The selection of electro-acupuncture parameters remains poorly unified between clinical studies. The present study observed the effects of electro-acupuncturing Renzhong （DU 26） with different stimulation parameters...The selection of electro-acupuncture parameters remains poorly unified between clinical studies. The present study observed the effects of electro-acupuncturing Renzhong （DU 26） with different stimulation parameters on motor function recovery following middle artery occlusion injury in rats. Results showed an optimal stimulation parameter for Renzhong electro-acupuncture that was low frequency and mild current （2 Hz, 1 mA） significantly improved cortical excitability and conductive function, and promoted recovery in a rat model of motor function in middle artery occlusion. Frequency had a greater impact than current or interaction, and played a critical role in electro-acupuncture therapy.展开更多
Purpose:Deep brain stimulation(DBS)of the subthalamic nucleus(STN)is an indispensable and effective surgery for patients with primary Parkinson’s disease(PD).Nonetheless,its postoperative effects can be decided by ma...Purpose:Deep brain stimulation(DBS)of the subthalamic nucleus(STN)is an indispensable and effective surgery for patients with primary Parkinson’s disease(PD).Nonetheless,its postoperative effects can be decided by many factors including the optimal programmed stimulation parameters.In this study,we analyzed the correlation between different postoperative programmed stimulation parameters and their efficacy after STN–DBS electrode implantation in patients with PD.Methods:A total of 87 patients underwent electrode implantation and completed at least one year follow-up.Then,various combinations of stimulation parameters,including stimulus intensity,frequency,and pulse width,were examined for their effects on the clinical improvement of the patients.Improvements in motor and nonmotor symptoms were analyzed using Mini-Mental State Examination,Parkinson’s Disease Quality of Life Questionnaire-39,and Unified Parkinson’s Disease Rating Scale(UPDRS)scores before and after surgery.Results:We found significantly improved UPDRS scores,quality of life,and neuropsychiatric symptoms postoperatively considering the findings of the aforementioned stimulation parameters compared with those observed preoperatively.Conclusion:This study provides a better understanding on how pro-grammed stimulation parameters help relieve PD symptoms and improve quality of life in patients with PD undergoing STN–DBS.展开更多
Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure ...Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,展开更多
Objective The purpose of the study was to investigate the effective parameters of electric cortex stimulation (ECS) for functional brain mapping. Methods We collected 21 subjects who underwent epilepsy surgeries conse...Objective The purpose of the study was to investigate the effective parameters of electric cortex stimulation (ECS) for functional brain mapping. Methods We collected 21 subjects who underwent epilepsy surgeries consecutively in Beijing Institute of Functional Neurosurgery with the epileptogenic zone located in perirolandic areas from展开更多
Spinal cord injury(SCI)population with injury below T10 or injury to the cauda equina region is characterized by denervated muscles,extensive muscle atrophy,infiltration of intramuscular fat and formation of fibrous t...Spinal cord injury(SCI)population with injury below T10 or injury to the cauda equina region is characterized by denervated muscles,extensive muscle atrophy,infiltration of intramuscular fat and formation of fibrous tissue.These morphological changes may put individuals with SCI at higher risk for developing other diseases such as various cardiovascular diseases,diabetes,obesity and osteoporosis.Currently,there is no available rehabilitation intervention to rescue the muscles or restore muscle size in SCI individuals with lower motor neuron denervation.We,hereby,performed a review of the available evidence that supports the use of electrical stimulation in restoration of denervated muscle following SCI.Long pulse width stimulation(LPWS)technique is an upcoming method of stimulating denervated muscles.Our primary objective is to explore the best stimulation paradigms(stimulation parameters,stimulation technique and stimulation wave)to achieve restoration of the denervated muscle.Stimulation parameters,such as the pulse duration,need to be 100–1000 times longer than in innervated muscles to achieve desirable excitability and contraction.The use of electrical stimulation in animal and human models induces muscle hypertrophy.Findings in animal models indicate that electrical stimulation,with a combination of exercise and pharmacological interventions,have proven to be effective in improving various aspects like relative muscle weight,muscle cross sectional area,number of myelinated regenerated fibers,and restoring some level of muscle function.Human studies have shown similar outcomes,identifying the use of LPWS as an effective strategy in increasing muscle cross sectional area,the size of muscle fibers,and improving muscle function.Therefore,displaying promise is an effective future stimulation intervention.In summary,LPWS is a novel stimulation technique for denervated muscles in humans with SCI.Successful studies on LPWS of denervated muscles will help in translating this stimulation technique to the clinical level as a rehabilitation intervention after SCI.展开更多
