Seed maturation is a critical development transition and it largely affects the final yield and quality of crops.Abscisic acid(ABA)-activated sucrose-non-fermentation kinase subfamily 2(SnRK2s)constitute a well-known ...Seed maturation is a critical development transition and it largely affects the final yield and quality of crops.Abscisic acid(ABA)-activated sucrose-non-fermentation kinase subfamily 2(SnRK2s)constitute a well-known regulatory network that modulate seed maturation in Arabidopsis;however,the underlying genetic and regulatory mechanisms in cereal crops remain largely unknown.Here,we found that ABA levels exhibited two distinct peaks during kernel development in maize,corresponding to the lag and maturation phase,respectively.Integrated transcriptome and proteome profiling of kernels treated with exogenous ABA at the pre-maturation stage suggested that the second peak of ABA acts as a trigger for kernel maturation program.Knockout of ZmSnRK2s demonstrated that subclassⅢZmSnRK2s are required for kernel maturation in maize,and the loss-of-function of subclassⅢZmSnRK2s showed a disruption in kernel dehydration and dormancy.We identified a conserved ABA–SnRK2–b ZIP signaling pathway mediating this process in maize.Additionally,ZmSnRK2.10 overexpression accelerates kernel dehydration during maturity,achieving reduced kernel moisture content(KMC)at physiological maturity(PM).Overall,our findings establish ABA-activated SnRK2s as central regulators of kernel maturation in maize and provide valuable genetic resources for breeding maize varieties with low moisture content at harvest.展开更多
In this paper, we obtain a distortion theorem of Jacobian matrix for biholomorphic subclasses of starlike mappings along a unit direction on the unit polydisc. These results extend the classical distortion theorem of ...In this paper, we obtain a distortion theorem of Jacobian matrix for biholomorphic subclasses of starlike mappings along a unit direction on the unit polydisc. These results extend the classical distortion theorem of starlike mappings to higher dimensions. We then give an upper bound estimate for biholomorphic subclasses of starlike mappings along a unit direction in a complex Banach space.展开更多
In this paper,We mainly discuss some subclasses of analytic functions for operators onac, and determine a representation formula and sufficient condition for the class 4;(a.p,r,E,7) and prove a sufficient and necessar...In this paper,We mainly discuss some subclasses of analytic functions for operators onac, and determine a representation formula and sufficient condition for the class 4;(a.p,r,E,7) and prove a sufficient and necessary condition.coefficient estimates and distortiontheorem for the subclass O;o (a,p,Y,e,9) of the class ac;(a,p,y,c,V).Furthermore,the analogues also are true for operators on Hilbert space.展开更多
The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same ...The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same period, workflow management has experienced significant development, but has become more focused on the industry. However, it seems to us that document workflows have not had the same interest for the scientific community. But nowadays, the emergence and supremacy of the Internet in electronic exchanges are leading to a massive dematerialization of documents;which requires a conceptual reconsideration of the organizational framework for the processing of said documents in both public and private administrations. This problem seems open to us and deserves the interest of the scientific community. Indeed, EDM has mainly focused on the storage (referencing) and circulation of documents (traceability). It paid little attention to the overall behavior of the system in processing documents. The purpose of our researches is to model document processing systems. In the previous works, we proposed a general model and its specialization in the case of small documents (any document processed by a single person at a time during its processing life cycle), which represent 70% of documents processed by administrations, according to our study. In this contribution, we extend the model for processing small documents to the case where they are managed in a system comprising document classes organized in subclasses;which is the case for most administrations. We have thus observed that this model is a Markovian <i>M<sup>L×K</sup>/M<sup>L×K</sup>/</i>1 queues network. We have analyzed the constraints of this model and deduced certain characteristics and metrics. <span style="white-space:normal;"><i></i></span><i>In fine<span style="white-space:normal;"></span></i>, the ultimate objective of our work is to design a document workflow management system, integrating a component of global behavior prediction.展开更多
Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (...Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (CLL). Objective: The present study of interphase cytogenetics and conventional karyotyping was undertaken to perform comprehensive analysis of CLL genetics with an approach to refine early prognostication of disease. Material & Methods: Retrospective analysis by fluorescence in situ hybridization (FISH) was carried out on total 671 patients of CLL at diagnosis between 2008 and 2015. Conventional cytogenetics studies were performed in 50 of 671 patients using CPG Oligonucleotide + IL-2 and TPA (12-O-Tetradecanyl Phorbol 13-acetate) for stimulation of lymphocytes cultures. Results: Interphase cytogenetics could detect recurrent abnormalities such as del(13q14), +12, del(17p13), del(11q22), del(6q23) in 71% of cases. The incidence of del(13q) was higher in Rai stage 0, I, II (p = 0.0005);whereas patients with ≥2 aberrations were more common in advance stage III, IV (p = 0.001). Frequency of IgH translocation was 7%. Morphology and immunophenotypic analysis revealed atypical CLL with higher frequency of t(14;19) than t(14;18). Conventional karyotype could detect abnormal karyotype in 97% of cases which displayed targeted FISH abnormalities along with additional non-targeted chromosomal abnormalities. Patients with negative FISH markers showed clonal non-recurrent numerical and structural changes. The complex karyotype was identified in 24% cases which included targeted FISH aberrations as well as non-targeted numerical and structural abnormalities like deletions, and unbalanced translocations. A significant association was observed between complex karyotype and coexistence of ≥2 FISH markers (p = 0.009) and del(11q22) &/or del(17p) (p = 0.03). Conclusion: Our data of interphase FISH with integration of conventional karyotyping revealed genomic complexity that helped identification of biological subclasses with clinical impact at diagnosis. Further, these cytogenetic subclasses along with molecular markers are likely to evolve more refined prognostic groups, which will help design risk-adapted therapies in B-CLL.展开更多
Objective Hyperspectral remote sensing has attracted much attention in remote sensing research during recent years. It can elaborately identiry spectral characteristics of different objects by acquiring continuous sp...Objective Hyperspectral remote sensing has attracted much attention in remote sensing research during recent years. It can elaborately identiry spectral characteristics of different objects by acquiring continuous spectral curves of ground objects, and can thus provide more information for geological research （Zhao Yingjun et al., 2015）. With the deepening hyperspectral remote sensing research, scholars have focused from the classification of alteration minerals to the identification of subclass minerals in order to explore their significance fbr ore prospecting. This work utilized hyperspectral remote sensing technology in the Xitan region of Gansu Province to identify limonite and two types of sericite subclass minerals, and conducted field verification and geochemical survey. In addition, we analyzed the geological environment of subclass sericite minerals （Van Ruitenbeek et al., 2006） to provide evidence for gold ore prospecting.展开更多
Let K be the familiar class of normalized convex functions in the unit disk.In[14],Keogh and Merkes proved that for a function f(z)=z+∑k=2∞a k z k in the class K,|a 3−λa 22|≤max{13,|λ−1|},λ∈C.The above estimate...Let K be the familiar class of normalized convex functions in the unit disk.In[14],Keogh and Merkes proved that for a function f(z)=z+∑k=2∞a k z k in the class K,|a 3−λa 22|≤max{13,|λ−1|},λ∈C.The above estimate is sharp for eachλ.In this article,we establish the corresponding inequality for a normalized convex function f on U such that z=0 is a zero of order k+1 of f(z)−z,and then we extend this result to higher dimensions.These results generalize some known results.展开更多
The pneumococcal septic arthritis is uncommon in healthy adults. In most cases, it occurs in patients with immune deficiency. Its exceptional location at the wrist can maintain doubt with rheumatic causes which are mo...The pneumococcal septic arthritis is uncommon in healthy adults. In most cases, it occurs in patients with immune deficiency. Its exceptional location at the wrist can maintain doubt with rheumatic causes which are more frequent. IgG4 deficiency found in this patient was the only cause that could be impugned. We report the case of a young woman of 46 years without any evident cause of immunodeficiency and any particular risk factor, managed for septic arthritis of the wrist due to Streptococcus pneumoniae. This case without any apparent risk factors demonstrates that pneumococcal infection in a more distant articulation of the ENT is still possible. Scan has been a very significant contribution in confirming the positive diagnosis that leads to surgical drainage. The approach of the systematic search for the gateway must be done. In the study of the patient’s immune status, the realization of the protein profile could be interesting and then guide the practitioner in the decision to vaccinate the patient against Streptococcus pneumoniae if he was not. We recommend looking always for a cause of immunodeficiency including primary Ig defiencies even among adult.展开更多
Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f（z） be a normalized locally biholomorphic mapping on Ω such that Jf^-1 （z...Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f（z） be a normalized locally biholomorphic mapping on Ω such that Jf^-1 （z） f（z） ∈Mg and z = 0 is the zero of order k＋1 of f（z） - z. We obtain the growth and covering theorems for f（z）. Especially, as corollaries, we unify and generalize many known results. Moreover, in view of proofs of corollaries, the essential relations among the subclasses of starlike mappings are shown.展开更多
Let S~* be the familiar class of normalized univalent functions in the unit disk.In [9], Keogh and Merkes proved that for a function f(z) = z +∑k=2∞ a_kz^k in the class S~*,then |a_3-λa_2~2| ≤ max{1, |3-4λ|}, λ...Let S~* be the familiar class of normalized univalent functions in the unit disk.In [9], Keogh and Merkes proved that for a function f(z) = z +∑k=2∞ a_kz^k in the class S~*,then |a_3-λa_2~2| ≤ max{1, |3-4λ|}, λ∈ C. In this article, we investigate the corresponding problem for the subclass of starlike mappings defined on the unit ball in a complex Banach space, on the unit polydisk in Cnand the bounded starlike circular domain in C~■, respectively.展开更多
Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of...Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of cervical lesions.Methods:The expressions of IgG subclasses in 32 cases of human papillomavirus(HPV) infection,30 cervical intraepithelial neoplasia(CIN I),43 CIN Ⅱ-Ⅲ,and 24 hysteromyoma and chronic cervicitis were examined by ELISA.Results:The absorbance values of HPV16VLPs-IgG,IgG1 increased with the grade of CIN(P < 0.05).The IgG2 dominance(IgG2/IgG1 ratio > 1) from control group was 100%,87.50% for HPV infection group,75% for CIN I group,compared with that from CIN Ⅱ-Ⅲ patients(9.52%)(P < 0.05).The positive rates and absorbance values of HPV16VLPs-IgG,IgG1 and IgG2 from HPV16-DNA positive group were significantly higher than those from non-HPV16-DNA positive group(P < 0.05).There was a moderate correlation between the HPV16-DNA testing and detection of HPV16VLPs-IgG(r = 0.531,P < 0.05).Conclusion:An increase of the expressions of HPV16VLPs-IgG and its subclasses in the serum of the patients with cervical precancerous lesions,especially those with CIN II-III,might be associated with duration of HPV infection and severity of cervical lesions.An increase of the IgG2 dominance(IgG2/IgG1 > 1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions.展开更多
The serum IgG subclass concentrations in 47 cases and specific IgG subclass antibodies against pneumococcal polysaccharides (PnPs) were measured in 18 cases with iron deficiency. IgG subclass deficiencies were found i...The serum IgG subclass concentrations in 47 cases and specific IgG subclass antibodies against pneumococcal polysaccharides (PnPs) were measured in 18 cases with iron deficiency. IgG subclass deficiencies were found in 28 (59.6%) cases with the frequency in order as IgG4 (27.7%, 13 / 47), IgGl (21.3%, 10/47), IgG3 (14.9%, 7/47), and IgG2 (2.1%, 1 / 47). Compared with age-atched healthy children, the mean concentration of serum IgG4 and IgGl, and PnPs specific IgGl, IgG2 antibodies were decreased in children with iron deficiency. Decreased CD4 cells and CD4 / CD8 ratio in peripheral blood, low interleukin? (IL-6) activity, reduced lymphocyte proliferative responsiveness and increased recurrent respiratory tract infections (RRTI) were found in iron deticiency children. These results suggested that serum IgG subclass and PnPs specific IgG subclass antibody deficiencies caused by dysfunction of the regulation of T lymphocyte on B lymphocyte may be related to the susceptibility to RRTI in children with iron deficiency.展开更多
Immunoglobulin G(IgG)subclasses in human health and immunity have only be sporadically studied in the half century since their discovery.Different patterns of IgG subclass production are seen if the immune response is...Immunoglobulin G(IgG)subclasses in human health and immunity have only be sporadically studied in the half century since their discovery.Different patterns of IgG subclass production are seen if the immune response is deviated towards type 1 versus type 2.The current state of our knowledge of IgG subclasses in liver transplantation is reviewed here.While several studies have been conducted in liver disease,only four relatively small studies have been undertaken in liver transplant recipients.Total IgG4 elevation in serum is related to sclerosing pancreatico-cholangiopathy that is sensitive to treatment with steroids.Conventional immunosuppressive regimes,especially with a combination of tacrolimus and sirolimus,reduce the production of all IgG subclasses after transplantation but it is not known if they deviate the immune response.Presence of anti-donor IgG3 before transplantation,or its expansion after transplantation,has been associated with rejection and liver graft loss.Anti-GSTT1 IgG4 production after transplantation is associated with de-novo immune hepatitis.Greater knowledge of anti-donor IgG subclass responses after transplantation will allow us tailor novel treatments for greater effect.展开更多
