In the present paper,with the help of the resolvent operator and some analytic methods,the exact controllability and continuous dependence are investigated for a fractional neutral integro-differential equations with ...In the present paper,with the help of the resolvent operator and some analytic methods,the exact controllability and continuous dependence are investigated for a fractional neutral integro-differential equations with state-dependent delay.As an application,we also give one example to demonstrate our results.展开更多
This work is devoted to the following suspension bridge with state-dependent delay: . The main goal of this paper is to investigate the long-time behavior of the system. Under suitable hypothesis, the quasi-stability ...This work is devoted to the following suspension bridge with state-dependent delay: . The main goal of this paper is to investigate the long-time behavior of the system. Under suitable hypothesis, the quasi-stability estimates of the system are established, based on which the existence of global attractor with finite fractal dimension is obtained. Furthermore, the existence of exponential attractor is proved.展开更多
We propose and study a predator prey model with state-dependent delay where the prey population is assumed to have an age structure. The state-dependent delay appears due to the mature condition that the prey must spe...We propose and study a predator prey model with state-dependent delay where the prey population is assumed to have an age structure. The state-dependent delay appears due to the mature condition that the prey must spend an amount of time in the immature stage sufficient to accumulate a threshold amount of food. We perform a qualitative analysis of the solutions, which includes studying positivity and boundedness, existence and local stability of equilibria. For the global dynamics of the system, we discuss an attracting region which is determined by solutions, and the region collapses to the interior equilibrium in the constant delay case.展开更多
By utilizing the Krasnoselskii＇s fixed point theorem in cones we obtain some sufficient conditions which guarantee the existence of positive periodic solution for a class of differential equations with state-dependen...By utilizing the Krasnoselskii＇s fixed point theorem in cones we obtain some sufficient conditions which guarantee the existence of positive periodic solution for a class of differential equations with state-dependent delays. The results in the papers [1,2] have been improved.展开更多
This paper deals with the approximate controllability of semilinear neutral functional differential systems with state-dependent delay. The fractional power theory and α-norm are used to discuss the problem so that t...This paper deals with the approximate controllability of semilinear neutral functional differential systems with state-dependent delay. The fractional power theory and α-norm are used to discuss the problem so that the obtained results can apply to the systems involving derivatives of spatial variables. By methods of functional analysis and semigroup theory, sufficient conditions of approximate controllability are formulated and proved. Finally, an example is provided to illustrate the applications of the obtained results.展开更多
This paper is mainly concerned with the existence of mild solutions to a first order impulsive neutral evolution differential equations with state-dependent delay. By suitable fixed point theorems combined with theori...This paper is mainly concerned with the existence of mild solutions to a first order impulsive neutral evolution differential equations with state-dependent delay. By suitable fixed point theorems combined with theories of evolution systems,we prove some existence theorems. As an application,an example is also given to illustrate the obtained results.展开更多
Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay di...Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data.展开更多
This paper is concerned with the global stabilization of state-dependent switching neural networks(SDSNNs)viadiscontinuous event-triggered control with network-induced communication delay.Aiming at decreasing triggeri...This paper is concerned with the global stabilization of state-dependent switching neural networks(SDSNNs)viadiscontinuous event-triggered control with network-induced communication delay.Aiming at decreasing triggering times,a discontinuous event-trigger scheme is utilized to determine whether the sampling information is required to be sent outor not.Meanwhile,under the effect of communication delay,the trigger condition and SDSNNs are transformed into twotractable models by designing a fictitious delay function.Then,using the Lyapunov–Krasovskii stability theory,someinequality estimation techniques,and extended reciprocally convex combination method,two sufficient criteria are established for ensuring the global stabilization of the resulting closed-loop SDSNNs,respectively.A unified framework isderived that has the ability to handle the simultaneous existence of the communication delay,the properties of discontinuousevent-trigger scheme,as well as feedback controller design.Additionally,the developed results demonstrate a quantitativerelationship among the event trigger parameter,communication delay,and triggering times.Finally,two numerical examples are presented to illustrate the usefulness of the developed stabilization scheme.展开更多
