The axial piston pump usually works under variable speed conditions.It is important to evaluate the health status of the axial piston pump under the variable speed condition.Aiming at the characteristic signals obtain...The axial piston pump usually works under variable speed conditions.It is important to evaluate the health status of the axial piston pump under the variable speed condition.Aiming at the characteristic signals obtained under different wear levels of the port plate,a feature signal extraction method under variable speed conditions is proposed.Firstly,the combination of complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN)energy spectrum and fast spectral kurtosis principle is used to accurately extract the intrinsic mode function(IMF)component containing the sensitive information of the degraded feature.Then,the aspect ratio analysis method of the angle domain variational mode decomposition(VMD)is used to process the feature index containing the sensitive information of the degraded feature.In order to evaluate the health status of the axial piston pump under variable speed,the vibration reliability analysis method for axial piston pump based on Weibull proportional failure rate model is proposed.The experimental results show that the proposed method can accurately evaluate the health status of the axial piston pump.展开更多
Using historical and 2010 field data, the distribution of nutrients in the northern Beibu Gulf of China is described. There was a decreasing trend in the concentration of nutrients from the north coast to offshore wat...Using historical and 2010 field data, the distribution of nutrients in the northern Beibu Gulf of China is described. There was a decreasing trend in the concentration of nutrients from the north coast to offshore waters of the northern Beibu Gulf, reflecting the influence of inputs from land-based sources. High concentrations of dissolved inorganic nitrogen （DIN） and phosphate （PO4-P） occurred mainly at Fangchenggang Bay, Qinzhou Bay, and Lianzhou Bay. Four different methods were used to assess eutrophication. The trophic status of the Beibu Gulf was characterized using the single factor, Eutrophication index （El）, Trophic index （TRIX） and Assessment of Estuarine Trophic Status （ASSETS） methods. Based on nutrient concentrations, 73.9% of DIN and 26.7% of PO4-P samples exceeded the fourth grade Seawater Quality Standard of China. Eutrophication index values varied widely, but higher levels of eutrophication were generally found in bays and estuaries. TRIX values ranged from 2.61 to 7.27, with an average of 4.98, indicating a mesotrophic and moderately productive system. A positive correlation between TRIX and harmful algal species richness and abundance was observed. The ASSETS model evaluates eutrophication status based on a Pressure-State-Response approach, including three main indices： influencing factors, overall eutrophic condition, and future outlook. The Beibu Gulf was graded as moderate using ASSETS. The single factor and Chinese nutrient index methods were considered inadequate for the assessment of trophic status. TRIX can be used as an indicator of trophic state and ASSETS showed good potential to assess eutrophication. The results of TRIX and ASSETS depend on threshold values. To establish these values, further research is required within the northern Beibu Gulf.展开更多
Eco-security assessment is a hot research area in resource and environmental science,which involves data with much spatial,non-linear,and random features.Geographic information system(GIS),as a useful tool to analyze ...Eco-security assessment is a hot research area in resource and environmental science,which involves data with much spatial,non-linear,and random features.Geographic information system(GIS),as a useful tool to analyze and manage spatial information,has a superior advantage in this field.A case study in the western part of the Liaohe River featuring a method of eco-security spatial differences(ESSD)based on GIS is developed in this paper.The method includes four steps:1)developing the pressure-state-response(P-S-R)framework with site data;2)digitizing West-Liaohe River and setting its GRID database of eco-security assessment indicators;3)figuring out the relative membership degree(RMD)of eco-security indicators by using the analytical hierarchy process with the weight of indicator;4)classifying the security zone and mapping the assessment result of eco-security status in grid by GIS method of assigning and clustering.The visual spatial differences of eco-security based on GIS enables decision makers to know the status of eco-security better in making policies for achieving sustainability.展开更多
To assess the status and change trend of forest in China,an indicator framework was developed using SDG sub-indicators.In this paper,we propose an improved methodology and a set of workflows for calculating SDG indica...To assess the status and change trend of forest in China,an indicator framework was developed using SDG sub-indicators.In this paper,we propose an improved methodology and a set of workflows for calculating SDG indicators.The main modification include the use of moderate and high spatial resolution satellite data,as well as state-of-the-art machine learning techniques for forest cover classification and estimation of forest above-ground biomass(AGB).This research employs GF-1 and GF-2 data with enhanced texture information to map forest cover,while time series Landsat data is used to estimate forest AGB across the whole territory of China.The study calculate two SDG sub-indicators:SDG_(15.1.1) for forest area and SDG_(15.2.1) for sustainable forest management.The evaluation results showed that the total forest area in China was approximately 219 million hectares at the end of 2021,accounting for about 23.51%of the land area.The average annual forest AGB from 2015 to 2021 was estimated to be 105.01Mg/ha,and the overall trend of forest AGB change in China was positive,albeit with some spatial differences.展开更多
