Diabetic kidney disease (DKD)is one of the most common and severe microvascular complications of type 2 diabetes mellitus (T2DM). It is also a major cause of end-stage renal disease (ESRD), making early identification...Diabetic kidney disease (DKD)is one of the most common and severe microvascular complications of type 2 diabetes mellitus (T2DM). It is also a major cause of end-stage renal disease (ESRD), making early identification and intervention crucial. Insulin resistance (IR)is a key pathophysiological mechanism of T2DM and plays a central role in the progression of DKD. In recent years, a series of novel surrogate indicators of IR, such as the triglyceride-glucose (TyG) index, TyG-body mass index (TyG-BMI), triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), and metabolic score for insulin resistance (METS-IR), have attracted widespread attention due to their simplicity and cost-effectiveness. This article reviews the research progress of novel surrogate indicators of insulin resistance (IR) in type 2 diabetic kidney disease (DKD), aiming to provide references for the early prevention and improved prognosis of DKD.展开更多
Objective To investigate the correlation between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes mellitus(T2DM).Methods A total of 918 T2DM patients hospitalized in the Endocri...Objective To investigate the correlation between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes mellitus(T2DM).Methods A total of 918 T2DM patients hospitalized in the Endocrinology Department of Xinhua Hospital from January 2018 to December 2020 were selected,including 313 patients with early-stage kidney injury and 605 without.Differences in insulin resistance surrogate indicators,including triglycerideetohigh-density lipoprotein cholesterol ratio(TG/HDL-C),triglyceride glucose(TyG)index,and triglyceride glucose-body mass index(TyG-BMI),were compared between the two groups.Factors associated with early-stage kidney injury in T2DM were analyzed,and the impact of TG/HDL-C,TyG index,and TyG-BMI on early-stage kidney injury in T2DM were explored.Results Compared with T2DM patients without early-stage kidney injury,those with early-stage kidney injury exhibited significantly elevated levels of TG/HDL-C,TyG index,and TyG-BMI(P<0.001).TG/HDL-C,TyG index,TyG-BMI,age,duration of diabetes,systolic blood pressure,fasting insulin,and HbAic were identified as independent risk factors for early-stage kidney injury in T2DM.Compared to the Q_(1) quartile,the risk in the Q_(4) quartile was 3.168 times(95%CI 1.993-5.036)for TG/HDL-C,2.714 times(95%CI 1.710-4.306)for TyG index,and 2.893 times(95%CI 1.820-5.598)for TyG-BMI.Conclusion Insulin resistance surrogate indicators TG/HDL-C,TyG index,and TyG-BMI are significantly elevated in T2DM patients with early-stage kidney injury,serving as independent risk factors for early-stage renal impairment in T2DM.展开更多
文摘Diabetic kidney disease (DKD)is one of the most common and severe microvascular complications of type 2 diabetes mellitus (T2DM). It is also a major cause of end-stage renal disease (ESRD), making early identification and intervention crucial. Insulin resistance (IR)is a key pathophysiological mechanism of T2DM and plays a central role in the progression of DKD. In recent years, a series of novel surrogate indicators of IR, such as the triglyceride-glucose (TyG) index, TyG-body mass index (TyG-BMI), triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), and metabolic score for insulin resistance (METS-IR), have attracted widespread attention due to their simplicity and cost-effectiveness. This article reviews the research progress of novel surrogate indicators of insulin resistance (IR) in type 2 diabetic kidney disease (DKD), aiming to provide references for the early prevention and improved prognosis of DKD.
文摘Objective To investigate the correlation between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes mellitus(T2DM).Methods A total of 918 T2DM patients hospitalized in the Endocrinology Department of Xinhua Hospital from January 2018 to December 2020 were selected,including 313 patients with early-stage kidney injury and 605 without.Differences in insulin resistance surrogate indicators,including triglycerideetohigh-density lipoprotein cholesterol ratio(TG/HDL-C),triglyceride glucose(TyG)index,and triglyceride glucose-body mass index(TyG-BMI),were compared between the two groups.Factors associated with early-stage kidney injury in T2DM were analyzed,and the impact of TG/HDL-C,TyG index,and TyG-BMI on early-stage kidney injury in T2DM were explored.Results Compared with T2DM patients without early-stage kidney injury,those with early-stage kidney injury exhibited significantly elevated levels of TG/HDL-C,TyG index,and TyG-BMI(P<0.001).TG/HDL-C,TyG index,TyG-BMI,age,duration of diabetes,systolic blood pressure,fasting insulin,and HbAic were identified as independent risk factors for early-stage kidney injury in T2DM.Compared to the Q_(1) quartile,the risk in the Q_(4) quartile was 3.168 times(95%CI 1.993-5.036)for TG/HDL-C,2.714 times(95%CI 1.710-4.306)for TyG index,and 2.893 times(95%CI 1.820-5.598)for TyG-BMI.Conclusion Insulin resistance surrogate indicators TG/HDL-C,TyG index,and TyG-BMI are significantly elevated in T2DM patients with early-stage kidney injury,serving as independent risk factors for early-stage renal impairment in T2DM.
