Herein,we developed a tertiary amine-catalyzed stereoretentive multi-component cascade reaction featuring an amidation/[4+1]annulation/decarboxylation/Curtius rearrangement/[2+n]annulation sequence.This metal-free and...Herein,we developed a tertiary amine-catalyzed stereoretentive multi-component cascade reaction featuring an amidation/[4+1]annulation/decarboxylation/Curtius rearrangement/[2+n]annulation sequence.This metal-free and step-economic method provided a broad range of cyclic ureas/urethanes in green solvent under mild conditions without employing explosive and toxic reagents.Importantly,this reaction generated isocyanates in situ under catalytic conditions via a decarboxylation/Curtius rearrangement process of dioxazolones.展开更多
基金financial support provided by the National Natural Science Foundation of China(22207063)111 Project(D20015),Hubei Provincial Central Government Guided Local Science and Technology Development Project(2024BSB016)+1 种基金Natural Science Research Project of Yichang City(A23-2-002)the Opening Funding of Hubei Key Laboratory of Natural Products Research and Development,China Three Gorges University(2024NPRD03,2024NPRD04,2024NPRD05).
文摘Herein,we developed a tertiary amine-catalyzed stereoretentive multi-component cascade reaction featuring an amidation/[4+1]annulation/decarboxylation/Curtius rearrangement/[2+n]annulation sequence.This metal-free and step-economic method provided a broad range of cyclic ureas/urethanes in green solvent under mild conditions without employing explosive and toxic reagents.Importantly,this reaction generated isocyanates in situ under catalytic conditions via a decarboxylation/Curtius rearrangement process of dioxazolones.
