Objectives:The climate crisis demands urgent action from all sectors of society,including young people in higher education.While previous research has explored individual and contextual predictors of pro-environmental...Objectives:The climate crisis demands urgent action from all sectors of society,including young people in higher education.While previous research has explored individual and contextual predictors of pro-environmental behaviour(PEB),the contribution of Positive Youth Development(PYD)remains underexplored.This study investigates the relationship between PYD dimensions(Competence,Confidence,Connection,Character,and Caring)and two environmental outcomes:environmental habits and climate change awareness,considering gender differences.Methods:A cross-sectional study was conducted with a sample of 1779 students from 10 universities in Andalusia(Spain).Data were collected through an online survey assessing PYD indicators,PEB,and sociodemographic variables.Descriptive statistics,t-tests,correlation analyses,and multiple mediation models were performed.Results:Descriptive analyses indicated moderate levels of PYD dimensions and PEB across the sample.Among the 5 Cs,Caring had a positive association with environmental habits(r 0.22,p 0.001)and climate change awareness(r=<=0.30,p 0.001).Character also had a positive effect on both environmental habits(r 0.23,p 0.001)and climate<=<change awareness(r 0.30,p 0.001).Competence and Confidence were not significantly associated,and Connection=<demonstrated limited predictive value,potentially influenced by contextual or social factors.Gender differences were also identified,with women showing higher scores in Character(d 0.29,p 0.001),Caring(d 0.63,p 0.001),=<=<environmental habits(d 0.20,p 0.001)and climate change awareness(d 0.40,p 0.001),while men scored higher in=<=<Competence(d 0.57,p 0.001)and Confidence(d 0.22,p 0.001).Mediation analyses indicated that the association=<=<between gender and environmental habits was totally explained by Character(β95%CI:and=-0.02;-0.04;-0.01)Caring(β95%CI:Furthermore,the relationship between gender and climate change awareness=-0.04;-0.05,-0.02).was partially mediated by Character(β95%CI:and Caring(β95%CI:=-0.03;-0.05;-0.02)=-0.05;-0.07,-0.03).Conclusions:Females showed more environmental habits and climate change awareness than males,because of their greater scores in both Caring and Character dimensions of PYD.These findings highlight the importance of the PYD for promoting PEB and engaged citizens among young adults.Gender-sensitive and interdisciplinary interventions,such as environmental volunteering and community-based programmes,are recommended for university contexts to enhance sustainable development behaviours and values.展开更多
This study examines the current state of informatization education among county high school students.While students demonstrate a strong demand for informatization education,they face significant challenges,including ...This study examines the current state of informatization education among county high school students.While students demonstrate a strong demand for informatization education,they face significant challenges,including inadequate hardware,limited access to online learning resources,and insufficient teacher proficiency in informatization education.Through a questionnaire survey,the research reveals an urgent need for expanded information technology courses and specialized training programs.In response,this paper proposes strategies such as increasing investment in IT education,optimizing teaching methodologies,and providing additional learning opportunities to enhance student engagement and comprehensively improve the quality of IT education and learning outcomes in county high schools.展开更多
The purpose of this study is to explore the mental health status of college students in Beijing and develop a scientific assessment scale.First,a systematic review of domestic and international literature related to c...The purpose of this study is to explore the mental health status of college students in Beijing and develop a scientific assessment scale.First,a systematic review of domestic and international literature related to college students’mental health was conducted,and a three-dimensional model covering adaptation,distress,and resilience was proposed.Then,open-ended questionnaire surveys were carried out based on the literature review to collect data,and a preliminary scale was developed through factor analysis.This study further tested and optimized the preliminary scale to ensure its reliability and validity,so as to form a formal scale.As a result,a formal scale is devised after three testing processes that consist of 134 items.The scale primarily consists of three subscales:adaptation,distress,and resilience.The adaptation subscale covers six points:interpersonal relationships,learning,career choice,emotions,self-adaptation,and satisfaction.The distress subscale includes seven aspects:depression,anxiety,somatization,compulsion,Internet addiction,withdrawal and aggression.The resilience subscale consists of four features:self-confidence,positive cognition,problem-solving,and social support.The results show that all three subscales have good reliability and validity.This scale enables mental health assessment from three distinct levels:adaptation,distress,and resilience,thus objectively reporting the developmental characteristics of college students’mental health.The division of these three levels not only remedies the deficiencies of previous mental health measurements but also meets the practical needs of developmental psychological counseling in universities,clarifying the tasks of mental health education.展开更多
