A recent study published in Nature has uncovered a novel regulatory mechanism that enhances start-codon selection during mitosis in mammalian cells by intensifying the interaction between the 40S ribosome subunit,whic...A recent study published in Nature has uncovered a novel regulatory mechanism that enhances start-codon selection during mitosis in mammalian cells by intensifying the interaction between the 40S ribosome subunit,which binds messenger RNA(mRNA)and initiates translation,and the eukaryotic translation initiation factor 1(eIF1),a central regulator of start-codon selection.1 This discovery reveals a sophisticated layer of translational control that helps maintain cell viability and cell cycle stability,with potential implications for understanding cellular regulation and improving cancer therapies.展开更多
Natural resource management is indispensable keeping in view their positive economic impacts as well as their detrimental environmental consequences.To achieve certain SDGs,it is inevitable to manage natural resources...Natural resource management is indispensable keeping in view their positive economic impacts as well as their detrimental environmental consequences.To achieve certain SDGs,it is inevitable to manage natural resources through effective policies that help to inhibit adverse environmental impacts.Based on this approach,the current empirical analysis aims to probe whether environmental policy stringency intensifies,meagres,and/or halts the abysmal environmental impact of natural resources in G-7 countries(United Kingdom,United States,Canada,Italy,France,Japan,and Germany)for the period from 1990 to 2020.To that end,we rely on the second-generation panel data approaches and panel quantile regression.The outcomes reveal that natural resources increase carbon dioxide emission whereas the synergy of natural resources and environmental policy stringency plunges emissions across the quantiles.These findings suggest adoption of a strict environmental policy for attaining the targets of SGD-08(economic growth),SDG-09(innovations),SDG-11(sustainable cities),SDG-12(responsible consumption of natural resources),and SDG-13(climate action).展开更多
Background The transmission dynamics and severity of coronavirus disease 2019(COVID-19)pandemic is different across countries or regions.Differences in governments’policy responses may explain some of these differenc...Background The transmission dynamics and severity of coronavirus disease 2019(COVID-19)pandemic is different across countries or regions.Differences in governments’policy responses may explain some of these differences.We aimed to compare worldwide government responses to the spread of COVID-19,to examine the relationship between response level,response timing and the epidemic trajectory.Methods Free publicly-accessible data collected by the Coronavirus Government Response Tracker(OxCGRT)were used.Nine sub-indicators reflecting government response from 148 countries were collected systematically from January 1 to May 1,2020.The sub-indicators were scored and were aggregated into a common Stringency Index(SI,a value between 0 and 100)that reflects the overall stringency of the government’s response in a daily basis.Group-based trajectory modelling method was used to identify trajectories of SI.Multivariable linear regression models were used to analyse the association between time to reach a high-level SI and time to the peak number of daily new cases.Results Our results identified four trajectories of response in the spread of COVID-19 based on when the response was initiated:before January 13,from January 13 to February 12,from February 12 to March 11,and the last stage—from March 11(the day WHO declared a pandemic of COVID-19)on going.Governments’responses were upgraded with further spread of COVID-19 but varied substantially across countries.After the adjustment of SI level,geographical region and initiation stages,each day earlier to a high SI level(SI>80)from the start of response was associated with 0.44(standard error:0.08,P<0.001,R2=0.65)days earlier to the peak number of daily new case.Also,each day earlier to a high SI level from the date of first reported case was associated with 0.65(standard error:0.08,P<0.001,R2=0.42)days earlier to the peak number of daily new case.Conclusions Early start of a high-level response to COVID-19 is associated with early arrival of the peak number of daily new cases.This may help to reduce the delays in flattening the epidemic curve to the low spread level.展开更多
Compatible with the increasing public interest on climate change,countries have taken measures to combat climate change and support environmental sustainability.Considering this fact,this study investigates whether en...Compatible with the increasing public interest on climate change,countries have taken measures to combat climate change and support environmental sustainability.Considering this fact,this study investigates whether environmental measures,proxied by the environmental policy stringency(EPS)index,are efficient in achieving sustainability of environment in G7 countries as the leading economies;uses multiple environmental sustainability indicators,and applies quantile methods from 1991/Q1 to through 2020/Q4.The results show that(i)EPS curbs carbon dioxide emissions in France and the United States across all quantiles.Also,it has a declining effect in Germany and Italy at lower quantiles and in Canada at lower and higher quantiles;(ii)EPS declines ecological footprint in United States across all quantiles,while it curbs in Canada and Germany at lower quantiles as well as in Italy and United Kingdom at higher quantiles;(iii)EPS stimulates load capacity factor in France,United Kingdom,and United States across all quantiles and in Canada at higher quantiles;(iv)causal effect of EPS on the environment varies throughout quantiles;(v)the robustness of the results by quantile regression method is verified.Overall,the results reveal that the effect of EPS on environmental sustainability differentiates across environmental indicators,countries,and quantiles.In ensuring environmental quality,EPS is completely helpful in the United States,fully inefficient in Japan,and has a mixed effect in remaining G7 countries.展开更多