A health status assessment method based on cross entropy and support vector machine(SVM)is proposed for the new urban rail vehicle traction systems.First,an index system for health assessment of the traction system is...A health status assessment method based on cross entropy and support vector machine(SVM)is proposed for the new urban rail vehicle traction systems.First,an index system for health assessment of the traction system is established,and combined weights of the index layer are obtained via cross entropy.Then,an SVM assessment model considering actual operating data and each status level of the traction system is established.Finally,the model is simulated in Matlab to obtain assessment results.The results indicate that the proposed method can provide the health status information of the traction system intuitively and complete the health status assessment of the traction system of the new urban rail vehicle effectively,by exploiting the traction system’s layered analysis model.The health status can be assessed accurately and reliably by adopting the cross entropy theory and SVM theory.展开更多
Mine environmental evaluation is the key to mine environmental study. On the basis of the characteristics of the mine environmental problems, they are classified into （1） three wastes problem, （2） ground distortio...Mine environmental evaluation is the key to mine environmental study. On the basis of the characteristics of the mine environmental problems, they are classified into （1） three wastes problem, （2） ground distortion, （3） contradiction among mine drainage, water supply, ecological environment, （4） desertification, and （5） soil erosion. The evaluation is the basis of mine environmental problem classification and investigation, mine environmental rehabilitation, and the information system constructed can be used for subsequent research of evaluation techniques. A synthetic assessment of the 5 kinds of mine environmental problems can be divided into single-factor or multi-factor synthetic assessments; while by the viewpoint of time, the mine environmental assessment can be classified as the historical assessment, the current status assessment and the forecasting assessment.展开更多
The river ecosystem in the Hai River Basin（HRB）, an important economic region in China, is seriously degraded. With the aim of river restoration in the HRB, we developed a method to assess the river＇s ecological st...The river ecosystem in the Hai River Basin（HRB）, an important economic region in China, is seriously degraded. With the aim of river restoration in the HRB, we developed a method to assess the river＇s ecological status and conducted a preliminary application of the method.The established method was a predictive model, which used macroinvertebrates as indicator organisms. The river＇s ecological status was determined by calculating the ratio of observed to expected values（O/E）. The method included ecoregionalization according to natural factors, and the selection of reference sites based on combinations of habitat quality and macroinvertebrate community. Macroinvertebrate taxa included Insecta,Crustacea, Gastropoda, and Oligochaeta, with 39 families and 95 genera identified in the HRB. The HRB communities were dominated by pollution tolerant taxa, such as Lymnaeidae, Chironomus, Limnodrilus, Glyptotendipes, and Tubifex. The average Shannon–Wiener index was 1.40 ± 0.5, indicating a low biodiversity. In the river length of 3.31 × 10^4 km, 55% of the sites were designated poor, with a bad ecological status. Among nine secondary river systems, Luan and Zi-ya had the best and worst river conditions,respectively. Only 17 reference site groups were selected for river management in the 41 ecoregions examined. This study lays the foundation for river restoration and related research in the HRB, and we anticipate further developments of this novel method.展开更多
The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical field.Patients with COVID-19 usually have respiratory symptoms.Ho...The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical field.Patients with COVID-19 usually have respiratory symptoms.However,liver dysfunction is not an uncommon presentation.Additionally,the degree of liver dysfunction is associated with the severity and prognosis of COVID-19.Prevention,diagnosis,and treatment of malnutrition should be routinely recommended in the management of patients with COVID-19,especially in those with liver dysfunction.Recently,a large number of studies have reported that nutrition therapy measures,including natural dietary supplements,vitamins,minerals and trace elements,and probiotics,might have potential hepatoprotective effects against COVID-19-related liver dysfunction via their antioxidant,antiviral,anti-inflammatory,and positive immunomodulatory effects.This review mainly focuses on the possible relationship between COVID-19 and liver dysfunction,nutritional and metabolic characteristics,nutritional status assessment,and nutrition therapy to provide a reference for the nutritionists while making evidence-based nutritional decisions during the COVID-19 pandemic.展开更多