The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled p...The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.展开更多
In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave so...In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.展开更多
This paper investigates the stability of switched systems with time-varying delay and all unstable subsystems. According to the stable convex combination, we design a state-dependent switching rule. By employing Wirti...This paper investigates the stability of switched systems with time-varying delay and all unstable subsystems. According to the stable convex combination, we design a state-dependent switching rule. By employing Wirtinger integral inequality and Leibniz-Newton formula, the stability results of nonlinear delayed switched systems whose nonlinear terms satisfy Lipschitz condition under the designed state-dependent switching rule are established for different assumptions on time delay. Moreover,some new stability results for linear delayed switched systems are also presented. The effectiveness of the proposed results is validated by three typical numerical examples.展开更多
The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivativ...The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivative operator.Additionally,time delays in the potential field force and coupling force transmission are both considered.Firstly,based on the delay decoupling formula,combined with statistical mean method and the fractional-order Shapiro–Loginov formula,the“statistic synchronization”among particles is obtained,revealing the statistical equivalence between the mean field behavior of the system and the behavior of individual particles.Due to the existence of the coupling delay,the impact of the coupling force on synchronization exhibits non-monotonic,which is different from the previous monotonic effects.Then,two kinds of theoretical expression of output amplitude gains G and G are derived by time-delay decoupling formula and small delay approximation theorem,respectively.Compared to G,G is an exact theoretical solution,which means that G is not only more accurate in the region of small delay,but also applies to the region of large delay.Finally,the study of the output amplitude gain G and its resonance behavior are explored.Due to the presence of the potential field delay,a new resonance phenomenon termed“periodic resonance”is discovered,which arises from the periodic matching between the potential field delay and the driving frequency.This resonance phenomenon is analyzed qualitatively and quantitatively,uncovering undiscovered characteristics in previous studies.展开更多
Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid...Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid(RA)can suppress the neurotoxic effects of CO.This study further explores,in vivo and in vitro,the molecular mechanisms by which RA alleviates CO-induced central nervous system damage.Methods:A cytotoxic model was established using the mouse hippocampal neuronal cell line HT22 and primary oligodendrocytes exposed to CO,and a DEACMP animal model was established in adult Kunming mice.Cell viability and apoptosis of hippocampal neurons and oligodendrocytes were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay and Annexin V/propidium iodide(PI)double staining.The transcriptional and protein expression of each gene was detected using real time fluorescence quantitative PCR(RT-qPCR)and Western blotting.Long noncoding RNA(lncRNA)SNHG15 and LINGO-1 were knocked down or overexpressed to observe changes in neurons and oligodendrocytes.In DEACMP mice,SNHG15 or LINGO-1 were knocked down to assess changes in central nervous tissue and downstream protein expression.Results:RA at 10 and 20μmol/L significantly reversed CO-induced apoptosis of hippocampal neurons and oligodendrocytes,downregulation of SNHG15 and LINGO-1,and upregulation of brain-derived neurotrophic factor(BDNF)and tyrosine kinase receptor B(TrkB)(all P<0.05).Overexpression of SNHG15 or LINGO-1 weakened the protective effect of RA against CO-induced cytotoxicity(all P<0.05).Knockdown of SNHG15 or LINGO-1 alleviated CO-induced apoptosis of hippocampal neurons and oligodendrocytes and upregulated BDNF and TrkB expression levels(all P<0.05).Experiments in DEACMP model mice showed that knockdown of SNHG15 or LINGO-1 mitigated central nervous system injury in DEACMP(all P<0.05).Conclusion:RA alleviates CO-induced apoptosis of hippocampal neurons and oligodendrocytes,thereby reducing central nervous system injury and exerting neuroprotective effects.LncRNA SNHG15 and LINGO-1 are key molecules mediating RA induced inhibition of neuronal apoptosis and are associated with the BDNF/TrkB pathway.These findings provide a theoretical framework for optimizing the clinical treatment of DEACMP and lay an experimental foundation for elucidating its molecular mechanisms.展开更多
