch can operate with weaker fields and can be further optimized by the application of an incoherent field.展开更多
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ...The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.展开更多
Unlike animals, plants cannot move away from unfavorable environments. Instead, they must continuously adjust their growth to external conditions. When the environment is favorable, plants sustain vigorous growth. Con...Unlike animals, plants cannot move away from unfavorable environments. Instead, they must continuously adjust their growth to external conditions. When the environment is favorable, plants sustain vigorous growth. Conversely, when challenged by drought, salinity, temperature extremes, or other stresses, they must rapidly suppress growth to conserve energy and minimize damage. This capacity to switch growth on or off in response to external cues represents one of the most successful adaptive strategies that enables plants to thrive worldwide. A central mediator of this growth suppression is the phytohormone abscisic acid(ABA). Abscisic acid plays pivotal roles in stomata closure, germination inhibition, and root development modulation, thereby orchestrating defense responses under abiotic stresses(e.g., Chen et al., 2020, for a review). For this reason, ABA is often referred to as the“stress hormone” of plants. However,growth arrest is only half of the story. Once environmental conditions improve, plants must promptly resume growth to recover and compete effectively. For survival, the decision of whether“to grow or not to grow” is critical, and yet, the molecular mechanisms that enable plants to toggle this switch have long remained elusive.展开更多
Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines stil...Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.展开更多
Optoelectronic memristor is generating growing research interest for high efficient computing and sensing-memory applications.In this work,an optoelectronic memristor with Au/a-C:Te/Pt structure is developed.Synaptic ...Optoelectronic memristor is generating growing research interest for high efficient computing and sensing-memory applications.In this work,an optoelectronic memristor with Au/a-C:Te/Pt structure is developed.Synaptic functions,i.e.,excita-tory post-synaptic current and pair-pulse facilitation are successfully mimicked with the memristor under electrical and optical stimulations.More importantly,the device exhibited distinguishable response currents by adjusting 4-bit input electrical/opti-cal signals.A multi-mode reservoir computing(RC)system is constructed with the optoelectronic memristors to emulate human tactile-visual fusion recognition and an accuracy of 98.7%is achieved.The optoelectronic memristor provides potential for developing multi-mode RC system.展开更多
Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resistance against osteoarthritis(OA).However,the underlying mechanisms governing mitochondrial self...Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resistance against osteoarthritis(OA).However,the underlying mechanisms governing mitochondrial self-renewal and energy production remain elusive.In this study,we demonstrated mitochondrial damage and aberrant mitophagy in OA chondrocytes.Genetically overexpressing PTEN-induced putative kinase 1(PINK1)protects against cartilage degeneration by removing defective mitochondria.PINK1 knockout aggravated cartilage damage due to impaired mitophagy.SIRT3 directly deacetylated PINK1 to promote mitophagy and cartilage anabolism.Specifically,PINK1 phosphorylated PKM2 at the Ser127 site,preserving its active tetrameric form.This inhibited nuclear translocation and the interaction withβ-catenin,resulting in a metabolic shift and increased energy production.Finally,a double-knockout mouse model demonstrated the role of the SIRT3-PINK1-PKM2 axis in safeguarding the structural integrity of articular joints and improving motor functions.Overall,this study provides a novel insight into the regulation of mitochondrial renewal and metabolic switches in OA.展开更多
