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Complete f-Moment Convergence for Sung’s Type Weighted Sums of Negatively Superadditive Dependent Random Variables
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作者 HU Xueping WANG Liuliu +1 位作者 HU Ke XU Zhonghao 《应用概率统计》 北大核心 2025年第4期585-601,共17页
In this paper,by utilizing the Marcinkiewicz-Zygmund inequality and Rosenthal-type inequality of negatively superadditive dependent(NSD)random arrays and truncated method,we investigate the complete f-moment convergen... In this paper,by utilizing the Marcinkiewicz-Zygmund inequality and Rosenthal-type inequality of negatively superadditive dependent(NSD)random arrays and truncated method,we investigate the complete f-moment convergence of NSD random variables.We establish and improve a general result on the complete f-moment convergence for Sung’s type randomly weighted sums of NSD random variables under some general assumptions.As an application,we show the complete consistency for the randomly weighted estimator in a nonparametric regression model based on NSD errors. 展开更多
关键词 Marcinkiewicz-Zygmund inequality Rosenthal-type inequality Sung’s type randomly weighted sums negatively superadditive dependent random variables complete f-moment convergence
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Complete q-Order Moment Convergence of Moving Average Processes Generated by Negatively Dependent Random Variables under Sub-Linear Expectations
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作者 Mingzhou XU 《Journal of Mathematical Research with Applications》 2025年第3期395-410,共16页
Assume that{a_(i),−∞<i<∞}is an absolutely summable sequence of real numbers.We establish the complete q-order moment convergence for the partial sums of moving average processes{X_(n)=Σ_(i=−∞)^(∞)a_(i)Y_(i+... Assume that{a_(i),−∞<i<∞}is an absolutely summable sequence of real numbers.We establish the complete q-order moment convergence for the partial sums of moving average processes{X_(n)=Σ_(i=−∞)^(∞)a_(i)Y_(i+n),n≥1}under some proper conditions,where{Yi,-∞<i<∞}is a doubly infinite sequence of negatively dependent random variables under sub-linear expectations.These results extend and complement the relevant results in probability space. 展开更多
关键词 moving average processes negatively dependent random variables complete moment convergence sub-linear expectations
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Precise Control of the Recollision Dynamics in Nonsequential Double Ionization by Spatially Inhomogeneous Few-Cycle Negatively Chirped Laser Pulses
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作者 Yingbin Li Fengrun Wu +10 位作者 Fanfei Liu Shuaijie Kang Zhengfa Li Ke Zhang Yifan Liu Kuo Li Chunyang Zhai Jingkun Xu Pu Wang Qiming Zhao Benhai Yu 《Chinese Physics Letters》 2025年第5期26-32,共7页
With a three-dimensional semiclassical ensemble method, we theoretically investigated the nonsequential double ionization of Ar driven by the spatially inhomogeneous few-cycle negatively chirped laser pulses. Our resu... With a three-dimensional semiclassical ensemble method, we theoretically investigated the nonsequential double ionization of Ar driven by the spatially inhomogeneous few-cycle negatively chirped laser pulses. Our results show that the recollision time window can be precisely controlled within an isolated time interval of several hundred attoseconds, which is useful for understanding the subcycle correlated electron dynamics. More interestingly, the correlated electron momentum distribution (CEMD) exhibits a strong dependence on laser intensity. That is, at lower laser intensity, CEMD is located in the first quadrant. As the laser intensity increases,CEMD shifts almost completely to the second and fourth quadrants, and then gradually to the third quadrant.The underlying physics governing the CEMD's dependence on laser intensity is explained. 展开更多
