BACKGROUND In pediatric age group patients(<18 years old)treated operatively for distal radius/both bone fractures extending imaging beyond the initial postoperative period-particularly in uncomplicated cases-appea...BACKGROUND In pediatric age group patients(<18 years old)treated operatively for distal radius/both bone fractures extending imaging beyond the initial postoperative period-particularly in uncomplicated cases-appears to provide limited additional benefit.AIM To determine the necessary number of follow-up X-rays to use resources efficiently.METHODS Participants included in this study are pediatric age group patients who were treated operatively for distal radius/both bone fractures and were identified from a prospected collected data from the operating room database between the years 2009 and 2017.The data in the study included patients who had distal radius fractures and underwent fixation surgery(n=88).RESULTS When assessing the difference in the odds of conducting 1 or less X-ray compared to 2 or more X-rays in regard to the type of fixation,the only significant difference is the closed reduction fixation method.Patients who underwent closed reduction method procedure have significantly lower odds of having 2 more X-rays compared to those who didn’t have closed reduction method.Open reduction,internal fixation,and other fixation methods(close reduction and internal fixation,debridement,or epiphysiodesis)have higher odds of having two or more X-rays compared to patients who did not receive these methods;however,these odds are not statistically significant.CONCLUSION The findings of this study reveal notable absence of a statistically significant association between the frequency of postoperative X-rays and the outcome of children with distal radius fractures.展开更多
This study analyzes the evolution and dynamics of intensity oscillations in coronal sunspots and their surroundings using multi-wavelength image data from the Atmospheric Imaging Assembly(AIA)and Helioseismic and Magn...This study analyzes the evolution and dynamics of intensity oscillations in coronal sunspots and their surroundings using multi-wavelength image data from the Atmospheric Imaging Assembly(AIA)and Helioseismic and Magnetic Imager(HMI)on board the Solar Dynamics Observatory(SDO).Intensity time series were extracted and analyzed from consecutive macropixels along thin coronal loop paths originating in a quiet sunspot.Fourier and wavelet analyses of corrected intensity time series reveal dominant 3 and 5 minute oscillations.Signals were filtered using the Fourier and inverse transforms to isolate narrow bands around the dominant oscillation periods.Diagrams and time-distance maps of intensity time series were plotted for Fourierfiltered AIA 131A,171A,193A,and 211A channels,along with SDO/HMI magnetograms and dopplergrams at 6173A.The plots clearly show propagating oscillations with amplitude modulation(AM)across all macropixels along selected coronal paths in nearly all AIA and HMI channels.The phase speeds of the filtered oscillations,measured via slope calculations in time-distance maps,indicate that the intensity disturbances are slow magneto-acoustic waves.These results suggest that AM likely arises from the superposition of counterpropagating waves with slightly different frequencies(beta-like phenomena)due to Doppler shifts from background plasma flow along loop paths.Validating this hypothesis could establish AM's significance in solar coronal seismology for determining background plasma flow speed,the source of long-period oscillations,and coronal plasma heating mechanisms.展开更多
In winter,the weather is usually cold and everything seems a bit dull.Butthe sun in winter is special.When the sun shines brightly in the clear blue sky,it brings warm(1)to thecold world.The golden sunlight spreads he...In winter,the weather is usually cold and everything seems a bit dull.Butthe sun in winter is special.When the sun shines brightly in the clear blue sky,it brings warm(1)to thecold world.The golden sunlight spreads here and there and it makes the whitesnow shine like diamonds.Although the trees are usually bare in winter,but(2)they look beautiful with the sunlight falling on them.展开更多
The large-aperture reflective cameras on the geostationary orbit are susceptible to significant temperature fluctuations due to the“Sun transit”effect.To address the shortcomings of existing thermal control measures...The large-aperture reflective cameras on the geostationary orbit are susceptible to significant temperature fluctuations due to the“Sun transit”effect.To address the shortcomings of existing thermal control measures using camera sunshades to suppress the“Sun transit”and the issue of excessively large solar avoidance angles determined solely by geometric relationships,a thermal control design method is proposed that involves adding multi-layer thermal protection at the secondary mirror position of the camera.The goal is to optimize the avoidance angle and enhance the camera’s tolerance to“Sun transit”.A heat balance and motion relationship between the avoidance angle and duration is established.Then,the minimum solar avoidance angle after adopting the multi-layer thermal protection design is calculated.This angle is compared with the one determined by geometric relationships,leading to the conclusion that this method can effectively enhance the camera’s tolerance to“Sun transit”.A heat dissipation scheme is proposed that involves a coupled north-south heat spreader design with low-temperature compensation for the internal heat source.The calculation results of the two avoidance angles are applied to the calculation of the heat dissipation area and low-temperature compensation power,achieving a closed-loop heat dissipation scheme.Puls,the superiority of the multi-layer thermal protection design method is demonstrated from the perspectives of heat dissipation area and low-temperature compensation power requirements.A comparative analysis of simulation analysis,thermal balance tests,and in-orbit temperature data further validates the effectiveness of this method.展开更多
