On July 11,2025,the global intellectual property(IP)spotlight fell on Geneva,Switzerland.At the 2025 World Intellectual Property Organization(WIPO)Global Awards,Chinese robotics firm Unitree Robotics was named one of ...On July 11,2025,the global intellectual property(IP)spotlight fell on Geneva,Switzerland.At the 2025 World Intellectual Property Organization(WIPO)Global Awards,Chinese robotics firm Unitree Robotics was named one of 10 winners,selected from more than 780 small and medium-sized enterprises(SMEs)and startups across 95 countries and regions.Since the awards were launched in 2022.Chinese companies have won prizes for four consecutive years.展开更多
Rapid and accurate identification of high-quality patents can accelerate the transformation process of scientific and technological achievements, optimize the management of intellectual property rights and enhance the...Rapid and accurate identification of high-quality patents can accelerate the transformation process of scientific and technological achievements, optimize the management of intellectual property rights and enhance the vitality of innovation. Aiming at the shortcomings of the traditional high-value patent assessment method, which is relatively simple and seldom considers the influence of patentees, this paper proposes a high-quality patent method HMFM (High-Value Patent Multi-Feature Fusion Method) that fuses multi-dimensional features. A weighted node importance assessment method in complex network called GLE (Glob-Local-struEntropy) based on improved structural entropy is designed to calculate the influence of the patentee to form the patentee’s features, and the patent text features are extracted by BERT-DPCNN deep learning model, which is supplemented to the basic patent indicator system. Finally a machine learning algorithm is used to assess the value of patents. Experiment results show that our method can identify high-value patents more effectively and accurately.展开更多
As the world transitions to a more environment-friendly and sustainable global economy,innovations in green technology are playing a crucial role.Recognizing this,China,along with many other nations,is adapting its pa...As the world transitions to a more environment-friendly and sustainable global economy,innovations in green technology are playing a crucial role.Recognizing this,China,along with many other nations,is adapting its pat⁃ent system to better support green innovations,establishing what is known as a green patent regime.While extensive empirical research highlights the significance of China's green patent regime in achieving environmental sustainabil⁃ity,there is a noticeable lack of normative studies on enhancing its efficacy.This work aims to fill this gap by conduct⁃ing a normative study using doctrinal analysis and proposing that transparency and accessibility are key factors in evaluating the effectiveness of a green patent regime.Through a doctrinal analysis of China's green patent legislation and regulations,this work assesses the legal rights conferred by this regime and identifies how these rights are con⁃strained by substantive and procedural norms.The findings reveal significant limitations to the transparency and acces⁃sibility of China's green patent regime and propose improvements.These recommendations offer insights for policymak⁃ers in China and other countries.The doctrinal analysis conducted in this research could stimulate further theoretical discussion in the field of sustainable development and intellectual property law.Moreover,it might enlighten more hy⁃potheses for future empirical studies.展开更多
BACKGROUND The Food and Drug Administration has approved percutaneous atrial septal defect(ASD)and patent foramen ovale(PFO)closure devices for hemodynamically significant interatrial shunts,paradoxical emboli includi...BACKGROUND The Food and Drug Administration has approved percutaneous atrial septal defect(ASD)and patent foramen ovale(PFO)closure devices for hemodynamically significant interatrial shunts,paradoxical emboli including stroke,and decompression sickness.We aimed to study the trends in utilization and reimbursements of transcatheter ASD/PFO closure devices.AIM To analyze trends in utilization and Medicare reimbursements for transcatheter ASD/PFO closure procedures from 2013 to 2022.METHODS A query of administrative data on United States Medicare beneficiaries undergoing transcatheter ASD/PFO was conducted from 2013 to 2022 using the Centers for Medicare and Medicaid Services Part B National Summary Data File.Inflation adjustments were made using the 2023 Consumer Price Index.Trend analysis was quantified using growth rate and simple linear regression calculations.All analyses were performed using Microsoft Excel 16.77.1(2023).RESULTS The annual number of transcatheter ASD/PFO closure procedures increased by 81%since 2013,with an average yearly growth rate of 44%cases per year(P<0.001).Annual Medicare reimbursements for transcatheter ASD/PFO therapies mirrored the annual procedure trends.The per-case reimbursements decreased by 18%,i.e.,$1128.80 in 2013 and$770.21 in 2022(P<0.001).There was a significant drop in the number of procedures in the year 2020,which correlates to the onset of the coronavirus disease 2019 pandemic,followed by a sharp uptick in the number of cases in 2021 and 2022.CONCLUSION Medicare utilization of transcatheter ASD/PFO closure therapies has grown significantly in procedural volume from 2013 to 2022.However,this has been accompanied by a decrease in per-case reimbursements.展开更多