Hepatocellular carcinoma(HCC)is a heterogeneous disease and the second most common cause of cancer-related death worldwide.Marked developments in genomic technologies helped scientists to understand the heterogeneity ...Hepatocellular carcinoma(HCC)is a heterogeneous disease and the second most common cause of cancer-related death worldwide.Marked developments in genomic technologies helped scientists to understand the heterogeneity of HCC and identified multiple HCC-related molecular subclasses.An integrative analysis of genomic datasets including 196 patients from The Cancer Genome Atlas(TCGA)group has recently reported a new HCC subclass,which contains three subgroups(iCluster1,iCluster2,and iCluster3).However,the transcriptional molecular characteristics underlying the iClusters have not been thoroughly investigated.Herein,we identified a more aggressive subset of HCC patients in the iCluster1,and re-clustered the TCGA samples into novel HCC subclasses referred to as aggressive(Ag),moderate-aggressive(M-Ag),and less-aggressive(L-Ag)subclasses.The Ag subclass had a greater predictive power than the TCGA iCluster1,and a higher level of alpha fetoprotein,microscopic vascular invasion,immune infiltration,isocitrate dehydrogenase 1/2 mutation status,and a worse survival than MAg and L-Ag subclasses.Global transcriptomic analysis showed that activation of hedgehog signaling in the Ag subclass may play key roles in tumor development of aggressive HCC.GLI1,a key transcriptional regulator of hedgehog signaling upregulated in the Ag subclass,was correlated with poor prognosis of HCC,and may be a potential prognostic biomarker and therapeutic target for Ag subclass HCC patients.展开更多
Accurate high-resolution maps of oil palm plantations underpin effective management of environmental and socio-economic impacts at global,regional,and national levels.However,young industrial and highly irregular smal...Accurate high-resolution maps of oil palm plantations underpin effective management of environmental and socio-economic impacts at global,regional,and national levels.However,young industrial and highly irregular small-holder plantations are mostly unmapped and not included in official FAO statistics.This issue is addressed here by discriminating global oil palm plantation in 2020 into four subclasses:Industrial Mature Oil Palm(IMOP);Industrial Young Oil Palm(IYOP);Smallholder Mature Oil Palm(SMOP);and Smallholder Young Oil Palm(SYOP).Data,resolved to 4.77 m,from Planet&NICFI,Sentinel-1/2,were combined with other layers using the image-oriented classification and regression tree(CART)algorithm which performed best in classification tests.Results show that SMOP dominates distributional extent,but it was also the most accurately mapped subclass typically found at 500–1000 m altitude.IMOP had the most extensive altitude range of 500–1300 m,while IYOP and SYOP were found at similar altitudes of 500–800 m and 500–900 m respectively.Recent developments in South East Asia show oil palm plantations expanding into new areas with a slope of 24 degrees.Results provide data to support Sustainable Development Goal by assisting future oil palm-related development planning and monitoring in the world’s major oil palm-growing countries.展开更多
A general theorem on the limiting distribution of the generalized t-distribution is obtained,many applications of this theorem to some subclasses of elliptically contoured distributions in cluding multivariate normal ...A general theorem on the limiting distribution of the generalized t-distribution is obtained,many applications of this theorem to some subclasses of elliptically contoured distributions in cluding multivariate normal and multivariate t distributions are discussed.Further,their limiting distributions by density function are derived.展开更多
Objective To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA) Methods IgG subclasses were tested in 40 patients with idiopathic or secondary A...Objective To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA) Methods IgG subclasses were tested in 40 patients with idiopathic or secondary AIHA by Coombs test with monoclonal antibodies Hb, TBil, RC and FHb, as hemolytic parameters, were used to analyze the clinical implications of subclasses of AIHA warm autoantibody IgG Results In most patients IgG incomplete warm autoantibody was IgG1(27 patients), but IgG3(20 patients), rarely IgG2(14 patients) and IgG4(9 patients) also occurred Three groups were analyzed: Group A included 20 patients with IgG3; Group B included 14 patients with IgG1 but without IgG3; Group C included 6 patients without IgG1 and IgG3 There were significant differences ( P <0 01) between groups in Hb, TBil, RC and FHb Moreover, we also found that the sensitivity of Coombs test with polyclonal antiserums was 90 0%, while that of Coombs test with monoclonal antibodies was 97 5% The effect of treatment was worst in patients with positive IgG3 autoantibody, whose hemolysis recurred frequently Conclusion IgG3 autoantibody was the most effective in bringing about red cell destruction, IgG1 autoantibody was less effective, IgG2 even less, whereas IgG4 autoantibody was shown to hardly affect red cell survival Coombs test with monoclonal antibodies was more sensitive than that with polyclonal antiserums Patients’ respondence to treatment correlated with the type of IgG subclasses展开更多
