Static magnetic field(SMF)exposure exerts notable regulatory effects on metabolic disorders,yet its influence on metabolic dysfunction-associated fatty liver disease(MAFLD)and gut microbiota during disease progression...Static magnetic field(SMF)exposure exerts notable regulatory effects on metabolic disorders,yet its influence on metabolic dysfunction-associated fatty liver disease(MAFLD)and gut microbiota during disease progression remains unclear.In this study,MAFLD was induced in mice via a high-fat diet(HFD),followed by exposure to a 0.2 T SMF for 12 h per day over a 10 week period.SMF treatment significantly attenuated body weight gain,alleviated hepatic lipid accumulation,and improved liver function.Sequencing analysis of intestinal contents revealed a significant increase in microbial diversity and enrichment of beneficial bacterial taxa under SMF exposure.Integrated multi-omics analysis and Spearman correlation further demonstrated that SMF significantly reduced the expression of genes involved in fatty acid synthesis and modulated pathways related to polyunsaturated fatty acid and glutamate metabolism,in close association with shifts in beneficial gut microbiota.Furthermore,transcriptomic profiling of liver tissue indicated that SMF inhibited fatty acid synthesis and elongation by regulating the expression of peroxisome proliferator-activated receptorγ(PPARγ),thereby contributing to reduced hepatic burden.These findings highlight SMF as a promising non-invasive strategy for MAFLD intervention and provide insights into the microbiota-mediated metabolic axis underlying its therapeutic effects.展开更多
A geomagnetic field is a significant factor dur-ing the growth and development of trees.Changes in the magnetic field(MF)will result in reactions at the biochemi-cal,molecular,cellular and gene levels.However,it is no...A geomagnetic field is a significant factor dur-ing the growth and development of trees.Changes in the magnetic field(MF)will result in reactions at the biochemi-cal,molecular,cellular and gene levels.However,it is not clear how a magnetic field affects metabolism and home-ostasis under stressful conditions such as salinity.In this study,a novel method was developed of a static magnetic field(SMF)to investigate magnetobiological changes in trees.The results show that pre-treatment of poplar(Popu-lus×euramericana‘Neva’)cuttings with a static magnetic field significantly mitigated the negative effects of salinity stress on their growth and physiological activities.Bio-chemical assays revealed that several chemical messengers,including hydrogen peroxide(H2O2)and O_(2)^(·-),were sig-nificantly improved in roots treated with salt,implying an increase reactive oxygen species.A static magnetic field also significantly increased proline concentrations,soluble protein contents,and CAT and SOD activities.Electrophysiological experiments further revealed that pre-treatment with a static magnetic field remarkably decreased salt-induced Na^(+)influx and H^(+)efflux which control plant salt tolerance.In pharmacological experiments,because the Na^(+)/H^(+)cor-relation was closely related to the SMF-activated plasma membrane and Na^(+)antiporter activity alleviated the mas-sive accumulation of salt-induced reactive oxygen spe-cies(ROS)within the roots.In addition,a static magnetic field dramatically increased the transcriptional activity of stress-responsive genes,including PtrRBOHD and PtrHA5.Together,these results indicate that SMF reduced Na^(+)influx by activating Na^(+)/H^(+)antiporters and plasma membrane H^(+)-ATPase to effectively maintain homeostasis by regu-lating the reactive oxygen species system and cytoplasmic osmotic potential.Ultimately,these static magnetic field methods improved salt tolerance in poplar cuttings,and,for future research,similar methods could be applied to other plants.展开更多
The large and small sized Cu（solid）/Al（liquid） couples were prepared to investigate the directional growth behavior of primary a（Al） phase during a concentration-gradient-controlled solidification process under ...The large and small sized Cu（solid）/Al（liquid） couples were prepared to investigate the directional growth behavior of primary a（Al） phase during a concentration-gradient-controlled solidification process under various static magnetic fields（SMFs）.The results show that in the large couples,the α（Al） dendrites reveal a directional growth character whether without or with the SMF.However,the 12 T magnetic field induces regular growth,consistent deflection and the decrease of secondary arm spacing of the dendrites.In the small couples,the α（Al） dendrites still reveal a directional growth character to some extent with a SMF of ≤5 T.However,an 8.8 T SMF destroys the directional growth and induces severe random deflections of the dendrites.When the SMF increases to 12 T,the a（Al） dendrites become quite regular despite of the consistent deflection.The directional growth arises from the continuous long-range concentration gradient field built in the melt.The morphological modification is mainly related to the suppression of natural convections and the induction of thermoelectric magnetic convection by the SMF.展开更多
A series of three-dimensional numerical computations were conducted to understand the effects of different static magnetic fields on thermal fluctuation and melt flow during the detached solidification of CdZnTe. Nume...A series of three-dimensional numerical computations were conducted to understand the effects of different static magnetic fields on thermal fluctuation and melt flow during the detached solidification of CdZnTe. Numerical calculations were carried out by three different configurations of magnetic field: without magnetic field, with an axial magnetic field (AMF) and with a cusp-shaped magnetic field (CMF). The results reveal that the magnetic fields can effectively suppress the melt flow and thermal fluctuation and the suppression effect of the AMF is stronger than that of the CMF. Besides, the physical mechanism of thermocapillary?buoyancy convection instability was discussed and the effects of magnetic field on the critical Marangoni number were also obtained.展开更多
Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.unifo...Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.展开更多