While the significant role of technological innovation in promoting renewable energy has been extensively explored in the literature,limited attention has been paid to the impact of energy patents,particularly clean e...While the significant role of technological innovation in promoting renewable energy has been extensively explored in the literature,limited attention has been paid to the impact of energy patents,particularly clean energy patents and fossil fuel patents.This study pioneers an investigation into the effects of energy patents and energy prices on renewable energy consumption.The study utilizes data from 2000Q1 to 2023Q4 and,due to the nonlinear nature of the series,applies wavelet quantile-based methods.Specifically,it introduces the wavelet quantile cointegration approach to evaluate cointegration across different quantiles and time horizons,along with the wavelet quantile-on-quantile regression method.The results confirm cointegration across different periods and quantiles,highlighting the significant relationships between energy patents,economic factors,and renewable energy consumption.Furthermore,we found that fossil energy patents negatively affect renewable energy consumption,while clean energy patents have a similar but weaker effect,especially in the short term.In addition,higher energy prices promote renewable energy adoption while economic growth positively influences renewable energy consumption,particularly in the short term.The study formulates specific policies based on these findings.展开更多
A"verdict"on the economic value of the patent system by the US economist Fritz Machlup published in 1958 still has an important impact on assessing the effects of the patent system on economic development by...A"verdict"on the economic value of the patent system by the US economist Fritz Machlup published in 1958 still has an important impact on assessing the effects of the patent system on economic development by intellec-tual property scholars worldwide.This contribution analyses Machlup's study as is and in the light of subsequent US and global legal and economic developments.Machlup's assessment was examined based on empirical data generated by the US Bayh-Dole type legislation as regards the translation of basic research into innovative products and pro-cesses.Moreover,it analyses the impact of the new world economic order instituted in the framework of the World Trade Organization(WTO)mandatorily requiring effective patent protection in all WTO Member States on the eco-nomic development of developing and emerging economies.The case of China,which adopted its first Patent Law in 1984,is addressed in the context of Machlup's verdict and in light of the subsequent economic,scientific and techno-logical development of that country.Concluding thoughts consider today's value of Machlup's"verdict".展开更多
The recent surge in global financial and patent innovations and rising CO_(2) emissions in the global energy sector have drawn significant attention to China’s transportation industry.This study examines how financia...The recent surge in global financial and patent innovations and rising CO_(2) emissions in the global energy sector have drawn significant attention to China’s transportation industry.This study examines how financial innovations(FINI),patent innovations(PTIN),and bioenergy(BIOE)affect CO_(2) emissions in China’s transportation sector(TBCO_(2))using quarterly data from 2000 to 2018.This study employed a novel wavelet local multiple correlation(WLMC)methodology,alongside the time-varying causality test,to examine the time–frequency nexus,addressing a critical gap in the current literature.The WLMC bivariate analyses revealed a negative long-term relationship between PTIN and FINI with TBCO_(2).At the same time,BIOE showed only a short-term mitigating effect,with PTIN playing a dominant role in this nexus at various frequency levels.Furthermore,the three-and four-variate assessments highlight the consistent positive influence of all included factors on TBCO_(2).A timevarying causality test also demonstrated significant causal relationships between FINI,PTIN,BIOE,and TBCO_(2) across different periods,confirming the robustness of our WLMC results.This study provides crucial insights,emphasizing the urgency of promoting FINIs,technological advancement,and bioenergy usage to reduce transportation emissions and pursue sustainable solutions to address China’s environmental challenges.展开更多
Compared with traditional nickel-titanium alloy patent foramen ovale occluders,which are widely used in clinical practice,biodegradable patent foramen ovale occluders have obvious differences in material characteristi...Compared with traditional nickel-titanium alloy patent foramen ovale occluders,which are widely used in clinical practice,biodegradable patent foramen ovale occluders have obvious differences in material characteristics,interventional operation mode and postoperative management strategy.This article gives expert consensus on the selection of clinical indications and standardized operating procedures,so as to standardize the clinical application of biodegradable patent foramen ovale occluders.展开更多
The contribution of knowledge capital to firm value has increased significantly,from 25%in the 1970s to 45%in the 2010s(Belo et al.in Decomposing firm value J Financ Econ 143:619–639,2022).However,what influences fi...The contribution of knowledge capital to firm value has increased significantly,from 25%in the 1970s to 45%in the 2010s(Belo et al.in Decomposing firm value J Financ Econ 143:619–639,2022).However,what influences firms’ability to maximize the effect of knowledge capital on firm value?Drawing on insights from upper echelons,agency,and behavioral agency theories,we show that CEO characteristics are crucial in enabling firms to take advantage of knowledge stock.We empirically demonstrate that short-term CEO compensation structures are detrimental to a firm’s ability to take advantage of its knowledge stock.We further show that CEO power enhances knowledge stock and R&D intensity.Our study provides direct empirical evidence of the importance of CEO compensation structure and corporate governance in understanding firm value in a knowledge economy.展开更多
