[Objectives]To determine the optimal preparation technology of Clerodendrum bungei Steud.extract gel by orthogonal test and gel quality test method in General Rule 0114 of Chinese Pharmacopoeia(Volume IV,2020 Edition)...[Objectives]To determine the optimal preparation technology of Clerodendrum bungei Steud.extract gel by orthogonal test and gel quality test method in General Rule 0114 of Chinese Pharmacopoeia(Volume IV,2020 Edition),and to study its anorectal pharmacodynamics and drug release in vitro.[Methods]Carbomer 940,propylene glycol and absolute ethyl alcohol were selected as the main factors,and the preparation technology of C.bungei Steud.extract gel was optimized by orthogonal test.The mouse model of ulcerative hemorrhoids was established with glacial acetic acid(HAC)and compared with Ma Yinglong musk hemorrhoids ointment.The recovery of trauma was compared between the two groups.At the same time,porcine small intestine was used as semi-permeable membrane to make diffusion cell to simulate anal environment,and the drug release in vitro was studied.[Results]The C.bungei Steud.extract gel was smooth in appearance and good in stability.It could effectively treat anal ulcer in mice and release quickly in vitro.[Conclusions]The formula is reasonable,and the effect of animal experiment is remarkable,which can provide a new treatment plan for ulcerative hemorrhoids.展开更多
针对玉米杂草识别过程中因光照变化导致识别精确度低及漏检问题,该研究以幼苗期玉米及其伴生杂草为研究对象,设计一种基于WEED-YOLOv10的玉米杂草检测方法。首先,通过无人机快速采集田间高分辨率图像构建了玉米杂草数据集;其次,以YOLOv...针对玉米杂草识别过程中因光照变化导致识别精确度低及漏检问题,该研究以幼苗期玉米及其伴生杂草为研究对象,设计一种基于WEED-YOLOv10的玉米杂草检测方法。首先,通过无人机快速采集田间高分辨率图像构建了玉米杂草数据集;其次,以YOLOv10n为基线网络,将骨干网络替换为ConvNeXtV2以增强特征提取能力;继而,为避免因模块拼接可能带来的信息冗余或丢失问题提升对光照干扰的鲁棒性,嵌入CBAM注意力机制;然后,引入SlimNeck结构优化网络计算效率,有效平衡了模型计算资源消耗与特征表征能力;最后,使用Focaler-EIoU损失函数进一步提高模型定位精度。试验结果表明,WEED-YOLOv10在精确率、召回率、mAP@50、mAP@50:95和F1分数上分别达到85.4%、88.1%、90.9%、48.5%和86.7%,较基准模型分别提升了2.4、2.9、3.5、7.0、2.6个百分点,各项精度指标均优于其他对比模型,部署在NVIDIA Jetson orin NX上的图片推理速度达到28.7帧/s,实现了检测速度与精度的平衡。进一步地,基于WEED-YOLOv10开发对靶喷药系统,该系统实时捕捉并解析来自模型的识别信号,实现对除草喷施装置的精准调控。田间试验结果显示,对靶喷药系统施药准确率为93.7%,喷洒覆盖率为90.5%,对靶偏差为1.45cm,杂草实时检测速度为20.1帧/s,实现了自动化的玉米田间除草作业。该研究为复杂光照场景下农田杂草治理提供了可靠的技术方案,对推动农业智能化作业具有重要意义。展开更多
基金Supported by National Natural Science Foundation of China(31671954)。
文摘[Objectives]To determine the optimal preparation technology of Clerodendrum bungei Steud.extract gel by orthogonal test and gel quality test method in General Rule 0114 of Chinese Pharmacopoeia(Volume IV,2020 Edition),and to study its anorectal pharmacodynamics and drug release in vitro.[Methods]Carbomer 940,propylene glycol and absolute ethyl alcohol were selected as the main factors,and the preparation technology of C.bungei Steud.extract gel was optimized by orthogonal test.The mouse model of ulcerative hemorrhoids was established with glacial acetic acid(HAC)and compared with Ma Yinglong musk hemorrhoids ointment.The recovery of trauma was compared between the two groups.At the same time,porcine small intestine was used as semi-permeable membrane to make diffusion cell to simulate anal environment,and the drug release in vitro was studied.[Results]The C.bungei Steud.extract gel was smooth in appearance and good in stability.It could effectively treat anal ulcer in mice and release quickly in vitro.[Conclusions]The formula is reasonable,and the effect of animal experiment is remarkable,which can provide a new treatment plan for ulcerative hemorrhoids.
文摘针对玉米杂草识别过程中因光照变化导致识别精确度低及漏检问题,该研究以幼苗期玉米及其伴生杂草为研究对象,设计一种基于WEED-YOLOv10的玉米杂草检测方法。首先,通过无人机快速采集田间高分辨率图像构建了玉米杂草数据集;其次,以YOLOv10n为基线网络,将骨干网络替换为ConvNeXtV2以增强特征提取能力;继而,为避免因模块拼接可能带来的信息冗余或丢失问题提升对光照干扰的鲁棒性,嵌入CBAM注意力机制;然后,引入SlimNeck结构优化网络计算效率,有效平衡了模型计算资源消耗与特征表征能力;最后,使用Focaler-EIoU损失函数进一步提高模型定位精度。试验结果表明,WEED-YOLOv10在精确率、召回率、mAP@50、mAP@50:95和F1分数上分别达到85.4%、88.1%、90.9%、48.5%和86.7%,较基准模型分别提升了2.4、2.9、3.5、7.0、2.6个百分点,各项精度指标均优于其他对比模型,部署在NVIDIA Jetson orin NX上的图片推理速度达到28.7帧/s,实现了检测速度与精度的平衡。进一步地,基于WEED-YOLOv10开发对靶喷药系统,该系统实时捕捉并解析来自模型的识别信号,实现对除草喷施装置的精准调控。田间试验结果显示,对靶喷药系统施药准确率为93.7%,喷洒覆盖率为90.5%,对靶偏差为1.45cm,杂草实时检测速度为20.1帧/s,实现了自动化的玉米田间除草作业。该研究为复杂光照场景下农田杂草治理提供了可靠的技术方案,对推动农业智能化作业具有重要意义。