The voltage was recorded to investigate the influence of the static magnetic field on droplet evolution during the mag-netically controlled electroslag remelting （MC-ESR） process. MC-ESR experiments were carried out...The voltage was recorded to investigate the influence of the static magnetic field on droplet evolution during the mag-netically controlled electroslag remelting （MC-ESR） process. MC-ESR experiments were carried out under differentremelting current, and transverse static magnetic fields （TSMF） of 85 mT, 130 mT and 160 mT were superimposed.Statistical work was performed to obtain the quantitative data of the droplets. The ASPEX Explorer was utilized toinvestigate the inclusions evolution of GCr15 ingots. The number of the droplets was 31 in 20 s during the traditional ESRprocess and reached 50 and 51 under the MC-ESR process with the TSMF of 85 mT and 130 mT, respectively. Whencompared the traditional ESR process with the MC-ESR process, the inclusions amount reduced 67%.展开更多
The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directio...The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directional solidification,focusing on the formation of freckle.Our experimental and numerical simulation results indicate that the TEMC circulation at sample scale under transverse static magnetic field leads to the enrichment of solute Al on one side of the sample.The TEMC and the solute enrichment degree increase with the increase of magnetic field when the magnetic field increases to 0.5 T.The enrichment degree of solute elements under magnetic field is affected by temperature gradient and growth rate.The non-uniform distribution of solute Al in the radial direction of the sample results in the non-uniform distribution of primary dendrite arm spacing(PDAS).Moreover,the applied magnetic field can lead to freckle formation and its number increases with the increase of magnetic field.The change of freckle is consistent with the anisotropy TEMC caused by the anisotropy of primary dendrite or primary dendrite network under magnetic field.Finally,the mechanism of synergism effect of the anisotropy TEMC,the distribution of solute Al and the PDAS on freckle formation and evolution is studied during directional solidification under magnetic field.展开更多
A three-dimensional mathematical model was established to investigate the behavior of molten steel flow and steel/slag interface with different processes and electromagnetic parameters under two different static magne...A three-dimensional mathematical model was established to investigate the behavior of molten steel flow and steel/slag interface with different processes and electromagnetic parameters under two different static magnetic field configurations [ruler-type electromagnetic brake （EMBr ruler） and vertical electromagnetic brake （V-EMBr）] in a continuous casting mold. The results showed that the brake effect of EMBr ruler is significantly influenced by its configuration parameters, the distance between the pole and bottom of the submerged entry nozzle （SEN）, and the port angle of the SEN outlet; therefore, it is not helpful to depress the diffusion of jet flow along the thickness direction of mold. For a constant SEN depth and port angle, there is a reasonable pole position （P = 0 mm） where the pole simultaneously covers three key zones, i.e., the jet flow impact zone and the upward and downward backflow zones. For V-EMBr, the magnetic field can simultaneously cover the three key zones and depress the diffusion of jet flow along the casting and thickness directions of the mold. Both the meniscus height and the impact intensity of the jet flow can be obviously depressed by V-EMBr even if the SEN depth and port angle have changed in the continuous casting process.展开更多
Compression waves propagating through molten metals are contributed to degassing, accelerating reaction rate,removing exclusions from molten metals and refining solidification structures during metallurgical processin...Compression waves propagating through molten metals are contributed to degassing, accelerating reaction rate,removing exclusions from molten metals and refining solidification structures during metallurgical processing of materials. In the present study, two electromagnetic methods are proposed to generate intense compression wavesdirectly in liquid metals. One is the simultaneous imposition of a high frequency electrical current field and a staticmagnetic field; the other is that of a high frequency magnetic field and a static magnetic field. A mathematical modelbased on compressible fluid dynamics and electromagnetic fields theory has been developed to derive pressure distributions of the generated waves in a metal. It shows that the intensity of compression waves is proportional to thatof the high frequency electromagnetic force. And the frequency is the same as that of the imposed electromagneticforce. On the basis of theoretical analyses, pressure change in liquid gallium was examined by a pressure transducerunder various conditions. The observed results approximately agreed with the predictions derived from the theoreticalanalyses and calculations. Moreover, the effect of the generated waves on improvement of solidification structureswas also examined. It shows that the generated compression waves can refine solidification structures when they wereapplied to solidification process of Sn-Pb alloy. This study indicates a new method to generate compression wavesby imposing high frequency electromagnetic force locally on molten metals and this kind of compression waves canprobably overcome the difficulties when waves are excited by mechanical vibration in high temperature environments.展开更多
Objective: To investigate the effects of static magnetic field(SMF) on the viability, adhesion molecule expression of human umbilical vessel endothelial cell. Methods: Magnetic flux intensity was 0. 1 mT, 1 mT, 10 mT....Objective: To investigate the effects of static magnetic field(SMF) on the viability, adhesion molecule expression of human umbilical vessel endothelial cell. Methods: Magnetic flux intensity was 0. 1 mT, 1 mT, 10 mT. Cell viability and proliferation were measured with 3H-TdR and MTT methods; and apoptosis of human umbilical vein endothelial cell (HUVEC) was studied by flow cytometry and transmission electric microscopy. ELISA was used to measure the expression of ICAM-1 and VCAM-1 on endothelium. Results: 0. 1 mT SMF had no effects on the growth of HUVEC. however,SMF of 1 mT, 10 mT attenuated growth of HUVEC. 10 mT static magnetic field could induce apoptosis and necrosis of HUVEC. 10 mT SMF enhanced the expression of ICAM-1 and VCAM-1 on endothelium. Conclusion: The effect of SMF depends on the intensity of SMF. 10 mT SMF has adverse effects on human umbilical vessel endothelial cell.展开更多