Objective To explore the current state of biopharmaceutical innovation in Africa by analyzing patent data related to biopharmaceutical products in African countries.Methods Based on patent data,simple descriptive stat...Objective To explore the current state of biopharmaceutical innovation in Africa by analyzing patent data related to biopharmaceutical products in African countries.Methods Based on patent data,simple descriptive statistical methods were used to analyze the trend of patent applications,the geographical distribution of patents,and the distribution of applicants in the pharmaceutical field in Africa.Besides,Excel software was used to draw charts to visualize statistical information.Results and Conclusion According to the result,a large number of patents has been granted in these countries and the number is steadily rising each year.From the figure below,we can see that the largest number of patents was granted to Morocco in 2014 with a total number of 613 patents followed by Tunisia with 315 patents,the African Intellectual Property Organization(OAPI)with 124 patents,South Africa with 106 and Mozambique with 1 patent based on data availability(IncoPat Global Patent Search Database).It was observed that,as patents were granted,the number of applications filed on this continent increased.The largest number of patents has been recorded by Morocco,Tunisia and South Africa.Patent applications in Morocco increased fast with an average annual growth of 7.3%.The increase in patent applications is due to improved research infrastructure and enhanced research activities,which shows the importance of biopharmaceutical innovation in the continent.展开更多
Embodied intelligence represents a new paradigm for the cross-integration development of artificial intelli⁃gence.By endowing AI with a"physical body",it enables interaction with the real world,allowing AI t...Embodied intelligence represents a new paradigm for the cross-integration development of artificial intelli⁃gence.By endowing AI with a"physical body",it enables interaction with the real world,allowing AI to move beyond digital environments into the physical realm and demonstrate intelligence that simulates or even surpasses human capa⁃bilities.Although embodied artificial intelligence demonstrates substantial potential in the realm of invention and cre⁃ation,there remain challenges in obtaining patent authorization for its generated technical solutions,specifically con⁃cerning subject,object,and market aspects.To address these issues,the feasibility of the subject should be demon⁃strated from the perspective of embodied cognition theory,while the object should be justified from a techno-centric standpoint.Subsequently,a regulatory framework for the patentability of technical solutions generated by embodied in⁃telligence should be proposed.First,a more inclusive subject framework should be established,recognizing embodied artificial intelligence as an inventor alongside humans,thereby affirming a coexistent"inventor"identity.Second,pat⁃ent rights should be assigned to developers of embodied artificial intelligence,referencing the rights distribution para⁃digm under employment relationships.Third,the criteria for patent eligibility and the"three-aspect"examination stan⁃dards should be refined.Finally,mechanisms for optimizing the implementation of rights and risk prevention should be developed.展开更多
Background:Atherosclerotic cardiovascular disease remains the leading cause of death worldwide.This study aims to explore the impact of national volume-based procurement(NVBP)on Chinese patent medicines and provide ev...Background:Atherosclerotic cardiovascular disease remains the leading cause of death worldwide.This study aims to explore the impact of national volume-based procurement(NVBP)on Chinese patent medicines and provide evidence for improving policies and promoting rational drug use.Methods:The study was based on data from the China National Health Insurance Agency that spanned January 2019 to December 2020.Descriptive analysis was conducted using volume and expenditure as variables.Interrupted time series analysis was applied to further analyze Chinese patent medicines.Results:The unit prices of atorvastatin and rosuvastatin decreased by 25%-96%,whereas the prices of Zhibitai and Xuezhikang fluctuated slightly.The affordability is measured as the monthly expenditure on treatment divided by the daily wage.After policy implementation,the affordability of atorvastatin and rosuvastatin improved from 0.242 to 0.014 and from 0.247 to 0.019,respectively.The defined daily doses(DDDs)for atorvastatin and rosuvastatin also increased,whereas total expenditures decreased in hospitals of all levels.Both at the national level and at all levels of hospital,the policy had no significant impact on expenditures for Zhibitai and Xuezhikang and their defined daily doses.Conclusions:The NVBP saved costs in the short term by incorporating high-quality,widely used lipid-lowering drugs.Notably,the policy impacted lipid-lowering chemical drugs,whereas Chinese patent medicines remained largely unaffected.Doctors'use of Chinese patent medicines did not decline,highlighting the clinical specificity of these medicines.展开更多
