Prepulse inhibition （PPI） of the startle response is a psychophysiological measure of sensorimotor gating believed to be cross-modal between different sensory systems. We analyzed the tactile startle response （TSR...Prepulse inhibition （PPI） of the startle response is a psychophysiological measure of sensorimotor gating believed to be cross-modal between different sensory systems. We analyzed the tactile startle response （TSR） and PPI of TSR （tPPI）, using light as a prepulse stimulus, in the mouse strains A/J and C57BL/6J and 36 recombinant congenic strains derived from them. Parental strains were significantly different for TSR, but were comparable for tPPI. Among the congenic strains, variation for TSR was significant in both genetic backgrounds, but that of tPPI was significant only for the C57BL/6J background. Provisional mapping for loci modulating TSR and tPPI was carried out. Using mapping data from our previous study on acoustic startle responses （ASR） and PPI of ASR （aPPI）, no common markers for aPPI and tPPI were identified. However, some markers were significantly associated with both ASR and TSR, at least in one genetic background. These results indicate cross-modal genetic regulation for the startle response but not for PPI, in these mouse strains.展开更多
The reward-related effects of addictive drugs primarily act via the dopamine system,which also plays an important role in sensorimotor gating.The mesolimbic dopamine system is the common pathway of drug addiction and ...The reward-related effects of addictive drugs primarily act via the dopamine system,which also plays an important role in sensorimotor gating.The mesolimbic dopamine system is the common pathway of drug addiction and sensorimotor gating.However,the way in which addictive drugs affect sensorimotor gating is currently unclear.In previous studies,we examined the effects of morphine treatment on sensory gating in the hippocampus.The present study investigated the effects of morphine on sensorimotor gating in rats during chronic morphine treatment and withdrawal.Rats were examined during treatment with morphine for 10 successive days,followed by a withdrawal period.Acoustic startle responses to a single startle stimulus(115 dB SPL)and prepulse inhibition responses were recorded.The results showed that acoustic startle responses were attenuated during morphine treatment,but not during withdrawal.PPI was impaired in the last 2 morphine treatment days,but returned to a normal level during withdrawal.展开更多
Zebrafish an emerging animal model for studies comparability with humans, good accessibility to the hearing utilize this animal model, methodologies need to be used to on auditory system. This model presents high org...Zebrafish an emerging animal model for studies comparability with humans, good accessibility to the hearing utilize this animal model, methodologies need to be used to on auditory system. This model presents high organ, and high throughput capacity. To better quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows： the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.展开更多
文摘Prepulse inhibition （PPI） of the startle response is a psychophysiological measure of sensorimotor gating believed to be cross-modal between different sensory systems. We analyzed the tactile startle response （TSR） and PPI of TSR （tPPI）, using light as a prepulse stimulus, in the mouse strains A/J and C57BL/6J and 36 recombinant congenic strains derived from them. Parental strains were significantly different for TSR, but were comparable for tPPI. Among the congenic strains, variation for TSR was significant in both genetic backgrounds, but that of tPPI was significant only for the C57BL/6J background. Provisional mapping for loci modulating TSR and tPPI was carried out. Using mapping data from our previous study on acoustic startle responses （ASR） and PPI of ASR （aPPI）, no common markers for aPPI and tPPI were identified. However, some markers were significantly associated with both ASR and TSR, at least in one genetic background. These results indicate cross-modal genetic regulation for the startle response but not for PPI, in these mouse strains.
基金supported by the National Natural Science Foundation of China(Grant Nos.30470553,30770700 and 30530270)National High-Tech Research and Development Program of China(Grant No.O7013810)+1 种基金Major State Basic Research Development Program of China(Grant Nos.2005CB522803 and 2007CB947703)Yunnan Science and Technology Program(Grant No.2006PT08-2)
文摘The reward-related effects of addictive drugs primarily act via the dopamine system,which also plays an important role in sensorimotor gating.The mesolimbic dopamine system is the common pathway of drug addiction and sensorimotor gating.However,the way in which addictive drugs affect sensorimotor gating is currently unclear.In previous studies,we examined the effects of morphine treatment on sensory gating in the hippocampus.The present study investigated the effects of morphine on sensorimotor gating in rats during chronic morphine treatment and withdrawal.Rats were examined during treatment with morphine for 10 successive days,followed by a withdrawal period.Acoustic startle responses to a single startle stimulus(115 dB SPL)and prepulse inhibition responses were recorded.The results showed that acoustic startle responses were attenuated during morphine treatment,but not during withdrawal.PPI was impaired in the last 2 morphine treatment days,but returned to a normal level during withdrawal.
文摘Zebrafish an emerging animal model for studies comparability with humans, good accessibility to the hearing utilize this animal model, methodologies need to be used to on auditory system. This model presents high organ, and high throughput capacity. To better quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows： the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.