Utilizing ANSYS CFX commercial software and volume fraction of fluid （VOF） model, fluctuation behav- ior of steel/slag interface was numerically simulated in continuous casting mold with static magnetic field, and t...Utilizing ANSYS CFX commercial software and volume fraction of fluid （VOF） model, fluctuation behav- ior of steel/slag interface was numerically simulated in continuous casting mold with static magnetic field, and the influence of metal jet characteristics on the behavior of steel/slag interface was investigated. The results indicated that the behavior of steel/slag interface is similar at different process parameters, which is closely related to the characteristic of the flow field. The steel/slag interface has an obvious trough characteristic, which can be divided in- to three zones： frontal valley zone, back valley zone and horizontal zone~ as the magnetic flux density increases, the fluctuation of liquid level increases firstly and then decreases, and a reasonable magnetic flux density can make steel/ slag interface obtain a relatively flat interface, which can prevent slag from being entrapped into liquid steel. For a thin slab continuous casting process, when the casting speed is 4 m/min, a reasonable magnetic flux density is about 0.5 T, and the interfacial fluctuation is weaker. No matter the position of magnetic field is horizontal or vertical, for different operating parameters, there is a corresponding reasonable magnetic field position where the steel/slag inter- face fluctuation can be properly controlled and slag entrapment can be prevented.展开更多
Electromagnetic relay is a widely used apparatus which usually works in a magnetic disturbance environment. To evaluate its electromagnetic compatibility (EMC) in a static magnetic field, dynamic characteristics of a ...Electromagnetic relay is a widely used apparatus which usually works in a magnetic disturbance environment. To evaluate its electromagnetic compatibility (EMC) in a static magnetic field, dynamic characteristics of a clapper relay in a uniform static magnetic field situation based on the finite element method (FEM) is studied. Influences of the magnetic field on dynamic parameters (delay time, pick-up time, end pressure, and final velocity) as well as a situation in which the relay cannot function normally are analyzed. Simulation reveals that the external magnetic field which weakens the relay’s air-gap field has a greater influence on the relay’s dynamic parameters than the one strengthening the field. The validity of the simulation is verified by measured results of coil current and armature displacement.展开更多
A weak transverse static magnetic field(WTSMF,0–0.5 T)is applied to the directional solidification process of a DD3 Ni-based SX superalloy,aiming to tailor the microstructure and microsegregation of alloys.The mechan...A weak transverse static magnetic field(WTSMF,0–0.5 T)is applied to the directional solidification process of a DD3 Ni-based SX superalloy,aiming to tailor the microstructure and microsegregation of alloys.The mechanisms of microstructural refinement and microsegregation distribution caused by a WTSMF during directional solidification are discussed.It is shown that the primary dendrite arm spacing is rapidly reduced from 181 to 143μm,and the average size ofγ′phase is significantly refined from 0.85 to 0.25μm as the magnetic field increases from 0 to 0.5 T.At the same time,the volumefractions ofγ/γ′eutectic and the segregation coefficient are also gradually decreased.The 3D numerical simulations of the multiscale convection in liquid phase show that the modifications of the microstructure and microsegregation in DD3 are mainly attributed to the enhanced liquid flow caused by thermoelectric magnetic convection(TEMC)at dendrite/sample scale under the WTSMF.The maximum of the TEMC increases with increasing the magnetic field intensity.This work paves a simple way to optimize the microstructure and microsegregation in directionally solidified Ni-based SX superalloys without changing the processing parameters and composition.展开更多
As concentration distribution changes have important effects on material structures and properties,controlling the concentration distribution is essential to alloy performance.The aim of the present work is to control...As concentration distribution changes have important effects on material structures and properties,controlling the concentration distribution is essential to alloy performance.The aim of the present work is to control and adjust the concentration distribution by the static magnetic field.It is found that the magnetic field disperses grain boundary segregation and causes the uniform distribution of concentration.Further,by the three-dimensional computed tomography(3 D-CT) reconstruction,the flow distribution is seen and the effect mechanism of the magnetic field is revealed.The present work may clarify the ambiguous understanding on the effect of the static magnetic field on solidification process.展开更多
The present work investigates how axial static magnetic field affects the solidification structure and the solute distribution in directionally solidified GCr18Mo steel. Experimental results show that grain refinement...The present work investigates how axial static magnetic field affects the solidification structure and the solute distribution in directionally solidified GCr18Mo steel. Experimental results show that grain refinement and the colunmar to equiaxed transition is enhanced with the increases in the magnetic field intensity （B） and temperature gradient （G） and the decrease in the growth speed. This phenomenon is simultaneously accompanied by more uniformly distributed alloying elements. The corresponding numerical simulations verify a thermoelectric （TE） magnetic convection pattern in the mushy zone due to the interaction between the magnetic field and TE current. The TE magnetic convection in the liquid should be responsible for the motion of dendrite fragments. The TE magnetic force acting on the dendrite is one of the driving forces trigging fragmentation.展开更多
