In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the ...In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.展开更多
This paper investigates and analyzes the general situation of the tomato seed production industry in Lintong District,Xi'an City.Development strategies and suggestions are proposed to address existing problems.The...This paper investigates and analyzes the general situation of the tomato seed production industry in Lintong District,Xi'an City.Development strategies and suggestions are proposed to address existing problems.These include strengthening technological innovation and variety R&D,promoting industrial standardization and intelligent upgrading,enhancing brand building and market expansion,improving policy support and industrial chain coordination,strengthening intellectual property protection and talent cultivation,and expanding sales channels to promote industrial transformation and upgrading.展开更多
impacting quality of life.This study aimed to identify technological nursing interventions that promote self-care and improve the nutritional status of middle-aged and older adults undergoing hemodialysis.Methods:A sy...impacting quality of life.This study aimed to identify technological nursing interventions that promote self-care and improve the nutritional status of middle-aged and older adults undergoing hemodialysis.Methods:A systematic literature review was conducted in accordance with the Joanna Briggs Institute(JBI)and PRISMA guidelines.Searches were conducted in Medline,CINAHL,the Cochrane Library,Scopus,Web of Science,and grey literature,Studies published between 2018 and 2024,involving patients aged 40 years or more undergoing regular hemodialysis,and available in Portuguese,English,or Spanish,were included.JBI's critical appraisal tools were used to conduct a rigorous analysis and methodological quality assessment of the articles.Results:Out of a total of 738 articles,10 were included for analysis.Five key dimensions of technologydriven self-care interventions were established.1)Mobile applications and digital platforms with features like nutritional databases,food logging,and personalized feedback;2)E-learning and virtual education using social media and chat-based communication;3)Telenursing employing a hybrid follow-up model of face-to-face,telephone,and SMS contact;4)Educational strategies focused on nutritional status,utilizing methods such as teach-back and pictorial learning within a multidisciplinary team;and 5)Comprehensive assessment tools evaluating treatment adherence(hemodialysis,medication,diet,fluid)and laboratory markers.Significant improvements were reported across several outcomes:eight studies showed enhanced biochemical markers(e.g.,phosphorus,sodium,potassium,calcium,iron,albumin,urea,and hemoglobin)and nutritional status,three demonstrated increased selfefficacy,and two reported improved quality of life.Conclusion:Integrating technology and face-to-face education enhances nutritional status,highlighting the importance of comprehensive strategies to improve treatment adherence and prevent malnutrition in hemodialysis patients.展开更多
BACKGROUND Hypertension is a common chronic disease in the elderly population,and its association with cognitive impairment has been increasingly recognized.Cognitive impairment,including mild cognitive impairment and...BACKGROUND Hypertension is a common chronic disease in the elderly population,and its association with cognitive impairment has been increasingly recognized.Cognitive impairment,including mild cognitive impairment and dementia,can significantly affect the quality of life and independence of elderly individuals.Therefore,identifying risk factors for cognitive impairment in elderly hypertensive patients is crucial for developing effective interventions and improving health outcomes.Nutritional status is one of the potential factors that may influence cognitive function in elderly hypertensive patients.Malnutrition or inadequate nutrition can lead to various health problems,including weakened immune system,increased susceptibility to infections,and impaired physical and mental function.Furthermore,poor nutritional status has been linked to increased risk of cognitive decline and dementia in various populations.In this observational study,we aimed to investigate the nutritional status of elderly hypertensive patients and its relationship to the occurrence of cognitive impairment.By collecting baseline data on general information,body composition,and clinical indicators,we hope to identify risk factors for cognitive impairment in this patient population.The results of this study are expected to provide more scientific basis for the health management of elderly patients with hypertension,particularly in terms of maintaining good nutritional status and reducing the risk of cognitive impairment.AIM To explore the differences between clinical data and cognitive function of elderly hypertensive patients with different nutritional status,analyze the internal relationship between nutritional statuses and cognitive impairment,and build a nomogram model for predicting nutritional status in elderly hypertensive patients.METHODS The present study retrospectively analyzed 200 elderly patients admitted to our hospital for a hypertension during the period July 1,2024 to September 30,2024 as study subjects,and the 200 patients were divided into a modeling cohort(140 patients)and a validation cohort(60 patients)according to the ratio of 7:3.The modeling cohort were divided into a malnutrition group(26 cases),a malnutrition risk group(42 cases),and a normal nutritional status group(72 cases)according to the patients’Mini-Nutritional Assessment Scale(MNA)scores,and the modeling cohort was divided into a hypertension combined with cognitive impairment group(34 cases)and a hypertension cognitively normal group(106 cases)according to the Montreal Cognitive Assessment Scale(MoCA)scores,and the validation cohort was divided into a hypertension combined with cognitive impairment group(14 cases)and hypertension cognitively normal group(46 cases).The study outcome was the occurrence of cognitive impairment in elderly hypertensive patients.Univariate and multivariate logistic regression was used to explore the relationship between the general information of the elderly hypertensive patients and the influence indicators and the occurrence of cognitive impairment,the roadmap prediction model was established and validated,the patient work receiver operating characteristic curve was used to evaluate the predictive efficacy of the model,the calibration curve was used to assess the consistency between the predicted events and the actual events,and the decision curve analysis was used to evaluate the validity of the model.Pearson correlation analysis was used to explore the relationship between nutrition-related indicators and MoCA scores.RESULTS In this research,the modeling cohort comprised 140 cases,while the verification cohort consisted of 60 cases,with no notable discrepancy in the data between the two groups.In the modeling cohort,there were significant differences in body mass index(BMI),albumin(ALB),hemoglobin(Hb)and homocysteine levels among the malnourished group,the malnourished risk group and the normal nutritional status group.The results of univariate and multivariate analysis showed that BMI[odds ratio(OR)=0.830,P=0.014],ALB(OR=0.860,P=0.028),Hb(OR=0.939,P=0.035)and MNA score(OR=0.640,P=0.000)were independent protective factors for patients without cognitive impairment,and alkaline phosphatase(ALP)(OR=1.074,P=0.000)was an independent risk factor for patients with cognitive impairment.In this study,the prediction nomogram tailored for cognitive deterioration in elderly patients with hypertension demonstrated robust predictive power and a close correspondence between predicted and observed outcomes.This model offers significant potential as a means to forestall cognitive decline in hypertensive elderly patients.ALP was negatively correlated with MoCA score,while BMI,MNA score,Hb and ALB were positively correlated with MoCA score.CONCLUSION BMI,MNA score,Hb and ALB were independent protective factors for cognitive impairment in elderly hypertensive patients and were positively correlated with MoCA score.ALP was an independent risk factor for cognitive impairment in elderly hypertensive patients and was negatively correlated with the MoCA score.The column line graph model established in the study has a good predictive value.展开更多
