Digitalization is a bridge for traditional Chinese medicine(TCM)striding towards information age.Application of digital technologies such as computers and mathematical statistics methods has played a revolutionary rol...Digitalization is a bridge for traditional Chinese medicine(TCM)striding towards information age.Application of digital technologies such as computers and mathematical statistics methods has played a revolutionary role in TCM diagnosis and syndrome standardization studies.展开更多
At the '1995 China Summit',and international economicforum, heldnotlongago, Vice-Premier Li Lanqing made areport entitled'China is striding towards the 21stcentury'. He elaborated on issuesconcerning C...At the '1995 China Summit',and international economicforum, heldnotlongago, Vice-Premier Li Lanqing made areport entitled'China is striding towards the 21stcentury'. He elaborated on issuesconcerning China’s reform anddevelopment and China’ s economic co-operation with other countries. On the reform and development in1994, Vice-Premier Li Lanqing said thatthe year 1994 was the first year to witnesscomprehensive progress in economicrestructuring. We carried out a series ofimportant reforms in finance, taxation,展开更多
Unresectable hepatocellular carcinoma(HCC)remains a global challenge,with limited effective treatment options for advanced-stage disease.The HIMALAYA trial(phase III randomized study that evaluated the STRIDE regimen)...Unresectable hepatocellular carcinoma(HCC)remains a global challenge,with limited effective treatment options for advanced-stage disease.The HIMALAYA trial(phase III randomized study that evaluated the STRIDE regimen)introduced the Single Tremelimumab Regular Interval Durvalumab(STRIDE)regimen,an immunotherapy-based approach that achieved a median overall survival(OS)of 16.43 months compared to 13.77 months with sorafenib.While statistically significant,this~2.7 months OS gain warrants scrutiny in light of STRIDE’s increased immune-related toxicity and cost.This commentary evaluates STRIDE’s impact within the broader landscape of first-line systemic therapy for unresectable HCC,alongside other regimens such as atezolizumab plus bevacizumab and nivolumab plus ipilimumab.We explore STRIDE’s mechanism of action,safety profile,modest progression-free survival(PFS)improvement,and implementation challenges,incorporating insights from 2023-2025 research.In addition,we discussed its limitations in non-viral HCC and Child-Pugh B patients,the role of emerging biomarkers,and the potential of radiation to enhance immunotherapy efficacy.As a dual immune checkpoint inhibitor(ICI)strategy,STRIDE offers an important advance that may not only extend survival but also open the door to future curative approaches.However,optimizing its use will require refined patient selection and further investigation of synergistic combination therapies.展开更多
解决高校关键业务系统潜在的风险和漏洞的方法有很多种,现利用STRIDE威胁模型对高校关键业务系统所面临的威胁进行实践研究。通过建立STRIDE安全威胁模型,对关键业务系统的数据流进行梳理和风险分析,量化和细化各类安全威胁,并结合OWASP...解决高校关键业务系统潜在的风险和漏洞的方法有很多种,现利用STRIDE威胁模型对高校关键业务系统所面临的威胁进行实践研究。通过建立STRIDE安全威胁模型,对关键业务系统的数据流进行梳理和风险分析,量化和细化各类安全威胁,并结合OWASP TOP 10进行漏洞验证,进而有针对性地提出各类威胁相应的解决方法和应对策略。展开更多
The equivalent mechanism of the system is often considered as one specific mechanism in most existing studies of multi-legged robots, however the equivalent mechanism is varying while the robot moves on the ground. Fo...The equivalent mechanism of the system is often considered as one specific mechanism in most existing studies of multi-legged robots, however the equivalent mechanism is varying while the robot moves on the ground. Four typical tripod period gaits of a radial symmetrical six-legged robot are analyzed. Similar to the metamorphic mechanism, the locomotion of multi-legged robot is considered as a series of varying hybrid serial-parallel mechanisms by assuming the constraints of the feet on the ground with hinges. One gait cycle is divided into several periods, and in different walking period there is a specific equivalent mechanism corresponding to it, and the walking process of multi-legged robot is composed by these series of equivalent mechanisms. Walking performance can be got by analyzing these series of equivalent mechanisms. Kinematics model of the equivalent mechanism is established, workspaces of equivalent mechanisms are illustrated by simulation and a concept of static stability workspace is proposed to evaluate the static stability of these four gaits. A new method to calculate the stride length of multi-legged robots is presented by analyzing the relationship between the workspace of two adjacent equivalent parallel mechanisms in one gait cycle. The stride lengths of four gaits are given by simulations. Comparison of stride length and static stability among these four typical tripod gaits are given. It has been proved that mixed gait and insect-wave gait II have better static stability than mammal kick-off gait and insect-wave gait I. Insect-wave gait II displays its advantage on stride length while the height of robot body lower than 87 mm, mammal kick-off gait has superiority on stride length while the height of robot body higher than 115 mm, and insect-wave gait I shows its shortcoming in stride length. The proposed method based on metamorphic theory and combining the footholds and body height of robot provides a new method to comprehensive analyze the performance of multi-legged robot.展开更多
文摘Digitalization is a bridge for traditional Chinese medicine(TCM)striding towards information age.Application of digital technologies such as computers and mathematical statistics methods has played a revolutionary role in TCM diagnosis and syndrome standardization studies.
