The paper utilized a standardized methodology to identify prognostic biomarkers in hepatocellular carcinoma(HCC)by analyzing transcriptomic and clinical data from The Cancer Genome Atlas(TCGA)database.The approach,whi...The paper utilized a standardized methodology to identify prognostic biomarkers in hepatocellular carcinoma(HCC)by analyzing transcriptomic and clinical data from The Cancer Genome Atlas(TCGA)database.The approach,which included stringent data preprocessing,differential gene expression analysis,and Kaplan-Meier survival analysis,provided valuable insights into the genetic underpinnings of HCC.The comprehensive analysis of a dataset involving 370 HCC patients uncovered correlations between survival status and pathological characteristics,including tumor size,lymph node involvement,and distant metastasis.The processed transcriptome dataset,comprising 420 samples and annotating 26,783 genes,served as a robust platform for identifying differential gene expression patterns.Among the significant differential expression genes,the key genes such as FBXO43,HAGLROS,CRISPLD1,LRRC3.DT,and ERN2,were pinpointed,which showed significant associations with patient survival outcomes,indicating their potential as novel prognostic biomarkers.This study can not only enhance the understanding of HCC’s genetic landscape but also establish a blueprint for a standardized process to discover prognostic biomarkers of various diseases using genetic big data.Future research should focus on validating these biomarkers through independent cohorts and exploring their utility in the development of personalized treatment strategies.展开更多
Three dimensional models of shaft were completed on CATIA Part Design module with the Chinese national standard （GB） process structures such as chamfers, threads and tool withdrawal grooves, center holes, flat/woodr...Three dimensional models of shaft were completed on CATIA Part Design module with the Chinese national standard （GB） process structures such as chamfers, threads and tool withdrawal grooves, center holes, flat/woodruff/gib head taper keyseats, grinding undercuts, straight-sidedsplines, circlip slots and collars. The modeling steps are arranged in dialog menu interface by VB 6.0, the shaft creator, that permits users input geometric feature based parameters explicitly, and the standardized processdata are reorganized in Excel files that can be invoked correspondingly in the modeling procedure. It is aimed that this process may supply a simple way for shaft rapid modeling and comprehensive discipline for engineering students in their professional design activities.展开更多
Forest biomass resources are available in enormous quantities in China. The development of forest biomass briquetting densification fuel, which has a high calorific value, can ease the energy shortage in China. But th...Forest biomass resources are available in enormous quantities in China. The development of forest biomass briquetting densification fuel, which has a high calorific value, can ease the energy shortage in China. But the molding technology is still at the primary stage with many questions unresolved, such as unequal distribution of resources, imperfect technology and an inadequate mechanism of market supply and demand. There are no consistent production and quality standards to refer to, which seriously hinder the industrialization of biomass molding technology. Hence, it is imperative to speed up the formulation of production standards of biomass briquetting densification fuel which not only conform to international standards, but are in accordance with national condi- tions in China. Drawing on the standards of biomass briquetting densification fuel in Europe, a standard system should be concerned with raw material collection, transport and storage of the end products, terminology, denomination and classification of molding equipment, as well as with technical conditions, testing methods, safety and environmental protection. The establishment of a stan- dard system is useful for the development of a healthy, orderly and sustainable biomass fuel industry.展开更多
It is reported that the work of re-structuring the frame of China nationalstandards system for processing food has been finished with the print and distribution of 2004-2005Development Plan of National Standards for F...It is reported that the work of re-structuring the frame of China nationalstandards system for processing food has been finished with the print and distribution of 2004-2005Development Plan of National Standards for Food (hereinafter Plan). According to the demand of thePlan, there will be great changes among the current national standards and the professionalstandards for processing food, in which some standards will be integrated with others, somestandards will be cancelled, and some will be brought into the new standards system after the reviewof standards. The standards after being changed and the new national standards and the professionalstandards that need to be developed compose the new standards system for processing food.展开更多