Human dignity is a core concept in contemporary moral philosophy,political science,and jurisprudence.The“social status theory”proposed by Jeremy Waldron argues that human dignity is a social construct,focusing on th...Human dignity is a core concept in contemporary moral philosophy,political science,and jurisprudence.The“social status theory”proposed by Jeremy Waldron argues that human dignity is a social construct,focusing on the fundamental equal social status of individuals.It addresses behaviors of humiliation or devaluation by others,emphasizing both the negative prohibition of such harms and the positive promotion of protections against them.Unlike traditional theories of dignity that often rely on abstract or metaphysical justifications,the social status theory adopts a bottom-up approach grounded in the social practices of dignity.This perspective avoids entanglement in endless value debates over the concept and provides new rationale for affirming human dignity.Furthermore,it refines the understanding of human dignity by identifying three specific types of social harm to dignity and corresponding protective measures.The social status theory significantly mitigates cultural skepticism regarding the concept of human dignity,offering a relatively objective and practicable framework for defining dignity norms.Practically,the theory aligns well with the application of human dignity in both public and private law domains and effectively explains the concept as utilized in international human rights conventions and practices.While there is room for further refinement,the social status theory currently stands out as the most advantageous and robust framework for understanding and promoting human dignity.展开更多
Background: Hepatitis B virus (HBV) is a primary reason for liver cancer and continues to be a worldwide public health issue. The likelihood of contracting HBV is greater in healthcare workers (HCWs) compared to indiv...Background: Hepatitis B virus (HBV) is a primary reason for liver cancer and continues to be a worldwide public health issue. The likelihood of contracting HBV is greater in healthcare workers (HCWs) compared to individuals who are not in healthcare professions. Medical students are classified as a high-risk demographic since, like HCWs, they often come into contact with bodily fluids and blood during their clinical training. By 2030, a greater proportion of people will have received HBV vaccinations, thereby halting the spread of new infections—The Somali Ministry of Health with the help of various agencies announced to eradicate hepatitis from Somalia. The priority actions are national hepatitis strategy, hepatitis survey, public awareness, training, and capacity building. Objectives: This study aims to assess the knowledge, attitude, and vaccination status of Hepatitis B infection among medical university students in Mogadishu, Somalia, 2024. Methods: Cross-sectional study design was used in this study and the survey was carried out among medical students enrolled in Universities from April 1, 2023 to June 30, 2023. The data was analyzed using SPSS version 26.0 software, Chi-square analysis and Logistic regression analysis to identify associations between demographic factors and HBV knowledge, attitudes, and vaccination status, as well as perspectives and immunization status concerning viral hepatitis. Results: The study achieved a response rate of (96%), with 230 participants. Most students (76.5%) were aged 26 - 30 years, and (60.8%) were male. Nearly half (48.7%) were in their third year of study, and the majority (36.1%) were from the Medicine and Surgery department. While 92.2% had heard of HBV, gaps in understanding were evident. About 37.8% erroneously believed HBV could spread via handshakes, and only 33.9% were aware HBV is treatable. Awareness of HBV’s severe complications, such as liver cirrhosis and liver cancer, was reported by 61.3%, and 83% understood that vaccination could prevent infection. Positive attitudes towards HBV vaccination were prevalent. Most participants (81.3%) supported vaccination before sexual activity, and 78.3% endorsed mandatory HBV vaccination policies for healthcare workers. However, 87.4% expressed concerns about the vaccine promoting unsafe sexual behavior, and 96.1% cited cultural resistance as a barrier to vaccination. A significant proportion (80.86%) of students had not been vaccinated against HBV. Among vaccinated students, 17.4%, 15.7%, and 47.82% had received one, two, and three doses, respectively. Barriers to vaccination included safety concerns (77.4%), lack of time (86.52%), and doubts about efficacy (42.61%). Conclusion: This study highlights gaps in knowledge and vaccination coverage among medical students, which are critical for their health and future clinical practice. Enhancing awareness and vaccination rates can empower students to advocate for preventative measures in their professional environments. Despite high awareness of HBV, knowledge gaps and cultural barriers persist, affecting attitudes and vaccination uptake among medical students. Educational interventions addressing misconceptions, cultural resistance, and vaccine safety are critical. Increased advocacy for mandatory vaccination policies in healthcare settings is also essential to improve HBV prevention methods.展开更多
Dongshan Bay,along with Xiamen Bay,serves as a significant distribution area for amphioxus in Fujian Province.In this survey,we observed that the sedimentary environment of Dongshan Bay has been seriously silted due t...Dongshan Bay,along with Xiamen Bay,serves as a significant distribution area for amphioxus in Fujian Province.In this survey,we observed that the sedimentary environment of Dongshan Bay has been seriously silted due to rapid economic development and the thriving aquaculture industry.Consequently,there has been a significant reduction in suitable habitats for amphioxus and a sharp decline in its resource abundance.Totally 9 amphioxuses were collected from its eastern region in 2022 with a population density of 18.75 ind m^(-2) and a body length from 34.15 to 48.02 mm.The amphioxuses acquired in this investigation were classified as Branchiostoma japonicum based on morphological traits,such as a cuspate rostral fin,measurements of angles between the dorsal and super-caudal fins,angles between the pre-anal and sub-caudal fins,along with an accurate count of pre-anal fin chambers which matched those observed in B.japonicum.Moreover,a molecular barcoding analysis was conducted using a fragment of the mitochondrial COI gene.The results indicated that Branchiostoma sp.from Dongshan Bay in this study belongs to B.japonicum,providing additional support for the morphological identification results.Considering amphioxuses are still surviving in Dongshan Bay despite the destruction of their habitat,it is recommended to implement measures to safeguard their resources and habitats.The measures may include designating protection areas,strengthening law enforcement management to prohibit sand mining,regulating the scale of cage aquaculture,and augmenting wild resources through artificial breeding and release.展开更多
Objective This study examines the sequential mediating roles of body pain and self-reported health in the association between sleep duration and self-reported life satisfaction among elderly Chinese adults.Methods Dat...Objective This study examines the sequential mediating roles of body pain and self-reported health in the association between sleep duration and self-reported life satisfaction among elderly Chinese adults.Methods Data from the fifth wave of the China Health and Retirement Longitudinal Survey(CHARLS)were used to analyse the relationships between sleep duration and body pain,self-reported health,and life satisfaction through logistic regression and Restricted Cubic Spline(RCS)analyses.The sequential mediation effects of body pain and self-reported health status were examined via chain mediation analysis.Results Logistic regression analysis showed that sleeping fewer than 6 hours or 6-7 hours was linked to higher risks of body pain,poor health,and dissatisfaction with life compared to sleeping 7-8 hours(all P<0.05).Additionally,those sleeping more than 9 hours also had increased risks of poor health and dissatisfaction with life compared to those sleeping 7-8 hours(all P<0.05).Chain mediation analysis showed that body pain and self-reported health status sequentially mediated 46.15%of the association between sleep duration and life satisfaction.Conclusion Body pain and self-reported health may shape the relationship between sleep duration and life satisfaction in elderly Chinese adults.展开更多
