Su FEx点击反应自2014年被提出以后取得了快速的进展,分别从小分子制备与聚合物合成方面介绍硅醚与有机硫(VI)氟化合物之间的点击化学反应,对目前发展的硅醚与硫(Ⅵ)氟化合物Su FEx典型点击反应重点按照底物类型进行了梳理,探讨了未来...Su FEx点击反应自2014年被提出以后取得了快速的进展,分别从小分子制备与聚合物合成方面介绍硅醚与有机硫(VI)氟化合物之间的点击化学反应,对目前发展的硅醚与硫(Ⅵ)氟化合物Su FEx典型点击反应重点按照底物类型进行了梳理,探讨了未来的研究方向.展开更多
Improper abuse of roxarsone(ROX)in industrial production leads to harmful effects on water,soil,food,and living creatures.It is significant to detect its concentration in the environment and biosystem.Herein,two aggre...Improper abuse of roxarsone(ROX)in industrial production leads to harmful effects on water,soil,food,and living creatures.It is significant to detect its concentration in the environment and biosystem.Herein,two aggregation-induced emission(AIE)-active fluorescence probes,TPE-TPE and TPE-TPE-CN,are successfully synthesized via a sulfur(VI)fluoride exchange(SuFEx)click reaction and first employed to detect ROX in the environment and living 3T3 cells.These two probes can selectively detect ROX in water due to the synergistic effect of photoinduced electron transfer(PET)and fluorescence resonance energy transfer(FRET)between the probes and ROX.The detection limit of TPE-TPE and TPE-TPE-CN is 0.154 and 0.385μmol/L,respectively,much lower than the safety concentration stipulated by the World Health Organization(WHO).In addition,with the aid of a color discrimination application in a smartphone,these two probes can also detect ROX in real samples(such as water,soil,and cabbage),demonstrating their excellent potential for monitoring ROX in a practical environment.展开更多
High throughput screening towards chemical libraries is the primary way to discover lead compounds in developing innovative drugs,especially new molecular entities.Accordingly,the preparation of chemical libraries is ...High throughput screening towards chemical libraries is the primary way to discover lead compounds in developing innovative drugs,especially new molecular entities.Accordingly,the preparation of chemical libraries is the key step for drug development.Now,con-ventional small molecule chemical libraries and DNA-encoded chemical libraries are the main models of chemical libraries for high-throughput screening.Recently,a new model of chemical library,calledmodular click chemistry library,was proposed,which gives us an alternative choice to construct chemical libraries for high throughput screening and exhibits broad prospects to accelerate drug development.Herein,this article mainly focuses on the strategy to prepare the modular click chemistry library.展开更多
基金financial support from the National Natural Science Foundation of China(Nos.21938006,21776190)Basic Research Project of Leading Technology(No.BK20202012)+2 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.20KJA610001)PAPD in Jiangsu Province,China Postdoctoral Science Foundation(No.2022M722308)Jiangsu Province Excellent Postdoctoral Program(No.2022ZB563)。
文摘Improper abuse of roxarsone(ROX)in industrial production leads to harmful effects on water,soil,food,and living creatures.It is significant to detect its concentration in the environment and biosystem.Herein,two aggregation-induced emission(AIE)-active fluorescence probes,TPE-TPE and TPE-TPE-CN,are successfully synthesized via a sulfur(VI)fluoride exchange(SuFEx)click reaction and first employed to detect ROX in the environment and living 3T3 cells.These two probes can selectively detect ROX in water due to the synergistic effect of photoinduced electron transfer(PET)and fluorescence resonance energy transfer(FRET)between the probes and ROX.The detection limit of TPE-TPE and TPE-TPE-CN is 0.154 and 0.385μmol/L,respectively,much lower than the safety concentration stipulated by the World Health Organization(WHO).In addition,with the aid of a color discrimination application in a smartphone,these two probes can also detect ROX in real samples(such as water,soil,and cabbage),demonstrating their excellent potential for monitoring ROX in a practical environment.
文摘High throughput screening towards chemical libraries is the primary way to discover lead compounds in developing innovative drugs,especially new molecular entities.Accordingly,the preparation of chemical libraries is the key step for drug development.Now,con-ventional small molecule chemical libraries and DNA-encoded chemical libraries are the main models of chemical libraries for high-throughput screening.Recently,a new model of chemical library,calledmodular click chemistry library,was proposed,which gives us an alternative choice to construct chemical libraries for high throughput screening and exhibits broad prospects to accelerate drug development.Herein,this article mainly focuses on the strategy to prepare the modular click chemistry library.