Objective To understand the iodine nutritional status of people in Qinghai Province after implementation of new standard of salt iodine,and provide the basis for prevention and control of iodine deficiency disorders.M...Objective To understand the iodine nutritional status of people in Qinghai Province after implementation of new standard of salt iodine,and provide the basis for prevention and control of iodine deficiency disorders.Methods The monitoring data of 2011 and 2014展开更多
Introduction:To construct a set of evaluation indicators suitable for the public health system in primary and secondary schools in Beijing,this study aimed to provide a basis for objectively assessing the current stat...Introduction:To construct a set of evaluation indicators suitable for the public health system in primary and secondary schools in Beijing,this study aimed to provide a basis for objectively assessing the current status of system development and identifying future directions for improvement.Methods:An indicator pool was established based on literature reviews and expert consultation.The indicator system was then refined and finalized through two rounds of the Delphi method,and the weights of the indicators were determined using the analytic hierarchy process.Results:The expert participation rate reached 100%,and the average expert authority coefficient was 0.87.The indicator coordination coefficient W was statistically significant(P<0.001).Ultimately,an evaluation system comprising 5 first-level indicators,15 second-level indicators,and 39 third-level indicators was developed.Conclusion:The indicator system constructed in this study shows good expert consistency and credibility.It can effectively pinpoint key components of system development,providing a scientific foundation for optimizing resource allocation and supporting ongoing improvement.展开更多
Objective To assess the frailty status of patients with heart failure undergoing CRT-D and then explore the predictive value of frailty for all-cause mortality and heart failure-related readmissions in these patients....Objective To assess the frailty status of patients with heart failure undergoing CRT-D and then explore the predictive value of frailty for all-cause mortality and heart failure-related readmissions in these patients.Methods We retrospectively included 374 patients with chronic heart failure who underwent CRT-D treatment at the First Affiliated Hospitalof Xinjiang NMedical University between June 2020 and June 2024.Based on the Tilburg Debilitation Assessment Scale,175 patients(46.8%)were classified as frail while 199(53.2%)were classified as non-frail.The baseline data between the two groups was compared using Cox regression analysis and Kaplan-Meier curveswere used for survival analysis.P-values of<0.05 indicated statistically significant differences.Results A total of 374 patients aged 25-93(68±11)years were enrolled in this study,101(27.0%)of whom were female.Among these,175(46.8%)were categorized as frail,and 199(53.2%)were classified as non-frail.Over a median follow-up time of 23(5,45)months,35(9.4%)patients experienced all-cause mortality,with 30(17.1%)deaths occurring in the frail group and 5(2.5%)in the non-frail group;meanwhile,readmission events due to heart failure occurred in a total of 174(46.5%)patients,including 122(70.1%)in the frail group,and 52(29.9%)in the non-frail group.Cox analysis showed that frailty was a significant determinant of all-cause mortality(HR=21.25,95%CI 3.99-113.30,P<0.001)and readmission among heart failure patients receiving CRT-D(HR=2.52,95%CI 1.73-3.68,P<0.001).Log-rank tests showed that the survival rate of patients in the frail group was significantly lower than that of patients in the non-frail group(HR=7.22,95%CI 2.80-18.60,P<0.001)and the risk of readmission events due to heart failure was significantly higher among patients in the frail group than among those in the non-frail group(HR=2.75,95%CI 1.98-3.81,P<0.001).Conclusion Frailty is an independent predictor of postoperative all-cause mortality and the occurrenceof heart failure-related readmissions in patients with heart failure receiving CRT-D.展开更多
To the Editor:Immune checkpoint inhibitors(ICIs)have shown remarkable clinical responses;however,their efficacy remains limited to a small subset of patients.Peripheral blood mononuclear cells(PBMCs)offer an effective...To the Editor:Immune checkpoint inhibitors(ICIs)have shown remarkable clinical responses;however,their efficacy remains limited to a small subset of patients.Peripheral blood mononuclear cells(PBMCs)offer an effective,accessible,and minimally invasive approach to assess tumor immune status and identify ICI responders.In this study,we aimed to elucidate the role of PBMC gene expression in ICI treatment response and prognosis.This study received approval from the Biomedical Ethics Committee of West China Hospital,Sichuan University(No.2019[1045])and the requirement to obtain informed consent was waived.展开更多
基金Supported by the National Key Research and Development Program of China(No.2019YFB2005204)the National Natural Science Foundation of China(No.52075469,51675461,11673040)+1 种基金the Key Research and Development Program of Hebei Province(No.19273708D)the Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems(No.GZKF-201922).