The development of interest can improve the efficiency and quality of students’learning activities.Previous research mainly explored professional interest,but less on subject interest.This study designed and validate...The development of interest can improve the efficiency and quality of students’learning activities.Previous research mainly explored professional interest,but less on subject interest.This study designed and validated a subject interest questionnaire for primary school students to assess their potential to predict academic performance and offer reference for educational assessment and counseling.A sample of 545 students from two primary schools in Beijing was selected.The questionnaire consisted of 138 questions involving eight major courses,such as Chinese,mathematics and English.Through analysis,questions with good discrimination and social desirability were screened out,and nine questions of each sub-scale were finally retained.According to the result,the reliability and validity of the questionnaire reached an acceptable level.Further analysis of exploratory and confirmatory factors revealed that the subject interest can be summarized into two dimensions:“humanities-related factor”and“mathematics-related factor”.The two dimensions are consistent with the“human and material dimensions”proposed by ACT.As a preliminary exploration,this study lays a foundation for further research on the relationship between subject interest and basic interest and provides a practical evaluation tool for primary education.展开更多
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You...Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.展开更多
China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
The article discusses issues related to listening autonomy including the definition of listening and autonomy.The foster of listening involve the collaborated effort of the listening teacher and student.Meanwhile thre...The article discusses issues related to listening autonomy including the definition of listening and autonomy.The foster of listening involve the collaborated effort of the listening teacher and student.Meanwhile three specific ways to improve listen ing autonomy are presented-keeping a listening diary,extensive listening and forming a listening online community.展开更多
To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction fou...To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).展开更多
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i...Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.展开更多
BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this ...BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.展开更多
The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While...N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance.展开更多
Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event ...Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.展开更多
This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat...This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.展开更多
Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetland...Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms...In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms’GVC advancement,measured by the domestic value-added rate(DVAR)in exports.Using integrated Chinese microdata(2000-2014),we find this complementarity significantly boosts export DVAR,explaining about one-quarter of its observed growth.Two mechanisms drive this effect:increased use of domestic intermediates and gains in firm productivity.The benefits are especially large for firms with lower human capital and for those in accessible,innovation-peripheral regions,helping narrow productivity gaps across firms and space.Affected firms also exhibit broader export scopes,higher product quality,more diversified destinations,and greater markups-firm-level evidence of GVC upgrading.These findings highlight how external technological linkages drive upgrading and underscore the importance of fostering inter-regional synergies for balanced development.展开更多
Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction ...Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction of cardiac organoids,categorizing them into three main types:cardiac spheroids,self-organizing/assembloid organoids,and organoid-on-a-chip systems.This review uniquely integrates the advances in vascularization,organ-on-chip design,and environmental cardiotoxicity modeling within cardiac organoid platforms,offering a critical synthesis that is absent in the literature.In the context of escalating environmental threats to cardiovascular health,there is an urgent need for physiologically relevant models to accurately identify cardiac toxicants and elucidate their underlying mechanisms of action.This review highlights advances in cardiac organoid applications for disease modeling—including congenital heart defects and acquired cardiovascular diseases—drug development,toxicity screening,and the study of environmentally induced cardiovascular pathogenesis.In addition,it critically examines ongoing challenges and underscores opportunities brought by bioengineering approaches.Finally,we propose future directions for developing standardized cardiac organoid platforms with clinical predictability,aiming to expand the utility of this technology across broader research applications.展开更多
