Interconnection networks are hardware fabrics supporting communications between individual processors in multi- computers. The low-dimensional k-ary n-cubes （or torus） with adaptive wormhole switching have attracted...Interconnection networks are hardware fabrics supporting communications between individual processors in multi- computers. The low-dimensional k-ary n-cubes （or torus） with adaptive wormhole switching have attracted significant research efforts to construct high-performance interconnection networks in contemporary multi-computers. The arrival process and destination distribution of messages have great effects on network performance. With the aim of capturing the characteristics of the realistic traffic pattern and obtaining a deep understanding of the performance behaviour of interconneetion networks, this paper presents an analytical model to investigate the message latency in adaptive-routed wormhole-switched torus networks where there exists hot-spot nodes and the message arrivals follow a batch arrival process. Each generated message has a given probability to be directed to the hot-spot node. The average degree of virtual channel multiplexing is computed by the GE/G/1/V queueing system with finite buffer capacity. We compare analytical results of message latency with those obtained through the simulation experiments in order to validate the accuracy of the derived model.展开更多
In wireless sensor networks(WSNs),nodes are often scheduled to alternate between working mode and sleeping mode from energy efficiency point of view.When delay is tolerable,it is not necessary to preserve network conn...In wireless sensor networks(WSNs),nodes are often scheduled to alternate between working mode and sleeping mode from energy efficiency point of view.When delay is tolerable,it is not necessary to preserve network connectivity during activity(working or sleeping) scheduling,enabling more sensors to be switched to sleeping mode and thus more energy savings.In this paper,the nodal behavior in such delay-tolerant WSNs(DT-WSNs) is modeled and analyzed.The maximum hop count with a routing path is derived in order not to violate a given sensor-to-sink delay constraint,along with extensive simulation results.展开更多
目的:运用网络药理学研究方法对黄连-葛根药对治疗2型糖尿病(T2DM)的作用机制进行分析。方法:采用中药系统药理学分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)筛选出黄连-葛根(C...目的:运用网络药理学研究方法对黄连-葛根药对治疗2型糖尿病(T2DM)的作用机制进行分析。方法:采用中药系统药理学分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)筛选出黄连-葛根(Coptis Chinensis-Pueraria Lobata,C-P)药对的有效活性成分及作用靶点蛋白,再使用Unipro数据库将筛选出的靶点蛋白转换为基因名,通过GeneCards数据库收集T2DM疾病基因,然后对药物作用基因及疾病相关基因进行韦恩(Venn)分析,寻找交集靶点,用交集靶点与对应活性成分构建活性成分-靶点相互作用网络,并对交集基因进行GO功能富集分析和KEGG通路富集分析。结果:研究得到13个作用于T2DM疾病靶点的活性成分和146个作用靶点,GO功能富集分析确定了284个条目,KEGG通路分析共发现77条作用通路。结论:本研究结果初步探讨了C-P药对治疗T2MD的基本药理作用及其机制,并为进一步的试验研究奠定了良好的基础。展开更多
基金supported by the UK EPSRC research grant(No. EP/C525027/1) Nuffield Foundation (No. NAL/00682/G).
文摘Interconnection networks are hardware fabrics supporting communications between individual processors in multi- computers. The low-dimensional k-ary n-cubes （or torus） with adaptive wormhole switching have attracted significant research efforts to construct high-performance interconnection networks in contemporary multi-computers. The arrival process and destination distribution of messages have great effects on network performance. With the aim of capturing the characteristics of the realistic traffic pattern and obtaining a deep understanding of the performance behaviour of interconneetion networks, this paper presents an analytical model to investigate the message latency in adaptive-routed wormhole-switched torus networks where there exists hot-spot nodes and the message arrivals follow a batch arrival process. Each generated message has a given probability to be directed to the hot-spot node. The average degree of virtual channel multiplexing is computed by the GE/G/1/V queueing system with finite buffer capacity. We compare analytical results of message latency with those obtained through the simulation experiments in order to validate the accuracy of the derived model.
基金Sponsored by the Shanghai Education Bureau(Grant No. 11YZ93,A-3101-10-035)the Shanghai Baiyulan Funding(Grant No. 2010B086)the National Natural Science Foundation of China(Grant No. 61003215)
文摘In wireless sensor networks(WSNs),nodes are often scheduled to alternate between working mode and sleeping mode from energy efficiency point of view.When delay is tolerable,it is not necessary to preserve network connectivity during activity(working or sleeping) scheduling,enabling more sensors to be switched to sleeping mode and thus more energy savings.In this paper,the nodal behavior in such delay-tolerant WSNs(DT-WSNs) is modeled and analyzed.The maximum hop count with a routing path is derived in order not to violate a given sensor-to-sink delay constraint,along with extensive simulation results.
文摘目的:运用网络药理学研究方法对黄连-葛根药对治疗2型糖尿病(T2DM)的作用机制进行分析。方法:采用中药系统药理学分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)筛选出黄连-葛根(Coptis Chinensis-Pueraria Lobata,C-P)药对的有效活性成分及作用靶点蛋白,再使用Unipro数据库将筛选出的靶点蛋白转换为基因名,通过GeneCards数据库收集T2DM疾病基因,然后对药物作用基因及疾病相关基因进行韦恩(Venn)分析,寻找交集靶点,用交集靶点与对应活性成分构建活性成分-靶点相互作用网络,并对交集基因进行GO功能富集分析和KEGG通路富集分析。结果:研究得到13个作用于T2DM疾病靶点的活性成分和146个作用靶点,GO功能富集分析确定了284个条目,KEGG通路分析共发现77条作用通路。结论:本研究结果初步探讨了C-P药对治疗T2MD的基本药理作用及其机制,并为进一步的试验研究奠定了良好的基础。