The hollow-cup Permanent Magnet(PM) motors have the characteristics of low power consumption, and are widely used in the aerospace field. At present, the tile-shaped PMs used by hollow-cup PM motors have poor sinusoid...The hollow-cup Permanent Magnet(PM) motors have the characteristics of low power consumption, and are widely used in the aerospace field. At present, the tile-shaped PMs used by hollow-cup PM motors have poor sinusoidal characteristics of the air gap magnetic flux density waveform, which will cause torque ripple. The existing method for improving the air gap magnetic flux density waveform is not very effective when applied to hollow cup, a special motor with no stator core and large air gap. A bow-shaped PMs structure is designed for the hollow-cup motor in this paper. First, the equivalent surface current method is used to calculate the analytical formula of the static magnetic field of the model. Then, the Finite Element(FE) method is used to calculate the static air gap flux density waveform of conventional tile-shaped PMs and bow-shaped PMs with different bow heights, and the corresponding harmonics and sine distortion are obtained by Fourier decomposition. The simulation results show that the bow-shaped PMs can effectively improve the sinusoidal characteristics of the static air gap flux density waveform. And the suitable bow height is determined. Finally, a prototype is made based on the suitable bow height for experiments, and compared with the analytical result and the FE result, and the accuracy and effectiveness of the bow-shaped PMs with the suitable bow height are verified.展开更多
Freezing processes of several liquids under static magnetic field(SMF) less than 50 mT were investigated. Central temperature of liquid samples held in glass test tubes immersed in a liquid bath was measured and colle...Freezing processes of several liquids under static magnetic field(SMF) less than 50 mT were investigated. Central temperature of liquid samples held in glass test tubes immersed in a liquid bath was measured and collected. Nucleation temperature and phase transition time were obtained from freezing curves. Normality tests were performed for nucleation temperature of these liquids with/without magnetic field and normality distributions were justified. Analysis of variances was carried out for nucleation temperature of these liquids with magnetic field flux density as the influencing factor. Results showed that no significant difference was found for deionized water with or without SMF. However, differences exist in 0.9% NaCl solution and 5% ethylene glycol solution with and without SMF. Nucleation temperature of 0.9% NaCl with SMF is lower than that without SMF, while its phase transition time is shorter than that without SMF. Nucleation temperature of 5% ethylene glycol with SMF is higher than that without SMF, while its phase transition time is not modified with SMF.展开更多
In this research,sintering Fe-6.5wt%Si Compact specimen in static magnetic field is proposed for preparing high silicon steel.It is found that the densifications of the compacts are affected remarkably by superimposin...In this research,sintering Fe-6.5wt%Si Compact specimen in static magnetic field is proposed for preparing high silicon steel.It is found that the densifications of the compacts are affected remarkably by superimposing magnetic field.The density of the compacts can be increased when the MFD is higher than 0.2 T.The highest relative density of the samples is 97.2%.The magnetic property of silicon steel could be improved when superimpose static magnetic field in sintering process,the permeability of the compact are two times of that without magnetic field,and the magnetic property parallel to the direction of the magnetic field was evidently higher than that in perpendicular direction.展开更多
Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in Europe.The predominant pharmacolog...Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in Europe.The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late stage.In the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery stage.During the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte proliferation.Moreover,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially declines.Overall,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP overdose.Of note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.展开更多
The effect of the axial static magnetic field(ASMF)on cleanliness and microstructure in magnetically controlled electroslag remelted GCr15 bearing steel ingots was investigated experimentally.The results show that a m...The effect of the axial static magnetic field(ASMF)on cleanliness and microstructure in magnetically controlled electroslag remelted GCr15 bearing steel ingots was investigated experimentally.The results show that a magnetically controlled spin-vibration induced by the interaction of the ASMFs and the remelting current exists at the consumable electrode tip,resulting in thinner liquid melt film and smaller droplets.With the increase in magnetic flux density,the optimization effect of ASMFs on electroslag remelting process increases and reaches the peak with a 40 mT ASMF,then decreases.The cleanliness of the ingots was improved,and the count of inclusions larger than 5μm was reduced.The microstructure of the ingots processed with a 40 mT ASMF was significantly refined.The depth of the metallic molten pool was reduced from 45.2 to 17.5 mm with the application of 40 mT ASMF.The tensile strength,impact toughness,and Rockwell hardness of the ingots obtained under the 40 mT ASMF were significantly improved.The mechanisms of the spin-vibration occurring at the electrode tip end were interpreted in detail to elucidate the effect of ASMFs.展开更多
基金supported by the National Natural Science Foundation of China(32470122)Heye Health Technology Chong Ming Project(HYCMP-2023006)。
文摘Static magnetic field(SMF)exposure exerts notable regulatory effects on metabolic disorders,yet its influence on metabolic dysfunction-associated fatty liver disease(MAFLD)and gut microbiota during disease progression remains unclear.In this study,MAFLD was induced in mice via a high-fat diet(HFD),followed by exposure to a 0.2 T SMF for 12 h per day over a 10 week period.SMF treatment significantly attenuated body weight gain,alleviated hepatic lipid accumulation,and improved liver function.Sequencing analysis of intestinal contents revealed a significant increase in microbial diversity and enrichment of beneficial bacterial taxa under SMF exposure.Integrated multi-omics analysis and Spearman correlation further demonstrated that SMF significantly reduced the expression of genes involved in fatty acid synthesis and modulated pathways related to polyunsaturated fatty acid and glutamate metabolism,in close association with shifts in beneficial gut microbiota.Furthermore,transcriptomic profiling of liver tissue indicated that SMF inhibited fatty acid synthesis and elongation by regulating the expression of peroxisome proliferator-activated receptorγ(PPARγ),thereby contributing to reduced hepatic burden.These findings highlight SMF as a promising non-invasive strategy for MAFLD intervention and provide insights into the microbiota-mediated metabolic axis underlying its therapeutic effects.
