Rice callus suspension culture(RCSC)has been shown to have anticancer activity based on cytotoxic activity on human colon and lung cancer cell lines.In the present study,the effect of RCSC on the expression of protein...Rice callus suspension culture(RCSC)has been shown to have anticancer activity based on cytotoxic activity on human colon and lung cancer cell lines.In the present study,the effect of RCSC on the expression of proteins in lung(A549)and colon(HT29)cancer cell lines was examined by using proteomics analysis.The protein-protein interaction study of differentially expressed proteins was done by using the Search Tool for the Retrieval of Interacting Genes(STRING),and the results showed that the proteins interacting with each other belong to different pathways.展开更多
The deepwater test string is an important but vulnerable component in offshore petroleum exploration,and its durability significantly affects the success of deepwater test operations.Considering the influence of rando...The deepwater test string is an important but vulnerable component in offshore petroleum exploration,and its durability significantly affects the success of deepwater test operations.Considering the influence of random waves and the interaction between the test string and the riser,a time-domain nonlinear dynamic model of a deepwater test string is developed.The stress-time history of the test string is obtained to study vibration mechanisms and fatigue development in the test string.Several recommendations for reducing damage are proposed.The results indicate that the amplitude of dynamic response when the string is subjected to random loads gradually decreases along the test string,and that the von Mises stress is higher in the string sections near the top of the test string and the flex joints.In addition,the fatigue damage fluctuates with the water depth,and the maximum damage occurs in string sections adjacent to the lower flex joint and in the splash zone.Several measures are proposed to improve the operational safety of deepwater test strings：applying greater top tension,operating in a favorable marine environment,managing the order of the test string joints,and performing nondestructive testing of components at vulnerable positions.展开更多
文摘Rice callus suspension culture(RCSC)has been shown to have anticancer activity based on cytotoxic activity on human colon and lung cancer cell lines.In the present study,the effect of RCSC on the expression of proteins in lung(A549)and colon(HT29)cancer cell lines was examined by using proteomics analysis.The protein-protein interaction study of differentially expressed proteins was done by using the Search Tool for the Retrieval of Interacting Genes(STRING),and the results showed that the proteins interacting with each other belong to different pathways.
基金supported by the National Key Basic Research Program of China (973 Program,Grant No.2015CB251203)the Fundamental Research Funds for the Central Universities (14CX06119A)
文摘The deepwater test string is an important but vulnerable component in offshore petroleum exploration,and its durability significantly affects the success of deepwater test operations.Considering the influence of random waves and the interaction between the test string and the riser,a time-domain nonlinear dynamic model of a deepwater test string is developed.The stress-time history of the test string is obtained to study vibration mechanisms and fatigue development in the test string.Several recommendations for reducing damage are proposed.The results indicate that the amplitude of dynamic response when the string is subjected to random loads gradually decreases along the test string,and that the von Mises stress is higher in the string sections near the top of the test string and the flex joints.In addition,the fatigue damage fluctuates with the water depth,and the maximum damage occurs in string sections adjacent to the lower flex joint and in the splash zone.Several measures are proposed to improve the operational safety of deepwater test strings：applying greater top tension,operating in a favorable marine environment,managing the order of the test string joints,and performing nondestructive testing of components at vulnerable positions.