Objective: to explore the application value of standardized nursing process of PICC in patients with tumor undergoing chemotherapy and catheterization. Methods: cases were selected from January 2019 to December 2020. ...Objective: to explore the application value of standardized nursing process of PICC in patients with tumor undergoing chemotherapy and catheterization. Methods: cases were selected from January 2019 to December 2020. Case type: PICC catheter for tumor chemotherapy;Total cases: 82;Grouping method: random envelope method;Group: reference group and observation group;Number of groups: 41;Nursing methods: routine nursing and standardized nursing process of PICC;Comparative items: nursing satisfaction, complications and phlebitis. Results: the nursing satisfaction of the observation group and the reference group was 97.56% and 8.48% respectively, with significant difference (χ2 = 6.1157). The incidence of complications in the observation group and the reference group was 7.32% and 24.39% respectively, with significant difference (χ2 = 4.4794). The incidence of phlebitis in the observation group (grade 0: 73.17%, grade 1-2: 24.39%, grade 3-4: 2.44%) was lower than that in the reference group (grade 0: 34.15%, grade 1-2: 48.78%, grade 3-4: 17.07%). there was a significant difference between the groups (χ2 = 12.5550, 5.2564, 4.9865), with statistical significance (P < 0.05). Conclusion: the implementation of PICC standardized nursing process for tumor chemotherapy patients can improve the incidence of phlebitis and reduce complications. The nursing effect is significant, which is worthy of clinical reference.展开更多
Objective: to effectively improve the standardized emergency care procedures for patients with ST-segment elevation myocardial infarction. Methods: Seventy-two patients with ST segment elevation myocardial infarction ...Objective: to effectively improve the standardized emergency care procedures for patients with ST-segment elevation myocardial infarction. Methods: Seventy-two patients with ST segment elevation myocardial infarction who were admitted to our hospital from January 2020 to December 2020 were selected as the main subjects of this study. They were divided into the control group/observation group. Among them, the control group received routine emergency care while the observation group received standardized emergency care procedures based on the routine emergency care measures, so as to compare the differences in the care procedures and patient care quality of the two patients during the emergency treatment. The difference was large, and the condition of the observation group was better. Finally, through the analysis of two groups of patients after treatment, and then investigate the family members and patients' satisfaction with care. The clinical results showed that the efficacy of 88.9% in the observation group was significantly superior to 66.7% in the control group, and the difference was statistically significant (P < 0.05). Conclusion: through analyzing the different nursing procedures of patients in two groups, it was found that the standardized emergency nursing procedures shortened the basic treatment time of patients and improved the success rate of rescue, providing a larger space for the treatment of patients, and the families were also satisfied with it.展开更多
A new standard parametric modeling method of the micro-structure of plain woven composite is proposed. It is based on good analysis of the mechanical property of the yarn, weaving law of plain woven, and other factors...A new standard parametric modeling method of the micro-structure of plain woven composite is proposed. It is based on good analysis of the mechanical property of the yarn, weaving law of plain woven, and other factors. The method implements a woven fabric composite visual engineering modeling process standardization, and it gives five steps to calculate the key micro-structural parameters of the yarn including the cross-section and the trajectory of the central Line. On the basis, the digital model of a plain woven composite has been constructed. The experimental result shows that the forecast for the mechanical property of the model using finite-element simulation analysis is consistent with the actual value. The shape and the structure of the model are also consistent with the solid.展开更多
Single-poly,576bit non-volatile memory is designed and implemented in an SMIC 0.18μm standard CMOS process for the purpose of reducing the cost and power of passive RFID tag chips. The memory bit cell is designed wit...Single-poly,576bit non-volatile memory is designed and implemented in an SMIC 0.18μm standard CMOS process for the purpose of reducing the cost and power of passive RFID tag chips. The memory bit cell is designed with conventional single-poly pMOS transistors, based on the bi-directional Fowler-Nordheim tunneling effect, and the typical program/erase time is 10ms for every 16bits. A new ,single-ended sense amplifier is proposed to reduce the power dissipation in the current sensing scheme. The average current consumption of the whole memory chip is 0.8μA for the power supply voltage of 1.2V at a reading rate of 640kHz.展开更多