Sun Chemical将提高其在欧洲、中东和非洲(EMEA)的多种油墨产品组合的价格,立即生效。近几个月来,彩色和白色颜料的供应链受到各种挑战的严重影响,包括中断、短缺、破产、反倾销进口税以及来自亚洲的海运费进一步上涨。这些因素一直推...Sun Chemical将提高其在欧洲、中东和非洲(EMEA)的多种油墨产品组合的价格,立即生效。近几个月来,彩色和白色颜料的供应链受到各种挑战的严重影响,包括中断、短缺、破产、反倾销进口税以及来自亚洲的海运费进一步上涨。这些因素一直推高了太阳化学油墨产品的成本,包括彩色和白色油墨。展开更多
Our understanding of grain-level bursts of plasticity in polycrystals remains limited by current techniques.By employing a modified Synchrotron transmission X-ray Laue diffraction method(beam size larger than the grai...Our understanding of grain-level bursts of plasticity in polycrystals remains limited by current techniques.By employing a modified Synchrotron transmission X-ray Laue diffraction method(beam size larger than the grain size),we tracked grain rotations for the first 1%of tensile strain,in 4400 time steps.We indexed 33 grains and quantified the magnitude and frequency of intermittent bursts of grain rotation.We interpret these events in terms of bursts of plastic deformation.The events are highly coordinated amongst nearby grains,and their frequency and magnitude,as well as the number of grains participating,peaked at around the onset of full plasticity.At this point,7 out of the 10 indexed grains with orientations favorable for twinning showed significant drops in diffracted intensity(a mean value of 8%),due to twin induced re-orientation.For other orientations,20 out of 23 grains displayed bursts attributable to lattice dislocation glide(interpreted in terms of basal and prismatic <α> slip).The mean value of the magnitude of these bursts is∼0.08°,implying accumulated shear strains of the order of 3×10^(-3).These bursts,in many cases,were due to the activation of more than a single slip/twin system within the grain,and co-ordination amongst neighboring grains also involved collaboration between slip and twinning events.展开更多
Pathological cardiac hypertrophy contributes to the development of heart failure(HF).NOL1/NOP2/Sun domain family member 2(NSUN2)is implicated in pathophysiological processes of many diseases.However,the function and o...Pathological cardiac hypertrophy contributes to the development of heart failure(HF).NOL1/NOP2/Sun domain family member 2(NSUN2)is implicated in pathophysiological processes of many diseases.However,the function and operation of NSUN2 in cardiac hypertrophy and HF remain unclear.Here,we observed a significant increase in the levels of NSUN2 expression in both human hearts with HF and in mouse hearts with hypertrophy induced by transverse aortic constriction(TAC)and angiotensin II(Ang II)treatment.Cardiomyocyte-specific knockout of NSUN2 attenuated the reduced cardiac ejection fraction(EF)and fractional shortening(FS)and the increased heart weight to tibial length(HW/TL)upon either TAC or Ang II infusion.Conversely,cardiac-specific overexpression of NSUN2 resulted in cardiac remodeling as indicated by a prominent increase in hypertrophic growth and cardiac fibrosis and a robust decline in cardiac EF and FS.Mechanistically,NSUN2 induces 5-methylcytosine(m5C)modification of La-related protein 1(LARP1)to enhance its messenger RNA(mRNA)stability,which is mediated by Y-box binding protein 1(YBX1).Increased LARP1 further interacts with GATA binding protein 4(GATA4)mRNA and prevents its degradation.LARP1 silencing partially attenuates TAC and NSUN2 induced cardiac hypertrophy and HF.Collectively,this study provides a new insight into the central role of NSUN2 in cardiac hypertrophy,indicating that NSUN2 may serve as a novel therapeutic target for HF.展开更多
In this study, we examined variability of sun-related energies, auroral electrojet current, ring current, and magnetopause current during solar cycles 23 and 24. The study revealed a dependence of sun-related energies...In this study, we examined variability of sun-related energies, auroral electrojet current, ring current, and magnetopause current during solar cycles 23 and 24. The study revealed a dependence of sun-related energies to the Sun and Earth currents systems with solar activity from 1996 to 2019. A decrease in the correlation between sun-related energies and sunspot number was observed over solar cycles 23 and 24 (0.88 for the solar cycle 23 and 0.66 for the solar cycle 24), with a drop in the speed of magnetic disturbances in the solar wind. These results could be attributed to the decrease in Sun’s magnetic field toroidal component magnitude induced by a weak in sunspots number and solar flares during the solar cycle 24. A weak in the Earth currents systems (auroral electrojet current, ring current, and magnetopause current) is also observed. During the decrease in the Earth currents, several peaks are observed, indicating a nonlinear dependence in the Earth currents variation (ring current, auroral electrojet current, and magnetopause current) from solar cycle 23 to solar cycle 24. This could be attributed to the Corotating Interaction Regions (CIRs) observed during the declining phase of solar cycle 23 and the deep minimum preceding solar cycle 24.展开更多
