Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of...Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of cervical lesions.Methods:The expressions of IgG subclasses in 32 cases of human papillomavirus(HPV) infection,30 cervical intraepithelial neoplasia(CIN I),43 CIN Ⅱ-Ⅲ,and 24 hysteromyoma and chronic cervicitis were examined by ELISA.Results:The absorbance values of HPV16VLPs-IgG,IgG1 increased with the grade of CIN(P < 0.05).The IgG2 dominance(IgG2/IgG1 ratio > 1) from control group was 100%,87.50% for HPV infection group,75% for CIN I group,compared with that from CIN Ⅱ-Ⅲ patients(9.52%)(P < 0.05).The positive rates and absorbance values of HPV16VLPs-IgG,IgG1 and IgG2 from HPV16-DNA positive group were significantly higher than those from non-HPV16-DNA positive group(P < 0.05).There was a moderate correlation between the HPV16-DNA testing and detection of HPV16VLPs-IgG(r = 0.531,P < 0.05).Conclusion:An increase of the expressions of HPV16VLPs-IgG and its subclasses in the serum of the patients with cervical precancerous lesions,especially those with CIN II-III,might be associated with duration of HPV infection and severity of cervical lesions.An increase of the IgG2 dominance(IgG2/IgG1 > 1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions.展开更多
Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f（z） be a normalized locally biholomorphic mapping on Ω such that Jf^-1 （z...Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f（z） be a normalized locally biholomorphic mapping on Ω such that Jf^-1 （z） f（z） ∈Mg and z = 0 is the zero of order k＋1 of f（z） - z. We obtain the growth and covering theorems for f（z）. Especially, as corollaries, we unify and generalize many known results. Moreover, in view of proofs of corollaries, the essential relations among the subclasses of starlike mappings are shown.展开更多
文摘Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of cervical lesions.Methods:The expressions of IgG subclasses in 32 cases of human papillomavirus(HPV) infection,30 cervical intraepithelial neoplasia(CIN I),43 CIN Ⅱ-Ⅲ,and 24 hysteromyoma and chronic cervicitis were examined by ELISA.Results:The absorbance values of HPV16VLPs-IgG,IgG1 increased with the grade of CIN(P < 0.05).The IgG2 dominance(IgG2/IgG1 ratio > 1) from control group was 100%,87.50% for HPV infection group,75% for CIN I group,compared with that from CIN Ⅱ-Ⅲ patients(9.52%)(P < 0.05).The positive rates and absorbance values of HPV16VLPs-IgG,IgG1 and IgG2 from HPV16-DNA positive group were significantly higher than those from non-HPV16-DNA positive group(P < 0.05).There was a moderate correlation between the HPV16-DNA testing and detection of HPV16VLPs-IgG(r = 0.531,P < 0.05).Conclusion:An increase of the expressions of HPV16VLPs-IgG and its subclasses in the serum of the patients with cervical precancerous lesions,especially those with CIN II-III,might be associated with duration of HPV infection and severity of cervical lesions.An increase of the IgG2 dominance(IgG2/IgG1 > 1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions.
基金Supported by NNSF of China(10571164)Supported by SRFDP of Higher Education(20050358052)
文摘Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f（z） be a normalized locally biholomorphic mapping on Ω such that Jf^-1 （z） f（z） ∈Mg and z = 0 is the zero of order k＋1 of f（z） - z. We obtain the growth and covering theorems for f（z）. Especially, as corollaries, we unify and generalize many known results. Moreover, in view of proofs of corollaries, the essential relations among the subclasses of starlike mappings are shown.