Ambient air quality standards are the core strategic goal of ambient air quality management.Countries worldwide have given importance to research on the development of ambient air quality standards.To understand the h...Ambient air quality standards are the core strategic goal of ambient air quality management.Countries worldwide have given importance to research on the development of ambient air quality standards.To understand the history of the development of China’s ambient air quality standards,this study analyzed the background associated with all previous formulations and revisions of the standards,classification of functional areas,standard grading,pollutants,and evolution of the standard limits over the past 40 years.The results show that since the initial release of the“Ambient Air Quality Standard”by China in 1982,it has been supplemented once,revised twice,and modified twice.The first ambient air quality standard specified the standard limits of six pollutants commonly found in ambient air.With the development of ambient air quality management,the number of pollutants has increased to ten.Since the release of the“Ambient Air Quality Standards”in 2012,the ambient air quality in China has significantly improved.However,the proportion of cities meeting these standards is still low.At present,China is suitably positioned to make the standards associated with 24 hr SO2concentrations more stringent such that it meets the values defined in the World Health Organization(WHO)interim target-2 and the WHO air quality guideline(AQG).We further suggested that the SO2standard should be revised promptly.Simultaneously,regions with a relatively high proportion of cities meeting the standard are encouraged to introduce more stringent interim target limits in due course to manage the local ambient air quality.展开更多
This paper begins by analysing the mutual influence between international trade and the environment, and then proceeds to explore the environment and trade conflicts. On the basis of sustainable development theories a...This paper begins by analysing the mutual influence between international trade and the environment, and then proceeds to explore the environment and trade conflicts. On the basis of sustainable development theories and the above discussion, the article suggests taking sustainable trade as a solution to the existing conflicts. This paper aims to find the way to strike a balance between international trade and environment based on the present situation in China.展开更多
Background: The incidence of cancer pain in patients with malignant tumors is relatively high, and pain control is poor, which is closely related to many factors, especially the nursing way. Objective: To explore the ...Background: The incidence of cancer pain in patients with malignant tumors is relatively high, and pain control is poor, which is closely related to many factors, especially the nursing way. Objective: To explore the effect of standardized nursing model on pain control in patients with malignant tumors. Methods: 50 patients with malignant tumors treated in the Affiliated Hospital of Chengde Medical College from January to December in 2021 were randomly divided into 25 cases in the control group and 25 cases in the observation group. The pain control and medication compliance of the two groups were compared. Results: There was no difference in the corresponding score of admission pain between the two groups (P > 0.05), and the pain score of the observation group was lower than that of the control group (P P Conclusion: Standardized cancer pain nursing can ease the pain of patients, and the medication compliance is better.展开更多
We present a monolithic ultraviolet（UV） image sensor based on a standard CMOS process.A compact UV sensitive device structure is designed as a pixel for the image sensor.This UV image sensor consists of a CMOS pixel...We present a monolithic ultraviolet（UV） image sensor based on a standard CMOS process.A compact UV sensitive device structure is designed as a pixel for the image sensor.This UV image sensor consists of a CMOS pixel array,high-voltage switches,a readout circuit and a digital control circuit.A 16×16 image sensor prototype chip is implemented in a 0.18μm standard CMOS logic process.The pixel and image sensor were measured. Experimental results demonstrate that the image sensor has a high sensitivity of 0.072 V/（mJ/cm^2） and can capture a UV image.It is suitable for large-scale monolithic bio-medical and space applications.展开更多