文摘The axial piston pump usually works under variable speed conditions.It is important to evaluate the health status of the axial piston pump under the variable speed condition.Aiming at the characteristic signals obtained under different wear levels of the port plate,a feature signal extraction method under variable speed conditions is proposed.Firstly,the combination of complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN)energy spectrum and fast spectral kurtosis principle is used to accurately extract the intrinsic mode function(IMF)component containing the sensitive information of the degraded feature.Then,the aspect ratio analysis method of the angle domain variational mode decomposition(VMD)is used to process the feature index containing the sensitive information of the degraded feature.In order to evaluate the health status of the axial piston pump under variable speed,the vibration reliability analysis method for axial piston pump based on Weibull proportional failure rate model is proposed.The experimental results show that the proposed method can accurately evaluate the health status of the axial piston pump.
基金Supported by the Natural Science Foundation of Guangxi Province,China(Nos.2012GXNSFEA053001,2010GXNSFE013001,2011GXNSFE018002,2011GXNSFA018108)
文摘Using historical and 2010 field data, the distribution of nutrients in the northern Beibu Gulf of China is described. There was a decreasing trend in the concentration of nutrients from the north coast to offshore waters of the northern Beibu Gulf, reflecting the influence of inputs from land-based sources. High concentrations of dissolved inorganic nitrogen （DIN） and phosphate （PO4-P） occurred mainly at Fangchenggang Bay, Qinzhou Bay, and Lianzhou Bay. Four different methods were used to assess eutrophication. The trophic status of the Beibu Gulf was characterized using the single factor, Eutrophication index （El）, Trophic index （TRIX） and Assessment of Estuarine Trophic Status （ASSETS） methods. Based on nutrient concentrations, 73.9% of DIN and 26.7% of PO4-P samples exceeded the fourth grade Seawater Quality Standard of China. Eutrophication index values varied widely, but higher levels of eutrophication were generally found in bays and estuaries. TRIX values ranged from 2.61 to 7.27, with an average of 4.98, indicating a mesotrophic and moderately productive system. A positive correlation between TRIX and harmful algal species richness and abundance was observed. The ASSETS model evaluates eutrophication status based on a Pressure-State-Response approach, including three main indices： influencing factors, overall eutrophic condition, and future outlook. The Beibu Gulf was graded as moderate using ASSETS. The single factor and Chinese nutrient index methods were considered inadequate for the assessment of trophic status. TRIX can be used as an indicator of trophic state and ASSETS showed good potential to assess eutrophication. The results of TRIX and ASSETS depend on threshold values. To establish these values, further research is required within the northern Beibu Gulf.
基金This work was supported by the National Natural Science Foundation of China(Grant No.70073003)the Specialized Research Found for the Doctoral Program of Higher Education of MOE of China(Grant No.20020141027)the Fund for Youth Scholars from the Department of Education of Liaoning Province(Grant No.2004F010).
文摘Eco-security assessment is a hot research area in resource and environmental science,which involves data with much spatial,non-linear,and random features.Geographic information system(GIS),as a useful tool to analyze and manage spatial information,has a superior advantage in this field.A case study in the western part of the Liaohe River featuring a method of eco-security spatial differences(ESSD)based on GIS is developed in this paper.The method includes four steps:1)developing the pressure-state-response(P-S-R)framework with site data;2)digitizing West-Liaohe River and setting its GRID database of eco-security assessment indicators;3)figuring out the relative membership degree(RMD)of eco-security indicators by using the analytical hierarchy process with the weight of indicator;4)classifying the security zone and mapping the assessment result of eco-security status in grid by GIS method of assigning and clustering.The visual spatial differences of eco-security based on GIS enables decision makers to know the status of eco-security better in making policies for achieving sustainability.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA 19090300,XDA 19090124)the National Natural Science Foundation of China(61731022)+1 种基金the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK030701)Chinese Academy of Sciences Net-work Security and Informatization Special Project(CAS-WX2021PY-0107-01).