文摘At the '1995 China Summit',and international economicforum, heldnotlongago, Vice-Premier Li Lanqing made areport entitled'China is striding towards the 21stcentury'. He elaborated on issuesconcerning China’s reform anddevelopment and China’ s economic co-operation with other countries. On the reform and development in1994, Vice-Premier Li Lanqing said thatthe year 1994 was the first year to witnesscomprehensive progress in economicrestructuring. We carried out a series ofimportant reforms in finance, taxation,
文摘Unresectable hepatocellular carcinoma(HCC)remains a global challenge,with limited effective treatment options for advanced-stage disease.The HIMALAYA trial(phase III randomized study that evaluated the STRIDE regimen)introduced the Single Tremelimumab Regular Interval Durvalumab(STRIDE)regimen,an immunotherapy-based approach that achieved a median overall survival(OS)of 16.43 months compared to 13.77 months with sorafenib.While statistically significant,this~2.7 months OS gain warrants scrutiny in light of STRIDE’s increased immune-related toxicity and cost.This commentary evaluates STRIDE’s impact within the broader landscape of first-line systemic therapy for unresectable HCC,alongside other regimens such as atezolizumab plus bevacizumab and nivolumab plus ipilimumab.We explore STRIDE’s mechanism of action,safety profile,modest progression-free survival(PFS)improvement,and implementation challenges,incorporating insights from 2023-2025 research.In addition,we discussed its limitations in non-viral HCC and Child-Pugh B patients,the role of emerging biomarkers,and the potential of radiation to enhance immunotherapy efficacy.As a dual immune checkpoint inhibitor(ICI)strategy,STRIDE offers an important advance that may not only extend survival but also open the door to future curative approaches.However,optimizing its use will require refined patient selection and further investigation of synergistic combination therapies.
文摘解决高校关键业务系统潜在的风险和漏洞的方法有很多种,现利用STRIDE威胁模型对高校关键业务系统所面临的威胁进行实践研究。通过建立STRIDE安全威胁模型,对关键业务系统的数据流进行梳理和风险分析,量化和细化各类安全威胁,并结合OWASP TOP 10进行漏洞验证,进而有针对性地提出各类威胁相应的解决方法和应对策略。
基金supported by National Science Foundation for Distinguished Young Scholoars, China (Grant No. 51125020)Program for New Century Excellent Talents in University, China
文摘The equivalent mechanism of the system is often considered as one specific mechanism in most existing studies of multi-legged robots, however the equivalent mechanism is varying while the robot moves on the ground. Four typical tripod period gaits of a radial symmetrical six-legged robot are analyzed. Similar to the metamorphic mechanism, the locomotion of multi-legged robot is considered as a series of varying hybrid serial-parallel mechanisms by assuming the constraints of the feet on the ground with hinges. One gait cycle is divided into several periods, and in different walking period there is a specific equivalent mechanism corresponding to it, and the walking process of multi-legged robot is composed by these series of equivalent mechanisms. Walking performance can be got by analyzing these series of equivalent mechanisms. Kinematics model of the equivalent mechanism is established, workspaces of equivalent mechanisms are illustrated by simulation and a concept of static stability workspace is proposed to evaluate the static stability of these four gaits. A new method to calculate the stride length of multi-legged robots is presented by analyzing the relationship between the workspace of two adjacent equivalent parallel mechanisms in one gait cycle. The stride lengths of four gaits are given by simulations. Comparison of stride length and static stability among these four typical tripod gaits are given. It has been proved that mixed gait and insect-wave gait II have better static stability than mammal kick-off gait and insect-wave gait I. Insect-wave gait II displays its advantage on stride length while the height of robot body lower than 87 mm, mammal kick-off gait has superiority on stride length while the height of robot body higher than 115 mm, and insect-wave gait I shows its shortcoming in stride length. The proposed method based on metamorphic theory and combining the footholds and body height of robot provides a new method to comprehensive analyze the performance of multi-legged robot.