The Longwangmiao Fm group gas reservoirs in the Moxi structure in central Sichuan Basin feature high temperature,high pressure and high H2S content.The thickness of such high permeable reservoirs with great homogeneit...The Longwangmiao Fm group gas reservoirs in the Moxi structure in central Sichuan Basin feature high temperature,high pressure and high H2S content.The thickness of such high permeable reservoirs with great homogeneity is a geologic basis for a high-productivity gas well,and good match of natural fractures and vugs is the key factor to high well productivity.Overbalance drilling is likely to cause the opening-up of natural fractures,which will lead to the leakage of drilling fluid and severe damage to the reservoir.Experimental evaluation results show that the damage rate of the drilling fluid to the rock sample is between 82.2%and 89.2%,which severely restricts the productivity of gas wells.Therefore,it is necessary to deepen the experimental evaluation technologies and methods to promote the design pertinence of technical parameters.The study shows:first,the optimized gelling acid and steering acid are effective in slowing down speed and removing blockage,forming acidizing wormholes and effectively eliminating the blockage effect caused by drilling liquid pollution;second,the self-developed fiber steering agent and soluble temporary blocking ball can divert the acid,increasing the processing pressure at the well bottom by 5-15 MPa,realizing the even stimulation of heterogeneous reservoirs;third,based on experimental evaluation such as the acid penetration and acid rock reaction,it is recommended that the pumping rate be 3.0-3.5 m^(3)/min in acidizing treatment and the acid intensity for blockage removal be 3.0-5.0 m^(3)/m;fourth,the established blockage removal and steering acidizing technology have been applied in more than 20 wells with a remarkable productivity-increase effect,which gives full play to the natural productivity of gas wells and decreases the acid application scale.All these technologies and measures effectively enhance the development quality and profit of the gas reservoir.展开更多
Deep brain stimulation(DBS)is a neurosurgical procedure that allows targeted circuit-based neuromodulation;it is also a standard of care for Parkinson’s disease(PD).[1]Postoperative DBS programming is a crucial step ...Deep brain stimulation(DBS)is a neurosurgical procedure that allows targeted circuit-based neuromodulation;it is also a standard of care for Parkinson’s disease(PD).[1]Postoperative DBS programming is a crucial step that can specify the best stimulation parameters and release symptoms to promote patients’quality of life.The“Chinese Expert Consensus on Programming Deep Brain Stimulation for Patients with Parkinson’s Disease”,which was published in 2016,regulated the application of postoperative programming for PD patients.[2]However,multiple aspects limited patients’ability to attend face-to-face programming,including their mobility and the geological distance between their residences and the DBS center,which led to a higher rate of patients using remote programming with increasing frequency,making it an urgent demand.[3,4]Therefore,it is important to create a standard protocol to guide the application of this remote treatment.展开更多
Objective We review the targets of the deep brain and the responsive neurostimulation system （RNS） to identify the best optimal stimulation parameters and the best mode of stimulation, whether cyclical, continuous, ...Objective We review the targets of the deep brain and the responsive neurostimulation system （RNS） to identify the best optimal stimulation parameters and the best mode of stimulation, whether cyclical, continuous, or smarter. Data sources This review is based on data obtained from published articles from 1950 to 2013. To perform the PubMed literature search, the following keywords were input： deep brain stimulation （DBS）, RNS, and refractory epilepsy. Study selection Articles containing information related to brain stimulation or RNS for the treatment of refractory epilepsy were selected. Results The currently available treatment options for those patients who resist multiple antiepileptic medications and surgical procedures include electric stimulation, both direct and indirect, of brain nuclei thought to be involved in epileptogenesis. The number of potential targets has increased over the years to include the anterior nucleus of the thalamus, the centromedian nucleus of the thalamus, the hippocampus, the subthalamic nucleus, the caudate nucleus, and the cerebellum, among others. The results of a randomized controlled trial and the RNS trial were published to reveal the effectiveness. Conclusions Although statistically significant reductions in seizures have been observed using several different stimulation techniques, including vagus nerve stimulation, DBS, and RNS, these effects are currently only palliative and do not approach the efficacy comparable with that seen in resection in appropriately selected patients. More research is needed to determine optimal stimulation targets and techniques as well as to determine which epilepsy patients will benefit most from this technology.展开更多
Barker first used transcranial magnetic stimulation in 1985 in human brain function research. Since then, it has gradually been developed into a secure and non-invasive treatment method for neurological diseases. In 1...Barker first used transcranial magnetic stimulation in 1985 in human brain function research. Since then, it has gradually been developed into a secure and non-invasive treatment method for neurological diseases. In 1994, Pascual Leone first used it for the treatment of Parkinson's disease(PD) and observed an improvement in the motor symptoms of most of the patients. Recent studies have confirmed that both motor and non-motor symptoms of patients with PD could be improved through biochemical, electrophysiological, and functional magnetic resonance imaging analysis. Different therapeutic applications can be achieved by adjusting the stimulation parameters.Physical factors affecting the therapeutic effect include the shape and size of the coil, array orientation, materials and intensity, frequency of stimulus, etc.; the biological factors include stimulating targets, baseline, circadian rhythms, cerebral cortex thickness, and so on. This paper will review these factors and provide a reference for future research.展开更多
基金the National Natural Science Foundation of China,No.30873304
文摘The selection of electro-acupuncture parameters remains poorly unified between clinical studies. The present study observed the effects of electro-acupuncturing Renzhong （DU 26） with different stimulation parameters on motor function recovery following middle artery occlusion injury in rats. Results showed an optimal stimulation parameter for Renzhong electro-acupuncture that was low frequency and mild current （2 Hz, 1 mA） significantly improved cortical excitability and conductive function, and promoted recovery in a rat model of motor function in middle artery occlusion. Frequency had a greater impact than current or interaction, and played a critical role in electro-acupuncture therapy.