文摘To assess the status and change trend of forest in China,an indicator framework was developed using SDG sub-indicators.In this paper,we propose an improved methodology and a set of workflows for calculating SDG indicators.The main modification include the use of moderate and high spatial resolution satellite data,as well as state-of-the-art machine learning techniques for forest cover classification and estimation of forest above-ground biomass(AGB).This research employs GF-1 and GF-2 data with enhanced texture information to map forest cover,while time series Landsat data is used to estimate forest AGB across the whole territory of China.The study calculate two SDG sub-indicators:SDG_(15.1.1) for forest area and SDG_(15.2.1) for sustainable forest management.The evaluation results showed that the total forest area in China was approximately 219 million hectares at the end of 2021,accounting for about 23.51%of the land area.The average annual forest AGB from 2015 to 2021 was estimated to be 105.01Mg/ha,and the overall trend of forest AGB change in China was positive,albeit with some spatial differences.
基金Supported by the Basic Ability Improvement Project for Young and Middle-aged Teachers in Guangxi Province(2018KY1159).
文摘A health status assessment method based on cross entropy and support vector machine(SVM)is proposed for the new urban rail vehicle traction systems.First,an index system for health assessment of the traction system is established,and combined weights of the index layer are obtained via cross entropy.Then,an SVM assessment model considering actual operating data and each status level of the traction system is established.Finally,the model is simulated in Matlab to obtain assessment results.The results indicate that the proposed method can provide the health status information of the traction system intuitively and complete the health status assessment of the traction system of the new urban rail vehicle effectively,by exploiting the traction system’s layered analysis model.The health status can be assessed accurately and reliably by adopting the cross entropy theory and SVM theory.
基金China National Natural Science Foundation（Grant No.40572149,40772162）；National Key Project of Scientific and Technical Supporting Programs （2007BAK24B01,2006BAB16B04）；the “973” Project(Grant No.2006CB202205）the Key Projects of Ministry of Education of P.R.China（Grant No.2004-295）.
文摘Mine environmental evaluation is the key to mine environmental study. On the basis of the characteristics of the mine environmental problems, they are classified into （1） three wastes problem, （2） ground distortion, （3） contradiction among mine drainage, water supply, ecological environment, （4） desertification, and （5） soil erosion. The evaluation is the basis of mine environmental problem classification and investigation, mine environmental rehabilitation, and the information system constructed can be used for subsequent research of evaluation techniques. A synthetic assessment of the 5 kinds of mine environmental problems can be divided into single-factor or multi-factor synthetic assessments; while by the viewpoint of time, the mine environmental assessment can be classified as the historical assessment, the current status assessment and the forecasting assessment.
基金provided by the ‘National Water Pollution Control and Management Technology Major Projects of China (2012ZX07203-006)’
文摘The river ecosystem in the Hai River Basin（HRB）, an important economic region in China, is seriously degraded. With the aim of river restoration in the HRB, we developed a method to assess the river＇s ecological status and conducted a preliminary application of the method.The established method was a predictive model, which used macroinvertebrates as indicator organisms. The river＇s ecological status was determined by calculating the ratio of observed to expected values（O/E）. The method included ecoregionalization according to natural factors, and the selection of reference sites based on combinations of habitat quality and macroinvertebrate community. Macroinvertebrate taxa included Insecta,Crustacea, Gastropoda, and Oligochaeta, with 39 families and 95 genera identified in the HRB. The HRB communities were dominated by pollution tolerant taxa, such as Lymnaeidae, Chironomus, Limnodrilus, Glyptotendipes, and Tubifex. The average Shannon–Wiener index was 1.40 ± 0.5, indicating a low biodiversity. In the river length of 3.31 × 10^4 km, 55% of the sites were designated poor, with a bad ecological status. Among nine secondary river systems, Luan and Zi-ya had the best and worst river conditions,respectively. Only 17 reference site groups were selected for river management in the 41 ecoregions examined. This study lays the foundation for river restoration and related research in the HRB, and we anticipate further developments of this novel method.