基金supported by the the National Natural Science Foundation of China(32071751).
文摘A geomagnetic field is a significant factor dur-ing the growth and development of trees.Changes in the magnetic field(MF)will result in reactions at the biochemi-cal,molecular,cellular and gene levels.However,it is not clear how a magnetic field affects metabolism and home-ostasis under stressful conditions such as salinity.In this study,a novel method was developed of a static magnetic field(SMF)to investigate magnetobiological changes in trees.The results show that pre-treatment of poplar(Popu-lus×euramericana‘Neva’)cuttings with a static magnetic field significantly mitigated the negative effects of salinity stress on their growth and physiological activities.Bio-chemical assays revealed that several chemical messengers,including hydrogen peroxide(H2O2)and O_(2)^(·-),were sig-nificantly improved in roots treated with salt,implying an increase reactive oxygen species.A static magnetic field also significantly increased proline concentrations,soluble protein contents,and CAT and SOD activities.Electrophysiological experiments further revealed that pre-treatment with a static magnetic field remarkably decreased salt-induced Na^(+)influx and H^(+)efflux which control plant salt tolerance.In pharmacological experiments,because the Na^(+)/H^(+)cor-relation was closely related to the SMF-activated plasma membrane and Na^(+)antiporter activity alleviated the mas-sive accumulation of salt-induced reactive oxygen spe-cies(ROS)within the roots.In addition,a static magnetic field dramatically increased the transcriptional activity of stress-responsive genes,including PtrRBOHD and PtrHA5.Together,these results indicate that SMF reduced Na^(+)influx by activating Na^(+)/H^(+)antiporters and plasma membrane H^(+)-ATPase to effectively maintain homeostasis by regu-lating the reactive oxygen species system and cytoplasmic osmotic potential.Ultimately,these static magnetic field methods improved salt tolerance in poplar cuttings,and,for future research,similar methods could be applied to other plants.
基金Projects(51201029,51071042,51374067)supported by the National Natural Science Foundation of ChinaProjects(N130409002,N130209001)supported by the Research Funds for the Central UniversitiesProject(2012M520637)supported by the China Postdoctoral Science Foundation
文摘The large and small sized Cu（solid）/Al（liquid） couples were prepared to investigate the directional growth behavior of primary a（Al） phase during a concentration-gradient-controlled solidification process under various static magnetic fields（SMFs）.The results show that in the large couples,the α（Al） dendrites reveal a directional growth character whether without or with the SMF.However,the 12 T magnetic field induces regular growth,consistent deflection and the decrease of secondary arm spacing of the dendrites.In the small couples,the α（Al） dendrites still reveal a directional growth character to some extent with a SMF of ≤5 T.However,an 8.8 T SMF destroys the directional growth and induces severe random deflections of the dendrites.When the SMF increases to 12 T,the a（Al） dendrites become quite regular despite of the consistent deflection.The directional growth arises from the continuous long-range concentration gradient field built in the melt.The morphological modification is mainly related to the suppression of natural convections and the induction of thermoelectric magnetic convection by the SMF.
基金Project(51276203)supported by the National Natural Science Foundation of China
文摘A series of three-dimensional numerical computations were conducted to understand the effects of different static magnetic fields on thermal fluctuation and melt flow during the detached solidification of CdZnTe. Numerical calculations were carried out by three different configurations of magnetic field: without magnetic field, with an axial magnetic field (AMF) and with a cusp-shaped magnetic field (CMF). The results reveal that the magnetic fields can effectively suppress the melt flow and thermal fluctuation and the suppression effect of the AMF is stronger than that of the CMF. Besides, the physical mechanism of thermocapillary?buoyancy convection instability was discussed and the effects of magnetic field on the critical Marangoni number were also obtained.
基金supported by the National Natural Science Foundation of China (U21A20148, 31900506, 52007185)International Partnership Program of the Chinese Academy of Sciences(116134KYSB20210052)+2 种基金Heye Health Technology Chong Ming Project(HYCMP2021010)CAS President’s International Fellowship Initiative Grant(2022VMA0009)CASHIPS Director’s Fund (BJPY2021A06,2021YZGH04, YZJJ2020QN26, YZJJZX202014, YZJJ2021QN32,YZJJ2023QN43)。
文摘Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.
基金financial support of the National Key Research and Development Program of China(No.2016YFB0300401)the National Natural Science Foundation of China(Nos.U1732276 and 51704193)+2 种基金the General Financial Grant from the China Postdoctoral Science Foundation(No.2017M621431)the Science and Technology Commission of Shanghai Municipality(No.15520711000)Independent Research and Development Project of State Key of Advanced Special Steel,Shanghai University(SKLASS2015-Z021,SELF-2014-02)
文摘The voltage was recorded to investigate the influence of the static magnetic field on droplet evolution during the mag-netically controlled electroslag remelting （MC-ESR） process. MC-ESR experiments were carried out under differentremelting current, and transverse static magnetic fields （TSMF） of 85 mT, 130 mT and 160 mT were superimposed.Statistical work was performed to obtain the quantitative data of the droplets. The ASPEX Explorer was utilized toinvestigate the inclusions evolution of GCr15 ingots. The number of the droplets was 31 in 20 s during the traditional ESRprocess and reached 50 and 51 under the MC-ESR process with the TSMF of 85 mT and 130 mT, respectively. Whencompared the traditional ESR process with the MC-ESR process, the inclusions amount reduced 67%.