文摘BACKGROUND In pediatric age group patients(<18 years old)treated operatively for distal radius/both bone fractures extending imaging beyond the initial postoperative period-particularly in uncomplicated cases-appears to provide limited additional benefit.AIM To determine the necessary number of follow-up X-rays to use resources efficiently.METHODS Participants included in this study are pediatric age group patients who were treated operatively for distal radius/both bone fractures and were identified from a prospected collected data from the operating room database between the years 2009 and 2017.The data in the study included patients who had distal radius fractures and underwent fixation surgery(n=88).RESULTS When assessing the difference in the odds of conducting 1 or less X-ray compared to 2 or more X-rays in regard to the type of fixation,the only significant difference is the closed reduction fixation method.Patients who underwent closed reduction method procedure have significantly lower odds of having 2 more X-rays compared to those who didn’t have closed reduction method.Open reduction,internal fixation,and other fixation methods(close reduction and internal fixation,debridement,or epiphysiodesis)have higher odds of having two or more X-rays compared to patients who did not receive these methods;however,these odds are not statistically significant.CONCLUSION The findings of this study reveal notable absence of a statistically significant association between the frequency of postoperative X-rays and the outcome of children with distal radius fractures.
文摘This study analyzes the evolution and dynamics of intensity oscillations in coronal sunspots and their surroundings using multi-wavelength image data from the Atmospheric Imaging Assembly(AIA)and Helioseismic and Magnetic Imager(HMI)on board the Solar Dynamics Observatory(SDO).Intensity time series were extracted and analyzed from consecutive macropixels along thin coronal loop paths originating in a quiet sunspot.Fourier and wavelet analyses of corrected intensity time series reveal dominant 3 and 5 minute oscillations.Signals were filtered using the Fourier and inverse transforms to isolate narrow bands around the dominant oscillation periods.Diagrams and time-distance maps of intensity time series were plotted for Fourierfiltered AIA 131A,171A,193A,and 211A channels,along with SDO/HMI magnetograms and dopplergrams at 6173A.The plots clearly show propagating oscillations with amplitude modulation(AM)across all macropixels along selected coronal paths in nearly all AIA and HMI channels.The phase speeds of the filtered oscillations,measured via slope calculations in time-distance maps,indicate that the intensity disturbances are slow magneto-acoustic waves.These results suggest that AM likely arises from the superposition of counterpropagating waves with slightly different frequencies(beta-like phenomena)due to Doppler shifts from background plasma flow along loop paths.Validating this hypothesis could establish AM's significance in solar coronal seismology for determining background plasma flow speed,the source of long-period oscillations,and coronal plasma heating mechanisms.
文摘In winter,the weather is usually cold and everything seems a bit dull.Butthe sun in winter is special.When the sun shines brightly in the clear blue sky,it brings warm(1)to thecold world.The golden sunlight spreads here and there and it makes the whitesnow shine like diamonds.Although the trees are usually bare in winter,but(2)they look beautiful with the sunlight falling on them.
基金supported by the Na⁃tional Key Research and Development Program of China(No.2021YFC2202102)。
文摘The large-aperture reflective cameras on the geostationary orbit are susceptible to significant temperature fluctuations due to the“Sun transit”effect.To address the shortcomings of existing thermal control measures using camera sunshades to suppress the“Sun transit”and the issue of excessively large solar avoidance angles determined solely by geometric relationships,a thermal control design method is proposed that involves adding multi-layer thermal protection at the secondary mirror position of the camera.The goal is to optimize the avoidance angle and enhance the camera’s tolerance to“Sun transit”.A heat balance and motion relationship between the avoidance angle and duration is established.Then,the minimum solar avoidance angle after adopting the multi-layer thermal protection design is calculated.This angle is compared with the one determined by geometric relationships,leading to the conclusion that this method can effectively enhance the camera’s tolerance to“Sun transit”.A heat dissipation scheme is proposed that involves a coupled north-south heat spreader design with low-temperature compensation for the internal heat source.The calculation results of the two avoidance angles are applied to the calculation of the heat dissipation area and low-temperature compensation power,achieving a closed-loop heat dissipation scheme.Puls,the superiority of the multi-layer thermal protection design method is demonstrated from the perspectives of heat dissipation area and low-temperature compensation power requirements.A comparative analysis of simulation analysis,thermal balance tests,and in-orbit temperature data further validates the effectiveness of this method.
