Objective:to describe the clinical fea-tures of a case of infective endocarditis caused by Staph-ylococcus lugdunensis,followed by cerebral embolism,spleen embolism and tendon rupture.Methods:the clin-ical data of a 2...Objective:to describe the clinical fea-tures of a case of infective endocarditis caused by Staph-ylococcus lugdunensis,followed by cerebral embolism,spleen embolism and tendon rupture.Methods:the clin-ical data of a 22-year-old female patient with aphasia hemiplegia and abdominal pain were collected.Relevant examinations such as routine blood test,myocardial en-zyme spectrum,electrocardiogram(ECG),cardiac color Doppler ultrasound,brain magnetic resonance,abdomi-nal computed tomography(CT)and blood culture were completed,and anti infection treatment was carried out according to the drug sensitivity test.Results:brain mag-netic resonance imaging(MRI)showed cerebral infarction in the left basal ganglia,cardiac color Doppler ultrasound showed mitral valve vegetation and abscess formation,and abdominal CT showed splenic infarction.After anti infection treatment,the patient’s condition gradually improved,but the patient had sudden arrhythmia in the recovery period.Color Doppler ultrasound showed rup-ture of the mitral tendinous cord and valve prolapse.The condition was improved after surgical treatment.Conclu-sion:the first manifestation of Staphylococcus lugdunen-sis infection is cerebral infarction,which is relatively rare in the clinic setting.The main manifestation of this case is aphasia hemiplegia with abdominal pain.Blood cul-ture and identification show Staphylococcus lugdunensis,which is rare in adolescent patients.The infection has a rapid onset,rapid progress and causes serious valve dam-age.Timely strain identification and drug sensitivity test are conducive to accurate diagnosis and treatment.Valve surgery is often necessary.展开更多
Importance:Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative staphylococcus(CoNS),found commonly as skin flora in humans.While most species of CoNS are clinically benign,S.lugdunensis can exhibit a simi...Importance:Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative staphylococcus(CoNS),found commonly as skin flora in humans.While most species of CoNS are clinically benign,S.lugdunensis can exhibit a similar virulence to that ofS.aureus.However,there is scant data concerningS.lugdunensis infection in the pediatric population.Objective:To ascertain localS.lugdunensis infection rates and sensitivity patterns in the pediatric population.Methods:A retrospective analysis was undertaken of allS.lugdunensis isolates across a 6-year period from 2015 to 2020.Data were collected from electronic patient notes and laboratory records.Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates.Results:Ninety-six isolates ofS.lugdunensis were identified from 86 patients.Of these,34 isolates were treated as an infection.Twenty-three(67.6%)were found to have skin as the primary source of infection.While the observed number was small,central nervous system(CNS)sources ofS.lugdunensis infection appear to be a significant source:all three isolates cultured from cerebrospinal fluid were clinically managed as infection.All three were associated with ventriculoperitoneal(VP)shunt infection.No cases ofS.lugdunensis infective endocarditis were identified.About 18.6%ofS.lugdunensis isolates were resistant to flucloxacillin.Interpretation:S.lugdunensis is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection,particularly when associated with VP shunts.Flucloxacillin is recommended locally as the first choice of antibiotic.展开更多
基金Scientific Research Program of Hubei Provincial Department of Education in 2019(Q20192103).
文摘Objective:to describe the clinical fea-tures of a case of infective endocarditis caused by Staph-ylococcus lugdunensis,followed by cerebral embolism,spleen embolism and tendon rupture.Methods:the clin-ical data of a 22-year-old female patient with aphasia hemiplegia and abdominal pain were collected.Relevant examinations such as routine blood test,myocardial en-zyme spectrum,electrocardiogram(ECG),cardiac color Doppler ultrasound,brain magnetic resonance,abdomi-nal computed tomography(CT)and blood culture were completed,and anti infection treatment was carried out according to the drug sensitivity test.Results:brain mag-netic resonance imaging(MRI)showed cerebral infarction in the left basal ganglia,cardiac color Doppler ultrasound showed mitral valve vegetation and abscess formation,and abdominal CT showed splenic infarction.After anti infection treatment,the patient’s condition gradually improved,but the patient had sudden arrhythmia in the recovery period.Color Doppler ultrasound showed rup-ture of the mitral tendinous cord and valve prolapse.The condition was improved after surgical treatment.Conclu-sion:the first manifestation of Staphylococcus lugdunen-sis infection is cerebral infarction,which is relatively rare in the clinic setting.The main manifestation of this case is aphasia hemiplegia with abdominal pain.Blood cul-ture and identification show Staphylococcus lugdunensis,which is rare in adolescent patients.The infection has a rapid onset,rapid progress and causes serious valve dam-age.Timely strain identification and drug sensitivity test are conducive to accurate diagnosis and treatment.Valve surgery is often necessary.
文摘Importance:Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative staphylococcus(CoNS),found commonly as skin flora in humans.While most species of CoNS are clinically benign,S.lugdunensis can exhibit a similar virulence to that ofS.aureus.However,there is scant data concerningS.lugdunensis infection in the pediatric population.Objective:To ascertain localS.lugdunensis infection rates and sensitivity patterns in the pediatric population.Methods:A retrospective analysis was undertaken of allS.lugdunensis isolates across a 6-year period from 2015 to 2020.Data were collected from electronic patient notes and laboratory records.Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates.Results:Ninety-six isolates ofS.lugdunensis were identified from 86 patients.Of these,34 isolates were treated as an infection.Twenty-three(67.6%)were found to have skin as the primary source of infection.While the observed number was small,central nervous system(CNS)sources ofS.lugdunensis infection appear to be a significant source:all three isolates cultured from cerebrospinal fluid were clinically managed as infection.All three were associated with ventriculoperitoneal(VP)shunt infection.No cases ofS.lugdunensis infective endocarditis were identified.About 18.6%ofS.lugdunensis isolates were resistant to flucloxacillin.Interpretation:S.lugdunensis is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection,particularly when associated with VP shunts.Flucloxacillin is recommended locally as the first choice of antibiotic.