基金the National Natural Science Foundation of China(Nos.51571056,51690164 and 51904183)the Technological Innovation Projects of Universities in Guangdong Province(Nos.2017KTSCX177 and 2020KQNCX084)+2 种基金China Postdoctoral Science Foundation(No.2020M683463)Guangdong Basic and Applied Basic Research Foundation(No.2019A1515110135)the Natural Science Foundation of Guangdong Province(No.2018A030310024)。
文摘The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directional solidification,focusing on the formation of freckle.Our experimental and numerical simulation results indicate that the TEMC circulation at sample scale under transverse static magnetic field leads to the enrichment of solute Al on one side of the sample.The TEMC and the solute enrichment degree increase with the increase of magnetic field when the magnetic field increases to 0.5 T.The enrichment degree of solute elements under magnetic field is affected by temperature gradient and growth rate.The non-uniform distribution of solute Al in the radial direction of the sample results in the non-uniform distribution of primary dendrite arm spacing(PDAS).Moreover,the applied magnetic field can lead to freckle formation and its number increases with the increase of magnetic field.The change of freckle is consistent with the anisotropy TEMC caused by the anisotropy of primary dendrite or primary dendrite network under magnetic field.Finally,the mechanism of synergism effect of the anisotropy TEMC,the distribution of solute Al and the PDAS on freckle formation and evolution is studied during directional solidification under magnetic field.
基金This work was financially supported by the National Natural Science Foundation of China （No. 51574083） and the Program of Introducing Talents of Discipline to Universities （The 111 Project of China, No. B07015）. The authors would also like to thank the referees for their work which has contributed to this paper.
文摘A three-dimensional mathematical model was established to investigate the behavior of molten steel flow and steel/slag interface with different processes and electromagnetic parameters under two different static magnetic field configurations [ruler-type electromagnetic brake （EMBr ruler） and vertical electromagnetic brake （V-EMBr）] in a continuous casting mold. The results showed that the brake effect of EMBr ruler is significantly influenced by its configuration parameters, the distance between the pole and bottom of the submerged entry nozzle （SEN）, and the port angle of the SEN outlet; therefore, it is not helpful to depress the diffusion of jet flow along the thickness direction of mold. For a constant SEN depth and port angle, there is a reasonable pole position （P = 0 mm） where the pole simultaneously covers three key zones, i.e., the jet flow impact zone and the upward and downward backflow zones. For V-EMBr, the magnetic field can simultaneously cover the three key zones and depress the diffusion of jet flow along the casting and thickness directions of the mold. Both the meniscus height and the impact intensity of the jet flow can be obviously depressed by V-EMBr even if the SEN depth and port angle have changed in the continuous casting process.
基金This work has been partially performed under the financial supports from the National Natural Science Foundation of China (Grant No.50204004)the National Fundamental Research Project - new generation steel research project of China (Grant No.G1998061
文摘Compression waves propagating through molten metals are contributed to degassing, accelerating reaction rate,removing exclusions from molten metals and refining solidification structures during metallurgical processing of materials. In the present study, two electromagnetic methods are proposed to generate intense compression wavesdirectly in liquid metals. One is the simultaneous imposition of a high frequency electrical current field and a staticmagnetic field; the other is that of a high frequency magnetic field and a static magnetic field. A mathematical modelbased on compressible fluid dynamics and electromagnetic fields theory has been developed to derive pressure distributions of the generated waves in a metal. It shows that the intensity of compression waves is proportional to thatof the high frequency electromagnetic force. And the frequency is the same as that of the imposed electromagneticforce. On the basis of theoretical analyses, pressure change in liquid gallium was examined by a pressure transducerunder various conditions. The observed results approximately agreed with the predictions derived from the theoreticalanalyses and calculations. Moreover, the effect of the generated waves on improvement of solidification structureswas also examined. It shows that the generated compression waves can refine solidification structures when they wereapplied to solidification process of Sn-Pb alloy. This study indicates a new method to generate compression wavesby imposing high frequency electromagnetic force locally on molten metals and this kind of compression waves canprobably overcome the difficulties when waves are excited by mechanical vibration in high temperature environments.
文摘Objective: To investigate the effects of static magnetic field(SMF) on the viability, adhesion molecule expression of human umbilical vessel endothelial cell. Methods: Magnetic flux intensity was 0. 1 mT, 1 mT, 10 mT. Cell viability and proliferation were measured with 3H-TdR and MTT methods; and apoptosis of human umbilical vein endothelial cell (HUVEC) was studied by flow cytometry and transmission electric microscopy. ELISA was used to measure the expression of ICAM-1 and VCAM-1 on endothelium. Results: 0. 1 mT SMF had no effects on the growth of HUVEC. however,SMF of 1 mT, 10 mT attenuated growth of HUVEC. 10 mT static magnetic field could induce apoptosis and necrosis of HUVEC. 10 mT SMF enhanced the expression of ICAM-1 and VCAM-1 on endothelium. Conclusion: The effect of SMF depends on the intensity of SMF. 10 mT SMF has adverse effects on human umbilical vessel endothelial cell.