关键词 recollision time window recollision dynamics correlated electron momentum distribution nonsequential double ionization precise control understanding subcycle correlated electron dynamics three dimensional semiclassical ensemble method spatially inhomogeneous few cycle negatively chirped laser pulses
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Clinical Effect Analysis of Negative Pressure Chest Drainage in Patients after Two-Port Thoracoscopic Valve Surgery
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作者 Yanfang Wei Aizhen Wei +3 位作者 Yuan Feng Jinmao Lu Shusong Li Linqiang Li 《Natural Science》 2025年第2期7-12,共6页
Objective: This study aims to investigate the drainage effect and clinical outcomes of negative pressure chest drainage in patients after two-port thoracoscopic valve surgery, comparing the differences in postoperativ... Objective: This study aims to investigate the drainage effect and clinical outcomes of negative pressure chest drainage in patients after two-port thoracoscopic valve surgery, comparing the differences in postoperative pain, hospital stay, and other factors between the negative pressure group and the control group. Methods: This study is a prospective controlled trial that selected patients undergoing two-port thoracoscopic valve surgery at a certain hospital from January 2019 to December 2024. Patients were randomly assigned to the control group and the negative pressure group using a random number table method. The control group consisted of 30 patients (20 males, 10 females, mean age 42.03 ± 12.89 years), and the negative pressure group consisted of 35 patients (26 males, 9 females, mean age 41.84 ± 11.83 years). The control group received traditional chest drainage, while the negative pressure group received negative pressure chest drainage. Postoperative pain scores, hospital stay, drainage time, number of tube blockages, and incidences of pneumothorax or subcutaneous emphysema were recorded and statistically analyzed. Results: The negative pressure group had a significantly shorter postoperative drainage time compared to the control group (49.09 ± 11.99 hours vs. 79.10 ± 7.32 hours, P < 0.001). The postoperative pain score was lower in the negative pressure group (4.49 ± 1.27 vs. 7.03 ± 0.85, P < 0.001), and the hospital stay was significantly shorter (9.83 ± 1.69 days vs. 14.73 ± 2.32 days, P < 0.001). The incidence of pneumothorax or subcutaneous emphysema was significantly lower in the negative pressure group than in the control group (14.29% vs. 56.67%, P = 0.0003). Conclusion: The application of negative pressure chest drainage in patients after two-port thoracoscopic valve surgery can effectively reduce postoperative pain, shorten hospital stay, and lower the incidence of tube blockage and pneumothorax, demonstrating good clinical outcomes. 展开更多
关键词 negative Pressure Chest Drainage Two-Port Thoracoscopy Valve Surgery Cardiac Surgery
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两体高维系统Negativity的研究
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作者 刘冬冬 陈凯 《徐州工程学院学报》 2007年第6期86-88,共3页
首先从理论上对Negativity的两种定义进行比较,然后推导出二参量两体高维量子系统Negativity的表达式.
关键词 纠缠度 negativity 部分转置 二参量纠缠态
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两体高维量子系统的Negativity
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作者 刘思平 《襄樊学院学报》 2007年第11期23-27,共5页
量子纠缠及其度量在量子通讯中起着至关重要的作用.文章采用一种量子纠缠的计算方法—Negativity,推导得到了二参量两体高维量子系统Negativity的一般解析表达式.此方法的优点是计算方便,物理意义明确.
关键词 量子纠缠态 二参量纠缠态 negativity 部分转置
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EAST装置中新型吸附剂泵(NEG)抽速标定研究
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作者 王超 余耀伟 +4 位作者 孙浩 曹斌 潘浩 凡斌 左桂忠 《真空与低温》 2024年第3期243-247,共5页
粒子排出是控制燃料粒子再循环、提升等离子体性能的关键因素之一。因此研究了新型吸附剂泵(NEG)在粒子排出技术中的潜在应用。NEG泵基于ZAO新型合金材料制成,对氢及其同位素抽速大、容量高,安装、运行、维护简单,兼容等离子体环境,适... 粒子排出是控制燃料粒子再循环、提升等离子体性能的关键因素之一。因此研究了新型吸附剂泵(NEG)在粒子排出技术中的潜在应用。NEG泵基于ZAO新型合金材料制成,对氢及其同位素抽速大、容量高,安装、运行、维护简单,兼容等离子体环境,适用于偏滤器区域的超高热流和复杂的空间结构。在EAST托卡马克装置安装4套HV800模组,开展了定期的抽速标定、再生研究以评估其周期性能变化。EAST真空室壁表面积较大,金属壁放气、杂质气体影响NEG泵抽速计算。通过计算EAST整体漏放率与氢及其同位素放气率,利用计算机模拟抽气过程,提出了一种用于修正NEG泵抽速的方法。研究结果表明在偏滤器区域工作压力下,对氘平均抽速可达1200 L/s。 展开更多