The rapid expansion of railways,especially High-Speed Railways(HSRs),has drawn considerable interest from both academic and industrial sectors.To meet the future vision of smart rail communications,the rail transport ...The rapid expansion of railways,especially High-Speed Railways(HSRs),has drawn considerable interest from both academic and industrial sectors.To meet the future vision of smart rail communications,the rail transport industry must innovate in key technologies to ensure high-quality transmissions for passengers and railway operations.These systems must function effectively under high mobility conditions while prioritizing safety,ecofriendliness,comfort,transparency,predictability,and reliability.On the other hand,the proposal of 6 G wireless technology introduces new possibilities for innovation in communication technologies,which may truly realize the current vision of HSR.Therefore,this article gives a review of the current advanced 6 G wireless communication technologies for HSR,including random access and switching,channel estimation and beamforming,integrated sensing and communication,and edge computing.The main application scenarios of these technologies are reviewed,as well as their current research status and challenges,followed by an outlook on future development directions.展开更多
Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely us...Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely used for artificial spiking synapses due to their relatively poor memrisitve performance.Here,for the first time,we present an organic memristor based on an electropolymerized dopamine-based memristive layer.This polydopamine-based memristor demonstrates the improve-ments in key performance,including a low threshold voltage of 0.3 V,a thin thickness of 16 nm,and a high parasitic capaci-tance of about 1μF·mm^(-2).By leveraging these properties in combination with its stable threshold switching behavior,we con-struct a capacitor-free and low-power artificial spiking neuron capable of outputting the oscillation voltage,whose spiking fre-quency increases with the increase of current stimulation analogous to a biological neuron.The experimental results indicate that our artificial spiking neuron holds potential for applications in neuromorphic computing and systems.展开更多
BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognit...BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.展开更多
Switched Reluctance Motors(SRMs),outfitted with rugged construction,good speed range,high torque density,and rare earth-free nature that outweigh induction motors(IM)and permanent magnet synchronous motor(PMSM),afford...Switched Reluctance Motors(SRMs),outfitted with rugged construction,good speed range,high torque density,and rare earth-free nature that outweigh induction motors(IM)and permanent magnet synchronous motor(PMSM),afford a broad range of applications in the domain of electric vehicles(EVs).Standard copper magnetic wire and low-carbon steel laminations are used to construct SRMs,which give them high efficiency in the range of 85-95%.Despite SRM's desirable features over traditional motor-speed drives,high torque ripples and radial distortions constrain their deployment in EVs.Precise rotor position is imperative for effective management of the speed and torque of SRMs.This paper provides an illustrative compendium on review of the torque-speed control and ripple mitigation techniques using design enhancements and control methods for SRM drives for EV applications.The various schemes were evaluated on their performance metricsoperational speed range,control complexity,practical realization,need for pre-stored parameters(look-up tables of current,inductance and torque profiles)and motor controller memory requirements.The findings provide valuable insights into balancing the gains and trade-offs associated with EV applications.Furthermore,they pinpoint opportunities for enhancement by analyzing the cost and technical aspects of different SRM controllers.展开更多
An experimental analysis of the slug-induced vibration(SIV)of a flexible catenary riser with an aspect ratio of 130 is reported in this work.The vibration responses and internal slug flow details at different gas-liqu...An experimental analysis of the slug-induced vibration(SIV)of a flexible catenary riser with an aspect ratio of 130 is reported in this work.The vibration responses and internal slug flow details at different gas-liquid ratios(Q_(g)/Q_(l))and mixture velocities(vm)are non-intrusively and simultaneously captured by high-speed cameras.Both the in-plane and out-of-plane responses of the catenary riser are excited in all considered cases.The slug flow characteristics,including translational velocities,slug lengths,recurrence frequencies,and pressure variations,are analyzed and dis-cussed,as are the dynamic responses of the riser in terms of the amplitudes,space-varying frequency,and modal weight.The dominant modal response based on the root-mean-square amplitude profiles does not match that based on the dominant frequency.Three mode switching types are identified based on the RMS amplitude profiles and the dominant frequency.When vm is small,no mode switching(NMS)is observed in either the in-plane or out-of-plane responses.For mode switching I(MS I),the switching between the first and second modes in the in-plane response is induced by slug flow with different recurrence frequencies in cases of large Q_(g)/Q_(l).However,there is no mode switching in the out-of-plane response.The switching between the first and third modes for the in-plane response and the second and fourth modes for the out-of-plane response(MS II)occurs in cases of relatively high vm and low Q_(g)/Q_(l).展开更多