Objective To analyze the current research status and development trend of active surveillance of drug safety in China,and to provide reference and suggestions for future research.Methods Using bibliometric methods and...Objective To analyze the current research status and development trend of active surveillance of drug safety in China,and to provide reference and suggestions for future research.Methods Using bibliometric methods and with the help of the CiteSpace 6.1.R6,the literature on active surveillance of drug safety in CNKI from 2010 to 2022 was visualized and analyzed in terms of authors,institutions and keywords.Results and Conclusion The research on active surveillance of drug safety in China started late and is in a stable development period.Some Chinese scholars have done more work on active surveillance of drug safety.Additionally,a number of institutions have published some articles and surveillance objects,surveillance methods,and surveillance results are the main research content.However,the cross-institutional cooperation is not close.The traditional Chinese medicine injection,centralized surveillance,and automatic surveillance are the hot spots of research.It is the latest research frontier to use the Chinese hospital pharmacovigilance system to actively monitor drug safety.At present,the research related to active surveillance of drug safety in China is still in the early stage,and more in-depth research is needed to follow up.展开更多
The Xuan Dai Bay,located in Phu Yen Province,Vietnam,is one of the most traditional and important aquaculture areas of the country.Using physico-chemical methods to evaluate the environmental quality of the bay shows ...The Xuan Dai Bay,located in Phu Yen Province,Vietnam,is one of the most traditional and important aquaculture areas of the country.Using physico-chemical methods to evaluate the environmental quality of the bay shows that the area is contaminated with nutrients.However,it is necessary to clarify the level of pollution and the impact of polluting factors on biological communities and ecological status in the area.Two marine biotic indices AZTI’s marine biotic index(AMBI)and multivariate-AMBI(M-AMBI)were used to shed light on these issues.This research reveals the outcomes of applying these indicators in evaluating the ecological status in the area.The results show that the environment of the Xuan Dai Bay is being polluted.The most severe pollution level is at stations close to denser farms sites;while the lower pollution is found at stations near the mouth of the bay.The benthic community was imbalanced at all sampling stations,ranging from mild to moderate levels;while the ecological status is moderate,except good-high quality status close to the mouth.展开更多
The objective of this study was to characterize the rumination time in lactating dairy cows fed with corn silage.Rumination time was recorded 24 h/day using direct visual observation.Six trials were conducted during 2...The objective of this study was to characterize the rumination time in lactating dairy cows fed with corn silage.Rumination time was recorded 24 h/day using direct visual observation.Six trials were conducted during 2018,2019 and 2020,and rumination time was recorded in 480-2-hour periods from 40 Holstein Friesian cows.In each trial,6 or 8 cows were selected and balanced for days in milk(DIM),milk production and number of lactations.Each cow was recorded continuously for periods of 2 h at a time to complete a full 24-h period per week(12 values per day).Data from all cows were associated with 4 reproductive statuses of cows:Inseminated(1-45 days after insemination),Open(45-150 days after calving),not-pregnant and pregnant.The longest rumination time(RT)was found in pregnant cows(average 536.9±29.87 min/day),and the shortest RT was in open cows(average 420.3±63.2 min/day).Inseminated and non-pregnant cows were found with intermediate values(527.3±82.4 min/day and 467.1±30.7 respectively).Significantly different RT means were found between pregnant and open cows(p<0.0001),pregnant vs.inseminated cows(p<0.0001),and between inseminated and open cows(p=0.0005).We concluded that some gynecological conditions of lactating cows affect the RT.Measurement of RT by visual observations proved to be acceptable for the conditions of this study when cows were housed indoors and were fed with partial mixed ration(PMR)based on corn silage.展开更多
In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be ...In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be deleted.The correct sentence is as below.展开更多
AIM:To investigate the occurrence of eye asthenopia in Chinese adults and pinpoint the factors contributing to it using a 17-item Asthenopia Survey Questionnaire(ASQ-17).METHODS:A total of 2509 Chinese adults aged 18 ...AIM:To investigate the occurrence of eye asthenopia in Chinese adults and pinpoint the factors contributing to it using a 17-item Asthenopia Survey Questionnaire(ASQ-17).METHODS:A total of 2509 Chinese adults aged 18 and above from 30 regions in China participated in a crosssectional online survey in February 2020.The survey utilized the ASQ-17,which had been proven reliable and validated for assessing asthenopia-related symptoms experienced in the past two weeks among the Chinese population.Data on demographics and living conditions,including age,gender,humidity,air quality in their residential areas,frequency of heightened anxiety or depression,daily duration of near vision activity,sleep duration,sleep quality,and history of eye surgery,were collected.Principal component analysis and multivariate logistic regression were employed to identify independent factors associated with asthenopia.RESULTS:Out of the 2502 participants,with an average age of 31±8y included in the analysis,asthenopia was prevalent in 35.2%of cases.Multivariate analysis revealed that the most influential risk factor was poor sleep and mental well-being,which encompassed shorter daily sleep duration,lower sleep quality,and more frequent feelings of heightened anxiety or depression[odds ratio(OR):2.07,95%confidence interval(CI):1.88–2.29,P<0.001].This was followed by each additional 2h of daily near vision activity relative to 4h(OR:1.33,95%CI:1.21–1.45,P<0.001),and lower humidity and worse air quality in the residential area(OR:1.10,95%CI:1.02–1.21,P=0.019).CONCLUSION:Asthenopia is a common issue among Chinese adults,and preventative measures should focus on improving sleep and mental well-being.Further research targeting physiological exposure,different age groups or longitudinal studies to establish causality are needed to explore the role of sleep and mental status as an influencing factor.展开更多
BACKGROUND In randomized controlled trials(RCTs),the placebo arm has often been ignored as the attention tends to be focused on the treatment arm.We undertook a meta-analysis based on the data from the placebo arm in ...BACKGROUND In randomized controlled trials(RCTs),the placebo arm has often been ignored as the attention tends to be focused on the treatment arm.We undertook a meta-analysis based on the data from the placebo arm in RCTs of hepatocellular carci-noma(HCC),the response rates and survival status,and adverse events(AEs)were summarized and evaluated.AIM To systematically evaluate the response rates,survival status and AEs in the placebo arms of RCTs for HCC.METHODS A systematic search was performed on PubMed,Ovid MEDLINE,Embase and Cochrane Library to identify relevant trials evaluating the efficacy of drugs for the treatment of HCC,published until December 31,2023.Statistical analysis was performed using R statistical software(version 4.3.2).RESULTS A total of 18 RCTs,involving 2390 patients,met the criteria for inclusion in the meta-analysis.The pooled overall disease control rate and objective response rate in the placebo group were 38%[95%confidence interval(CI):33%-42%]and 1%(95%CI:1%-2%),respectively.Overall survival and progression-free survival in the placebo group were 7.9 months(95%CI:7.6-8.31 months)and 1.9 months(95%CI:1.6-2.1 months),respectively.The incidence of grade 3 or 4 AEs was 37%(95%CI:30%-43%).Additionally,the incidence of interruptions or dose reductions due to AEs was 20%(95%CI:13%-27%),while the incidence of treatment discontinuation due to AEs was 9%(95%CI:6%-12%).CONCLUSION Over one-third of advanced HCC patients exhibit therapy-free disease control,with placebo-arm AEs observed.These findings guide single-arm trials design and enhance patient acceptance of anticancer therapies.展开更多
AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent dif...AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent different monochromatic lights irradiation for two weeks were randomly divided into 6 groups:white light(control),ultraviolet(UV),blue,green,red,and simulative sunlight(simSUN).The refractive status and axial length(AL)were measured.Transmission electron microscopy,Masson’s trichrome staining and hematoxylin-eosin staining were performed to observe the structural changes of retina and sclera.High-performance liquid chromatography(HPLC),western blotting and immunofluorescence were used to measure neurotransmitters and their receptors.RESULTS:Myopia models were established successfully.When compared the degrees of change in myopic eyes of control group,the UV group showed a minor decrease in AL and refraction,along with a significant increase in scleral thickness.In contrast,the red and green groups revealed a net increase in AL and refraction,coupled with a net decrease in scleral thickness(all,P<0.01).The dopamine concentration increased in the UV group,while concentrations of serotonin and melatonin significantly decreased(all,P<0.01).The groups that were exposed to UV,blue and simSUN,the expression of dopamine receptor D2(DRD2)increased,and the expression of hydroxytryptamine receptor 2A(HTR2A)and melatonin receptor type 2(MT2)decreased significantly when compared to the control group(all P<0.01).CONCLUSION:Exposure to short-wavelength light could slow the development of myopia by promoting the production of dopamine and suppressing the serotonin and melatonin concentration.The neurotransmitter receptors MT2,DRD2,and HTR2A in the sclera appear to play different roles by different color lights in myopic guinea pigs.展开更多
Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 wer...Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 were selected as the study subjects and divided into two groups by lottery method.The control group(55 cases)received routine care,while the observation group(56 cases)received a combination of routine care and progressive effect nutritional care.Results:After 4 weeks of care,the observation group demonstrated higher treatment adherence(P<0.05),better quality of life(P<0.05),and improved nutritional status(P<0.05)compared to the control group.Conclusion:Progressive effect nutritional care can significantly enhance treatment adherence,quality of life,and nutritional status in uremia patients undergoing dialysis.展开更多
This study examined the relationship between leader-employee calling congruence on employees’voice behaviour.Participants were 173 leader-employee dyads from the Chinese service industry.They completed online surveys...This study examined the relationship between leader-employee calling congruence on employees’voice behaviour.Participants were 173 leader-employee dyads from the Chinese service industry.They completed online surveys on calling,perceived insider status,and voice behaviour.Results from polynomial regression and response surface analysis showed that employees perceived insider status to be weaker with the low leader-low subordinate calling congruence,and stronger with high leader and high subordinate calling congruence.Employees perceived insider status is stronger in low leader and high subordinate calling incongruence compared with high leader and low subordinate calling incongruence.Perceived insider status plays a mediating role among calling congruence and voice behaviour.This study’sfindings suggest pathways of calling congruence on voice behaviour,which are important for promoting employee voice behaviour and guiding organisational recruitment in the workplace.展开更多
Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific hea...Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific health conditions(e.g.,diabetes or sepsis)for statistical analyses.However,there has been substantial variation in the algorithm development and validation,leading to frequently suboptimal performance and posing a significant threat to the validity of study findings.Unfortunately,these issues are often overlooked.Methods:We systematically developed guidance for the development,validation,and evaluation of algorithms designed to identify health status(DEVELOP-RCD).Our initial efforts involved conducting both a narrative review and a systematic review of published studies on the concepts and methodological issues related to algorithm development,validation,and evaluation.Subsequently,we conducted an empirical study on an algorithm for identifying sepsis.Based on these findings,we formulated specific workflow and recommendations for algorithm development,validation,and evaluation within the guidance.Finally,the guidance underwent independent review by a panel of 20 external experts who then convened a consensus meeting to finalize it.Results:A standardized workflow for algorithm development,validation,and evaluation was established.Guided by specific health status considerations,the workflow comprises four integrated steps:assessing an existing algorithm’s suitability for the target health status;developing a new algorithm using recommended methods;validating the algorithm using prescribed performance measures;and evaluating the impact of the algorithm on study results.Additionally,13 good practice recommendations were formulated with detailed explanations.Furthermore,a practical study on sepsis identification was included to demonstrate the application of this guidance.Conclusions:The establishment of guidance is intended to aid researchers and clinicians in the appropriate and accurate development and application of algorithms for identifying health status from RCD.This guidance has the potential to enhance the credibility of findings from observational studies involving RCD.展开更多
BACKGROUND The incidence of malignant tumors in the digestive system is increasing and is a threat to human health.However,the long duration from tumor detection to radical resection,stress responses due to surgical t...BACKGROUND The incidence of malignant tumors in the digestive system is increasing and is a threat to human health.However,the long duration from tumor detection to radical resection,stress responses due to surgical trauma,and insufficient nu-tritional intake increases the risk of malnutrition,immune function reduction,postoperative complications,and intestinal dysfunction among patients.AIM To systematically investigate the association of parenteral nutrition enriched with n-3 polyunsaturated fatty acids(PUFAs)with the nutritional status of patients after gastrointestinal treatment.METHODS Randomized controlled trials associated with PUFA-enriched parenteral nutrition administration in patients with digestive system malignancies were retrieved from online databases such as PubMed,EMBASE,ScienceDirect,Cochrane Li-brary,China Knowledge Network,China VIP,Wanfang,and China Biomedical Literature Database,with the retrieval time from database inception to present.Two researchers independently extracted data.Each article’s bias risk was ass-essed by referring to the Cochrane Handbook version 5.3 criteria and RevMan5.4 was used for data analysis.RESULTS This meta-analysis involved six randomized controlled trials involving a total of 505 cases.Random-effects model analysis indicated remarkably better impro-vements in various inflammatory factors in the study group(P<0.05).Meta-analysis of nutritional indicators revealed that the study group had higher total protein,albumin,and prealbumin levels,as well as lower transferrin levels compared to the control group(P<0.05).Meanwhile,meta-analysis of T-cell subsets revealed no remarkable inter-group difference in post-treatment CD8+cells(P>0.05).Moreover,the meta-analysis identified a notably lower incidence of adverse reactions in the study group(P<0.05).CONCLUSION Administration of PUFAs helps improve the nutritional status of patients with digestive malignancies in the perioperative period.It promotes immune function recovery,reduces the inflammatory response,and decreases the risk of adverse effects.These beneficial effects make it worth investigating and promoting their use in ap-propriate patient populations.However,further validation via high-quality studies with long intervention time and extended follow-up periods is required.展开更多
Laparoscopic and endoscopic cooperative surgery(LECS)is a hybrid minimally invasive technique originally developed for treatment of gastric submucosal tumors.Several modifications of LECS—including inverted LECS,non-...Laparoscopic and endoscopic cooperative surgery(LECS)is a hybrid minimally invasive technique originally developed for treatment of gastric submucosal tumors.Several modifications of LECS—including inverted LECS,non-exposed endoscopic wall-inversion surgery,and closed LECS have evolved over a period of time to address the earlier concerns about peritoneal contamination and tumor seeding.These innovations have led to the application of combined laparoendoscopic techniques to several gastrointestinal(GI)lesions such as the duodenum,colon,and rectum.This minireview explores the evolution,current applications,and future potential of laparoendoscopic surgery in GI diseases.展开更多
文摘In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.