关键词 neg 真空抽气系统 抽气速率标定
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Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness 被引量:14
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作者 Xiaoyu Wang Rao Fu +6 位作者 Xiaoyu Xia Xueling Chen Han Wu Nicole LANDi Ken Pugh Jianghong He Fengyu Cong 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第4期700-708,共9页
In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of fr... In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequencydeviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity (MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale- Revised (CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions (small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location (frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness. 展开更多
关键词 EEG Mismatch negativity Disorder ofconsciousness Vegetative state Minimally consciousstate
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Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity 被引量:6
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作者 Xiaohui Wen Ningyu Wang +2 位作者 Jinfeng Liu Zhanfeng Yan Zhonghai Xin 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第20期1591-1598,共8页
In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as... In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation 〈 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation 〉 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montrea Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients. 展开更多
关键词 obstructive sleep apnea hypopnea syndrome mismatch negativity cognitive function MontrealCognitive Assessment LATENCY DIAGNOSIS
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Geometrical quantum discord and negativity of two separable and mixed qubits 被引量:1
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作者 Tang-Kun Liu Fei Liu +1 位作者 Chuan-Jia Shan Ji-Bing Liu 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第9期107-113,共7页
We studied quantum correlation and quantum entanglement of a quantum system in which a coherent state light field interacts with two qubits that are initially prepared in a separable and mixed state.The influence of m... We studied quantum correlation and quantum entanglement of a quantum system in which a coherent state light field interacts with two qubits that are initially prepared in a separable and mixed state.The influence of mean photon number of the coherent field and distribution probability of the atom on the geometrical quantum discord and the negativity are discussed.Our results show that the mean photon number of light field and distribution function of the atom can regulate and control the quantum correlation and quantum entanglement. 展开更多
关键词 GEOMETRICAL QUANTUM DISCORD QUANTUM correlation negativity QUANTUM entanglement
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Monogamy Relations for Squared Entanglement Negativity 被引量:1
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作者 Feng Liu 《Communications in Theoretical Physics》 SCIE CAS CSCD 2016年第10期407-410,共4页
This paper contains two main contents.In the first part,we provide two counterexamples of monogamy inequalities for the squared entanglement negativity:one three-qutrit pure state which violates of the He–Vidal monog... This paper contains two main contents.In the first part,we provide two counterexamples of monogamy inequalities for the squared entanglement negativity:one three-qutrit pure state which violates of the He–Vidal monogamy conjecture,and one four-qubit pure state which disproves the squared-negativity-based Regula–Martino–Lee–Adessoclass strong monogamy conjecture.In the second part,we investigate the sharing of the entanglement negativity in a composite cavity-reservoir system using the corresponding multipartite entanglement scores,and then we find that there is no simple dominating relation between multipartite entanglement scores and the entanglement negativity in composite cavity-reservoir systems.As a by-product,we further validate that the entanglement of two cavity photons is a decreasing function of the evolution time,and the entanglement will suddenly disappear interacting with independent reservoirs. 展开更多
