A young Somali immigrant presents with a two-year history of a large, firm, painful right anterolateral chest wall sternal mass. The patient denied any history of trauma or infection at the site and did not have a fev...A young Somali immigrant presents with a two-year history of a large, firm, painful right anterolateral chest wall sternal mass. The patient denied any history of trauma or infection at the site and did not have a fever, erythematous lesion at the site, clubbing, or lymphadenopathy. A lateral chest radiograph demonstrated a low density mass isolated to the subcutaneous soft tissue overlying the sternum, ribs and clavicle. Computed tomography(CT) with contrast demonstrated a cystic lesion in the right anterolateral chest wall deep to the pectoralis muscle. Enhanced CT of the chest demonstrated sclerosis and destruction of the rib and costochondral joint and manubrio-sternal joint narrowing. Ultrasound-guided biopsy and aspiration returned 500 cc of purulent, cloudy yellow, foul-smelling fluid. Acidfact bacilli stain and the nucleic acid amplification test identified and confirmed Mycobacterium tuberculosis. A diagnosis of tuberculous osteomyelitis/septic arthritis was made and antibiotic coverage for tuberculosis was initiated.展开更多
BACKGROUND Chondrosarcoma,a cartilage matrix producing tumor,is the second most commonly observed primary bone tumor after osteosarcoma,accounting for 15%of all chest wall malignancies.We herein report the case of a p...BACKGROUND Chondrosarcoma,a cartilage matrix producing tumor,is the second most commonly observed primary bone tumor after osteosarcoma,accounting for 15%of all chest wall malignancies.We herein report the case of a patient with chondrosarcoma of the sternum and our management of the chest wall defects that presented following radical tumor resection.CASE SUMMARY A 31-year-old patient presented to our hospital with dull pain and a protruding mass overlying the chest for 3 mo.The presence of nocturnal pain and mass size progression was reported,as were overhead arm elevation-related limitations.Computed tomography showed a focal osteoblastic mass in the sternum with bony exostosis and adjacent soft tissue calcification.Positron emission tomography-computed tomography revealed hypermetabolic activity with a mass located over the upper sternum.Magnetic resonance imaging showed a focal illdefined bony mass of the sternum with cortical destruction and periosteal reaction.Preoperative biopsy showed a consistent result with chondrosarcoma with immunohistochemical positivity for S100 and focal positivity for IDH-1.The grade II chondrosarcoma diagnosis was confirmed by postoperative pathology.The patient underwent radical tumor resection and chest wall reconstruction with a locking plate and cement spacer.The patient was discharged 1 wk after surgery without any complications.At the 1-year follow-up,there was no local recurrence on imaging.The functional scores,including Constant Score,Nottingham Clavicle Score,and Oxford Shoulder Score,showed the absence of pain in the performance of daily activities or substantial functional disabilities.CONCLUSION The diagnosis of chondrosarcoma must be considered when chest wall tumors are encountered.The surgical reconstructive materials,with a locking plate and cement spacer,used in our study are cost-effective and readily-available for the sternum defect.展开更多
Chondrosarcoma is the most common malignant primary chest wall tumor, only 20% of these cases involve sternum. Current therapy for chondrosarcoma requires adequate surgical excision and radiation therapy, chemotherapy...Chondrosarcoma is the most common malignant primary chest wall tumor, only 20% of these cases involve sternum. Current therapy for chondrosarcoma requires adequate surgical excision and radiation therapy, chemotherapy have not been yet proved to be effective.展开更多
Thymic carcinoma is a malignancy of the anterior mediastinum with a poor prognosis that is thought to be derived from thymic epithelium and they represent approximately 6% of primary mediastinal tumors. Because of the...Thymic carcinoma is a malignancy of the anterior mediastinum with a poor prognosis that is thought to be derived from thymic epithelium and they represent approximately 6% of primary mediastinal tumors. Because of the lack of literature discussing the clinical and pathologic features and treatment of this tumor, thymic carcinoma has been a somewhat controversial disease up to now. Here, we report a female patient suffering from thymic carcinoma involving the sternum. The tumor was resected and the sternum was replaced with a refrigerated homograft.展开更多
文摘A young Somali immigrant presents with a two-year history of a large, firm, painful right anterolateral chest wall sternal mass. The patient denied any history of trauma or infection at the site and did not have a fever, erythematous lesion at the site, clubbing, or lymphadenopathy. A lateral chest radiograph demonstrated a low density mass isolated to the subcutaneous soft tissue overlying the sternum, ribs and clavicle. Computed tomography(CT) with contrast demonstrated a cystic lesion in the right anterolateral chest wall deep to the pectoralis muscle. Enhanced CT of the chest demonstrated sclerosis and destruction of the rib and costochondral joint and manubrio-sternal joint narrowing. Ultrasound-guided biopsy and aspiration returned 500 cc of purulent, cloudy yellow, foul-smelling fluid. Acidfact bacilli stain and the nucleic acid amplification test identified and confirmed Mycobacterium tuberculosis. A diagnosis of tuberculous osteomyelitis/septic arthritis was made and antibiotic coverage for tuberculosis was initiated.
文摘BACKGROUND Chondrosarcoma,a cartilage matrix producing tumor,is the second most commonly observed primary bone tumor after osteosarcoma,accounting for 15%of all chest wall malignancies.We herein report the case of a patient with chondrosarcoma of the sternum and our management of the chest wall defects that presented following radical tumor resection.CASE SUMMARY A 31-year-old patient presented to our hospital with dull pain and a protruding mass overlying the chest for 3 mo.The presence of nocturnal pain and mass size progression was reported,as were overhead arm elevation-related limitations.Computed tomography showed a focal osteoblastic mass in the sternum with bony exostosis and adjacent soft tissue calcification.Positron emission tomography-computed tomography revealed hypermetabolic activity with a mass located over the upper sternum.Magnetic resonance imaging showed a focal illdefined bony mass of the sternum with cortical destruction and periosteal reaction.Preoperative biopsy showed a consistent result with chondrosarcoma with immunohistochemical positivity for S100 and focal positivity for IDH-1.The grade II chondrosarcoma diagnosis was confirmed by postoperative pathology.The patient underwent radical tumor resection and chest wall reconstruction with a locking plate and cement spacer.The patient was discharged 1 wk after surgery without any complications.At the 1-year follow-up,there was no local recurrence on imaging.The functional scores,including Constant Score,Nottingham Clavicle Score,and Oxford Shoulder Score,showed the absence of pain in the performance of daily activities or substantial functional disabilities.CONCLUSION The diagnosis of chondrosarcoma must be considered when chest wall tumors are encountered.The surgical reconstructive materials,with a locking plate and cement spacer,used in our study are cost-effective and readily-available for the sternum defect.
文摘Chondrosarcoma is the most common malignant primary chest wall tumor, only 20% of these cases involve sternum. Current therapy for chondrosarcoma requires adequate surgical excision and radiation therapy, chemotherapy have not been yet proved to be effective.
文摘Thymic carcinoma is a malignancy of the anterior mediastinum with a poor prognosis that is thought to be derived from thymic epithelium and they represent approximately 6% of primary mediastinal tumors. Because of the lack of literature discussing the clinical and pathologic features and treatment of this tumor, thymic carcinoma has been a somewhat controversial disease up to now. Here, we report a female patient suffering from thymic carcinoma involving the sternum. The tumor was resected and the sternum was replaced with a refrigerated homograft.