This study aimed to evaluate the feasibility,safety,and efficacy of a noveltranscatheter suture closure system(HaloStitch^(®))for patent foramen ovale(PFO)closure in a swine model.Methods:Thirteen swine underwent...This study aimed to evaluate the feasibility,safety,and efficacy of a noveltranscatheter suture closure system(HaloStitch^(®))for patent foramen ovale(PFO)closure in a swine model.Methods:Thirteen swine underwentexperimental PF0 model creation.All animals received implantationof the transcatheter suture closure system to evaluate procedural success.Comprehensive follow-up over sixmonths included serial ultrasound imaging,histopathological analysis,and gross anatomical exaninationof cardiac specimens.Results:Successful HaloStitch^(®)device implantation was adhieved in 11 of 13 swine.Gross anatomical examination confirrned secure positioning of all sutures in the atrial septum,with noredundancy or thrombus formation.Postoperative ultrasound demonstrated stable suture and staplepositions throughout follow-up,with no evidence of suture breakage,displacement,or thrombus.Stapleswere clearly visualized under ultrasound imaging,Both the atrial septal defect orifice diameter and residualseptal shunt flow velocity decreased significantly during the observation period.Histopathological analysisrevealed partially organized thrombi at the implant head and fibrous connective tissue encapsulation withlocalized inflammatory cell infiltration surrounding the polymer material.Conclsions:The transcathetersuture closure system(HaloStitch^(®))demonstrated feasibility,safety,and biocompatib ility for PFO closure ina swine model,supporting its potential for clinical translation.展开更多
This study takes the patent information of China's electric agricultural machinery technology as the research object,and uses patent measurement analysis method and visual analysis tools to carry out statistical a...This study takes the patent information of China's electric agricultural machinery technology as the research object,and uses patent measurement analysis method and visual analysis tools to carry out statistical analysis and comparative research on the relevant patent information from the perspectives of annual patent applications,patent structure,technological key,main applicants,patent layout,technology lifecycle and so on.The research results show that China's electric agricultural machinery technology innovation is developing rapidly,and the patent categories are mainly utility model and invention patents,and the proportion of invention patents is lower than utility model patents.Universities are the most important innovation subjects in this field,and technology research and development focuses on IPC(international patent classification)subcategories such as A01C(seeding,fertilization),B60K(power,transmission),and A01D(harvesting.mowing).Jiangsu Province and Shandong Province rank the top 2 in the number of domestic patent applications,and the United States and Japan are the two countries with the most layout in China.At present,the growth of electric agricultural machinery technology is weak,but the new technology has strong features,there is no sign of maturity,and it does not have signs of technological aging and still has greater development potential.The results of the study can provide information reference for clarifying the status quo,characteristics and development trend of China's electric agricultural machinery technology innovation.展开更多
Nucleic acid drugs represent the third wave of innovation in drug research and development,succeeding small-molecule and antibody drugs.These drugs,particularly RNA interference(RNAi)therapies,have become a pivotal fo...Nucleic acid drugs represent the third wave of innovation in drug research and development,succeeding small-molecule and antibody drugs.These drugs,particularly RNA interference(RNAi)therapies,have become a pivotal focus in the pharmaceutical industry.RNAi drugs are extensively utilized in the treatment of chronic and rare diseases due to their exceptional gene-silencing efficiency,manageable side effects,and straightforward synthesis process.This study undertook a thorough analysis of the global landscape of RNAi drug patents,highlighting the latest technological advancements and trends.We meticulously identified and cataloged the key technologies that dominated this patent landscape.The goal was to provide valuable insights and references for researchers involved in the development of RNAi drugs within the domestic pharmaceutical sector.展开更多
Patent foramen ovale(PFO)is a common congenital heart disorder associated with stroke,decompression sickness and migraine.Combining synchronized contrast transcranial Doppler with contrast transthoracic echocardiograp...Patent foramen ovale(PFO)is a common congenital heart disorder associated with stroke,decompression sickness and migraine.Combining synchronized contrast transcranial Doppler with contrast transthoracic echocardiography has important clinical significance and can improve the accuracy of detecting right-left shunts(RLSs)in patients with PFO.In this letter,regarding an original study presented by Yao et al,we present our insights and discuss how to better help clinicians evaluate changes in PFO-related RLS.展开更多
Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A p...Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.展开更多
文摘On July 11,2025,the global intellectual property(IP)spotlight fell on Geneva,Switzerland.At the 2025 World Intellectual Property Organization(WIPO)Global Awards,Chinese robotics firm Unitree Robotics was named one of 10 winners,selected from more than 780 small and medium-sized enterprises(SMEs)and startups across 95 countries and regions.Since the awards were launched in 2022.Chinese companies have won prizes for four consecutive years.
