Strontium-90,a highly radioactive isotope,accumulates within the food chain and skeletal structure,posing significant risks to human health.There is a critical need for a sensitive detection strategy for Strontium-90 ...Strontium-90,a highly radioactive isotope,accumulates within the food chain and skeletal structure,posing significant risks to human health.There is a critical need for a sensitive detection strategy for Strontium-90 in complex environmental samples.Here,solid-state nanochannels,modified with metal-organic frameworks(MOF)and specific aptamers,were engineered for highly sensitive detection of strontium ion(Sr^(2+)).The synergistic effect between the reduced effective diameter of the nanochannels due to MOF and the specific binding of Sr^(2+) by aptamers amplifies the difference in ionic current signals,enhancing detection sensitivity significantly.The MOF-modified nanochannels exhibit highly sensitive detection of Sr^(2+),with a limit of detection(LOD)being 0.03 nmol·L^(-1),whereas the LOD for anodized aluminum oxide(AAO)without the modified MOF nanosheets is only 1000 nmol·L^(-1).These findings indicate that the LOD of Sr^(2+) detected by the MOF-modified nanochannels is approximately 33,000 times higher than that by the nanochannels without MOF modification.Additionally,the highly reliable detection of Sr^(2+) in various water samples was achieved,with a recovery rate ranging from 94.00%to 118.70%.This study provides valuable insights into the rapidly advancing field of advanced nanochannel-based sensors and their diverse applications for analyzing complex samples,including environmental contaminant detection,food analysis,medical diagnostics,and more.展开更多
Inflammation and ischemic microenvironments represent significant challenges in cardiac repair.To address these issues,we developed a series of dual-dynamically crosslinked alginate-based hydrogels(SA-PBA/E/Sr)contain...Inflammation and ischemic microenvironments represent significant challenges in cardiac repair.To address these issues,we developed a series of dual-dynamically crosslinked alginate-based hydrogels(SA-PBA/E/Sr)containing strontium ions(Sr^(2+))and epigallocatechin gallate(EGCG),which demonstrate microenvironment modulation and angiogenic capabilities in the myocardial infarction(MI)microenvironment.In the SA-PBA/E/Sr hydrogel system,alginate modified with aminophenylboronic acid(PBA)was synthesized to form boronic acid ester bonds with EGCG and an ionic coordination network with Sr^(2+)ions.The resulting hydrogel exhibits excellent injectability due to its dual-dynamically crosslinked structure,with its formation and mechanical properties being tunable modulated by the PBA substitution degree,EGCG concentration,and Sr^(2+)content.The incorporation of EGCG enables the hydrogel to efficiently scavenge reactive oxygen species(ROS)and mitigate oxidative stress-induced cellular damage under hypoxia.Furthermore,the introduction of Sr^(2+)significantly enhances the migratory capacity of endothelial cells,a critical factor in angiogenesis.In vivo experiments revealed that the injection of SA-PBA/E/Sr hydrogel into the infarcted myocardium of Sprague-Dawley(SD)rats led to reduced ROS levels,alleviated inflammatory responses,suppression of pro-inflammatory M1 macrophage expression,enhancement of anti-inflammatory M2 macrophage expression,and accelerated neovascularization in the damaged tissue.Echocardiographic and histological analyses demonstrated a remarkable increase in ejection fraction and a decreased infarct size,collectively indicating significant cardiac functional recovery.展开更多
The sorption removal of radionuclides Sr^(2+) using a freestanding functional membrane is an interesting and significant research area in the remediation of radioactive wastes.Herein,a novel self-assembled membrane co...The sorption removal of radionuclides Sr^(2+) using a freestanding functional membrane is an interesting and significant research area in the remediation of radioactive wastes.Herein,a novel self-assembled membrane consisting of metaleorganic framework(MOF)nanobelts and graphene oxides(GOs)are synthesized through a simple and facile filtration method.The membrane possesses a unique interwove morphology as evidenced from SEM images.Batch experiments suggest that the GO/Ni-MOF composite membrane could remove Sr^(2+) ions from aqueous solutions and the Sr^(2+) adsorption capacity and efficiency of the GO/Ni-MOF composite membrane is relevant to the MOF content in the composite.Thus,the dominant interaction mechanism was interface or surface complexation,electrostatic interaction as well as ion substitution.The maximum effective sorption of Sr^(2+) over GO/Ni-MOF membrane is 32.99% with 2 mg composite membrane containing a high content of Ni-MOF at 299 K in 100 mg/L Sr^(2+) aqueous solution.The FT-IR and XPS results suggest that the synergistic effect between GO and Ni-MOF is determinant in the sorption Sr^(2+) process.The GO/Ni-MOF composite membrane is demonstrated to have the advantages of efficient removal of Sr^(2+),low cost and simple synthesis route,which is promising in the elimination of radionuclide contamination.展开更多