基金Supported by Research Project on Food Detection Technology Innovation and Standard Integration 2024(YNXM-2024-FW-019).
文摘This paper investigates and analyzes the general situation of the tomato seed production industry in Lintong District,Xi'an City.Development strategies and suggestions are proposed to address existing problems.These include strengthening technological innovation and variety R&D,promoting industrial standardization and intelligent upgrading,enhancing brand building and market expansion,improving policy support and industrial chain coordination,strengthening intellectual property protection and talent cultivation,and expanding sales channels to promote industrial transformation and upgrading.
基金funded by national funds through the Foundation for Science and Technology,under the project UIDB/04923。
文摘impacting quality of life.This study aimed to identify technological nursing interventions that promote self-care and improve the nutritional status of middle-aged and older adults undergoing hemodialysis.Methods:A systematic literature review was conducted in accordance with the Joanna Briggs Institute(JBI)and PRISMA guidelines.Searches were conducted in Medline,CINAHL,the Cochrane Library,Scopus,Web of Science,and grey literature,Studies published between 2018 and 2024,involving patients aged 40 years or more undergoing regular hemodialysis,and available in Portuguese,English,or Spanish,were included.JBI's critical appraisal tools were used to conduct a rigorous analysis and methodological quality assessment of the articles.Results:Out of a total of 738 articles,10 were included for analysis.Five key dimensions of technologydriven self-care interventions were established.1)Mobile applications and digital platforms with features like nutritional databases,food logging,and personalized feedback;2)E-learning and virtual education using social media and chat-based communication;3)Telenursing employing a hybrid follow-up model of face-to-face,telephone,and SMS contact;4)Educational strategies focused on nutritional status,utilizing methods such as teach-back and pictorial learning within a multidisciplinary team;and 5)Comprehensive assessment tools evaluating treatment adherence(hemodialysis,medication,diet,fluid)and laboratory markers.Significant improvements were reported across several outcomes:eight studies showed enhanced biochemical markers(e.g.,phosphorus,sodium,potassium,calcium,iron,albumin,urea,and hemoglobin)and nutritional status,three demonstrated increased selfefficacy,and two reported improved quality of life.Conclusion:Integrating technology and face-to-face education enhances nutritional status,highlighting the importance of comprehensive strategies to improve treatment adherence and prevent malnutrition in hemodialysis patients.
基金Supported by the Wuxi Science and Technology Plan Project Plan,No.BJ21008.
文摘BACKGROUND Hypertension is a common chronic disease in the elderly population,and its association with cognitive impairment has been increasingly recognized.Cognitive impairment,including mild cognitive impairment and dementia,can significantly affect the quality of life and independence of elderly individuals.Therefore,identifying risk factors for cognitive impairment in elderly hypertensive patients is crucial for developing effective interventions and improving health outcomes.Nutritional status is one of the potential factors that may influence cognitive function in elderly hypertensive patients.Malnutrition or inadequate nutrition can lead to various health problems,including weakened immune system,increased susceptibility to infections,and impaired physical and mental function.Furthermore,poor nutritional status has been linked to increased risk of cognitive decline and dementia in various populations.In this observational study,we aimed to investigate the nutritional status of elderly hypertensive patients and its relationship to the occurrence of cognitive impairment.By collecting baseline data on general information,body composition,and clinical indicators,we hope to identify risk factors for cognitive impairment in this patient population.The results of this study are expected to provide more scientific basis for the health management of elderly patients with hypertension,particularly in terms of maintaining good nutritional status and reducing the risk of cognitive impairment.AIM To explore the differences between clinical data and cognitive function of elderly hypertensive patients with different nutritional status,analyze the internal relationship between nutritional statuses and cognitive impairment,and build a nomogram model for predicting nutritional status in elderly hypertensive patients.METHODS The present study retrospectively analyzed 200 elderly patients admitted to our hospital for a hypertension during the period July 1,2024 to September 30,2024 as study subjects,and the 200 patients were divided into a modeling cohort(140 patients)and a validation cohort(60 patients)according to the ratio of 7:3.The modeling cohort were divided into a malnutrition group(26 cases),a malnutrition risk group(42 cases),and a normal nutritional status group(72 cases)according to the patients’Mini-Nutritional Assessment Scale(MNA)scores,and the modeling cohort was divided into a hypertension combined with cognitive impairment group(34 cases)and a hypertension cognitively normal group(106 cases)according to the Montreal Cognitive Assessment Scale(MoCA)scores,and the validation cohort was divided into a hypertension combined with cognitive impairment group(14 cases)and hypertension cognitively normal group(46 cases).The study outcome was the occurrence of cognitive impairment in elderly hypertensive patients.Univariate and multivariate logistic regression was used to explore the relationship between the general information of the elderly hypertensive patients and the influence indicators and the occurrence of cognitive impairment,the roadmap prediction model was established and validated,the patient work receiver operating characteristic curve was used to evaluate the predictive efficacy of the model,the calibration curve was used to assess the consistency between the predicted events and the actual events,and the decision curve analysis was used to evaluate the validity of the model.Pearson correlation analysis was used to explore the relationship between nutrition-related indicators and MoCA scores.RESULTS In this research,the modeling cohort comprised 140 cases,while the verification cohort consisted of 60 cases,with no notable discrepancy in the data between the two groups.In the modeling cohort,there were significant differences in body mass index(BMI),albumin(ALB),hemoglobin(Hb)and homocysteine levels among the malnourished group,the malnourished risk group and the normal nutritional status group.The results of univariate and multivariate analysis showed that BMI[odds ratio(OR)=0.830,P=0.014],ALB(OR=0.860,P=0.028),Hb(OR=0.939,P=0.035)and MNA score(OR=0.640,P=0.000)were independent protective factors for patients without cognitive impairment,and alkaline phosphatase(ALP)(OR=1.074,P=0.000)was an independent risk factor for patients with cognitive impairment.In this study,the prediction nomogram tailored for cognitive deterioration in elderly patients with hypertension demonstrated robust predictive power and a close correspondence between predicted and observed outcomes.This model offers significant potential as a means to forestall cognitive decline in hypertensive elderly patients.ALP was negatively correlated with MoCA score,while BMI,MNA score,Hb and ALB were positively correlated with MoCA score.CONCLUSION BMI,MNA score,Hb and ALB were independent protective factors for cognitive impairment in elderly hypertensive patients and were positively correlated with MoCA score.ALP was an independent risk factor for cognitive impairment in elderly hypertensive patients and was negatively correlated with the MoCA score.The column line graph model established in the study has a good predictive value.