Existing nanogenerator technologies for harvesting high-power energy from wind encounter significant chal-lenges due to limitations in current output.Here,we propose a rotating-switch triboelectric nanogenerator(RS-TE...Existing nanogenerator technologies for harvesting high-power energy from wind encounter significant chal-lenges due to limitations in current output.Here,we propose a rotating-switch triboelectric nanogenerator(RS-TENG)that uses mechanical triggering switches(on-off-on)to enhance the instantaneous current pulses during rotation.The rotating-switch in the proposed device addresses the issue of low instantaneous current output in triboelectric nanogenerators while maintaining voltage stability.At a constant rotational speed,the RS-TENG achieves an instantaneous current of 3.2 times that of its nonswitching counterpart,with an 89%reduction in response time.Furthermore,at a wind speed of 2 m·s^(-1),the RS-TENG achieves a wind power density of 10.4 mW·m^(-2)·m^(-1)·s.Additionally,by integrating the RS-TENG with energy management circuits,the nanogenerator can power wireless signal transmitters and temperature sensors,offering a self-sustaining power solution for remote wireless services.This research presents a promising technology for powering electronic devices in energy-scarce environments.展开更多
This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanis...This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.展开更多
文摘D-π hybridization is a key structural feature that may significantly affect the intrinsic electronic properties of metallopolymers.Herein,we present the electrosynthesis and memristive properties of metallopolymers using the distinct d-π hybridization monomers R_(1) and R_(2).R_(1)(Ru^(Ⅱ)-(tpz)Cl_(2))features tetradentate ligands(tpz,6,6'-di(1H-pyrazol-1-yl)-2,2'-bipyridine)enforcing quasi-octahedral geometry;R_(2)(Ru^(Ⅱ)-(bpp)_(2))incorporates tridentate ligands(bpp,2,6-di(1H-pyrazol-1-yl)pyridine)inducing pronounced geometric distortion.The planar ligand(tpz)in R_(1) facilitates ordered molecular assembly through high conformational rigidity and extensive π-π stacking,resulting in increased molecular densities and enhanced morphological uniformity compared to R_(2) metallopolymers.Due to pyrazole’s weaker π-acceptance and strongerσ-donation compared to pyridine,R_(1) exhibits a 119 nm red-shift in metal-to-ligand charge transfer(MLCT)band and a 30 mV anodic shift in Ru^(+2/+3)redox potential relative to R_(2).Coupled with a reduced HOMO-LUMO gap,the uniform and ordered structure leads to a lower conductance decay constant in R_(1).Additionally,R_(2) metallopolymers exhibit superior memristive performance(characterized by lower switching voltage and higher switching ratio)via redox-induced aromatic transitions in axial ligands enhancing electronic delocalization.This work compares two metallopolymers with different ligand geometries,revealing how this difference leads to distinct charge transport and memristive behaviors.
基金financially supported by the National Natural Science Foundation of China(Grant No.12172093)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515012607)。
文摘High-entropy oxides(HEOs)have emerged as a promising class of memristive materials,characterized by entropy-stabilized crystal structures,multivalent cation coordination,and tunable defect landscapes.These intrinsic features enable forming-free resistive switching,multilevel conductance modulation,and synaptic plasticity,making HEOs attractive for neuromorphic computing.This review outlines recent progress in HEO-based memristors across materials engineering,switching mechanisms,and synaptic emulation.Particular attention is given to vacancy migration,phase transitions,and valence-state dynamics—mechanisms that underlie the switching behaviors observed in both amorphous and crystalline systems.Their relevance to neuromorphic functions such as short-term plasticity and spike-timing-dependent learning is also examined.While encouraging results have been achieved at the device level,challenges remain in conductance precision,variability control,and scalable integration.Addressing these demands a concerted effort across materials design,interface optimization,and task-aware modeling.With such integration,HEO memristors offer a compelling pathway toward energy-efficient and adaptable brain-inspired electronics.