文摘Purpose:Deep brain stimulation(DBS)of the subthalamic nucleus(STN)is an indispensable and effective surgery for patients with primary Parkinson’s disease(PD).Nonetheless,its postoperative effects can be decided by many factors including the optimal programmed stimulation parameters.In this study,we analyzed the correlation between different postoperative programmed stimulation parameters and their efficacy after STN–DBS electrode implantation in patients with PD.Methods:A total of 87 patients underwent electrode implantation and completed at least one year follow-up.Then,various combinations of stimulation parameters,including stimulus intensity,frequency,and pulse width,were examined for their effects on the clinical improvement of the patients.Improvements in motor and nonmotor symptoms were analyzed using Mini-Mental State Examination,Parkinson’s Disease Quality of Life Questionnaire-39,and Unified Parkinson’s Disease Rating Scale(UPDRS)scores before and after surgery.Results:We found significantly improved UPDRS scores,quality of life,and neuropsychiatric symptoms postoperatively considering the findings of the aforementioned stimulation parameters compared with those observed preoperatively.Conclusion:This study provides a better understanding on how pro-grammed stimulation parameters help relieve PD symptoms and improve quality of life in patients with PD undergoing STN–DBS.
基金supported by Japan Society for the Promotion of Science(JSPS)Grant-in-Aid for young scientists(B)15K19984JSPS Fujita Memorial Fund for Medical Research,Takeda Science Foundation+1 种基金Uehara Memorial FoundationCentral Research Institute of Fukuoka University(No.161042)
文摘Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,
文摘Objective The purpose of the study was to investigate the effective parameters of electric cortex stimulation (ECS) for functional brain mapping. Methods We collected 21 subjects who underwent epilepsy surgeries consecutively in Beijing Institute of Functional Neurosurgery with the epileptogenic zone located in perirolandic areas from
文摘Spinal cord injury(SCI)population with injury below T10 or injury to the cauda equina region is characterized by denervated muscles,extensive muscle atrophy,infiltration of intramuscular fat and formation of fibrous tissue.These morphological changes may put individuals with SCI at higher risk for developing other diseases such as various cardiovascular diseases,diabetes,obesity and osteoporosis.Currently,there is no available rehabilitation intervention to rescue the muscles or restore muscle size in SCI individuals with lower motor neuron denervation.We,hereby,performed a review of the available evidence that supports the use of electrical stimulation in restoration of denervated muscle following SCI.Long pulse width stimulation(LPWS)technique is an upcoming method of stimulating denervated muscles.Our primary objective is to explore the best stimulation paradigms(stimulation parameters,stimulation technique and stimulation wave)to achieve restoration of the denervated muscle.Stimulation parameters,such as the pulse duration,need to be 100–1000 times longer than in innervated muscles to achieve desirable excitability and contraction.The use of electrical stimulation in animal and human models induces muscle hypertrophy.Findings in animal models indicate that electrical stimulation,with a combination of exercise and pharmacological interventions,have proven to be effective in improving various aspects like relative muscle weight,muscle cross sectional area,number of myelinated regenerated fibers,and restoring some level of muscle function.Human studies have shown similar outcomes,identifying the use of LPWS as an effective strategy in increasing muscle cross sectional area,the size of muscle fibers,and improving muscle function.Therefore,displaying promise is an effective future stimulation intervention.In summary,LPWS is a novel stimulation technique for denervated muscles in humans with SCI.Successful studies on LPWS of denervated muscles will help in translating this stimulation technique to the clinical level as a rehabilitation intervention after SCI.
基金Special and Significant Project of National Science and Technology:“Research on Development Techniques of Complex Carbonate Gas Reservoirs”(No.2011ZX05015-003-005).