文摘Objectives:The climate crisis demands urgent action from all sectors of society,including young people in higher education.While previous research has explored individual and contextual predictors of pro-environmental behaviour(PEB),the contribution of Positive Youth Development(PYD)remains underexplored.This study investigates the relationship between PYD dimensions(Competence,Confidence,Connection,Character,and Caring)and two environmental outcomes:environmental habits and climate change awareness,considering gender differences.Methods:A cross-sectional study was conducted with a sample of 1779 students from 10 universities in Andalusia(Spain).Data were collected through an online survey assessing PYD indicators,PEB,and sociodemographic variables.Descriptive statistics,t-tests,correlation analyses,and multiple mediation models were performed.Results:Descriptive analyses indicated moderate levels of PYD dimensions and PEB across the sample.Among the 5 Cs,Caring had a positive association with environmental habits(r 0.22,p 0.001)and climate change awareness(r=<=0.30,p 0.001).Character also had a positive effect on both environmental habits(r 0.23,p 0.001)and climate<=<change awareness(r 0.30,p 0.001).Competence and Confidence were not significantly associated,and Connection=<demonstrated limited predictive value,potentially influenced by contextual or social factors.Gender differences were also identified,with women showing higher scores in Character(d 0.29,p 0.001),Caring(d 0.63,p 0.001),=<=<environmental habits(d 0.20,p 0.001)and climate change awareness(d 0.40,p 0.001),while men scored higher in=<=<Competence(d 0.57,p 0.001)and Confidence(d 0.22,p 0.001).Mediation analyses indicated that the association=<=<between gender and environmental habits was totally explained by Character(β95%CI:and=-0.02;-0.04;-0.01)Caring(β95%CI:Furthermore,the relationship between gender and climate change awareness=-0.04;-0.05,-0.02).was partially mediated by Character(β95%CI:and Caring(β95%CI:=-0.03;-0.05;-0.02)=-0.05;-0.07,-0.03).Conclusions:Females showed more environmental habits and climate change awareness than males,because of their greater scores in both Caring and Character dimensions of PYD.These findings highlight the importance of the PYD for promoting PEB and engaged citizens among young adults.Gender-sensitive and interdisciplinary interventions,such as environmental volunteering and community-based programmes,are recommended for university contexts to enhance sustainable development behaviours and values.
文摘This study examines the current state of informatization education among county high school students.While students demonstrate a strong demand for informatization education,they face significant challenges,including inadequate hardware,limited access to online learning resources,and insufficient teacher proficiency in informatization education.Through a questionnaire survey,the research reveals an urgent need for expanded information technology courses and specialized training programs.In response,this paper proposes strategies such as increasing investment in IT education,optimizing teaching methodologies,and providing additional learning opportunities to enhance student engagement and comprehensively improve the quality of IT education and learning outcomes in county high schools.
文摘The purpose of this study is to explore the mental health status of college students in Beijing and develop a scientific assessment scale.First,a systematic review of domestic and international literature related to college students’mental health was conducted,and a three-dimensional model covering adaptation,distress,and resilience was proposed.Then,open-ended questionnaire surveys were carried out based on the literature review to collect data,and a preliminary scale was developed through factor analysis.This study further tested and optimized the preliminary scale to ensure its reliability and validity,so as to form a formal scale.As a result,a formal scale is devised after three testing processes that consist of 134 items.The scale primarily consists of three subscales:adaptation,distress,and resilience.The adaptation subscale covers six points:interpersonal relationships,learning,career choice,emotions,self-adaptation,and satisfaction.The distress subscale includes seven aspects:depression,anxiety,somatization,compulsion,Internet addiction,withdrawal and aggression.The resilience subscale consists of four features:self-confidence,positive cognition,problem-solving,and social support.The results show that all three subscales have good reliability and validity.This scale enables mental health assessment from three distinct levels:adaptation,distress,and resilience,thus objectively reporting the developmental characteristics of college students’mental health.The division of these three levels not only remedies the deficiencies of previous mental health measurements but also meets the practical needs of developmental psychological counseling in universities,clarifying the tasks of mental health education.
基金Beijing Shidayidu Cultural Development Co.,Ltd:Research on the influencing factors and curriculum intervention of middle school students’career adaptability(No.BUU2023026).