基金supported by the National Natural Science Foundation of China(32201696)the Natural Science Foundation of Sichuan Province(23NSFSC4071)。
文摘Seed maturation is a critical development transition and it largely affects the final yield and quality of crops.Abscisic acid(ABA)-activated sucrose-non-fermentation kinase subfamily 2(SnRK2s)constitute a well-known regulatory network that modulate seed maturation in Arabidopsis;however,the underlying genetic and regulatory mechanisms in cereal crops remain largely unknown.Here,we found that ABA levels exhibited two distinct peaks during kernel development in maize,corresponding to the lag and maturation phase,respectively.Integrated transcriptome and proteome profiling of kernels treated with exogenous ABA at the pre-maturation stage suggested that the second peak of ABA acts as a trigger for kernel maturation program.Knockout of ZmSnRK2s demonstrated that subclassⅢZmSnRK2s are required for kernel maturation in maize,and the loss-of-function of subclassⅢZmSnRK2s showed a disruption in kernel dehydration and dormancy.We identified a conserved ABA–SnRK2–b ZIP signaling pathway mediating this process in maize.Additionally,ZmSnRK2.10 overexpression accelerates kernel dehydration during maturity,achieving reduced kernel moisture content(KMC)at physiological maturity(PM).Overall,our findings establish ABA-activated SnRK2s as central regulators of kernel maturation in maize and provide valuable genetic resources for breeding maize varieties with low moisture content at harvest.
基金supported by NSF of Zhejiang Province(D7080080, Y6090036, Y6090694, Y6100219)the National Natural Science Foundation of China (10971063,11001246, 11031008, 11101139)
文摘In this paper, we obtain a distortion theorem of Jacobian matrix for biholomorphic subclasses of starlike mappings along a unit direction on the unit polydisc. These results extend the classical distortion theorem of starlike mappings to higher dimensions. We then give an upper bound estimate for biholomorphic subclasses of starlike mappings along a unit direction in a complex Banach space.
文摘In this paper,We mainly discuss some subclasses of analytic functions for operators onac, and determine a representation formula and sufficient condition for the class 4;(a.p,r,E,7) and prove a sufficient and necessary condition.coefficient estimates and distortiontheorem for the subclass O;o (a,p,Y,e,9) of the class ac;(a,p,y,c,V).Furthermore,the analogues also are true for operators on Hilbert space.
文摘The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same period, workflow management has experienced significant development, but has become more focused on the industry. However, it seems to us that document workflows have not had the same interest for the scientific community. But nowadays, the emergence and supremacy of the Internet in electronic exchanges are leading to a massive dematerialization of documents;which requires a conceptual reconsideration of the organizational framework for the processing of said documents in both public and private administrations. This problem seems open to us and deserves the interest of the scientific community. Indeed, EDM has mainly focused on the storage (referencing) and circulation of documents (traceability). It paid little attention to the overall behavior of the system in processing documents. The purpose of our researches is to model document processing systems. In the previous works, we proposed a general model and its specialization in the case of small documents (any document processed by a single person at a time during its processing life cycle), which represent 70% of documents processed by administrations, according to our study. In this contribution, we extend the model for processing small documents to the case where they are managed in a system comprising document classes organized in subclasses;which is the case for most administrations. We have thus observed that this model is a Markovian <i>M<sup>L×K</sup>/M<sup>L×K</sup>/</i>1 queues network. We have analyzed the constraints of this model and deduced certain characteristics and metrics. <span style="white-space:normal;"><i></i></span><i>In fine<span style="white-space:normal;"></span></i>, the ultimate objective of our work is to design a document workflow management system, integrating a component of global behavior prediction.
