From May, 2000 to June, 2001, 27 patients with Parkinson disease (PD), including 10 cases of rigidity, 13 cases of tremor, 4 cases of rigidity and tremor, were treated by microelectrode guided technique. Among them, ...From May, 2000 to June, 2001, 27 patients with Parkinson disease (PD), including 10 cases of rigidity, 13 cases of tremor, 4 cases of rigidity and tremor, were treated by microelectrode guided technique. Among them, phlebotomy was carried out in 17 cases and thalamotomy in 10 cases. All the targets of lesion were anatomically located by using MR and neurophysiological signals on microelectrode. Our results showed that the efficiency of microelectrode guided technique for treatment of PD was 98 %. The postoperative unified parkinson disease rating scale were 12.3±9.1 and 13.2±8.9 respectively, which significantly improved as compared with those before operation. It was concluded that by recognizing special electrical signals in neurons microelectrode guided neuropsychological techniques can locate target at cellular level, which overcomes the individual difference in anatomy and function, and allow more accuracy, safety and efficiency of operation. This is especially true of PD patients who fail to respond to medical treatment.展开更多
Background:This study aimed to investigate the value of high field-strength intraoperative magnetic resonance imaging(iMRI)-guided stereotactic biopsy in the surgery of intracranial space-occupying lesions.Methods:A t...Background:This study aimed to investigate the value of high field-strength intraoperative magnetic resonance imaging(iMRI)-guided stereotactic biopsy in the surgery of intracranial space-occupying lesions.Methods:A total of 87 patients who underwent stereotactic biopsy of intracranial lesions in the Peking University International Hospital from March 2016 to August 2018 were retrospectively surveyed;among these,50 patients underwent MRI-guided stereotactic biopsy using the Leksell frame(iMRI group)and 37 cases received traditional stereotactic biopsy using the Leksell frame(control group).The accuracy rates and complications of the two groups were compared.Results:A 100%positive diagnosis was observed in all cases(n=50)in the iMRI group.In 4 cases,the biopsy site was clearly found to have deviated from the target point,and the biopsy was performed again.The control group had 33 cases(86.5%)with positive diagnosis.No severe complications like neural functional deficit were observed in the iMRI group,while two patients developed bleeding at the puncture site(1 case receiving surgery to remove the hematoma)in the control group.There were no deaths in either group.Conclusion:iMRI-assisted stereotactic biopsy can confirm the target position and adjust the puncture path in real time.Compared to the traditional stereotactic biopsy technique,the iMRI method has a higher positive diagnostic rate,though surgical trauma and complications have no significant difference.展开更多
The application ofstereotactic technique is rapidly growing. For instance, deep brain stimulation （DBS）, an important neurostimulation technique in the treatment of Parkinson＇s disease, dystonia, essential tremor, ...The application ofstereotactic technique is rapidly growing. For instance, deep brain stimulation （DBS）, an important neurostimulation technique in the treatment of Parkinson＇s disease, dystonia, essential tremor, and other diseases, uses the stereotactic method to implant electrodes.展开更多
文摘From May, 2000 to June, 2001, 27 patients with Parkinson disease (PD), including 10 cases of rigidity, 13 cases of tremor, 4 cases of rigidity and tremor, were treated by microelectrode guided technique. Among them, phlebotomy was carried out in 17 cases and thalamotomy in 10 cases. All the targets of lesion were anatomically located by using MR and neurophysiological signals on microelectrode. Our results showed that the efficiency of microelectrode guided technique for treatment of PD was 98 %. The postoperative unified parkinson disease rating scale were 12.3±9.1 and 13.2±8.9 respectively, which significantly improved as compared with those before operation. It was concluded that by recognizing special electrical signals in neurons microelectrode guided neuropsychological techniques can locate target at cellular level, which overcomes the individual difference in anatomy and function, and allow more accuracy, safety and efficiency of operation. This is especially true of PD patients who fail to respond to medical treatment.
文摘Background:This study aimed to investigate the value of high field-strength intraoperative magnetic resonance imaging(iMRI)-guided stereotactic biopsy in the surgery of intracranial space-occupying lesions.Methods:A total of 87 patients who underwent stereotactic biopsy of intracranial lesions in the Peking University International Hospital from March 2016 to August 2018 were retrospectively surveyed;among these,50 patients underwent MRI-guided stereotactic biopsy using the Leksell frame(iMRI group)and 37 cases received traditional stereotactic biopsy using the Leksell frame(control group).The accuracy rates and complications of the two groups were compared.Results:A 100%positive diagnosis was observed in all cases(n=50)in the iMRI group.In 4 cases,the biopsy site was clearly found to have deviated from the target point,and the biopsy was performed again.The control group had 33 cases(86.5%)with positive diagnosis.No severe complications like neural functional deficit were observed in the iMRI group,while two patients developed bleeding at the puncture site(1 case receiving surgery to remove the hematoma)in the control group.There were no deaths in either group.Conclusion:iMRI-assisted stereotactic biopsy can confirm the target position and adjust the puncture path in real time.Compared to the traditional stereotactic biopsy technique,the iMRI method has a higher positive diagnostic rate,though surgical trauma and complications have no significant difference.
基金This study was supported by grants from National Natural Science Foundation of China，Administration of Hospitals Clinical Medicine Development of Special Funding，Scientific Research Common Program of Beijing Municipal Commission of Education
文摘The application ofstereotactic technique is rapidly growing. For instance, deep brain stimulation （DBS）, an important neurostimulation technique in the treatment of Parkinson＇s disease, dystonia, essential tremor, and other diseases, uses the stereotactic method to implant electrodes.