To provide an energy-efficient and slab-demand-compliant rolling delay strategy,the simulation software is utilized to calculate the rolling delay process of the reheating furnace.Based on energy consumption evaluatio...To provide an energy-efficient and slab-demand-compliant rolling delay strategy,the simulation software is utilized to calculate the rolling delay process of the reheating furnace.Based on energy consumption evaluation,two optimization methods were employed.The bisection approach uses the needs of the slab to estimate the rolling delay temperature,and the golden section search method uses the energy consumption analysis of the slab to determine the high-temperature insulation duration.Generally,the slab closest to the discharge position in the control zone is selected as the optimization target.The optimized slab does not show a significant temperature rise after the end of the rolling delay process.When comparing the optimized rolling delay strategies with the traditional ones,the optimized rolling delay strategies not only meet the output requirements for slabs but also offer significant advantages in terms of energy efficiency,and this advantage increases with rolling delay time.展开更多
We report the fabrication of an 8-meter-long thin-flm lithium niobate optical true delay line using the photolithography-assisted chemomechanical etching technique,showing a low transmission loss of 0.036 dB/cm in the...We report the fabrication of an 8-meter-long thin-flm lithium niobate optical true delay line using the photolithography-assisted chemomechanical etching technique,showing a low transmission loss of 0.036 dB/cm in the conventional telecom band.展开更多
In this article,the global attractors of 2D g-Navier-Stokes equations are obtained in the space of C_(Hg) and CVg respectively.When the external force f is sufficiently small,the studies indicate that the global attra...In this article,the global attractors of 2D g-Navier-Stokes equations are obtained in the space of C_(Hg) and CVg respectively.When the external force f is sufficiently small,the studies indicate that the global attractor in C_(Hg) is equal to the global attractor in C_(Vg).展开更多
We present a compact optical delay line(ODL)with wide-range continuous tunability on thin-film lithium niobate platform.The proposed device integrates an unbalanced Mach-Zehnder interferometer(MZI)architecture with du...We present a compact optical delay line(ODL)with wide-range continuous tunability on thin-film lithium niobate platform.The proposed device integrates an unbalanced Mach-Zehnder interferometer(MZI)architecture with dual tunable couplers,where each coupler comprises two 2×2 multimode interferometers and a MZI phase-tuning section.Experimental results demonstrate continuous delay tuning from 0 to 293 ps through synchronized control of coupling coefficients,corresponding to a 4 cm path difference between interferometer arms.The measured delay range exhibits excellent agreement with theoretical predictions derived from ODL waveguide parameters.This result addresses critical challenges in integrated photonic systems that require precise temporal control,particularly for applications in optical communications and quantum information processing,where a wide tuning range is paramount.展开更多
BACKGROUND Visual impairment during early childhood can hinder motor,language,and social development,yet data on its developmental impact across common pediatric ocular diseases remain limited.AIM To investigate the d...BACKGROUND Visual impairment during early childhood can hinder motor,language,and social development,yet data on its developmental impact across common pediatric ocular diseases remain limited.AIM To investigate the developmental impact of low vision and blindness on children under six with common ocular diseases.METHODS This retrospective study reviewed records of new patients under six with visual impairment at Siriraj Hospital’s low vision rehabilitation center(January 2017-October 2022).We collected ocular,systemic,and developmental data;recorded visual acuity in the better-seeing eye after refractive correction;and assessed developmental domains with the DenverⅡ.Univariable and multi-variable logistic regression identified