A subchronic oral toxicity was conducted to evaluate the safety of total flavones of E. leptorrhizum Stearn in Sprague-Dawley rats. The test article was administered once daily by gavage in male and female rats at dos...A subchronic oral toxicity was conducted to evaluate the safety of total flavones of E. leptorrhizum Stearn in Sprague-Dawley rats. The test article was administered once daily by gavage in male and female rats at dose levels of 24, 48, and 96 mg/kg body weight/day for 180 days. 90 and 180 days after administration, ten and tweedy animals (each half of male and female) of each group were tested. 28 days after withdrawal, five male and female rats were tested. There were no significant toxicological changes shown in daily clinical signs, body weight, food consumption, hematology parameters, blood biochemistry, organ weights and histopathological examination except leukocyte differential count. It was concluded that the no-observed-effect level (NOEL) for total flavones of E. leptorrhizum Stearn was >96 mg/kg in SD rats.展开更多
目的基于文献研究归纳新外来中药海葱的中药药性,应用智能感官进一步验证并探讨其五味药性,为新外来中药的药性研究提供思路。方法通过中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(Wanfang Data)、PubMed、We...目的基于文献研究归纳新外来中药海葱的中药药性,应用智能感官进一步验证并探讨其五味药性,为新外来中药的药性研究提供思路。方法通过中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(Wanfang Data)、PubMed、Web of Science检索海葱相关研究文献,结合中医理论归纳海葱的中药药性。应用PEN3型电子鼻和SA402B型电子舌采集海葱的智能感官信息,利用主成分分析法辨识海葱的五味药性。结果通过文献研究归纳得到海葱具有抗氧化、抗肿瘤、强心利尿、止咳平喘等药理作用,结合理论探讨可知,海葱性微温,味苦、辛、甘,有小毒,归肺、脾、胃、心经。基于智能感官的海葱五味药性辨识结果为苦、微辛、微甘、咸、非酸,与文献研究结果基本一致。结论通过文献研究结合智能感官可以较好地归纳和辨识海葱的中药药性,本研究可为客观、充分地探析新外来中药的药性提供参考。展开更多
文摘A subchronic oral toxicity was conducted to evaluate the safety of total flavones of E. leptorrhizum Stearn in Sprague-Dawley rats. The test article was administered once daily by gavage in male and female rats at dose levels of 24, 48, and 96 mg/kg body weight/day for 180 days. 90 and 180 days after administration, ten and tweedy animals (each half of male and female) of each group were tested. 28 days after withdrawal, five male and female rats were tested. There were no significant toxicological changes shown in daily clinical signs, body weight, food consumption, hematology parameters, blood biochemistry, organ weights and histopathological examination except leukocyte differential count. It was concluded that the no-observed-effect level (NOEL) for total flavones of E. leptorrhizum Stearn was >96 mg/kg in SD rats.
文摘目的基于文献研究归纳新外来中药海葱的中药药性,应用智能感官进一步验证并探讨其五味药性,为新外来中药的药性研究提供思路。方法通过中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(Wanfang Data)、PubMed、Web of Science检索海葱相关研究文献,结合中医理论归纳海葱的中药药性。应用PEN3型电子鼻和SA402B型电子舌采集海葱的智能感官信息,利用主成分分析法辨识海葱的五味药性。结果通过文献研究归纳得到海葱具有抗氧化、抗肿瘤、强心利尿、止咳平喘等药理作用,结合理论探讨可知,海葱性微温,味苦、辛、甘,有小毒,归肺、脾、胃、心经。基于智能感官的海葱五味药性辨识结果为苦、微辛、微甘、咸、非酸,与文献研究结果基本一致。结论通过文献研究结合智能感官可以较好地归纳和辨识海葱的中药药性,本研究可为客观、充分地探析新外来中药的药性提供参考。