基金This paper is an interim result of the“Research on the Construction of China’s Independent Human Rights Knowledge System,”a major project of the National Human Rights Education and Training Base(Approval Number 24JJD820007).
文摘Human dignity is a core concept in contemporary moral philosophy,political science,and jurisprudence.The“social status theory”proposed by Jeremy Waldron argues that human dignity is a social construct,focusing on the fundamental equal social status of individuals.It addresses behaviors of humiliation or devaluation by others,emphasizing both the negative prohibition of such harms and the positive promotion of protections against them.Unlike traditional theories of dignity that often rely on abstract or metaphysical justifications,the social status theory adopts a bottom-up approach grounded in the social practices of dignity.This perspective avoids entanglement in endless value debates over the concept and provides new rationale for affirming human dignity.Furthermore,it refines the understanding of human dignity by identifying three specific types of social harm to dignity and corresponding protective measures.The social status theory significantly mitigates cultural skepticism regarding the concept of human dignity,offering a relatively objective and practicable framework for defining dignity norms.Practically,the theory aligns well with the application of human dignity in both public and private law domains and effectively explains the concept as utilized in international human rights conventions and practices.While there is room for further refinement,the social status theory currently stands out as the most advantageous and robust framework for understanding and promoting human dignity.
文摘Background: Hepatitis B virus (HBV) is a primary reason for liver cancer and continues to be a worldwide public health issue. The likelihood of contracting HBV is greater in healthcare workers (HCWs) compared to individuals who are not in healthcare professions. Medical students are classified as a high-risk demographic since, like HCWs, they often come into contact with bodily fluids and blood during their clinical training. By 2030, a greater proportion of people will have received HBV vaccinations, thereby halting the spread of new infections—The Somali Ministry of Health with the help of various agencies announced to eradicate hepatitis from Somalia. The priority actions are national hepatitis strategy, hepatitis survey, public awareness, training, and capacity building. Objectives: This study aims to assess the knowledge, attitude, and vaccination status of Hepatitis B infection among medical university students in Mogadishu, Somalia, 2024. Methods: Cross-sectional study design was used in this study and the survey was carried out among medical students enrolled in Universities from April 1, 2023 to June 30, 2023. The data was analyzed using SPSS version 26.0 software, Chi-square analysis and Logistic regression analysis to identify associations between demographic factors and HBV knowledge, attitudes, and vaccination status, as well as perspectives and immunization status concerning viral hepatitis. Results: The study achieved a response rate of (96%), with 230 participants. Most students (76.5%) were aged 26 - 30 years, and (60.8%) were male. Nearly half (48.7%) were in their third year of study, and the majority (36.1%) were from the Medicine and Surgery department. While 92.2% had heard of HBV, gaps in understanding were evident. About 37.8% erroneously believed HBV could spread via handshakes, and only 33.9% were aware HBV is treatable. Awareness of HBV’s severe complications, such as liver cirrhosis and liver cancer, was reported by 61.3%, and 83% understood that vaccination could prevent infection. Positive attitudes towards HBV vaccination were prevalent. Most participants (81.3%) supported vaccination before sexual activity, and 78.3% endorsed mandatory HBV vaccination policies for healthcare workers. However, 87.4% expressed concerns about the vaccine promoting unsafe sexual behavior, and 96.1% cited cultural resistance as a barrier to vaccination. A significant proportion (80.86%) of students had not been vaccinated against HBV. Among vaccinated students, 17.4%, 15.7%, and 47.82% had received one, two, and three doses, respectively. Barriers to vaccination included safety concerns (77.4%), lack of time (86.52%), and doubts about efficacy (42.61%). Conclusion: This study highlights gaps in knowledge and vaccination coverage among medical students, which are critical for their health and future clinical practice. Enhancing awareness and vaccination rates can empower students to advocate for preventative measures in their professional environments. Despite high awareness of HBV, knowledge gaps and cultural barriers persist, affecting attitudes and vaccination uptake among medical students. Educational interventions addressing misconceptions, cultural resistance, and vaccine safety are critical. Increased advocacy for mandatory vaccination policies in healthcare settings is also essential to improve HBV prevention methods.
基金supported by grants from the Science and Technology Bureau of Xiamen(No.3502Z20227207)。
文摘Dongshan Bay,along with Xiamen Bay,serves as a significant distribution area for amphioxus in Fujian Province.In this survey,we observed that the sedimentary environment of Dongshan Bay has been seriously silted due to rapid economic development and the thriving aquaculture industry.Consequently,there has been a significant reduction in suitable habitats for amphioxus and a sharp decline in its resource abundance.Totally 9 amphioxuses were collected from its eastern region in 2022 with a population density of 18.75 ind m^(-2) and a body length from 34.15 to 48.02 mm.The amphioxuses acquired in this investigation were classified as Branchiostoma japonicum based on morphological traits,such as a cuspate rostral fin,measurements of angles between the dorsal and super-caudal fins,angles between the pre-anal and sub-caudal fins,along with an accurate count of pre-anal fin chambers which matched those observed in B.japonicum.Moreover,a molecular barcoding analysis was conducted using a fragment of the mitochondrial COI gene.The results indicated that Branchiostoma sp.from Dongshan Bay in this study belongs to B.japonicum,providing additional support for the morphological identification results.Considering amphioxuses are still surviving in Dongshan Bay despite the destruction of their habitat,it is recommended to implement measures to safeguard their resources and habitats.The measures may include designating protection areas,strengthening law enforcement management to prohibit sand mining,regulating the scale of cage aquaculture,and augmenting wild resources through artificial breeding and release.
基金supported by This work was supported by the Ministry of Science and Technology of the People’s Republic of China(STI2030-Major Projects2021ZD0201900)。
文摘Objective This study examines the sequential mediating roles of body pain and self-reported health in the association between sleep duration and self-reported life satisfaction among elderly Chinese adults.Methods Data from the fifth wave of the China Health and Retirement Longitudinal Survey(CHARLS)were used to analyse the relationships between sleep duration and body pain,self-reported health,and life satisfaction through logistic regression and Restricted Cubic Spline(RCS)analyses.The sequential mediation effects of body pain and self-reported health status were examined via chain mediation analysis.Results Logistic regression analysis showed that sleeping fewer than 6 hours or 6-7 hours was linked to higher risks of body pain,poor health,and dissatisfaction with life compared to sleeping 7-8 hours(all P<0.05).Additionally,those sleeping more than 9 hours also had increased risks of poor health and dissatisfaction with life compared to those sleeping 7-8 hours(all P<0.05).Chain mediation analysis showed that body pain and self-reported health status sequentially mediated 46.15%of the association between sleep duration and life satisfaction.Conclusion Body pain and self-reported health may shape the relationship between sleep duration and life satisfaction in elderly Chinese adults.