factors associated with developmental delay.RESULTS A total of 161 pediatric patients(mean age 24.9±18.9 months)were enrolled and evaluated based on their ability to fix on and follow an object or light source.Some were further assessed using the Allen picture chart and all had visual acuity worse than 1.07±0.58 LogMAR,and 83.2%were identified as having global developmental delay(GDD).The three most common ocular causes were cortical visual impairment(CVI),optic neuropathy/atrophy,and optic nerve hypoplasia.Extremely poor visual acuity(inability to fixate and follow)was significantly associated with GDD[adjusted odds ratio(AOR)41.0]and delays in all developmental domains:Gross motor(AOR 10.0),fine motor(AOR 12.8),language(AOR 5.3),and personal-social skills(AOR 13.4)(P≤0.002).Multiple disabilities,most often visual impairment with cerebral palsy,were also significantly associated with gross motor delays(AOR 7.7)and fine motor delays(AOR 4.0)(P<0.05).CVI was also related to delays in language and personal-social skills(AOR 9.1 each)(P<0.05).CONCLUSION This study underscores the developmental issues in children with visual impairment,especially those with poorer acuity,CVI,and multiple disabilities.Significant delays were observed in all domains,including GDD.A timely referral to specialists is strongly recommended.展开更多
This paper considers the fundamental channel estimation problem for the multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM)system in the presence of multi-cell interference.Specificall...This paper considers the fundamental channel estimation problem for the multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM)system in the presence of multi-cell interference.Specifically,this paper focuses on both channel modelling and receiver design for interference estimation and mitigation.We propose a delay-calibrated block-wise linear model,which extracts the delay of the dominant tap of each interference as a key parameter and approximates the residual channel coefficients by the recently developed blockwise linear model.Based on the delay-calibrated block-wise linear model and the angle-domain channel sparsity,we further conceive a message passing algorithm to solve the channel estimation problem.Numerical results demonstrate the superior performance of the proposed algorithm over the state-of-the-art algorithms.展开更多
文摘In the present paper,with the help of the resolvent operator and some analytic methods,the exact controllability and continuous dependence are investigated for a fractional neutral integro-differential equations with state-dependent delay.As an application,we also give one example to demonstrate our results.
文摘This work is devoted to the following suspension bridge with state-dependent delay: . The main goal of this paper is to investigate the long-time behavior of the system. Under suitable hypothesis, the quasi-stability estimates of the system are established, based on which the existence of global attractor with finite fractal dimension is obtained. Furthermore, the existence of exponential attractor is proved.
文摘We propose and study a predator prey model with state-dependent delay where the prey population is assumed to have an age structure. The state-dependent delay appears due to the mature condition that the prey must spend an amount of time in the immature stage sufficient to accumulate a threshold amount of food. We perform a qualitative analysis of the solutions, which includes studying positivity and boundedness, existence and local stability of equilibria. For the global dynamics of the system, we discuss an attracting region which is determined by solutions, and the region collapses to the interior equilibrium in the constant delay case.
基金Project supported by the Scientific Research foundation of Fujian Province (No.Z0511026).
文摘By utilizing the Krasnoselskii＇s fixed point theorem in cones we obtain some sufficient conditions which guarantee the existence of positive periodic solution for a class of differential equations with state-dependent delays. The results in the papers [1,2] have been improved.
基金supported by the National Natural Science Foundation of China(Nos.11171110,11371087)the Science and Technology Commission of Shanghai Municipality(No.13dz2260400)the Shanghai Leading Academic Discipline Project(No.B407)
文摘This paper deals with the approximate controllability of semilinear neutral functional differential systems with state-dependent delay. The fractional power theory and α-norm are used to discuss the problem so that the obtained results can apply to the systems involving derivatives of spatial variables. By methods of functional analysis and semigroup theory, sufficient conditions of approximate controllability are formulated and proved. Finally, an example is provided to illustrate the applications of the obtained results.