基金Item Sponsored by National Natural Science Foundation of China(50604005,50834009)Natural Science Foundation of Liaoning Province of China(20102074)+2 种基金Fundamental Research Funds for the Central Universities of China(N100409005)Key Grant Project of Chinese Ministry of Education(311014)"111" Project of China(B07015)
文摘Utilizing ANSYS CFX commercial software and volume fraction of fluid （VOF） model, fluctuation behav- ior of steel/slag interface was numerically simulated in continuous casting mold with static magnetic field, and the influence of metal jet characteristics on the behavior of steel/slag interface was investigated. The results indicated that the behavior of steel/slag interface is similar at different process parameters, which is closely related to the characteristic of the flow field. The steel/slag interface has an obvious trough characteristic, which can be divided in- to three zones： frontal valley zone, back valley zone and horizontal zone~ as the magnetic flux density increases, the fluctuation of liquid level increases firstly and then decreases, and a reasonable magnetic flux density can make steel/ slag interface obtain a relatively flat interface, which can prevent slag from being entrapped into liquid steel. For a thin slab continuous casting process, when the casting speed is 4 m/min, a reasonable magnetic flux density is about 0.5 T, and the interfacial fluctuation is weaker. No matter the position of magnetic field is horizontal or vertical, for different operating parameters, there is a corresponding reasonable magnetic field position where the steel/slag inter- face fluctuation can be properly controlled and slag entrapment can be prevented.
基金Project (No. 513230502) supported by the PLA General ArmamentDepartment of China
文摘Electromagnetic relay is a widely used apparatus which usually works in a magnetic disturbance environment. To evaluate its electromagnetic compatibility (EMC) in a static magnetic field, dynamic characteristics of a clapper relay in a uniform static magnetic field situation based on the finite element method (FEM) is studied. Influences of the magnetic field on dynamic parameters (delay time, pick-up time, end pressure, and final velocity) as well as a situation in which the relay cannot function normally are analyzed. Simulation reveals that the external magnetic field which weakens the relay’s air-gap field has a greater influence on the relay’s dynamic parameters than the one strengthening the field. The validity of the simulation is verified by measured results of coil current and armature displacement.
基金financially supported by the National Natural Science Foundation of China(Nos.51690163,52130204,52174376,51822405)the Science and Technology Innovation Team Plan of Shaan Xi Province(No.2021TD-17)+3 种基金the Joint Research Funds of the Department of Science&Technology of Shaanxi Province and NPU(No.2020GXLH-Z-024)the Fundamental Research Funds for the Central Universities(No.D5000210902)the Key R&D Program of ShaanXi Province(No.2019ZDLGY 04-04)the Research Fund of the State Key Laboratory of Solidification Processing(NPU)(No.2019-QZ-02)。
文摘A weak transverse static magnetic field(WTSMF,0–0.5 T)is applied to the directional solidification process of a DD3 Ni-based SX superalloy,aiming to tailor the microstructure and microsegregation of alloys.The mechanisms of microstructural refinement and microsegregation distribution caused by a WTSMF during directional solidification are discussed.It is shown that the primary dendrite arm spacing is rapidly reduced from 181 to 143μm,and the average size ofγ′phase is significantly refined from 0.85 to 0.25μm as the magnetic field increases from 0 to 0.5 T.At the same time,the volumefractions ofγ/γ′eutectic and the segregation coefficient are also gradually decreased.The 3D numerical simulations of the multiscale convection in liquid phase show that the modifications of the microstructure and microsegregation in DD3 are mainly attributed to the enhanced liquid flow caused by thermoelectric magnetic convection(TEMC)at dendrite/sample scale under the WTSMF.The maximum of the TEMC increases with increasing the magnetic field intensity.This work paves a simple way to optimize the microstructure and microsegregation in directionally solidified Ni-based SX superalloys without changing the processing parameters and composition.
基金financially supported partly by National Natural Science Foundation of China (Nos. 51571056 and 51690164)“Shuguang Program” from Shanghai Municipal Education CommissionShanghai Science and Technology Committee Grant (19XD1401600, 19010500300)。
文摘As concentration distribution changes have important effects on material structures and properties,controlling the concentration distribution is essential to alloy performance.The aim of the present work is to control and adjust the concentration distribution by the static magnetic field.It is found that the magnetic field disperses grain boundary segregation and causes the uniform distribution of concentration.Further,by the three-dimensional computed tomography(3 D-CT) reconstruction,the flow distribution is seen and the effect mechanism of the magnetic field is revealed.The present work may clarify the ambiguous understanding on the effect of the static magnetic field on solidification process.
基金financially supported by the Joint Funds of the National Natural Science Foundation of China (No. U1560202)the National Natural Science Foundation of China (Nos. 51604171 and 51690162)+1 种基金the Shanghai Municipal Science and Technology Commission Grant (No. 17JC1400602)the United Innovation Program of Shanghai Commercial Aircraft Engine (Nos. AR910 and AR911)
文摘The present work investigates how axial static magnetic field affects the solidification structure and the solute distribution in directionally solidified GCr18Mo steel. Experimental results show that grain refinement and the colunmar to equiaxed transition is enhanced with the increases in the magnetic field intensity （B） and temperature gradient （G） and the decrease in the growth speed. This phenomenon is simultaneously accompanied by more uniformly distributed alloying elements. The corresponding numerical simulations verify a thermoelectric （TE） magnetic convection pattern in the mushy zone due to the interaction between the magnetic field and TE current. The TE magnetic convection in the liquid should be responsible for the motion of dendrite fragments. The TE magnetic force acting on the dendrite is one of the driving forces trigging fragmentation.