To identify alien chromosomes in recipient progenies and to analyze genome components in polyploidy, a genomic in situ hybridization （GISH） technique that is suitable for cotton was developed using increased stringe...To identify alien chromosomes in recipient progenies and to analyze genome components in polyploidy, a genomic in situ hybridization （GISH） technique that is suitable for cotton was developed using increased stringency conditions. The increased stringency conditions were a combination of the four factors in the following optimized state： 100：1 ratio of blocking DNA to probe, 60% formamide wash solution, 43 ℃ temperature wash and a 13 min wash. Under these specific conditions using gDNA from Gossypium sturtianum （C1 C1 ） as a probe, strong hybridization signals were only observed on chromosomes from the C1 genome in somatic cells of the hybrid F1 （G. hirsutum x G. sturtianum） （AtDtC1）. Therefore, GISH was able to discriminate parental chromosomes in the hybrid. Further, we developed a multi-color GISH to simultaneously discriminate the three genomes of the above hybrid. The results repeatedly displayed the three genomes, At, Dt, and C1, and each set of chromosomes with a unique color, making them easy to identify. The power of the multi-color GISH was proven by analysis of the hexaploid hybrid F1 （G. hirsutum x G. australe） （AtAtDtDtG2G2）. We believe that the powerful multi-color GISH technique could be applied extensively to analyze the genome component in polyploidy and to identify alien chromosomes in the recipient progenies.展开更多
This article investigates how the COVID-19 pandemic and related public health measures affected the consumption of food away from home(FAFH)among Chinese consumers.We obtained access to the complete sales records from...This article investigates how the COVID-19 pandemic and related public health measures affected the consumption of food away from home(FAFH)among Chinese consumers.We obtained access to the complete sales records from a major restaurant chain in China,for 111 sites located in 12 cities,covering over 5.6 million high-frequency dining transactions made between 1 January 2019 and 31 December 2020.By applying a high-dimensional fixed-effects model,we found that,on average,consumers spent more and ordered more calories(as well as carbohydrates,protein,fat,and sodium)after the COVID-19 outbreak than in thepre-COVID-19period.Our results do not support the hypothesis that COVID-19 led to healthier eating behaviors during and after the pandemic.Our results underline the importance of nutrition education and awareness programs to mitigate unhealthy eating habits generated by the pandemic and of the continued role of FAFH after the pandemic.展开更多
文摘A recent study published in Nature has uncovered a novel regulatory mechanism that enhances start-codon selection during mitosis in mammalian cells by intensifying the interaction between the 40S ribosome subunit,which binds messenger RNA(mRNA)and initiates translation,and the eukaryotic translation initiation factor 1(eIF1),a central regulator of start-codon selection.1 This discovery reveals a sophisticated layer of translational control that helps maintain cell viability and cell cycle stability,with potential implications for understanding cellular regulation and improving cancer therapies.
基金Guangdong University of Foreign Studies,Guangdong,China(Grant No.299-GK23G396)This research is funded by Thoungmai University,Hanoi,Vietnam.
文摘Natural resource management is indispensable keeping in view their positive economic impacts as well as their detrimental environmental consequences.To achieve certain SDGs,it is inevitable to manage natural resources through effective policies that help to inhibit adverse environmental impacts.Based on this approach,the current empirical analysis aims to probe whether environmental policy stringency intensifies,meagres,and/or halts the abysmal environmental impact of natural resources in G-7 countries(United Kingdom,United States,Canada,Italy,France,Japan,and Germany)for the period from 1990 to 2020.To that end,we rely on the second-generation panel data approaches and panel quantile regression.The outcomes reveal that natural resources increase carbon dioxide emission whereas the synergy of natural resources and environmental policy stringency plunges emissions across the quantiles.These findings suggest adoption of a strict environmental policy for attaining the targets of SGD-08(economic growth),SDG-09(innovations),SDG-11(sustainable cities),SDG-12(responsible consumption of natural resources),and SDG-13(climate action).
文摘Background The transmission dynamics and severity of coronavirus disease 2019(COVID-19)pandemic is different across countries or regions.Differences in governments’policy responses may explain some of these differences.We aimed to compare worldwide government responses to the spread of COVID-19,to examine the relationship between response level,response timing and the epidemic trajectory.Methods Free publicly-accessible data collected by the Coronavirus Government Response Tracker(OxCGRT)were used.Nine sub-indicators reflecting government response from 148 countries were collected systematically from January 1 to May 1,2020.The sub-indicators were scored and were aggregated into a common Stringency Index(SI,a value between 0 and 100)that reflects the overall stringency of the government’s response in a daily basis.Group-based trajectory modelling method was used to identify trajectories of SI.Multivariable linear regression models were used to analyse the association between time to reach a high-level SI and time to the peak number of daily new cases.Results Our results identified four trajectories of response in the spread of COVID-19 based on when the response was initiated:before January 13,from January 13 to February 12,from February 12 to March 11,and the last stage—from March 11(the day WHO declared a pandemic of COVID-19)on going.Governments’responses were upgraded with further spread of COVID-19 but varied substantially across countries.After the adjustment of SI level,geographical region and initiation stages,each day earlier to a high SI level(SI>80)from the start of response was associated with 0.44(standard error:0.08,P<0.001,R2=0.65)days earlier to the peak number of daily new case.Also,each day earlier to a high SI level from the date of first reported case was associated with 0.65(standard error:0.08,P<0.001,R2=0.42)days earlier to the peak number of daily new case.Conclusions Early start of a high-level response to COVID-19 is associated with early arrival of the peak number of daily new cases.This may help to reduce the delays in flattening the epidemic curve to the low spread level.