基金supported by the Natural Science Foundation of Guangdong Province,China (No.2025A1515011654)the National Natural Science Foundation of China (No.22090053)+3 种基金the Fundamental Research Funds for National Universities,China University of Geosciences (Wuhan)support from the program of China Scholarships Council (No.202406410155)Young Elite Scientists Sponsorship Program by CAST-Doctoral Student Special Plansupport from the S&T Special Program of Huzhou (No.2024GZ07)。
文摘Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has been verified to evaluate the performance of FENTs,but until recently,the response time,another crucial indicator,has been ignored.Employing finite-element method,we investigated the relationship among gate charge,switching ratio and response time by divisionally manipulating gate charge,including entrance surface and the surface of confinement space,for ion transport to optimize switching capability.The dual-split gate charge on FENTs exhibits synergistic effect on switching response.Based on the two regional gate charge on FENTs,multivalence ions in lower concentration,high aspect ratio and single channel show higher switching ratio but longer response time compared to monovalent ions.The findings highlight the necessity of balancing these two signals in FENTs and offer insights for optimizing their design and expanding applications to dual-signal-detection iontronics.
文摘BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic malignancies.CASE SUMMARY We herein report a rare case of a 59-year-old female who presented with acute left upper quadrant abdominal pain without any history of trauma.Abdominal imaging demonstrated a heterogeneous splenic lesion with hemoperitoneum,raising clinical suspicion of SSR.Emergency laparotomy revealed a pancreatic tumor invading the spleen and left kidney,with associated splenic rupture and dense adhesions,necessitating en bloc resection of the distal pancreas,spleen,and left kidney.Histopathology revealed a biphasic malignancy composed of moderately differentiated pancreatic ductal adenocarcinoma and an undifferentiated carcinoma with rhabdoid morphology and loss of SMARCB1 expression.Immunohistochemical analysis confirmed complete loss of SMARCB1/INI1 in the undifferentiated component,along with a high Ki-67 index(approximately 80%)and CD10 positivity.The ductal adenocarcinoma component retained SMARCB1/INI1 expression and was positive for CK7 and CK-pan.Transitional zones between the two tumor components suggested progressive dedifferentiation and underlying genomic instability.The patient received adjuvant chemotherapy with gemcitabine and nab-paclitaxel and maintained a satisfactory quality of life at the 6-month follow-up.CONCLUSION This study reports a rare case of SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma of the pancreas combined with ductal adenocarcinoma,presenting as SSR-an exceptionally uncommon initial manifestation of pancreatic malignancy.
基金supported by the national key research and development program of China under Grant 2020YFB1807901the National Science Foundation Project in China under grant 61931005.
文摘As investigated by 3GPP,support of UPF(user plane function)onboard satellite can reduce the latency of communications via satellite,and then it becomes a key enhancement in 5G network integrating with satellite communication.However,current 5G system cannot support UPF onboard LEO(low earth orbit)satellites,as it would face challenges like UPF mobility handling,synchronization between mobile network and satellite network,and condition of activating local data switching.To solve such challenges,this paper proposes a solution to support UPF onboard LEO satellite,which consists of enhanced network architecture,I-UPF(intermediate UPF)based local data switching scheme and communication latency based data path selection.We subsequently develop analytic models for performance evaluation and conduct simulations using the constellation configuration of iridium II.The simulation results show that the data switching via I-UPF onboard LEO satellite can reduce E2E(end to end)packet delivery latency and E2E packet loss ratio significantly compared with that of routing the data back to 5GC on the ground.The proposed scheme yet has increased signaling cost for handling UPF mobility.els,compared with existing similar companding algorithms.