文摘Rapid and accurate identification of high-quality patents can accelerate the transformation process of scientific and technological achievements, optimize the management of intellectual property rights and enhance the vitality of innovation. Aiming at the shortcomings of the traditional high-value patent assessment method, which is relatively simple and seldom considers the influence of patentees, this paper proposes a high-quality patent method HMFM (High-Value Patent Multi-Feature Fusion Method) that fuses multi-dimensional features. A weighted node importance assessment method in complex network called GLE (Glob-Local-struEntropy) based on improved structural entropy is designed to calculate the influence of the patentee to form the patentee’s features, and the patent text features are extracted by BERT-DPCNN deep learning model, which is supplemented to the basic patent indicator system. Finally a machine learning algorithm is used to assess the value of patents. Experiment results show that our method can identify high-value patents more effectively and accurately.
基金Funded by the National Key R&D Program of China (Grant No:2022YFC3303000)。
文摘As the world transitions to a more environment-friendly and sustainable global economy,innovations in green technology are playing a crucial role.Recognizing this,China,along with many other nations,is adapting its pat⁃ent system to better support green innovations,establishing what is known as a green patent regime.While extensive empirical research highlights the significance of China's green patent regime in achieving environmental sustainabil⁃ity,there is a noticeable lack of normative studies on enhancing its efficacy.This work aims to fill this gap by conduct⁃ing a normative study using doctrinal analysis and proposing that transparency and accessibility are key factors in evaluating the effectiveness of a green patent regime.Through a doctrinal analysis of China's green patent legislation and regulations,this work assesses the legal rights conferred by this regime and identifies how these rights are con⁃strained by substantive and procedural norms.The findings reveal significant limitations to the transparency and acces⁃sibility of China's green patent regime and propose improvements.These recommendations offer insights for policymak⁃ers in China and other countries.The doctrinal analysis conducted in this research could stimulate further theoretical discussion in the field of sustainable development and intellectual property law.Moreover,it might enlighten more hy⁃potheses for future empirical studies.
文摘BACKGROUND The Food and Drug Administration has approved percutaneous atrial septal defect(ASD)and patent foramen ovale(PFO)closure devices for hemodynamically significant interatrial shunts,paradoxical emboli including stroke,and decompression sickness.We aimed to study the trends in utilization and reimbursements of transcatheter ASD/PFO closure devices.AIM To analyze trends in utilization and Medicare reimbursements for transcatheter ASD/PFO closure procedures from 2013 to 2022.METHODS A query of administrative data on United States Medicare beneficiaries undergoing transcatheter ASD/PFO was conducted from 2013 to 2022 using the Centers for Medicare and Medicaid Services Part B National Summary Data File.Inflation adjustments were made using the 2023 Consumer Price Index.Trend analysis was quantified using growth rate and simple linear regression calculations.All analyses were performed using Microsoft Excel 16.77.1(2023).RESULTS The annual number of transcatheter ASD/PFO closure procedures increased by 81%since 2013,with an average yearly growth rate of 44%cases per year(P<0.001).Annual Medicare reimbursements for transcatheter ASD/PFO therapies mirrored the annual procedure trends.The per-case reimbursements decreased by 18%,i.e.,$1128.80 in 2013 and$770.21 in 2022(P<0.001).There was a significant drop in the number of procedures in the year 2020,which correlates to the onset of the coronavirus disease 2019 pandemic,followed by a sharp uptick in the number of cases in 2021 and 2022.CONCLUSION Medicare utilization of transcatheter ASD/PFO closure therapies has grown significantly in procedural volume from 2013 to 2022.However,this has been accompanied by a decrease in per-case reimbursements.