文摘Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (CLL). Objective: The present study of interphase cytogenetics and conventional karyotyping was undertaken to perform comprehensive analysis of CLL genetics with an approach to refine early prognostication of disease. Material & Methods: Retrospective analysis by fluorescence in situ hybridization (FISH) was carried out on total 671 patients of CLL at diagnosis between 2008 and 2015. Conventional cytogenetics studies were performed in 50 of 671 patients using CPG Oligonucleotide + IL-2 and TPA (12-O-Tetradecanyl Phorbol 13-acetate) for stimulation of lymphocytes cultures. Results: Interphase cytogenetics could detect recurrent abnormalities such as del(13q14), +12, del(17p13), del(11q22), del(6q23) in 71% of cases. The incidence of del(13q) was higher in Rai stage 0, I, II (p = 0.0005);whereas patients with ≥2 aberrations were more common in advance stage III, IV (p = 0.001). Frequency of IgH translocation was 7%. Morphology and immunophenotypic analysis revealed atypical CLL with higher frequency of t(14;19) than t(14;18). Conventional karyotype could detect abnormal karyotype in 97% of cases which displayed targeted FISH abnormalities along with additional non-targeted chromosomal abnormalities. Patients with negative FISH markers showed clonal non-recurrent numerical and structural changes. The complex karyotype was identified in 24% cases which included targeted FISH aberrations as well as non-targeted numerical and structural abnormalities like deletions, and unbalanced translocations. A significant association was observed between complex karyotype and coexistence of ≥2 FISH markers (p = 0.009) and del(11q22) &/or del(17p) (p = 0.03). Conclusion: Our data of interphase FISH with integration of conventional karyotyping revealed genomic complexity that helped identification of biological subclasses with clinical impact at diagnosis. Further, these cytogenetic subclasses along with molecular markers are likely to evolve more refined prognostic groups, which will help design risk-adapted therapies in B-CLL.
基金financially supported by the research project of China National Uranium Limited Company(grant No.201498)the China Geological Survey Project(grant No.12120113072900)
文摘Objective Hyperspectral remote sensing has attracted much attention in remote sensing research during recent years. It can elaborately identiry spectral characteristics of different objects by acquiring continuous spectral curves of ground objects, and can thus provide more information for geological research （Zhao Yingjun et al., 2015）. With the deepening hyperspectral remote sensing research, scholars have focused from the classification of alteration minerals to the identification of subclass minerals in order to explore their significance fbr ore prospecting. This work utilized hyperspectral remote sensing technology in the Xitan region of Gansu Province to identify limonite and two types of sericite subclass minerals, and conducted field verification and geochemical survey. In addition, we analyzed the geological environment of subclass sericite minerals （Van Ruitenbeek et al., 2006） to provide evidence for gold ore prospecting.
基金National Natural Science Foundation of China(11971165,11561030)。
文摘Let K be the familiar class of normalized convex functions in the unit disk.In[14],Keogh and Merkes proved that for a function f(z)=z+∑k=2∞a k z k in the class K,|a 3−λa 22|≤max{13,|λ−1|},λ∈C.The above estimate is sharp for eachλ.In this article,we establish the corresponding inequality for a normalized convex function f on U such that z=0 is a zero of order k+1 of f(z)−z,and then we extend this result to higher dimensions.These results generalize some known results.
文摘The pneumococcal septic arthritis is uncommon in healthy adults. In most cases, it occurs in patients with immune deficiency. Its exceptional location at the wrist can maintain doubt with rheumatic causes which are more frequent. IgG4 deficiency found in this patient was the only cause that could be impugned. We report the case of a young woman of 46 years without any evident cause of immunodeficiency and any particular risk factor, managed for septic arthritis of the wrist due to Streptococcus pneumoniae. This case without any apparent risk factors demonstrates that pneumococcal infection in a more distant articulation of the ENT is still possible. Scan has been a very significant contribution in confirming the positive diagnosis that leads to surgical drainage. The approach of the systematic search for the gateway must be done. In the study of the patient’s immune status, the realization of the protein profile could be interesting and then guide the practitioner in the decision to vaccinate the patient against Streptococcus pneumoniae if he was not. We recommend looking always for a cause of immunodeficiency including primary Ig defiencies even among adult.
基金Supported by NNSF of China(10571164)Supported by SRFDP of Higher Education(20050358052)
文摘Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f（z） be a normalized locally biholomorphic mapping on Ω such that Jf^-1 （z） f（z） ∈Mg and z = 0 is the zero of order k＋1 of f（z） - z. We obtain the growth and covering theorems for f（z）. Especially, as corollaries, we unify and generalize many known results. Moreover, in view of proofs of corollaries, the essential relations among the subclasses of starlike mappings are shown.