文摘The development of interest can improve the efficiency and quality of students’learning activities.Previous research mainly explored professional interest,but less on subject interest.This study designed and validated a subject interest questionnaire for primary school students to assess their potential to predict academic performance and offer reference for educational assessment and counseling.A sample of 545 students from two primary schools in Beijing was selected.The questionnaire consisted of 138 questions involving eight major courses,such as Chinese,mathematics and English.Through analysis,questions with good discrimination and social desirability were screened out,and nine questions of each sub-scale were finally retained.According to the result,the reliability and validity of the questionnaire reached an acceptable level.Further analysis of exploratory and confirmatory factors revealed that the subject interest can be summarized into two dimensions:“humanities-related factor”and“mathematics-related factor”.The two dimensions are consistent with the“human and material dimensions”proposed by ACT.As a preliminary exploration,this study lays a foundation for further research on the relationship between subject interest and basic interest and provides a practical evaluation tool for primary education.
文摘Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.
文摘China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
文摘The article discusses issues related to listening autonomy including the definition of listening and autonomy.The foster of listening involve the collaborated effort of the listening teacher and student.Meanwhile three specific ways to improve listen ing autonomy are presented-keeping a listening diary,extensive listening and forming a listening online community.
文摘To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
基金supported by the National Natural Science Foundation of China(Grant No.32160172)the Key Science-Technology Project of Inner Mongolia(2023KYPT0010)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN03006)the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project.
文摘Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.
文摘BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.
文摘The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
基金supported by the National Nature Science Foundation of China(Grant No.31660568)Guangxi Science and Technology major project(Grant No.GuikeAA22068088)+2 种基金start-up funding for introduced talents in Guangxi University,the Guangxi Colleges and Universities Young and Middle-aged Teachers'Basic Scientific Research Ability Improvement Project(Grant No.2024KY0010)Guangxi Graduate Education Innovation Program(Grant No.YCSW2024093)the Guangxi University Student Innovation and Entrepreneurship Training Program Funding Project(Grant Nos.202310593704,202310593714,202410953044S).
文摘N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance.
文摘Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.
基金the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC),which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e a Tecnologia FCT)under contract UIDB/UIDP/00134/2020.
文摘This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.
基金support through the“Trans-Disciplinary Research”Grant(No.R/Dev/IoE/TDRProjects/2023-24/61658),which played a crucial role in enabling this research endeavor.
文摘Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
基金supported by the following grants:National Social Science Fund of China(NSSFC)(Major Project)“Research on the Mechanism and Breakthrough Path for Achieving Key Core Technologies through the Coupling of Innovation Chains and Industrial Chains”(Grant No.22&ZD093)Key Research Institute of Humanities and Social Sciences,Ministry of Education“Research on Innovation Development Theory Based on Chinese Practice”(Grant No.23CEDRZ03).
文摘In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms’GVC advancement,measured by the domestic value-added rate(DVAR)in exports.Using integrated Chinese microdata(2000-2014),we find this complementarity significantly boosts export DVAR,explaining about one-quarter of its observed growth.Two mechanisms drive this effect:increased use of domestic intermediates and gains in firm productivity.The benefits are especially large for firms with lower human capital and for those in accessible,innovation-peripheral regions,helping narrow productivity gaps across firms and space.Affected firms also exhibit broader export scopes,higher product quality,more diversified destinations,and greater markups-firm-level evidence of GVC upgrading.These findings highlight how external technological linkages drive upgrading and underscore the importance of fostering inter-regional synergies for balanced development.
基金supported by the Innovation Promotion Program of NHC and Shanghai Key Labs,SIBPT(grant number PT2025-01)。
文摘Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction of cardiac organoids,categorizing them into three main types:cardiac spheroids,self-organizing/assembloid organoids,and organoid-on-a-chip systems.This review uniquely integrates the advances in vascularization,organ-on-chip design,and environmental cardiotoxicity modeling within cardiac organoid platforms,offering a critical synthesis that is absent in the literature.In the context of escalating environmental threats to cardiovascular health,there is an urgent need for physiologically relevant models to accurately identify cardiac toxicants and elucidate their underlying mechanisms of action.This review highlights advances in cardiac organoid applications for disease modeling—including congenital heart defects and acquired cardiovascular diseases—drug development,toxicity screening,and the study of environmentally induced cardiovascular pathogenesis.In addition,it critically examines ongoing challenges and underscores opportunities brought by bioengineering approaches.Finally,we propose future directions for developing standardized cardiac organoid platforms with clinical predictability,aiming to expand the utility of this technology across broader research applications.
