Based on the precedent discovery of a weak antifungal indole isolated from Aporpium caryae, which increased its activity when changing the N-alkyl chain, nineteen N-alkyl indoles, with alkyl chains from one to ten car...Based on the precedent discovery of a weak antifungal indole isolated from Aporpium caryae, which increased its activity when changing the N-alkyl chain, nineteen N-alkyl indoles, with alkyl chains from one to ten carbons and one or two hydroxyls, one amine or bromine functional groups, were prepared and fully characterized by spectroscopic methods. The aim of this study is the search for new synthetic agrochemical leads derived from natural products. The antifungal activity of the synthesized compounds against three fungal strains was measured in vitro. Six compounds presented good activity against Fusarium virguliforme, the causal agent of sudden-death syndrome (SDS) in soybean, in a bioautography assay. Four of them were tested in a germination test and in a greenhouse experiment. All tested compounds, applied as seed treatment, showed antifungal properties being effective to control SDS when there was low level of fungal contamination. Results indicate that some of the tested compounds are acting as growth inhibitors and represent new leads for the treatment of SDS for which no specific treatment has been previously reported.展开更多
目的定量评估高温热浪与居民猝死之间的暴露—反应关系,量化其超额死亡,并探究潜在的脆弱人群。方法以江苏省2015—2021年间猝死居民为研究对象开展时间分层病例交叉研究,利用中国气象局陆面数据同化系统(China Meteorological Administ...目的定量评估高温热浪与居民猝死之间的暴露—反应关系,量化其超额死亡,并探究潜在的脆弱人群。方法以江苏省2015—2021年间猝死居民为研究对象开展时间分层病例交叉研究,利用中国气象局陆面数据同化系统(China Meteorological Administration Land Data Assimilation System,CLDAS V2.0)温度数据识别江苏省不同定义下的高温热浪事件(结合相对温度阈值和持续时间进行定义),根据死亡日期和生前家庭住址评估研究对象的高温热浪暴露情况,采用条件logistic回归模型和分布滞后非线性模型(Distributed Lag Nonlinear Model,DLNM)评估高温热浪与猝死之间的暴露—反应关系,估算可归因于高温热浪暴露的超额死亡,根据性别和年龄进行分层分析并探讨其效应修饰作用。结果所有不同定义下的高温热浪暴露均与猝死风险增加有关,且随高温热浪强度增加,其猝死风险也随之增加。以P95_3d定义(温度超过第95百分位数且持续至少3 d)为例,高温热浪的人群猝死风险升高56%(95%CI:31%~86%),可归因于高温热浪暴露的猝死占总猝死人群的1.19%(95%CI:0.77%~1.58%)。分层分析结果提示,高温热浪暴露与猝死之间的关联在不同年龄和性别组中无显著差异。结论高温热浪暴露与猝死风险增加有关,在夏季减少热浪暴露可能有助于降低猝死的发生风险。展开更多
《2023欧洲心脏病学会心肌病管理指南》对心肌病的分类、诊断、治疗和综合管理提供了全面的指导,创新性提出了非扩张型左室心肌病(non-dilated left ventricular cardiomyopathy,NDLVC)这一分型,强调了NDLVC表型、基因检测和心脏磁共振(...《2023欧洲心脏病学会心肌病管理指南》对心肌病的分类、诊断、治疗和综合管理提供了全面的指导,创新性提出了非扩张型左室心肌病(non-dilated left ventricular cardiomyopathy,NDLVC)这一分型,强调了NDLVC表型、基因检测和心脏磁共振(cardiac magnetic resonance,CMR)成像在心肌病的早期诊断及风险评估中的重要价值,有助于更精准地识别心肌病的不同亚型,为心肌病的诊断、预后评估和风险分层提供了全新的思路,有望为NDLVC患者提供更早期、更精准的个体化风险分层和治疗策略。本文将围绕指南关于NDLVC新分类中CMR和基因在其疾病管理方面的应用进行核心解读,以期为临床和影像科医生提供参考。展开更多
文摘Based on the precedent discovery of a weak antifungal indole isolated from Aporpium caryae, which increased its activity when changing the N-alkyl chain, nineteen N-alkyl indoles, with alkyl chains from one to ten carbons and one or two hydroxyls, one amine or bromine functional groups, were prepared and fully characterized by spectroscopic methods. The aim of this study is the search for new synthetic agrochemical leads derived from natural products. The antifungal activity of the synthesized compounds against three fungal strains was measured in vitro. Six compounds presented good activity against Fusarium virguliforme, the causal agent of sudden-death syndrome (SDS) in soybean, in a bioautography assay. Four of them were tested in a germination test and in a greenhouse experiment. All tested compounds, applied as seed treatment, showed antifungal properties being effective to control SDS when there was low level of fungal contamination. Results indicate that some of the tested compounds are acting as growth inhibitors and represent new leads for the treatment of SDS for which no specific treatment has been previously reported.
文摘目的定量评估高温热浪与居民猝死之间的暴露—反应关系,量化其超额死亡,并探究潜在的脆弱人群。方法以江苏省2015—2021年间猝死居民为研究对象开展时间分层病例交叉研究,利用中国气象局陆面数据同化系统(China Meteorological Administration Land Data Assimilation System,CLDAS V2.0)温度数据识别江苏省不同定义下的高温热浪事件(结合相对温度阈值和持续时间进行定义),根据死亡日期和生前家庭住址评估研究对象的高温热浪暴露情况,采用条件logistic回归模型和分布滞后非线性模型(Distributed Lag Nonlinear Model,DLNM)评估高温热浪与猝死之间的暴露—反应关系,估算可归因于高温热浪暴露的超额死亡,根据性别和年龄进行分层分析并探讨其效应修饰作用。结果所有不同定义下的高温热浪暴露均与猝死风险增加有关,且随高温热浪强度增加,其猝死风险也随之增加。以P95_3d定义(温度超过第95百分位数且持续至少3 d)为例,高温热浪的人群猝死风险升高56%(95%CI:31%~86%),可归因于高温热浪暴露的猝死占总猝死人群的1.19%(95%CI:0.77%~1.58%)。分层分析结果提示,高温热浪暴露与猝死之间的关联在不同年龄和性别组中无显著差异。结论高温热浪暴露与猝死风险增加有关,在夏季减少热浪暴露可能有助于降低猝死的发生风险。
文摘《2023欧洲心脏病学会心肌病管理指南》对心肌病的分类、诊断、治疗和综合管理提供了全面的指导,创新性提出了非扩张型左室心肌病(non-dilated left ventricular cardiomyopathy,NDLVC)这一分型,强调了NDLVC表型、基因检测和心脏磁共振(cardiac magnetic resonance,CMR)成像在心肌病的早期诊断及风险评估中的重要价值,有助于更精准地识别心肌病的不同亚型,为心肌病的诊断、预后评估和风险分层提供了全新的思路,有望为NDLVC患者提供更早期、更精准的个体化风险分层和治疗策略。本文将围绕指南关于NDLVC新分类中CMR和基因在其疾病管理方面的应用进行核心解读,以期为临床和影像科医生提供参考。