关键词 monogamy relations entanglement negativity strong monogamy
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Superiority Effect in Detecting Phylogenetic Threats Under Unattentional Condition: A Visual Mismatch Negativity Study 被引量:1
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作者 ZHANG Shu GUO Qingke 《Psychology Research》 2019年第9期353-370,共18页
Rapid and accurate perception of threat information is a critical ability and a prerequisite to survive natural selection for humans.To investigate whether threatening stimuli,especially phylogenetic and ontogenetic t... Rapid and accurate perception of threat information is a critical ability and a prerequisite to survive natural selection for humans.To investigate whether threatening stimuli,especially phylogenetic and ontogenetic threats,are processed automatically,we analyzed the visual mismatch negativity(vMMN,an event-related potential component reflecting automatic processing)elicited by the threats with a cross-modal oddball paradigm,where participants were required to focus on the auditory stimuli and ignore the visual stimuli in each block.In this study,neutral(non-threatening)images served as standard stimuli(80%),and phylogenetic(10%)and ontogenetic(10%)threat stimuli served as deviant stimuli when testing a large sample(N=96)of healthy volunteers.Threat-related visual mismatch negativity(threat-vMMN)was obtained by subtracting the event-related potential(ERP)elicited by standard stimuli from that elicited by deviant stimuli.The results indicated that the vMMN can be elicited by threat information.More importantly,the phylogenetic threat information elicited larger threat-vMMN than ontogenetic threat information.These findings suggest that perception of threat information was automatic,providing an evidential basis for the attentional advantages of survival processing.That is,automatic perception of phylogenetic threats has a particular evolutionary origin. 展开更多
关键词 automatic processing visual mismatch negativity (vMMN) PHYLOGENETIC THREAT stimuli ONTOGENETIC THREAT stimuli EVENT-RELATED potential (ERP)
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Negativity of Quantumness and Non-Markovianity in a Qubit Coupled to a Thermal Ising Spin Bath System
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作者 胡征达 张逸新 张业奇 《Communications in Theoretical Physics》 SCIE CAS CSCD 2014年第11期634-640,共7页
We propose a scheme to characterize the non-Markovian dynamics and quantify the non-Markovianity via the non-classicality measured by the negativity of quantumness. By considering a qubit in contact with a critical Is... We propose a scheme to characterize the non-Markovian dynamics and quantify the non-Markovianity via the non-classicality measured by the negativity of quantumness. By considering a qubit in contact with a critical Ising spin bath and introducing an ancilla, we show that revivals of negativity of quantumness indicate the non-Markovian dynamics.Furthermore, a normalized measure of non-Markovianity based on the negativity of quantumness is introduced and the influences of bath criticality, bath temperature and bath size on the non-Markovianity are discussed. It is shown that,at the critical point, the decay of non-Markovianity versus the size of spin bath is the fastest and the non-Markovianity is exactly zero only in the thermodynamic limit. Besides, non-trivial behaviours of negativity of quantumness such as sudden change, double sudden changes and keeping constant are found for different relations between parameters of the initial state. Finally, how the non-classicality of the system is affected by a series of bang-bang pulses is also examined. 展开更多
关键词 non-Markovianity negativity of quantumness critical SPIN BATH