基金This work was supported by NNSF of China（Grant Nos. 11561030, 11261022）, the Jiangxi Provincial Natural Science Foundation of China （Grant Nos. 20152ACB20002, 20161BAB201019）, Natural Science Foundation of Department of Education of Jiangxi Province, China （Grant No. GJJ150301）, and the Jiangxi Provincial graduate student innovation project （Grant No. YC2016-S159）
文摘Let S~* be the familiar class of normalized univalent functions in the unit disk.In [9], Keogh and Merkes proved that for a function f(z) = z +∑k=2∞ a_kz^k in the class S~*,then |a_3-λa_2~2| ≤ max{1, |3-4λ|}, λ∈ C. In this article, we investigate the corresponding problem for the subclass of starlike mappings defined on the unit ball in a complex Banach space, on the unit polydisk in Cnand the bounded starlike circular domain in C~■, respectively.
文摘Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of cervical lesions.Methods:The expressions of IgG subclasses in 32 cases of human papillomavirus(HPV) infection,30 cervical intraepithelial neoplasia(CIN I),43 CIN Ⅱ-Ⅲ,and 24 hysteromyoma and chronic cervicitis were examined by ELISA.Results:The absorbance values of HPV16VLPs-IgG,IgG1 increased with the grade of CIN(P < 0.05).The IgG2 dominance(IgG2/IgG1 ratio > 1) from control group was 100%,87.50% for HPV infection group,75% for CIN I group,compared with that from CIN Ⅱ-Ⅲ patients(9.52%)(P < 0.05).The positive rates and absorbance values of HPV16VLPs-IgG,IgG1 and IgG2 from HPV16-DNA positive group were significantly higher than those from non-HPV16-DNA positive group(P < 0.05).There was a moderate correlation between the HPV16-DNA testing and detection of HPV16VLPs-IgG(r = 0.531,P < 0.05).Conclusion:An increase of the expressions of HPV16VLPs-IgG and its subclasses in the serum of the patients with cervical precancerous lesions,especially those with CIN II-III,might be associated with duration of HPV infection and severity of cervical lesions.An increase of the IgG2 dominance(IgG2/IgG1 > 1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions.
文摘The serum IgG subclass concentrations in 47 cases and specific IgG subclass antibodies against pneumococcal polysaccharides (PnPs) were measured in 18 cases with iron deficiency. IgG subclass deficiencies were found in 28 (59.6%) cases with the frequency in order as IgG4 (27.7%, 13 / 47), IgGl (21.3%, 10/47), IgG3 (14.9%, 7/47), and IgG2 (2.1%, 1 / 47). Compared with age-atched healthy children, the mean concentration of serum IgG4 and IgGl, and PnPs specific IgGl, IgG2 antibodies were decreased in children with iron deficiency. Decreased CD4 cells and CD4 / CD8 ratio in peripheral blood, low interleukin? (IL-6) activity, reduced lymphocyte proliferative responsiveness and increased recurrent respiratory tract infections (RRTI) were found in iron deticiency children. These results suggested that serum IgG subclass and PnPs specific IgG subclass antibody deficiencies caused by dysfunction of the regulation of T lymphocyte on B lymphocyte may be related to the susceptibility to RRTI in children with iron deficiency.
文摘Immunoglobulin G(IgG)subclasses in human health and immunity have only be sporadically studied in the half century since their discovery.Different patterns of IgG subclass production are seen if the immune response is deviated towards type 1 versus type 2.The current state of our knowledge of IgG subclasses in liver transplantation is reviewed here.While several studies have been conducted in liver disease,only four relatively small studies have been undertaken in liver transplant recipients.Total IgG4 elevation in serum is related to sclerosing pancreatico-cholangiopathy that is sensitive to treatment with steroids.Conventional immunosuppressive regimes,especially with a combination of tacrolimus and sirolimus,reduce the production of all IgG subclasses after transplantation but it is not known if they deviate the immune response.Presence of anti-donor IgG3 before transplantation,or its expansion after transplantation,has been associated with rejection and liver graft loss.Anti-GSTT1 IgG4 production after transplantation is associated with de-novo immune hepatitis.Greater knowledge of anti-donor IgG subclass responses after transplantation will allow us tailor novel treatments for greater effect.