基金supported by the National Natural Science Foundation of China(Nos.52075017,62073010)the Excellent Youth Science Foundation of China(No.51722501)。
文摘The hollow-cup Permanent Magnet(PM) motors have the characteristics of low power consumption, and are widely used in the aerospace field. At present, the tile-shaped PMs used by hollow-cup PM motors have poor sinusoidal characteristics of the air gap magnetic flux density waveform, which will cause torque ripple. The existing method for improving the air gap magnetic flux density waveform is not very effective when applied to hollow cup, a special motor with no stator core and large air gap. A bow-shaped PMs structure is designed for the hollow-cup motor in this paper. First, the equivalent surface current method is used to calculate the analytical formula of the static magnetic field of the model. Then, the Finite Element(FE) method is used to calculate the static air gap flux density waveform of conventional tile-shaped PMs and bow-shaped PMs with different bow heights, and the corresponding harmonics and sine distortion are obtained by Fourier decomposition. The simulation results show that the bow-shaped PMs can effectively improve the sinusoidal characteristics of the static air gap flux density waveform. And the suitable bow height is determined. Finally, a prototype is made based on the suitable bow height for experiments, and compared with the analytical result and the FE result, and the accuracy and effectiveness of the bow-shaped PMs with the suitable bow height are verified.
基金Supported by the National Natural Science Foundation of China(51306104)
文摘Freezing processes of several liquids under static magnetic field(SMF) less than 50 mT were investigated. Central temperature of liquid samples held in glass test tubes immersed in a liquid bath was measured and collected. Nucleation temperature and phase transition time were obtained from freezing curves. Normality tests were performed for nucleation temperature of these liquids with/without magnetic field and normality distributions were justified. Analysis of variances was carried out for nucleation temperature of these liquids with magnetic field flux density as the influencing factor. Results showed that no significant difference was found for deionized water with or without SMF. However, differences exist in 0.9% NaCl solution and 5% ethylene glycol solution with and without SMF. Nucleation temperature of 0.9% NaCl with SMF is lower than that without SMF, while its phase transition time is shorter than that without SMF. Nucleation temperature of 5% ethylene glycol with SMF is higher than that without SMF, while its phase transition time is not modified with SMF.
基金Item Sponsored by National Natural Science Foundation of China[No.51034010]
文摘In this research,sintering Fe-6.5wt%Si Compact specimen in static magnetic field is proposed for preparing high silicon steel.It is found that the densifications of the compacts are affected remarkably by superimposing magnetic field.The density of the compacts can be increased when the MFD is higher than 0.2 T.The highest relative density of the samples is 97.2%.The magnetic property of silicon steel could be improved when superimpose static magnetic field in sintering process,the permeability of the compact are two times of that without magnetic field,and the magnetic property parallel to the direction of the magnetic field was evidently higher than that in perpendicular direction.
基金supported by the National Key R&D Program of China(2023YFB3507004)National Natural Science Foundation of China(U21A20148)+5 种基金International Partnership Program of Chinese Academy of Sciences(116134KYSB20210052)Anhui Provincial Natural Science Foundation(2308085QE183,2308085QE181)CASHIPS Director’s Fund(YZJJ2024QN44,YZJJ2023QN43)Heye Health Technology Chong Ming Project(HYCMP2021010)China Post-doctoral Science Foundation(2023M743536)Science Research Fund for Postdoctoral in Anhui Province(2023B669)。
文摘Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in Europe.The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late stage.In the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery stage.During the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte proliferation.Moreover,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially declines.Overall,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP overdose.Of note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.
基金This work is supported by the National Key Research and Development Program of China under Grant numbers of 2016YFB0300401,2018YFF0109404,and 2016YFB0301401the National Natural Science Foundation of China under Grant numbers of U1860202,U1732276,50134010,51704193,51904184,and 52004156the Users with Excellence Program of Hefei Science Center CAS under Grant number of 2019HSC-UE010,and the Changjiang Scholar Program of Chinese Ministry of Education.
文摘The effect of the axial static magnetic field(ASMF)on cleanliness and microstructure in magnetically controlled electroslag remelted GCr15 bearing steel ingots was investigated experimentally.The results show that a magnetically controlled spin-vibration induced by the interaction of the ASMFs and the remelting current exists at the consumable electrode tip,resulting in thinner liquid melt film and smaller droplets.With the increase in magnetic flux density,the optimization effect of ASMFs on electroslag remelting process increases and reaches the peak with a 40 mT ASMF,then decreases.The cleanliness of the ingots was improved,and the count of inclusions larger than 5μm was reduced.The microstructure of the ingots processed with a 40 mT ASMF was significantly refined.The depth of the metallic molten pool was reduced from 45.2 to 17.5 mm with the application of 40 mT ASMF.The tensile strength,impact toughness,and Rockwell hardness of the ingots obtained under the 40 mT ASMF were significantly improved.The mechanisms of the spin-vibration occurring at the electrode tip end were interpreted in detail to elucidate the effect of ASMFs.