文摘The Longwangmiao Fm group gas reservoirs in the Moxi structure in central Sichuan Basin feature high temperature,high pressure and high H2S content.The thickness of such high permeable reservoirs with great homogeneity is a geologic basis for a high-productivity gas well,and good match of natural fractures and vugs is the key factor to high well productivity.Overbalance drilling is likely to cause the opening-up of natural fractures,which will lead to the leakage of drilling fluid and severe damage to the reservoir.Experimental evaluation results show that the damage rate of the drilling fluid to the rock sample is between 82.2%and 89.2%,which severely restricts the productivity of gas wells.Therefore,it is necessary to deepen the experimental evaluation technologies and methods to promote the design pertinence of technical parameters.The study shows:first,the optimized gelling acid and steering acid are effective in slowing down speed and removing blockage,forming acidizing wormholes and effectively eliminating the blockage effect caused by drilling liquid pollution;second,the self-developed fiber steering agent and soluble temporary blocking ball can divert the acid,increasing the processing pressure at the well bottom by 5-15 MPa,realizing the even stimulation of heterogeneous reservoirs;third,based on experimental evaluation such as the acid penetration and acid rock reaction,it is recommended that the pumping rate be 3.0-3.5 m^(3)/min in acidizing treatment and the acid intensity for blockage removal be 3.0-5.0 m^(3)/m;fourth,the established blockage removal and steering acidizing technology have been applied in more than 20 wells with a remarkable productivity-increase effect,which gives full play to the natural productivity of gas wells and decreases the acid application scale.All these technologies and measures effectively enhance the development quality and profit of the gas reservoir.
基金National Key Research and Development Program of China(Nos.2022YFC2405100 and 2021YFC2401200)National Natural Science Foundation of China(No.81830033)+1 种基金Key R&D Program of Jiangsu Science and Technology Project(No.BE2022049)Key Research and Development Program of Henan Province(No.241111310100)
文摘Deep brain stimulation(DBS)is a neurosurgical procedure that allows targeted circuit-based neuromodulation;it is also a standard of care for Parkinson’s disease(PD).[1]Postoperative DBS programming is a crucial step that can specify the best stimulation parameters and release symptoms to promote patients’quality of life.The“Chinese Expert Consensus on Programming Deep Brain Stimulation for Patients with Parkinson’s Disease”,which was published in 2016,regulated the application of postoperative programming for PD patients.[2]However,multiple aspects limited patients’ability to attend face-to-face programming,including their mobility and the geological distance between their residences and the DBS center,which led to a higher rate of patients using remote programming with increasing frequency,making it an urgent demand.[3,4]Therefore,it is important to create a standard protocol to guide the application of this remote treatment.
基金This work was supported partly by grants from the National Natural Science Foundation of China （No. 81071224, 81241048）, the Beijing Natural Science Foundation （No. 7123209）, and Beijing Health System Advanced Health Technology Talent Cultivation Plan （No. 2011-3-032）.
文摘Objective We review the targets of the deep brain and the responsive neurostimulation system （RNS） to identify the best optimal stimulation parameters and the best mode of stimulation, whether cyclical, continuous, or smarter. Data sources This review is based on data obtained from published articles from 1950 to 2013. To perform the PubMed literature search, the following keywords were input： deep brain stimulation （DBS）, RNS, and refractory epilepsy. Study selection Articles containing information related to brain stimulation or RNS for the treatment of refractory epilepsy were selected. Results The currently available treatment options for those patients who resist multiple antiepileptic medications and surgical procedures include electric stimulation, both direct and indirect, of brain nuclei thought to be involved in epileptogenesis. The number of potential targets has increased over the years to include the anterior nucleus of the thalamus, the centromedian nucleus of the thalamus, the hippocampus, the subthalamic nucleus, the caudate nucleus, and the cerebellum, among others. The results of a randomized controlled trial and the RNS trial were published to reveal the effectiveness. Conclusions Although statistically significant reductions in seizures have been observed using several different stimulation techniques, including vagus nerve stimulation, DBS, and RNS, these effects are currently only palliative and do not approach the efficacy comparable with that seen in resection in appropriately selected patients. More research is needed to determine optimal stimulation targets and techniques as well as to determine which epilepsy patients will benefit most from this technology.
文摘Barker first used transcranial magnetic stimulation in 1985 in human brain function research. Since then, it has gradually been developed into a secure and non-invasive treatment method for neurological diseases. In 1994, Pascual Leone first used it for the treatment of Parkinson's disease(PD) and observed an improvement in the motor symptoms of most of the patients. Recent studies have confirmed that both motor and non-motor symptoms of patients with PD could be improved through biochemical, electrophysiological, and functional magnetic resonance imaging analysis. Different therapeutic applications can be achieved by adjusting the stimulation parameters.Physical factors affecting the therapeutic effect include the shape and size of the coil, array orientation, materials and intensity, frequency of stimulus, etc.; the biological factors include stimulating targets, baseline, circadian rhythms, cerebral cortex thickness, and so on. This paper will review these factors and provide a reference for future research.