基金financial support from the National Key Program for Basic Research of China (2017YFC0906603, 2017YFC0908404, 2016YFA0501300)the National Natural Science Foundation of China (81530021)+1 种基金the Beijing Municipal Science and Technology Project (Z161100002616036)the Innovation Foundation of Medicine (BWS14J052, 16CXZ027)
文摘Hepatocellular carcinoma(HCC)is a heterogeneous disease and the second most common cause of cancer-related death worldwide.Marked developments in genomic technologies helped scientists to understand the heterogeneity of HCC and identified multiple HCC-related molecular subclasses.An integrative analysis of genomic datasets including 196 patients from The Cancer Genome Atlas(TCGA)group has recently reported a new HCC subclass,which contains three subgroups(iCluster1,iCluster2,and iCluster3).However,the transcriptional molecular characteristics underlying the iClusters have not been thoroughly investigated.Herein,we identified a more aggressive subset of HCC patients in the iCluster1,and re-clustered the TCGA samples into novel HCC subclasses referred to as aggressive(Ag),moderate-aggressive(M-Ag),and less-aggressive(L-Ag)subclasses.The Ag subclass had a greater predictive power than the TCGA iCluster1,and a higher level of alpha fetoprotein,microscopic vascular invasion,immune infiltration,isocitrate dehydrogenase 1/2 mutation status,and a worse survival than MAg and L-Ag subclasses.Global transcriptomic analysis showed that activation of hedgehog signaling in the Ag subclass may play key roles in tumor development of aggressive HCC.GLI1,a key transcriptional regulator of hedgehog signaling upregulated in the Ag subclass,was correlated with poor prognosis of HCC,and may be a potential prognostic biomarker and therapeutic target for Ag subclass HCC patients.
基金supported by the National Key Research and Development Program of China(No.2022YFC3103103)the Strategic Priority Research Program of Chinese Academy of Sciences(grant number XDA19060304).
文摘Accurate high-resolution maps of oil palm plantations underpin effective management of environmental and socio-economic impacts at global,regional,and national levels.However,young industrial and highly irregular small-holder plantations are mostly unmapped and not included in official FAO statistics.This issue is addressed here by discriminating global oil palm plantation in 2020 into four subclasses:Industrial Mature Oil Palm(IMOP);Industrial Young Oil Palm(IYOP);Smallholder Mature Oil Palm(SMOP);and Smallholder Young Oil Palm(SYOP).Data,resolved to 4.77 m,from Planet&NICFI,Sentinel-1/2,were combined with other layers using the image-oriented classification and regression tree(CART)algorithm which performed best in classification tests.Results show that SMOP dominates distributional extent,but it was also the most accurately mapped subclass typically found at 500–1000 m altitude.IMOP had the most extensive altitude range of 500–1300 m,while IYOP and SYOP were found at similar altitudes of 500–800 m and 500–900 m respectively.Recent developments in South East Asia show oil palm plantations expanding into new areas with a slope of 24 degrees.Results provide data to support Sustainable Development Goal by assisting future oil palm-related development planning and monitoring in the world’s major oil palm-growing countries.
基金This project is supported by the National Natural Science Foundation of Chinaby Grant DA01070 from U.S. Public Health Service
文摘A general theorem on the limiting distribution of the generalized t-distribution is obtained,many applications of this theorem to some subclasses of elliptically contoured distributions in cluding multivariate normal and multivariate t distributions are discussed.Further,their limiting distributions by density function are derived.
文摘Objective To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA) Methods IgG subclasses were tested in 40 patients with idiopathic or secondary AIHA by Coombs test with monoclonal antibodies Hb, TBil, RC and FHb, as hemolytic parameters, were used to analyze the clinical implications of subclasses of AIHA warm autoantibody IgG Results In most patients IgG incomplete warm autoantibody was IgG1(27 patients), but IgG3(20 patients), rarely IgG2(14 patients) and IgG4(9 patients) also occurred Three groups were analyzed: Group A included 20 patients with IgG3; Group B included 14 patients with IgG1 but without IgG3; Group C included 6 patients without IgG1 and IgG3 There were significant differences ( P <0 01) between groups in Hb, TBil, RC and FHb Moreover, we also found that the sensitivity of Coombs test with polyclonal antiserums was 90 0%, while that of Coombs test with monoclonal antibodies was 97 5% The effect of treatment was worst in patients with positive IgG3 autoantibody, whose hemolysis recurred frequently Conclusion IgG3 autoantibody was the most effective in bringing about red cell destruction, IgG1 autoantibody was less effective, IgG2 even less, whereas IgG4 autoantibody was shown to hardly affect red cell survival Coombs test with monoclonal antibodies was more sensitive than that with polyclonal antiserums Patients’ respondence to treatment correlated with the type of IgG subclasses