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Effect of escitalopram on cognitive function in depressionA mismatch negativity potentials study
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作者 Zhenhe Zhou Guozhen Yuan Jianjun Yao Zaohuo Cheng 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第31期2441-2445,共5页
We detected the event-related potential mismatch negativity (MMN) of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and durati... We detected the event-related potential mismatch negativity (MMN) of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and duration MMN were lower in depression patients compared with control patients,indicating abnormality in auditory processing (i.e.,cognitive impairment).Following escitalopram treatment for 8 weeks,the amplitudes of frequency and duration MMN were significantly increased and Hamilton Rating Scale for Depression scores were significantly decreased in depression patients.These data suggest that escitalopram can improve cognitive function of patients with depression.Further,MMN may be a useful tool for evaluating cognitive function and treatment effects. 展开更多
关键词 DEPRESSION event-related potentials mismatch negativity cognitive function ESCITALOPRAM
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Monogamous nature of symmetric N-qubit states of the W class: Concurrence and negativity tangle
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作者 P.J.Geetha K.O.Yashodamma Sudha 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第11期85-91,共7页
Using Majorana representation of symmetric N-qubit pure states, we have examined the monogamous nature of the family of states with two-distinct spinors, the W class of states. We have evaluated the N-concurrence tang... Using Majorana representation of symmetric N-qubit pure states, we have examined the monogamous nature of the family of states with two-distinct spinors, the W class of states. We have evaluated the N-concurrence tangle and showed that all the states in this family have vanishing concurrence tangle. The negativity tangle for the W class of states is shown to be non-zero, illustrating the fact that the concurrence tangle is always lesser than or equal to the negativity tangle in a pure N-qubit state. 展开更多
关键词 monogamy of quantum entanglement Majorana representation of symmetric pure states concur-rence tangle negativity tangle
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On extending the concept of double negativity to acoustic waves
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作者 陈子亭 李赞恒 冯建雄 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2006年第1期24-28,共5页
The realization of double negative electromagnetic wave media, sometimes called left-handed materials (LHMs) or metamaterials, have drawn considerable attention in the past few years. We will examine the possibility o... The realization of double negative electromagnetic wave media, sometimes called left-handed materials (LHMs) or metamaterials, have drawn considerable attention in the past few years. We will examine the possibility of extending the concept to acoustic waves. We will see that acoustic metamaterials require both the effective density and bulk modulus to be simultaneously negative in the sense of an effective medium. If we can find a double negative (negative density and bulk modulus) acoustic medium, it will be an acoustic analogue of Veselago’s medium in electromagnetism, and share many novel consequences such as negative refractive index and backward wave characteristics. We will give one example of such a medium. 展开更多
关键词 Double negativity METAMATERIALS ACOUSTIC
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差压法测定NEG吸氢性能
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作者 王婧华 王蓝陵 +3 位作者 林文豫 吴俊 曹青 王旭迪 《真空》 CAS 2024年第3期51-56,共6页
通过对定压法进行改进提出了差压法,用于测试非蒸散型吸气剂(NEG)的吸氢性能。该方法在进气室和吸气室之间安装固定流导元件,利用调节微调阀提供可控的进气流量,通过测量吸气室、进气室和参考室的压力计算NEG的吸气性能参数。利用两种NE... 通过对定压法进行改进提出了差压法,用于测试非蒸散型吸气剂(NEG)的吸氢性能。该方法在进气室和吸气室之间安装固定流导元件,利用调节微调阀提供可控的进气流量,通过测量吸气室、进气室和参考室的压力计算NEG的吸气性能参数。利用两种NEG比较了差压法和改进的定压法所测吸气性能。结果表明:差压法测得的吸气容量比改进的定压法测得的吸气容量低0.07268 Pa·L;腔室壁面吸附能力使改进定压法的试验结果高于理论结果,而差压法的试验结果不受影响;对改进的定压法进行优化后,其计算结果与差压法的接近。差压法可以获得更准确、更有效的吸气剂性能参数,在差压法中,参考部分和试验部分同时进行测试,可缩短测试时间,减少控制进气带来的误差。 展开更多