基金supported by the National Natural Science Foundation of China(Grants Nos.12304405,12275203,and 12075176)the Natural Science Foundation of Shaanxi Provincial Department of Education(Grant No.23JK0483)+2 种基金the Natural Science Basic Research Program of Shaanxi(Grant Nos.2024JC-YBMS-521 and 2024JC-YBMS-039)the 2022 Shaanxi University Youth Innovation Team Project(Grant No.K20220186)the College Students’Innovative Entrepreneurial Training Plan Program of Shaanxi(Grant No.S202410702178)。
文摘Coherent perfect absorption(CPA)and coherent perfect transmission(CPT)are two extreme states arising from the manipulation of optical fields.Generally,CPA and CPT occur under different input-field phases.Therefore,we propose a scheme to realize an all-optical switch based on phase-dependent CPA–CPT conversion.In our proposal,the CPT state and the CPA state are treated as the on state and the off state,respectively.Consequently,the efficiency of this all-optical switch can reach the maximum value of 1.With the introduction of an incoherent pump field,the CPA state can be achieved under a weaker input probe field or can be converted into a CPT state.The results show that the optical switch can operate with weaker fields and can be further optimized by the application of an incoherent field.
基金supported by NARI Relays Electric Co.,Ltd.under the Project“Research on Evaluation of Clearing Results and Switching Criteria for Primary-Backup Systems in Electricity SpotMarkets”(Project No.CGSQ240800443).
文摘The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.
基金supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science(JSPS KAKENHI)[Grant numbers JP22H02294 to M.M.,JP22K05365 and JP23K18058 to S.K.]by the commissioned research fund provided by F-REI(JPFR25020105)to S.K。
文摘Unlike animals, plants cannot move away from unfavorable environments. Instead, they must continuously adjust their growth to external conditions. When the environment is favorable, plants sustain vigorous growth. Conversely, when challenged by drought, salinity, temperature extremes, or other stresses, they must rapidly suppress growth to conserve energy and minimize damage. This capacity to switch growth on or off in response to external cues represents one of the most successful adaptive strategies that enables plants to thrive worldwide. A central mediator of this growth suppression is the phytohormone abscisic acid(ABA). Abscisic acid plays pivotal roles in stomata closure, germination inhibition, and root development modulation, thereby orchestrating defense responses under abiotic stresses(e.g., Chen et al., 2020, for a review). For this reason, ABA is often referred to as the“stress hormone” of plants. However,growth arrest is only half of the story. Once environmental conditions improve, plants must promptly resume growth to recover and compete effectively. For survival, the decision of whether“to grow or not to grow” is critical, and yet, the molecular mechanisms that enable plants to toggle this switch have long remained elusive.
基金supported by the National Key R&D Program of China(2023YFA1406200)the National Natural Science Foundation of China(T2521005,12174144,12474009,12174146,and 124B2059)the Special Construction Project Fund for Shan-dong Province Taishan Scholars.
文摘Multifunctional optical responsive materials have grown increasingly pivotal in addressingthe escalating demands of sensing,detection,and anti-counterfeiting applications[1,2].These materials exhibit distinct visible optical variations upon exposure to external stimuli,such as pressure,temperature,light,solvents,pH fluctuations,or mechanical force.Fluorescent sensing and anti-counterfeiting technologies leveraging these optical responses have emerged as highly promising solutions.
文摘Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.
基金supported by the"Science and Technology Development Plan Project of Jilin Province,China"(Grant No.20240101018JJ)the Fundamental Research Funds for the Central Universities(Grant No.2412023YQ004)the National Natural Science Foundation of China(Grant Nos.52072065,52272140,52372137,and U23A20568).
文摘Optoelectronic memristor is generating growing research interest for high efficient computing and sensing-memory applications.In this work,an optoelectronic memristor with Au/a-C:Te/Pt structure is developed.Synaptic functions,i.e.,excita-tory post-synaptic current and pair-pulse facilitation are successfully mimicked with the memristor under electrical and optical stimulations.More importantly,the device exhibited distinguishable response currents by adjusting 4-bit input electrical/opti-cal signals.A multi-mode reservoir computing(RC)system is constructed with the optoelectronic memristors to emulate human tactile-visual fusion recognition and an accuracy of 98.7%is achieved.The optoelectronic memristor provides potential for developing multi-mode RC system.