基金Supported by NNSF of China (10901075)the Key Project of Chinese Ministry of Education (210226)+1 种基金the Scientific Research Fund of Gansu Provincial Education Department (0804-08)"Qing Lan" Talent Engineering Funds (QL-05-16A) by Lanzhou Jiaotong University
文摘This paper is mainly concerned with the existence of mild solutions to a first order impulsive neutral evolution differential equations with state-dependent delay. By suitable fixed point theorems combined with theories of evolution systems,we prove some existence theorems. As an application,an example is also given to illustrate the obtained results.
文摘Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62003194,61973199,61573008,and 61973200).
文摘This paper is concerned with the global stabilization of state-dependent switching neural networks(SDSNNs)viadiscontinuous event-triggered control with network-induced communication delay.Aiming at decreasing triggering times,a discontinuous event-trigger scheme is utilized to determine whether the sampling information is required to be sent outor not.Meanwhile,under the effect of communication delay,the trigger condition and SDSNNs are transformed into twotractable models by designing a fictitious delay function.Then,using the Lyapunov–Krasovskii stability theory,someinequality estimation techniques,and extended reciprocally convex combination method,two sufficient criteria are established for ensuring the global stabilization of the resulting closed-loop SDSNNs,respectively.A unified framework isderived that has the ability to handle the simultaneous existence of the communication delay,the properties of discontinuousevent-trigger scheme,as well as feedback controller design.Additionally,the developed results demonstrate a quantitativerelationship among the event trigger parameter,communication delay,and triggering times.Finally,two numerical examples are presented to illustrate the usefulness of the developed stabilization scheme.
基金supported by Fund of State Key Laboratory of IPOC(BUPT)(No.IPOC2021ZT16),China.
文摘The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.
基金Supported by the National Natural Science Foundation of China(12261050)Science and Technology Project of Department of Education of Jiangxi Province(GJJ2201612 and GJJ211027)Natural Science Foundation of Jiangxi Province of China(20212BAB202021)。
文摘In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.
基金supported by the National Natural Science Foundation of China(61503052,61503050,61603065)the Scientific and Technological Research Program of Chongqing Municipal Education Commission(KJQN201801120,KJQN201801104,KJ1709206)+1 种基金the Opening Foundation of Hubei Key Laboratory of Applied Mathematics(Hubei University)(HBAM201805)Chongqing Science and Technology Commission Technology Innovation and Application Demonstration(Social Livelihood General)Project(cstc2018jscx-msyb X0049)。
文摘This paper investigates the stability of switched systems with time-varying delay and all unstable subsystems. According to the stable convex combination, we design a state-dependent switching rule. By employing Wirtinger integral inequality and Leibniz-Newton formula, the stability results of nonlinear delayed switched systems whose nonlinear terms satisfy Lipschitz condition under the designed state-dependent switching rule are established for different assumptions on time delay. Moreover,some new stability results for linear delayed switched systems are also presented. The effectiveness of the proposed results is validated by three typical numerical examples.
基金supported by the Natural Science Foundation of Sichuan Province,China(Youth Science Foundation)(Grant No.2022NSFSC1952).
文摘The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivative operator.Additionally,time delays in the potential field force and coupling force transmission are both considered.Firstly,based on the delay decoupling formula,combined with statistical mean method and the fractional-order Shapiro–Loginov formula,the“statistic synchronization”among particles is obtained,revealing the statistical equivalence between the mean field behavior of the system and the behavior of individual particles.Due to the existence of the coupling delay,the impact of the coupling force on synchronization exhibits non-monotonic,which is different from the previous monotonic effects.Then,two kinds of theoretical expression of output amplitude gains G and G are derived by time-delay decoupling formula and small delay approximation theorem,respectively.Compared to G,G is an exact theoretical solution,which means that G is not only more accurate in the region of small delay,but also applies to the region of large delay.Finally,the study of the output amplitude gain G and its resonance behavior are explored.Due to the presence of the potential field delay,a new resonance phenomenon termed“periodic resonance”is discovered,which arises from the periodic matching between the potential field delay and the driving frequency.This resonance phenomenon is analyzed qualitatively and quantitatively,uncovering undiscovered characteristics in previous studies.