A high efficiency charge pump circuit is designed and realized. The charge transfer switch is biased by the additional capacitor and transistor to eliminate the influence of the threshold voltage. Moreover, the bulk o...A high efficiency charge pump circuit is designed and realized. The charge transfer switch is biased by the additional capacitor and transistor to eliminate the influence of the threshold voltage. Moreover, the bulk of the switch transistor is dynamically biased so that the threshold voltage gets lower when it is turned on during charge transfer and gets higher when it is turned off. As a result, the efficiency of the charge pump circuit can be improved. A test chip has been implemented in a 0.18μm 3.3 V standard CMOS process. The measured output voltage of the eight-pumpingstage charge pump is 9.8 V with each pumping capacitor of 0.5 pF at an output current of 0.18 μA, when the clock frequency is 780 kHz and the supply voltage is 2 V. The charge pump and the clock driver consume a total current of 2.9 μA from the power supply. This circuit is suitable for low power applications.展开更多
基金the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project with the start-up funding from Linyi Vocational College。
文摘The paper utilized a standardized methodology to identify prognostic biomarkers in hepatocellular carcinoma(HCC)by analyzing transcriptomic and clinical data from The Cancer Genome Atlas(TCGA)database.The approach,which included stringent data preprocessing,differential gene expression analysis,and Kaplan-Meier survival analysis,provided valuable insights into the genetic underpinnings of HCC.The comprehensive analysis of a dataset involving 370 HCC patients uncovered correlations between survival status and pathological characteristics,including tumor size,lymph node involvement,and distant metastasis.The processed transcriptome dataset,comprising 420 samples and annotating 26,783 genes,served as a robust platform for identifying differential gene expression patterns.Among the significant differential expression genes,the key genes such as FBXO43,HAGLROS,CRISPLD1,LRRC3.DT,and ERN2,were pinpointed,which showed significant associations with patient survival outcomes,indicating their potential as novel prognostic biomarkers.This study can not only enhance the understanding of HCC’s genetic landscape but also establish a blueprint for a standardized process to discover prognostic biomarkers of various diseases using genetic big data.Future research should focus on validating these biomarkers through independent cohorts and exploring their utility in the development of personalized treatment strategies.
文摘Three dimensional models of shaft were completed on CATIA Part Design module with the Chinese national standard （GB） process structures such as chamfers, threads and tool withdrawal grooves, center holes, flat/woodruff/gib head taper keyseats, grinding undercuts, straight-sidedsplines, circlip slots and collars. The modeling steps are arranged in dialog menu interface by VB 6.0, the shaft creator, that permits users input geometric feature based parameters explicitly, and the standardized processdata are reorganized in Excel files that can be invoked correspondingly in the modeling procedure. It is aimed that this process may supply a simple way for shaft rapid modeling and comprehensive discipline for engineering students in their professional design activities.
基金supported by the Forestry Industrial Standard:Forest Biomass Briquetting Densification Fuel(No.2010-LY-125)the General Technical Specification of Forest Biomass Briquetting Densification Fuel Stove(No.2010-LY-124)the National Featured Major Construction Project(No.TS10040)
文摘Forest biomass resources are available in enormous quantities in China. The development of forest biomass briquetting densification fuel, which has a high calorific value, can ease the energy shortage in China. But the molding technology is still at the primary stage with many questions unresolved, such as unequal distribution of resources, imperfect technology and an inadequate mechanism of market supply and demand. There are no consistent production and quality standards to refer to, which seriously hinder the industrialization of biomass molding technology. Hence, it is imperative to speed up the formulation of production standards of biomass briquetting densification fuel which not only conform to international standards, but are in accordance with national condi- tions in China. Drawing on the standards of biomass briquetting densification fuel in Europe, a standard system should be concerned with raw material collection, transport and storage of the end products, terminology, denomination and classification of molding equipment, as well as with technical conditions, testing methods, safety and environmental protection. The establishment of a stan- dard system is useful for the development of a healthy, orderly and sustainable biomass fuel industry.