文摘Objective To analyze the current research status and development trend of active surveillance of drug safety in China,and to provide reference and suggestions for future research.Methods Using bibliometric methods and with the help of the CiteSpace 6.1.R6,the literature on active surveillance of drug safety in CNKI from 2010 to 2022 was visualized and analyzed in terms of authors,institutions and keywords.Results and Conclusion The research on active surveillance of drug safety in China started late and is in a stable development period.Some Chinese scholars have done more work on active surveillance of drug safety.Additionally,a number of institutions have published some articles and surveillance objects,surveillance methods,and surveillance results are the main research content.However,the cross-institutional cooperation is not close.The traditional Chinese medicine injection,centralized surveillance,and automatic surveillance are the hot spots of research.It is the latest research frontier to use the Chinese hospital pharmacovigilance system to actively monitor drug safety.At present,the research related to active surveillance of drug safety in China is still in the early stage,and more in-depth research is needed to follow up.
基金A project at the Joint Vietnam-Russia Tropical Science and Technology Research Center under contract No.1113/QD-TTNDVN.
文摘The Xuan Dai Bay,located in Phu Yen Province,Vietnam,is one of the most traditional and important aquaculture areas of the country.Using physico-chemical methods to evaluate the environmental quality of the bay shows that the area is contaminated with nutrients.However,it is necessary to clarify the level of pollution and the impact of polluting factors on biological communities and ecological status in the area.Two marine biotic indices AZTI’s marine biotic index(AMBI)and multivariate-AMBI(M-AMBI)were used to shed light on these issues.This research reveals the outcomes of applying these indicators in evaluating the ecological status in the area.The results show that the environment of the Xuan Dai Bay is being polluted.The most severe pollution level is at stations close to denser farms sites;while the lower pollution is found at stations near the mouth of the bay.The benthic community was imbalanced at all sampling stations,ranging from mild to moderate levels;while the ecological status is moderate,except good-high quality status close to the mouth.
文摘The objective of this study was to characterize the rumination time in lactating dairy cows fed with corn silage.Rumination time was recorded 24 h/day using direct visual observation.Six trials were conducted during 2018,2019 and 2020,and rumination time was recorded in 480-2-hour periods from 40 Holstein Friesian cows.In each trial,6 or 8 cows were selected and balanced for days in milk(DIM),milk production and number of lactations.Each cow was recorded continuously for periods of 2 h at a time to complete a full 24-h period per week(12 values per day).Data from all cows were associated with 4 reproductive statuses of cows:Inseminated(1-45 days after insemination),Open(45-150 days after calving),not-pregnant and pregnant.The longest rumination time(RT)was found in pregnant cows(average 536.9±29.87 min/day),and the shortest RT was in open cows(average 420.3±63.2 min/day).Inseminated and non-pregnant cows were found with intermediate values(527.3±82.4 min/day and 467.1±30.7 respectively).Significantly different RT means were found between pregnant and open cows(p<0.0001),pregnant vs.inseminated cows(p<0.0001),and between inseminated and open cows(p=0.0005).We concluded that some gynecological conditions of lactating cows affect the RT.Measurement of RT by visual observations proved to be acceptable for the conditions of this study when cows were housed indoors and were fed with partial mixed ration(PMR)based on corn silage.
文摘In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be deleted.The correct sentence is as below.
基金Supported by Wenzhou Science and Technology Bureau Project(No.Y20240062)the National Natural Science Foundation of China(No.82000861).
文摘AIM:To investigate the occurrence of eye asthenopia in Chinese adults and pinpoint the factors contributing to it using a 17-item Asthenopia Survey Questionnaire(ASQ-17).METHODS:A total of 2509 Chinese adults aged 18 and above from 30 regions in China participated in a crosssectional online survey in February 2020.The survey utilized the ASQ-17,which had been proven reliable and validated for assessing asthenopia-related symptoms experienced in the past two weeks among the Chinese population.Data on demographics and living conditions,including age,gender,humidity,air quality in their residential areas,frequency of heightened anxiety or depression,daily duration of near vision activity,sleep duration,sleep quality,and history of eye surgery,were collected.Principal component analysis and multivariate logistic regression were employed to identify independent factors associated with asthenopia.RESULTS:Out of the 2502 participants,with an average age of 31±8y included in the analysis,asthenopia was prevalent in 35.2%of cases.Multivariate analysis revealed that the most influential risk factor was poor sleep and mental well-being,which encompassed shorter daily sleep duration,lower sleep quality,and more frequent feelings of heightened anxiety or depression[odds ratio(OR):2.07,95%confidence interval(CI):1.88–2.29,P<0.001].This was followed by each additional 2h of daily near vision activity relative to 4h(OR:1.33,95%CI:1.21–1.45,P<0.001),and lower humidity and worse air quality in the residential area(OR:1.10,95%CI:1.02–1.21,P=0.019).CONCLUSION:Asthenopia is a common issue among Chinese adults,and preventative measures should focus on improving sleep and mental well-being.Further research targeting physiological exposure,different age groups or longitudinal studies to establish causality are needed to explore the role of sleep and mental status as an influencing factor.
文摘BACKGROUND In randomized controlled trials(RCTs),the placebo arm has often been ignored as the attention tends to be focused on the treatment arm.We undertook a meta-analysis based on the data from the placebo arm in RCTs of hepatocellular carci-noma(HCC),the response rates and survival status,and adverse events(AEs)were summarized and evaluated.AIM To systematically evaluate the response rates,survival status and AEs in the placebo arms of RCTs for HCC.METHODS A systematic search was performed on PubMed,Ovid MEDLINE,Embase and Cochrane Library to identify relevant trials evaluating the efficacy of drugs for the treatment of HCC,published until December 31,2023.Statistical analysis was performed using R statistical software(version 4.3.2).RESULTS A total of 18 RCTs,involving 2390 patients,met the criteria for inclusion in the meta-analysis.The pooled overall disease control rate and objective response rate in the placebo group were 38%[95%confidence interval(CI):33%-42%]and 1%(95%CI:1%-2%),respectively.Overall survival and progression-free survival in the placebo group were 7.9 months(95%CI:7.6-8.31 months)and 1.9 months(95%CI:1.6-2.1 months),respectively.The incidence of grade 3 or 4 AEs was 37%(95%CI:30%-43%).Additionally,the incidence of interruptions or dose reductions due to AEs was 20%(95%CI:13%-27%),while the incidence of treatment discontinuation due to AEs was 9%(95%CI:6%-12%).CONCLUSION Over one-third of advanced HCC patients exhibit therapy-free disease control,with placebo-arm AEs observed.These findings guide single-arm trials design and enhance patient acceptance of anticancer therapies.
基金Supported by the Zhejiang Traditional Chinese Medicine Science and Technology Plan(No.2023ZL241)Zhejiang Medical Science and Technology Plan(No.2025KY648).