基金supported by the Natural Science Foundation of Hunan Province(2021JJ31089)the Scientific Research Project of Health Commission of Hunan Province(202203104548),China。
文摘Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid(RA)can suppress the neurotoxic effects of CO.This study further explores,in vivo and in vitro,the molecular mechanisms by which RA alleviates CO-induced central nervous system damage.Methods:A cytotoxic model was established using the mouse hippocampal neuronal cell line HT22 and primary oligodendrocytes exposed to CO,and a DEACMP animal model was established in adult Kunming mice.Cell viability and apoptosis of hippocampal neurons and oligodendrocytes were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay and Annexin V/propidium iodide(PI)double staining.The transcriptional and protein expression of each gene was detected using real time fluorescence quantitative PCR(RT-qPCR)and Western blotting.Long noncoding RNA(lncRNA)SNHG15 and LINGO-1 were knocked down or overexpressed to observe changes in neurons and oligodendrocytes.In DEACMP mice,SNHG15 or LINGO-1 were knocked down to assess changes in central nervous tissue and downstream protein expression.Results:RA at 10 and 20μmol/L significantly reversed CO-induced apoptosis of hippocampal neurons and oligodendrocytes,downregulation of SNHG15 and LINGO-1,and upregulation of brain-derived neurotrophic factor(BDNF)and tyrosine kinase receptor B(TrkB)(all P<0.05).Overexpression of SNHG15 or LINGO-1 weakened the protective effect of RA against CO-induced cytotoxicity(all P<0.05).Knockdown of SNHG15 or LINGO-1 alleviated CO-induced apoptosis of hippocampal neurons and oligodendrocytes and upregulated BDNF and TrkB expression levels(all P<0.05).Experiments in DEACMP model mice showed that knockdown of SNHG15 or LINGO-1 mitigated central nervous system injury in DEACMP(all P<0.05).Conclusion:RA alleviates CO-induced apoptosis of hippocampal neurons and oligodendrocytes,thereby reducing central nervous system injury and exerting neuroprotective effects.LncRNA SNHG15 and LINGO-1 are key molecules mediating RA induced inhibition of neuronal apoptosis and are associated with the BDNF/TrkB pathway.These findings provide a theoretical framework for optimizing the clinical treatment of DEACMP and lay an experimental foundation for elucidating its molecular mechanisms.
文摘To provide an energy-efficient and slab-demand-compliant rolling delay strategy,the simulation software is utilized to calculate the rolling delay process of the reheating furnace.Based on energy consumption evaluation,two optimization methods were employed.The bisection approach uses the needs of the slab to estimate the rolling delay temperature,and the golden section search method uses the energy consumption analysis of the slab to determine the high-temperature insulation duration.Generally,the slab closest to the discharge position in the control zone is selected as the optimization target.The optimized slab does not show a significant temperature rise after the end of the rolling delay process.When comparing the optimized rolling delay strategies with the traditional ones,the optimized rolling delay strategies not only meet the output requirements for slabs but also offer significant advantages in terms of energy efficiency,and this advantage increases with rolling delay time.
基金supported by the National Natural Science Foundation of China(Grant Nos.12192251,12334014,92480001,12134001,12304418,12274130,12274133,12474378,and 12404378)the National Key R&D Program of China(Grant Nos.2022YFA1404600 and 2022YFA1205100)+2 种基金Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX01)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301403)the Engineering Research Center for Nanophotonics&Advanced Instrument,Ministry of Education,East China Normal University(Grant No.2023nmc005)。
文摘We report the fabrication of an 8-meter-long thin-flm lithium niobate optical true delay line using the photolithography-assisted chemomechanical etching technique,showing a low transmission loss of 0.036 dB/cm in the conventional telecom band.