文摘It is reported that the work of re-structuring the frame of China nationalstandards system for processing food has been finished with the print and distribution of 2004-2005Development Plan of National Standards for Food (hereinafter Plan). According to the demand of thePlan, there will be great changes among the current national standards and the professionalstandards for processing food, in which some standards will be integrated with others, somestandards will be cancelled, and some will be brought into the new standards system after the reviewof standards. The standards after being changed and the new national standards and the professionalstandards that need to be developed compose the new standards system for processing food.
文摘Objective: to explore the application value of standardized nursing process of PICC in patients with tumor undergoing chemotherapy and catheterization. Methods: cases were selected from January 2019 to December 2020. Case type: PICC catheter for tumor chemotherapy;Total cases: 82;Grouping method: random envelope method;Group: reference group and observation group;Number of groups: 41;Nursing methods: routine nursing and standardized nursing process of PICC;Comparative items: nursing satisfaction, complications and phlebitis. Results: the nursing satisfaction of the observation group and the reference group was 97.56% and 8.48% respectively, with significant difference (χ2 = 6.1157). The incidence of complications in the observation group and the reference group was 7.32% and 24.39% respectively, with significant difference (χ2 = 4.4794). The incidence of phlebitis in the observation group (grade 0: 73.17%, grade 1-2: 24.39%, grade 3-4: 2.44%) was lower than that in the reference group (grade 0: 34.15%, grade 1-2: 48.78%, grade 3-4: 17.07%). there was a significant difference between the groups (χ2 = 12.5550, 5.2564, 4.9865), with statistical significance (P < 0.05). Conclusion: the implementation of PICC standardized nursing process for tumor chemotherapy patients can improve the incidence of phlebitis and reduce complications. The nursing effect is significant, which is worthy of clinical reference.
文摘Objective: to effectively improve the standardized emergency care procedures for patients with ST-segment elevation myocardial infarction. Methods: Seventy-two patients with ST segment elevation myocardial infarction who were admitted to our hospital from January 2020 to December 2020 were selected as the main subjects of this study. They were divided into the control group/observation group. Among them, the control group received routine emergency care while the observation group received standardized emergency care procedures based on the routine emergency care measures, so as to compare the differences in the care procedures and patient care quality of the two patients during the emergency treatment. The difference was large, and the condition of the observation group was better. Finally, through the analysis of two groups of patients after treatment, and then investigate the family members and patients' satisfaction with care. The clinical results showed that the efficacy of 88.9% in the observation group was significantly superior to 66.7% in the control group, and the difference was statistically significant (P < 0.05). Conclusion: through analyzing the different nursing procedures of patients in two groups, it was found that the standardized emergency nursing procedures shortened the basic treatment time of patients and improved the success rate of rescue, providing a larger space for the treatment of patients, and the families were also satisfied with it.
文摘A new standard parametric modeling method of the micro-structure of plain woven composite is proposed. It is based on good analysis of the mechanical property of the yarn, weaving law of plain woven, and other factors. The method implements a woven fabric composite visual engineering modeling process standardization, and it gives five steps to calculate the key micro-structural parameters of the yarn including the cross-section and the trajectory of the central Line. On the basis, the digital model of a plain woven composite has been constructed. The experimental result shows that the forecast for the mechanical property of the model using finite-element simulation analysis is consistent with the actual value. The shape and the structure of the model are also consistent with the solid.
文摘Single-poly,576bit non-volatile memory is designed and implemented in an SMIC 0.18μm standard CMOS process for the purpose of reducing the cost and power of passive RFID tag chips. The memory bit cell is designed with conventional single-poly pMOS transistors, based on the bi-directional Fowler-Nordheim tunneling effect, and the typical program/erase time is 10ms for every 16bits. A new ,single-ended sense amplifier is proposed to reduce the power dissipation in the current sensing scheme. The average current consumption of the whole memory chip is 0.8μA for the power supply voltage of 1.2V at a reading rate of 640kHz.