关键词 差压法 吸氢性能 非蒸散型吸气剂(neg) 改进的定压法
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Non-Negativity Preserving Numerical Algorithms for Problems in Mathematical Finance 被引量:1
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作者 Yuan Yuan 《Applied Mathematics》 2018年第3期313-335,共23页
We give a study result to analyze a rather different, semi-analytical numerical algorithms based on splitting-step methods with their applications to mathematical finance. As certain subsistent numerical schemes may f... We give a study result to analyze a rather different, semi-analytical numerical algorithms based on splitting-step methods with their applications to mathematical finance. As certain subsistent numerical schemes may fail due to producing negative values for financial variables which require non-negativity preserving. These algorithms which we are analyzing preserve not only the non-negativity, but also the character of boundaries (natural, reflecting, absorbing, etc.). The derivatives of the CIR process and the Heston model are being extensively studied. Beyond plain vanilla European options, we creatively apply our splitting-step methods to a path-dependent option valuation. We compare our algorithms to a class of numerical schemes based on Euler discretization which are prevalent currently. The comparisons are given with respect to both accuracy and computational time for the European call option under the CIR model whereas with respect to convergence rate for the path-dependent option under the CIR model and the European call option under the Heston model. 展开更多
关键词 Stochastic Differential EQUATIONS Numerical Methods Splitting-Step Algorithm NON-negativity CONVERGENCE Simulation
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VSD联合胰岛素、庆大霉素、维生素B12对糖尿病足创面及组织中Bcl-2/Bax水平的影响 被引量:4
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作者 杨威 谭淑丹 +4 位作者 朱春雷 赵维彦 邱旭东 陈烨 孙雁 《北华大学学报(自然科学版)》 CAS 2025年第1期76-79,共4页
目的 探讨负压封闭引流(VSD)联合胰岛素、庆大霉素、维生素B12冲洗对糖尿病足创面及组织中Bcl-2、Bax水平的影响。方法 选取55例糖尿病足患者作为研究对象,按照不同治疗方法将其分为对照组(20例,应用VSD治疗糖尿病足创面)、试验组(35例... 目的 探讨负压封闭引流(VSD)联合胰岛素、庆大霉素、维生素B12冲洗对糖尿病足创面及组织中Bcl-2、Bax水平的影响。方法 选取55例糖尿病足患者作为研究对象,按照不同治疗方法将其分为对照组(20例,应用VSD治疗糖尿病足创面)、试验组(35例,应用VSD联合胰岛素、庆大霉素、维生素B12冲洗治疗)。对比治疗7、14 d后两组患者创面面积及创面组织中Bcl-2、Bax水平。结果 治疗后7 d,两组患者创面面积比较差异无统计学意义(P>0.05),Bax表达水平两组比较差异无统计学意义(P>0.05),Bcl-2水平试验组高于对照组(P<0.05);治疗后14 d,试验组创面面积明显小于对照组(P<0.05),Bax水平与对照组比较差异无统计学意义(P>0.05),Bcl-2水平明显高于对照组(P<0.05),Bcl-2/Bax高于对照组(P<0.05)。结论 VSD联合胰岛素、庆大霉素、维生素B12冲洗治疗糖尿病足创面的作用机制是通过激活Bcl-2介导相关抗凋亡途径,上调创面组织Bcl-2水平,提高Bcl-2/Bax,达到抑制局部细胞凋亡、促进创面愈合的效果。 展开更多
关键词 负压封闭引流 糖尿病足 Bcl-2 Bax
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HER2阴性晚期胃癌患者PD-1抑制剂信迪利单抗治疗过程中癌胚抗原变化及其与预后的关系 被引量:4
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作者 宋永波 杜小明 +1 位作者 张艳苓 赵璐 《中国免疫学杂志》 北大核心 2025年第2期402-407,共6页
目的:探究人类表皮生长因子受体2(HER2)阴性晚期胃癌患者程序性死亡蛋白1(PD-1)抑制剂信迪利单抗免疫过程中癌胚抗原(CEA)变化及其与预后的关系。方法:选择2020年5月至2022年4月于皖北煤电集团总医院治疗的HER2阴性晚期胃癌患者(88例)... 目的:探究人类表皮生长因子受体2(HER2)阴性晚期胃癌患者程序性死亡蛋白1(PD-1)抑制剂信迪利单抗免疫过程中癌胚抗原(CEA)变化及其与预后的关系。方法:选择2020年5月至2022年4月于皖北煤电集团总医院治疗的HER2阴性晚期胃癌患者(88例)为研究对象,均行PD-1抑制剂信迪利单抗治疗;根据预后情况分为死亡组(36例)和生存组(52例)。每6个月随访1次,收集患者治疗前后肿瘤标志物水平。分析肿瘤标志物(CEA、CA199、CA125)水平与临床分期、淋巴结转移及预后的关系。采用Kaplan-Meier生存曲线分析各肿瘤标志物阴性及阳性组患者的生存时间。采用多因素Cox回归模型和逐步回归分析影响预后的危险因素。采用Spearman进行相关性分析。结果:治疗2个周期后,疾病控制者72例(81.82%)、进展者16例(18.18%)。与治疗前相比,治疗后患者血清肿瘤标志物阳性率均显著降低(P<0.05)。CEA、CA199阳性率与临床分期显著相关(P<0.05)。预测患者死亡时,CEA水平的敏感度最高(48.57%),而CA125的特异度最高(95.62%),但敏感度最低(25.71%)。Kaplan-Meier生存曲线分析结果显示,各肿瘤标志物阳性患者的生存时间均显著短于阴性患者(P<0.05)。临床分期、血清CEA和CA199水平均为预测预后的独立因素(P<0.05)。Spearman相关性分析结果显示,CEA(r=-0.512,P=0.005)、CA199(r=-0.467,P=0.011)升高倍数与患者的生存时间均呈负相关。结论:经PD-1抑制剂信迪利单抗治疗后,HER2阴性晚期胃癌患者的血清肿瘤标志物水平均显著降低。患者血清高CEA、CA199、CA125水平均可预测不良预后,临床分期、血清CEA和CA199水平均为预测预后的独立因素。CEA、CA199升高倍数越高,患者生存时间越短。 展开更多
关键词 HER2阴性 胃癌 信迪利单抗 癌胚抗原 预后
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