文摘AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent different monochromatic lights irradiation for two weeks were randomly divided into 6 groups:white light(control),ultraviolet(UV),blue,green,red,and simulative sunlight(simSUN).The refractive status and axial length(AL)were measured.Transmission electron microscopy,Masson’s trichrome staining and hematoxylin-eosin staining were performed to observe the structural changes of retina and sclera.High-performance liquid chromatography(HPLC),western blotting and immunofluorescence were used to measure neurotransmitters and their receptors.RESULTS:Myopia models were established successfully.When compared the degrees of change in myopic eyes of control group,the UV group showed a minor decrease in AL and refraction,along with a significant increase in scleral thickness.In contrast,the red and green groups revealed a net increase in AL and refraction,coupled with a net decrease in scleral thickness(all,P<0.01).The dopamine concentration increased in the UV group,while concentrations of serotonin and melatonin significantly decreased(all,P<0.01).The groups that were exposed to UV,blue and simSUN,the expression of dopamine receptor D2(DRD2)increased,and the expression of hydroxytryptamine receptor 2A(HTR2A)and melatonin receptor type 2(MT2)decreased significantly when compared to the control group(all P<0.01).CONCLUSION:Exposure to short-wavelength light could slow the development of myopia by promoting the production of dopamine and suppressing the serotonin and melatonin concentration.The neurotransmitter receptors MT2,DRD2,and HTR2A in the sclera appear to play different roles by different color lights in myopic guinea pigs.
文摘Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 were selected as the study subjects and divided into two groups by lottery method.The control group(55 cases)received routine care,while the observation group(56 cases)received a combination of routine care and progressive effect nutritional care.Results:After 4 weeks of care,the observation group demonstrated higher treatment adherence(P<0.05),better quality of life(P<0.05),and improved nutritional status(P<0.05)compared to the control group.Conclusion:Progressive effect nutritional care can significantly enhance treatment adherence,quality of life,and nutritional status in uremia patients undergoing dialysis.
基金supported by the Major Research Project of Philosophy and Social Sciences in Universities of Henan Province(2025-JCZD-10)the Natural Science Foundation of Henan Province(242300421311).
文摘This study examined the relationship between leader-employee calling congruence on employees’voice behaviour.Participants were 173 leader-employee dyads from the Chinese service industry.They completed online surveys on calling,perceived insider status,and voice behaviour.Results from polynomial regression and response surface analysis showed that employees perceived insider status to be weaker with the low leader-low subordinate calling congruence,and stronger with high leader and high subordinate calling congruence.Employees perceived insider status is stronger in low leader and high subordinate calling incongruence compared with high leader and low subordinate calling incongruence.Perceived insider status plays a mediating role among calling congruence and voice behaviour.This study’sfindings suggest pathways of calling congruence on voice behaviour,which are important for promoting employee voice behaviour and guiding organisational recruitment in the workplace.
基金supported by the National Natural Science Foundation of China(82225049,72104155)the Sichuan Provincial Central Government Guides Local Science and Technology Development Special Project(2022ZYD0127)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD23004).
文摘Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific health conditions(e.g.,diabetes or sepsis)for statistical analyses.However,there has been substantial variation in the algorithm development and validation,leading to frequently suboptimal performance and posing a significant threat to the validity of study findings.Unfortunately,these issues are often overlooked.Methods:We systematically developed guidance for the development,validation,and evaluation of algorithms designed to identify health status(DEVELOP-RCD).Our initial efforts involved conducting both a narrative review and a systematic review of published studies on the concepts and methodological issues related to algorithm development,validation,and evaluation.Subsequently,we conducted an empirical study on an algorithm for identifying sepsis.Based on these findings,we formulated specific workflow and recommendations for algorithm development,validation,and evaluation within the guidance.Finally,the guidance underwent independent review by a panel of 20 external experts who then convened a consensus meeting to finalize it.Results:A standardized workflow for algorithm development,validation,and evaluation was established.Guided by specific health status considerations,the workflow comprises four integrated steps:assessing an existing algorithm’s suitability for the target health status;developing a new algorithm using recommended methods;validating the algorithm using prescribed performance measures;and evaluating the impact of the algorithm on study results.Additionally,13 good practice recommendations were formulated with detailed explanations.Furthermore,a practical study on sepsis identification was included to demonstrate the application of this guidance.Conclusions:The establishment of guidance is intended to aid researchers and clinicians in the appropriate and accurate development and application of algorithms for identifying health status from RCD.This guidance has the potential to enhance the credibility of findings from observational studies involving RCD.
基金Supported by the Guangxi Medical and Health Key(Cultivation)Discipline Construction ProjectGuilin Scientific Research and Technology Development Program Project,No.20210227-7-8.
文摘BACKGROUND The incidence of malignant tumors in the digestive system is increasing and is a threat to human health.However,the long duration from tumor detection to radical resection,stress responses due to surgical trauma,and insufficient nu-tritional intake increases the risk of malnutrition,immune function reduction,postoperative complications,and intestinal dysfunction among patients.AIM To systematically investigate the association of parenteral nutrition enriched with n-3 polyunsaturated fatty acids(PUFAs)with the nutritional status of patients after gastrointestinal treatment.METHODS Randomized controlled trials associated with PUFA-enriched parenteral nutrition administration in patients with digestive system malignancies were retrieved from online databases such as PubMed,EMBASE,ScienceDirect,Cochrane Li-brary,China Knowledge Network,China VIP,Wanfang,and China Biomedical Literature Database,with the retrieval time from database inception to present.Two researchers independently extracted data.Each article’s bias risk was ass-essed by referring to the Cochrane Handbook version 5.3 criteria and RevMan5.4 was used for data analysis.RESULTS This meta-analysis involved six randomized controlled trials involving a total of 505 cases.Random-effects model analysis indicated remarkably better impro-vements in various inflammatory factors in the study group(P<0.05).Meta-analysis of nutritional indicators revealed that the study group had higher total protein,albumin,and prealbumin levels,as well as lower transferrin levels compared to the control group(P<0.05).Meanwhile,meta-analysis of T-cell subsets revealed no remarkable inter-group difference in post-treatment CD8+cells(P>0.05).Moreover,the meta-analysis identified a notably lower incidence of adverse reactions in the study group(P<0.05).CONCLUSION Administration of PUFAs helps improve the nutritional status of patients with digestive malignancies in the perioperative period.It promotes immune function recovery,reduces the inflammatory response,and decreases the risk of adverse effects.These beneficial effects make it worth investigating and promoting their use in ap-propriate patient populations.However,further validation via high-quality studies with long intervention time and extended follow-up periods is required.
文摘Laparoscopic and endoscopic cooperative surgery(LECS)is a hybrid minimally invasive technique originally developed for treatment of gastric submucosal tumors.Several modifications of LECS—including inverted LECS,non-exposed endoscopic wall-inversion surgery,and closed LECS have evolved over a period of time to address the earlier concerns about peritoneal contamination and tumor seeding.These innovations have led to the application of combined laparoendoscopic techniques to several gastrointestinal(GI)lesions such as the duodenum,colon,and rectum.This minireview explores the evolution,current applications,and future potential of laparoendoscopic surgery in GI diseases.