基金supported by the National Key Research and Development Program of China(Nos.2019YFC0214800,2020YFC1806303 and 2016YFC0208100)the Fundamental Research Funds for the Central Public-interest Scientific Institution(No.2021YSKY-06)。
文摘Ambient air quality standards are the core strategic goal of ambient air quality management.Countries worldwide have given importance to research on the development of ambient air quality standards.To understand the history of the development of China’s ambient air quality standards,this study analyzed the background associated with all previous formulations and revisions of the standards,classification of functional areas,standard grading,pollutants,and evolution of the standard limits over the past 40 years.The results show that since the initial release of the“Ambient Air Quality Standard”by China in 1982,it has been supplemented once,revised twice,and modified twice.The first ambient air quality standard specified the standard limits of six pollutants commonly found in ambient air.With the development of ambient air quality management,the number of pollutants has increased to ten.Since the release of the“Ambient Air Quality Standards”in 2012,the ambient air quality in China has significantly improved.However,the proportion of cities meeting these standards is still low.At present,China is suitably positioned to make the standards associated with 24 hr SO2concentrations more stringent such that it meets the values defined in the World Health Organization(WHO)interim target-2 and the WHO air quality guideline(AQG).We further suggested that the SO2standard should be revised promptly.Simultaneously,regions with a relatively high proportion of cities meeting the standard are encouraged to introduce more stringent interim target limits in due course to manage the local ambient air quality.
基金Youth Science Fund of Chengdu University of Technology, No. 2005QJ10
文摘This paper begins by analysing the mutual influence between international trade and the environment, and then proceeds to explore the environment and trade conflicts. On the basis of sustainable development theories and the above discussion, the article suggests taking sustainable trade as a solution to the existing conflicts. This paper aims to find the way to strike a balance between international trade and environment based on the present situation in China.
文摘Background: The incidence of cancer pain in patients with malignant tumors is relatively high, and pain control is poor, which is closely related to many factors, especially the nursing way. Objective: To explore the effect of standardized nursing model on pain control in patients with malignant tumors. Methods: 50 patients with malignant tumors treated in the Affiliated Hospital of Chengde Medical College from January to December in 2021 were randomly divided into 25 cases in the control group and 25 cases in the observation group. The pain control and medication compliance of the two groups were compared. Results: There was no difference in the corresponding score of admission pain between the two groups (P > 0.05), and the pain score of the observation group was lower than that of the control group (P P Conclusion: Standardized cancer pain nursing can ease the pain of patients, and the medication compliance is better.
文摘We present a monolithic ultraviolet（UV） image sensor based on a standard CMOS process.A compact UV sensitive device structure is designed as a pixel for the image sensor.This UV image sensor consists of a CMOS pixel array,high-voltage switches,a readout circuit and a digital control circuit.A 16×16 image sensor prototype chip is implemented in a 0.18μm standard CMOS logic process.The pixel and image sensor were measured. Experimental results demonstrate that the image sensor has a high sensitivity of 0.072 V/（mJ/cm^2） and can capture a UV image.It is suitable for large-scale monolithic bio-medical and space applications.
基金supported by the Chinese National High-Tech Research and Development Program(No.2006AA04A108)the National Natural Science Foundation of China(No.2008AA010703).
文摘A high efficiency charge pump circuit is designed and realized. The charge transfer switch is biased by the additional capacitor and transistor to eliminate the influence of the threshold voltage. Moreover, the bulk of the switch transistor is dynamically biased so that the threshold voltage gets lower when it is turned on during charge transfer and gets higher when it is turned off. As a result, the efficiency of the charge pump circuit can be improved. A test chip has been implemented in a 0.18μm 3.3 V standard CMOS process. The measured output voltage of the eight-pumpingstage charge pump is 9.8 V with each pumping capacitor of 0.5 pF at an output current of 0.18 μA, when the clock frequency is 780 kHz and the supply voltage is 2 V. The charge pump and the clock driver consume a total current of 2.9 μA from the power supply. This circuit is suitable for low power applications.