基金supported by grants from National Nature Science Foundation of China(82272494,82472452,82402864)National Key R&D Program of China(2022YFC2502902)+4 种基金Key Project of Jiangsu Health Commission(K2023079)Natural Science Foundation of Jiangsu Province(BK20240368)Basic Research Pilot Project Suzhou(SSD2024062),China Postdoctoral Science Foundation(2024M762313)Boxi Youth Natural Science Foundation(BXQN2023014)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resistance against osteoarthritis(OA).However,the underlying mechanisms governing mitochondrial self-renewal and energy production remain elusive.In this study,we demonstrated mitochondrial damage and aberrant mitophagy in OA chondrocytes.Genetically overexpressing PTEN-induced putative kinase 1(PINK1)protects against cartilage degeneration by removing defective mitochondria.PINK1 knockout aggravated cartilage damage due to impaired mitophagy.SIRT3 directly deacetylated PINK1 to promote mitophagy and cartilage anabolism.Specifically,PINK1 phosphorylated PKM2 at the Ser127 site,preserving its active tetrameric form.This inhibited nuclear translocation and the interaction withβ-catenin,resulting in a metabolic shift and increased energy production.Finally,a double-knockout mouse model demonstrated the role of the SIRT3-PINK1-PKM2 axis in safeguarding the structural integrity of articular joints and improving motor functions.Overall,this study provides a novel insight into the regulation of mitochondrial renewal and metabolic switches in OA.
基金National Natural Science Foundation of China(U2468201,62122012,62221001).
文摘The rapid expansion of railways,especially High-Speed Railways(HSRs),has drawn considerable interest from both academic and industrial sectors.To meet the future vision of smart rail communications,the rail transport industry must innovate in key technologies to ensure high-quality transmissions for passengers and railway operations.These systems must function effectively under high mobility conditions while prioritizing safety,ecofriendliness,comfort,transparency,predictability,and reliability.On the other hand,the proposal of 6 G wireless technology introduces new possibilities for innovation in communication technologies,which may truly realize the current vision of HSR.Therefore,this article gives a review of the current advanced 6 G wireless communication technologies for HSR,including random access and switching,channel estimation and beamforming,integrated sensing and communication,and edge computing.The main application scenarios of these technologies are reviewed,as well as their current research status and challenges,followed by an outlook on future development directions.
基金support from the Beijing Natural Science Foundation-Xiaomi Innovation Joint Fund(No.L233009)National Natural Science Foundation of China(NSFC Nos.62422409,62174152,and 62374159)from the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2020115).
文摘Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely used for artificial spiking synapses due to their relatively poor memrisitve performance.Here,for the first time,we present an organic memristor based on an electropolymerized dopamine-based memristive layer.This polydopamine-based memristor demonstrates the improve-ments in key performance,including a low threshold voltage of 0.3 V,a thin thickness of 16 nm,and a high parasitic capaci-tance of about 1μF·mm^(-2).By leveraging these properties in combination with its stable threshold switching behavior,we con-struct a capacitor-free and low-power artificial spiking neuron capable of outputting the oscillation voltage,whose spiking fre-quency increases with the increase of current stimulation analogous to a biological neuron.The experimental results indicate that our artificial spiking neuron holds potential for applications in neuromorphic computing and systems.
基金Supported by Wuxi Taihu Talent Project,No.WXTTP 2021the General Scientific Research Program of Wuxi Municipal Health Commission,No.M202447.
文摘BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.