基金supported by the National Natural Science Foundation of China(No.22090050,No.22090052,No.22176180)National Basic Research Program of China(No.2021YFA1200400)+1 种基金the Natural Science Foundation of Hubei Province(No.2024AFA001)Shenzhen Science and Technology Program(No.JCYJ20220530162406014)。
文摘Strontium-90,a highly radioactive isotope,accumulates within the food chain and skeletal structure,posing significant risks to human health.There is a critical need for a sensitive detection strategy for Strontium-90 in complex environmental samples.Here,solid-state nanochannels,modified with metal-organic frameworks(MOF)and specific aptamers,were engineered for highly sensitive detection of strontium ion(Sr^(2+)).The synergistic effect between the reduced effective diameter of the nanochannels due to MOF and the specific binding of Sr^(2+) by aptamers amplifies the difference in ionic current signals,enhancing detection sensitivity significantly.The MOF-modified nanochannels exhibit highly sensitive detection of Sr^(2+),with a limit of detection(LOD)being 0.03 nmol·L^(-1),whereas the LOD for anodized aluminum oxide(AAO)without the modified MOF nanosheets is only 1000 nmol·L^(-1).These findings indicate that the LOD of Sr^(2+) detected by the MOF-modified nanochannels is approximately 33,000 times higher than that by the nanochannels without MOF modification.Additionally,the highly reliable detection of Sr^(2+) in various water samples was achieved,with a recovery rate ranging from 94.00%to 118.70%.This study provides valuable insights into the rapidly advancing field of advanced nanochannel-based sensors and their diverse applications for analyzing complex samples,including environmental contaminant detection,food analysis,medical diagnostics,and more.
基金supported by the National Natural Science Foundation of China(32471384).
文摘Inflammation and ischemic microenvironments represent significant challenges in cardiac repair.To address these issues,we developed a series of dual-dynamically crosslinked alginate-based hydrogels(SA-PBA/E/Sr)containing strontium ions(Sr^(2+))and epigallocatechin gallate(EGCG),which demonstrate microenvironment modulation and angiogenic capabilities in the myocardial infarction(MI)microenvironment.In the SA-PBA/E/Sr hydrogel system,alginate modified with aminophenylboronic acid(PBA)was synthesized to form boronic acid ester bonds with EGCG and an ionic coordination network with Sr^(2+)ions.The resulting hydrogel exhibits excellent injectability due to its dual-dynamically crosslinked structure,with its formation and mechanical properties being tunable modulated by the PBA substitution degree,EGCG concentration,and Sr^(2+)content.The incorporation of EGCG enables the hydrogel to efficiently scavenge reactive oxygen species(ROS)and mitigate oxidative stress-induced cellular damage under hypoxia.Furthermore,the introduction of Sr^(2+)significantly enhances the migratory capacity of endothelial cells,a critical factor in angiogenesis.In vivo experiments revealed that the injection of SA-PBA/E/Sr hydrogel into the infarcted myocardium of Sprague-Dawley(SD)rats led to reduced ROS levels,alleviated inflammatory responses,suppression of pro-inflammatory M1 macrophage expression,enhancement of anti-inflammatory M2 macrophage expression,and accelerated neovascularization in the damaged tissue.Echocardiographic and histological analyses demonstrated a remarkable increase in ejection fraction and a decreased infarct size,collectively indicating significant cardiac functional recovery.
基金supported by the National Key R&D Program of China(Grant No.2016YFC1402504).
文摘The sorption removal of radionuclides Sr^(2+) using a freestanding functional membrane is an interesting and significant research area in the remediation of radioactive wastes.Herein,a novel self-assembled membrane consisting of metaleorganic framework(MOF)nanobelts and graphene oxides(GOs)are synthesized through a simple and facile filtration method.The membrane possesses a unique interwove morphology as evidenced from SEM images.Batch experiments suggest that the GO/Ni-MOF composite membrane could remove Sr^(2+) ions from aqueous solutions and the Sr^(2+) adsorption capacity and efficiency of the GO/Ni-MOF composite membrane is relevant to the MOF content in the composite.Thus,the dominant interaction mechanism was interface or surface complexation,electrostatic interaction as well as ion substitution.The maximum effective sorption of Sr^(2+) over GO/Ni-MOF membrane is 32.99% with 2 mg composite membrane containing a high content of Ni-MOF at 299 K in 100 mg/L Sr^(2+) aqueous solution.The FT-IR and XPS results suggest that the synergistic effect between GO and Ni-MOF is determinant in the sorption Sr^(2+) process.The GO/Ni-MOF composite membrane is demonstrated to have the advantages of efficient removal of Sr^(2+),low cost and simple synthesis route,which is promising in the elimination of radionuclide contamination.