基金the Australian Research Council through the Discovery Grant DP200100727 and Laureate Fellowship FL210100147。
文摘Our understanding of grain-level bursts of plasticity in polycrystals remains limited by current techniques.By employing a modified Synchrotron transmission X-ray Laue diffraction method(beam size larger than the grain size),we tracked grain rotations for the first 1%of tensile strain,in 4400 time steps.We indexed 33 grains and quantified the magnitude and frequency of intermittent bursts of grain rotation.We interpret these events in terms of bursts of plastic deformation.The events are highly coordinated amongst nearby grains,and their frequency and magnitude,as well as the number of grains participating,peaked at around the onset of full plasticity.At this point,7 out of the 10 indexed grains with orientations favorable for twinning showed significant drops in diffracted intensity(a mean value of 8%),due to twin induced re-orientation.For other orientations,20 out of 23 grains displayed bursts attributable to lattice dislocation glide(interpreted in terms of basal and prismatic <α> slip).The mean value of the magnitude of these bursts is∼0.08°,implying accumulated shear strains of the order of 3×10^(-3).These bursts,in many cases,were due to the activation of more than a single slip/twin system within the grain,and co-ordination amongst neighboring grains also involved collaboration between slip and twinning events.
基金supported by grants from the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2024ZD0537909)the National Natural Science Foundation of China(82273928,82473919,82330011,82161148007)+2 种基金the Distinguished Young Scholars of Natural Science Foundation of Heilongjiang Province(JQ2024H002)the Chunyan Programme of Heilongjiang Province(CYQN2403)the CAMS Innovation Fund for Medical Sciences(CIFMS,2020-I2M-5-003).
文摘Pathological cardiac hypertrophy contributes to the development of heart failure(HF).NOL1/NOP2/Sun domain family member 2(NSUN2)is implicated in pathophysiological processes of many diseases.However,the function and operation of NSUN2 in cardiac hypertrophy and HF remain unclear.Here,we observed a significant increase in the levels of NSUN2 expression in both human hearts with HF and in mouse hearts with hypertrophy induced by transverse aortic constriction(TAC)and angiotensin II(Ang II)treatment.Cardiomyocyte-specific knockout of NSUN2 attenuated the reduced cardiac ejection fraction(EF)and fractional shortening(FS)and the increased heart weight to tibial length(HW/TL)upon either TAC or Ang II infusion.Conversely,cardiac-specific overexpression of NSUN2 resulted in cardiac remodeling as indicated by a prominent increase in hypertrophic growth and cardiac fibrosis and a robust decline in cardiac EF and FS.Mechanistically,NSUN2 induces 5-methylcytosine(m5C)modification of La-related protein 1(LARP1)to enhance its messenger RNA(mRNA)stability,which is mediated by Y-box binding protein 1(YBX1).Increased LARP1 further interacts with GATA binding protein 4(GATA4)mRNA and prevents its degradation.LARP1 silencing partially attenuates TAC and NSUN2 induced cardiac hypertrophy and HF.Collectively,this study provides a new insight into the central role of NSUN2 in cardiac hypertrophy,indicating that NSUN2 may serve as a novel therapeutic target for HF.
文摘In this study, we examined variability of sun-related energies, auroral electrojet current, ring current, and magnetopause current during solar cycles 23 and 24. The study revealed a dependence of sun-related energies to the Sun and Earth currents systems with solar activity from 1996 to 2019. A decrease in the correlation between sun-related energies and sunspot number was observed over solar cycles 23 and 24 (0.88 for the solar cycle 23 and 0.66 for the solar cycle 24), with a drop in the speed of magnetic disturbances in the solar wind. These results could be attributed to the decrease in Sun’s magnetic field toroidal component magnitude induced by a weak in sunspots number and solar flares during the solar cycle 24. A weak in the Earth currents systems (auroral electrojet current, ring current, and magnetopause current) is also observed. During the decrease in the Earth currents, several peaks are observed, indicating a nonlinear dependence in the Earth currents variation (ring current, auroral electrojet current, and magnetopause current) from solar cycle 23 to solar cycle 24. This could be attributed to the Corotating Interaction Regions (CIRs) observed during the declining phase of solar cycle 23 and the deep minimum preceding solar cycle 24.