基金supported in part by the Universitat Politècnica de València under grant PAID-10-21supported through AMRITA Seed Grant(Proposal ID:ASG2022188)。
文摘Switched Reluctance Motors(SRMs),outfitted with rugged construction,good speed range,high torque density,and rare earth-free nature that outweigh induction motors(IM)and permanent magnet synchronous motor(PMSM),afford a broad range of applications in the domain of electric vehicles(EVs).Standard copper magnetic wire and low-carbon steel laminations are used to construct SRMs,which give them high efficiency in the range of 85-95%.Despite SRM's desirable features over traditional motor-speed drives,high torque ripples and radial distortions constrain their deployment in EVs.Precise rotor position is imperative for effective management of the speed and torque of SRMs.This paper provides an illustrative compendium on review of the torque-speed control and ripple mitigation techniques using design enhancements and control methods for SRM drives for EV applications.The various schemes were evaluated on their performance metricsoperational speed range,control complexity,practical realization,need for pre-stored parameters(look-up tables of current,inductance and torque profiles)and motor controller memory requirements.The findings provide valuable insights into balancing the gains and trade-offs associated with EV applications.Furthermore,they pinpoint opportunities for enhancement by analyzing the cost and technical aspects of different SRM controllers.
基金financially supported by the National Natural Science Foundation of China(Grant No.52301338)the Sichuan Science and Technology Program(Grant No.2024NSFSC0968).
文摘An experimental analysis of the slug-induced vibration(SIV)of a flexible catenary riser with an aspect ratio of 130 is reported in this work.The vibration responses and internal slug flow details at different gas-liquid ratios(Q_(g)/Q_(l))and mixture velocities(vm)are non-intrusively and simultaneously captured by high-speed cameras.Both the in-plane and out-of-plane responses of the catenary riser are excited in all considered cases.The slug flow characteristics,including translational velocities,slug lengths,recurrence frequencies,and pressure variations,are analyzed and dis-cussed,as are the dynamic responses of the riser in terms of the amplitudes,space-varying frequency,and modal weight.The dominant modal response based on the root-mean-square amplitude profiles does not match that based on the dominant frequency.Three mode switching types are identified based on the RMS amplitude profiles and the dominant frequency.When vm is small,no mode switching(NMS)is observed in either the in-plane or out-of-plane responses.For mode switching I(MS I),the switching between the first and second modes in the in-plane response is induced by slug flow with different recurrence frequencies in cases of large Q_(g)/Q_(l).However,there is no mode switching in the out-of-plane response.The switching between the first and third modes for the in-plane response and the second and fourth modes for the out-of-plane response(MS II)occurs in cases of relatively high vm and low Q_(g)/Q_(l).
基金financially supported by the National Natural Science Foundation of China(Grant No.62431006)the Inner Mongolia Major Science and Technology Project(Grant No.2020ZD0024)+2 种基金Local Science and Technology Development Project of the Central Government(Grant Nos.2021ZY0006,2022ZY0011)Natural Science Foundation of Inner Mongolia(Grant No.2024LHMS05046)Inner Mongolia Autonomous Region Key Research and Technological Achievements Transformation Plan Project(Grant No.2023YFHH0063).
文摘Existing nanogenerator technologies for harvesting high-power energy from wind encounter significant chal-lenges due to limitations in current output.Here,we propose a rotating-switch triboelectric nanogenerator(RS-TENG)that uses mechanical triggering switches(on-off-on)to enhance the instantaneous current pulses during rotation.The rotating-switch in the proposed device addresses the issue of low instantaneous current output in triboelectric nanogenerators while maintaining voltage stability.At a constant rotational speed,the RS-TENG achieves an instantaneous current of 3.2 times that of its nonswitching counterpart,with an 89%reduction in response time.Furthermore,at a wind speed of 2 m·s^(-1),the RS-TENG achieves a wind power density of 10.4 mW·m^(-2)·m^(-1)·s.Additionally,by integrating the RS-TENG with energy management circuits,the nanogenerator can power wireless signal transmitters and temperature sensors,offering a self-sustaining power solution for remote wireless services.This research presents a promising technology for powering electronic devices in energy-scarce environments.
基金supported by the National Natural Science Foundation under Grant 62273189the Shandong Province Natural Science Foundation under Grant ZR2021MF005Systems Science Plus Joint Research Program of Qingdao University under Grant XT2024201 of China supporting this research work.
文摘This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.