文摘Compatible with the increasing public interest on climate change,countries have taken measures to combat climate change and support environmental sustainability.Considering this fact,this study investigates whether environmental measures,proxied by the environmental policy stringency(EPS)index,are efficient in achieving sustainability of environment in G7 countries as the leading economies;uses multiple environmental sustainability indicators,and applies quantile methods from 1991/Q1 to through 2020/Q4.The results show that(i)EPS curbs carbon dioxide emissions in France and the United States across all quantiles.Also,it has a declining effect in Germany and Italy at lower quantiles and in Canada at lower and higher quantiles;(ii)EPS declines ecological footprint in United States across all quantiles,while it curbs in Canada and Germany at lower quantiles as well as in Italy and United Kingdom at higher quantiles;(iii)EPS stimulates load capacity factor in France,United Kingdom,and United States across all quantiles and in Canada at higher quantiles;(iv)causal effect of EPS on the environment varies throughout quantiles;(v)the robustness of the results by quantile regression method is verified.Overall,the results reveal that the effect of EPS on environmental sustainability differentiates across environmental indicators,countries,and quantiles.In ensuring environmental quality,EPS is completely helpful in the United States,fully inefficient in Japan,and has a mixed effect in remaining G7 countries.
基金the National Natural Science Foundation of China (30571184)Jiangsu Provincial Natural Science Foundation (BK2007166)+3 种基金the Tenth Five-year Plan of the National Key Program (2004BA525B05)the 111 Project(B08025) the Eleventh Five-year Plan of the National Sci-technologicalSupporting Program (2006BAD13B04-1-08)the Changjiang Scholars and Innovative Research Team in University and the Teaching and Research AwardProgram for Outstanding Young Teachers in Higher Education Institutions ofMinistry of Education (MOE), China.
文摘To identify alien chromosomes in recipient progenies and to analyze genome components in polyploidy, a genomic in situ hybridization （GISH） technique that is suitable for cotton was developed using increased stringency conditions. The increased stringency conditions were a combination of the four factors in the following optimized state： 100：1 ratio of blocking DNA to probe, 60% formamide wash solution, 43 ℃ temperature wash and a 13 min wash. Under these specific conditions using gDNA from Gossypium sturtianum （C1 C1 ） as a probe, strong hybridization signals were only observed on chromosomes from the C1 genome in somatic cells of the hybrid F1 （G. hirsutum x G. sturtianum） （AtDtC1）. Therefore, GISH was able to discriminate parental chromosomes in the hybrid. Further, we developed a multi-color GISH to simultaneously discriminate the three genomes of the above hybrid. The results repeatedly displayed the three genomes, At, Dt, and C1, and each set of chromosomes with a unique color, making them easy to identify. The power of the multi-color GISH was proven by analysis of the hexaploid hybrid F1 （G. hirsutum x G. australe） （AtAtDtDtG2G2）. We believe that the powerful multi-color GISH technique could be applied extensively to analyze the genome component in polyploidy and to identify alien chromosomes in the recipient progenies.
基金supported financially by the National Natural Science Foundation of China(Nos.72103187 and 71973146)National Social Science Foundation of China(No.20&ZD164)+1 种基金the 2115 Talent Development Program at the Beijing Food Safety Policy and Strategy(FSP)Research Base,China Agricultural Universitythe Richard DelFavero Fund for Agricultural and Resource Economics at the University of Connecticut.
文摘This article investigates how the COVID-19 pandemic and related public health measures affected the consumption of food away from home(FAFH)among Chinese consumers.We obtained access to the complete sales records from a major restaurant chain in China,for 111 sites located in 12 cities,covering over 5.6 million high-frequency dining transactions made between 1 January 2019 and 31 December 2020.By applying a high-dimensional fixed-effects model,we found that,on average,consumers spent more and ordered more calories(as well as carbohydrates,protein,fat,and sodium)after the COVID-19 outbreak than in thepre-COVID-19period.Our results do not support the hypothesis that COVID-19 led to healthier eating behaviors during and after the pandemic.Our results underline the importance of nutrition education and awareness programs to mitigate unhealthy eating habits generated by the pandemic and of the continued role of FAFH after the pandemic.