基金Supported by the National Natural Science Foundation of China(11971378)Shaanxi Fundamental Science Research Project for Mathematics and Physics(23JSY050)Shaanxi Innovative Training Program for College Students(S202410719114)。
文摘In this article,the global attractors of 2D g-Navier-Stokes equations are obtained in the space of C_(Hg) and CVg respectively.When the external force f is sufficiently small,the studies indicate that the global attractor in C_(Hg) is equal to the global attractor in C_(Vg).
基金supported by the National Natural Science Foundation of China(Grant Nos.12192251,12334014,12404378,92480001,12134001,12174113,12174107,12474325,12404379,and 12474378)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301403)+1 种基金Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX01)Fundamental Research Funds for the Central Universities,the Engineering Research Center for Nanophotonics&Advanced Instrument,Ministry of Education,East China Normal University(Grant No.2023nmc005).
文摘We present a compact optical delay line(ODL)with wide-range continuous tunability on thin-film lithium niobate platform.The proposed device integrates an unbalanced Mach-Zehnder interferometer(MZI)architecture with dual tunable couplers,where each coupler comprises two 2×2 multimode interferometers and a MZI phase-tuning section.Experimental results demonstrate continuous delay tuning from 0 to 293 ps through synchronized control of coupling coefficients,corresponding to a 4 cm path difference between interferometer arms.The measured delay range exhibits excellent agreement with theoretical predictions derived from ODL waveguide parameters.This result addresses critical challenges in integrated photonic systems that require precise temporal control,particularly for applications in optical communications and quantum information processing,where a wide tuning range is paramount.
文摘BACKGROUND Visual impairment during early childhood can hinder motor,language,and social development,yet data on its developmental impact across common pediatric ocular diseases remain limited.AIM To investigate the developmental impact of low vision and blindness on children under six with common ocular diseases.METHODS This retrospective study reviewed records of new patients under six with visual impairment at Siriraj Hospital’s low vision rehabilitation center(January 2017-October 2022).We collected ocular,systemic,and developmental data;recorded visual acuity in the better-seeing eye after refractive correction;and assessed developmental domains with the DenverⅡ.Univariable and multi-variable logistic regression identified factors associated with developmental delay.RESULTS A total of 161 pediatric patients(mean age 24.9±18.9 months)were enrolled and evaluated based on their ability to fix on and follow an object or light source.Some were further assessed using the Allen picture chart and all had visual acuity worse than 1.07±0.58 LogMAR,and 83.2%were identified as having global developmental delay(GDD).The three most common ocular causes were cortical visual impairment(CVI),optic neuropathy/atrophy,and optic nerve hypoplasia.Extremely poor visual acuity(inability to fixate and follow)was significantly associated with GDD[adjusted odds ratio(AOR)41.0]and delays in all developmental domains:Gross motor(AOR 10.0),fine motor(AOR 12.8),language(AOR 5.3),and personal-social skills(AOR 13.4)(P≤0.002).Multiple disabilities,most often visual impairment with cerebral palsy,were also significantly associated with gross motor delays(AOR 7.7)and fine motor delays(AOR 4.0)(P<0.05).CVI was also related to delays in language and personal-social skills(AOR 9.1 each)(P<0.05).CONCLUSION This study underscores the developmental issues in children with visual impairment,especially those with poorer acuity,CVI,and multiple disabilities.Significant delays were observed in all domains,including GDD.A timely referral to specialists is strongly recommended.
基金supported in part by the National Key Research and Development Program of China under Grant 2020YFB1804800。
文摘This paper considers the fundamental channel estimation problem for the multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM)system in the presence of multi-cell interference.Specifically,this paper focuses on both channel modelling and receiver design for interference estimation and mitigation.We propose a delay-calibrated block-wise linear model,which extracts the delay of the dominant tap of each interference as a key parameter and approximates the residual channel coefficients by the recently developed blockwise linear model.Based on the delay-calibrated block-wise linear model and the angle-domain channel sparsity,we further conceive a message passing algorithm to solve the channel estimation problem.Numerical results demonstrate the superior performance of the proposed algorithm over the state-of-the-art algorithms.