基金Supported by Major Construction Program of Military Key Disciplines during the 13^(th)Five-Year Plan Period,No.2020SZ21-15。
文摘The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical field.Patients with COVID-19 usually have respiratory symptoms.However,liver dysfunction is not an uncommon presentation.Additionally,the degree of liver dysfunction is associated with the severity and prognosis of COVID-19.Prevention,diagnosis,and treatment of malnutrition should be routinely recommended in the management of patients with COVID-19,especially in those with liver dysfunction.Recently,a large number of studies have reported that nutrition therapy measures,including natural dietary supplements,vitamins,minerals and trace elements,and probiotics,might have potential hepatoprotective effects against COVID-19-related liver dysfunction via their antioxidant,antiviral,anti-inflammatory,and positive immunomodulatory effects.This review mainly focuses on the possible relationship between COVID-19 and liver dysfunction,nutritional and metabolic characteristics,nutritional status assessment,and nutrition therapy to provide a reference for the nutritionists while making evidence-based nutritional decisions during the COVID-19 pandemic.
文摘Objective To understand the iodine nutritional status of people in Qinghai Province after implementation of new standard of salt iodine,and provide the basis for prevention and control of iodine deficiency disorders.Methods The monitoring data of 2011 and 2014
基金Supported by an open research project of the Capital Institute of Health Management and Policy(2023JD05).
文摘Introduction:To construct a set of evaluation indicators suitable for the public health system in primary and secondary schools in Beijing,this study aimed to provide a basis for objectively assessing the current status of system development and identifying future directions for improvement.Methods:An indicator pool was established based on literature reviews and expert consultation.The indicator system was then refined and finalized through two rounds of the Delphi method,and the weights of the indicators were determined using the analytic hierarchy process.Results:The expert participation rate reached 100%,and the average expert authority coefficient was 0.87.The indicator coordination coefficient W was statistically significant(P<0.001).Ultimately,an evaluation system comprising 5 first-level indicators,15 second-level indicators,and 39 third-level indicators was developed.Conclusion:The indicator system constructed in this study shows good expert consistency and credibility.It can effectively pinpoint key components of system development,providing a scientific foundation for optimizing resource allocation and supporting ongoing improvement.
文摘Objective To assess the frailty status of patients with heart failure undergoing CRT-D and then explore the predictive value of frailty for all-cause mortality and heart failure-related readmissions in these patients.Methods We retrospectively included 374 patients with chronic heart failure who underwent CRT-D treatment at the First Affiliated Hospitalof Xinjiang NMedical University between June 2020 and June 2024.Based on the Tilburg Debilitation Assessment Scale,175 patients(46.8%)were classified as frail while 199(53.2%)were classified as non-frail.The baseline data between the two groups was compared using Cox regression analysis and Kaplan-Meier curveswere used for survival analysis.P-values of<0.05 indicated statistically significant differences.Results A total of 374 patients aged 25-93(68±11)years were enrolled in this study,101(27.0%)of whom were female.Among these,175(46.8%)were categorized as frail,and 199(53.2%)were classified as non-frail.Over a median follow-up time of 23(5,45)months,35(9.4%)patients experienced all-cause mortality,with 30(17.1%)deaths occurring in the frail group and 5(2.5%)in the non-frail group;meanwhile,readmission events due to heart failure occurred in a total of 174(46.5%)patients,including 122(70.1%)in the frail group,and 52(29.9%)in the non-frail group.Cox analysis showed that frailty was a significant determinant of all-cause mortality(HR=21.25,95%CI 3.99-113.30,P<0.001)and readmission among heart failure patients receiving CRT-D(HR=2.52,95%CI 1.73-3.68,P<0.001).Log-rank tests showed that the survival rate of patients in the frail group was significantly lower than that of patients in the non-frail group(HR=7.22,95%CI 2.80-18.60,P<0.001)and the risk of readmission events due to heart failure was significantly higher among patients in the frail group than among those in the non-frail group(HR=2.75,95%CI 1.98-3.81,P<0.001).Conclusion Frailty is an independent predictor of postoperative all-cause mortality and the occurrenceof heart failure-related readmissions in patients with heart failure receiving CRT-D.
基金National Natural Science Foundation of China(No.NSFC82372331)Project of Science and Technology Department of Sichuan Province(Nos.2024NSFSC1551 and 2023NSFSC0716)
文摘To the Editor:Immune checkpoint inhibitors(ICIs)have shown remarkable clinical responses;however,their efficacy remains limited to a small subset of patients.Peripheral blood mononuclear cells(PBMCs)offer an effective,accessible,and minimally invasive approach to assess tumor immune status and identify ICI responders.In this study,we aimed to elucidate the role of PBMC gene expression in ICI treatment response and prognosis.This study received approval from the Biomedical Ethics Committee of West China Hospital,Sichuan University(No.2019[1045])and the requirement to obtain informed consent was waived.