文摘While the significant role of technological innovation in promoting renewable energy has been extensively explored in the literature,limited attention has been paid to the impact of energy patents,particularly clean energy patents and fossil fuel patents.This study pioneers an investigation into the effects of energy patents and energy prices on renewable energy consumption.The study utilizes data from 2000Q1 to 2023Q4 and,due to the nonlinear nature of the series,applies wavelet quantile-based methods.Specifically,it introduces the wavelet quantile cointegration approach to evaluate cointegration across different quantiles and time horizons,along with the wavelet quantile-on-quantile regression method.The results confirm cointegration across different periods and quantiles,highlighting the significant relationships between energy patents,economic factors,and renewable energy consumption.Furthermore,we found that fossil energy patents negatively affect renewable energy consumption,while clean energy patents have a similar but weaker effect,especially in the short term.In addition,higher energy prices promote renewable energy adoption while economic growth positively influences renewable energy consumption,particularly in the short term.The study formulates specific policies based on these findings.
文摘A"verdict"on the economic value of the patent system by the US economist Fritz Machlup published in 1958 still has an important impact on assessing the effects of the patent system on economic development by intellec-tual property scholars worldwide.This contribution analyses Machlup's study as is and in the light of subsequent US and global legal and economic developments.Machlup's assessment was examined based on empirical data generated by the US Bayh-Dole type legislation as regards the translation of basic research into innovative products and pro-cesses.Moreover,it analyses the impact of the new world economic order instituted in the framework of the World Trade Organization(WTO)mandatorily requiring effective patent protection in all WTO Member States on the eco-nomic development of developing and emerging economies.The case of China,which adopted its first Patent Law in 1984,is addressed in the context of Machlup's verdict and in light of the subsequent economic,scientific and techno-logical development of that country.Concluding thoughts consider today's value of Machlup's"verdict".
基金supported by Key Project of National Social Fund of China(21AGL014).
文摘The recent surge in global financial and patent innovations and rising CO_(2) emissions in the global energy sector have drawn significant attention to China’s transportation industry.This study examines how financial innovations(FINI),patent innovations(PTIN),and bioenergy(BIOE)affect CO_(2) emissions in China’s transportation sector(TBCO_(2))using quarterly data from 2000 to 2018.This study employed a novel wavelet local multiple correlation(WLMC)methodology,alongside the time-varying causality test,to examine the time–frequency nexus,addressing a critical gap in the current literature.The WLMC bivariate analyses revealed a negative long-term relationship between PTIN and FINI with TBCO_(2).At the same time,BIOE showed only a short-term mitigating effect,with PTIN playing a dominant role in this nexus at various frequency levels.Furthermore,the three-and four-variate assessments highlight the consistent positive influence of all included factors on TBCO_(2).A timevarying causality test also demonstrated significant causal relationships between FINI,PTIN,BIOE,and TBCO_(2) across different periods,confirming the robustness of our WLMC results.This study provides crucial insights,emphasizing the urgency of promoting FINIs,technological advancement,and bioenergy usage to reduce transportation emissions and pursue sustainable solutions to address China’s environmental challenges.
基金Chinese Academy of Medical Sciences Fuwai Hospital High Level Hospital clinical research fund(2022-GSPGG-18).
文摘Compared with traditional nickel-titanium alloy patent foramen ovale occluders,which are widely used in clinical practice,biodegradable patent foramen ovale occluders have obvious differences in material characteristics,interventional operation mode and postoperative management strategy.This article gives expert consensus on the selection of clinical indications and standardized operating procedures,so as to standardize the clinical application of biodegradable patent foramen ovale occluders.
文摘The contribution of knowledge capital to firm value has increased significantly,from 25%in the 1970s to 45%in the 2010s(Belo et al.in Decomposing firm value J Financ Econ 143:619–639,2022).However,what influences firms’ability to maximize the effect of knowledge capital on firm value?Drawing on insights from upper echelons,agency,and behavioral agency theories,we show that CEO characteristics are crucial in enabling firms to take advantage of knowledge stock.We empirically demonstrate that short-term CEO compensation structures are detrimental to a firm’s ability to take advantage of its knowledge stock.We further show that CEO power enhances knowledge stock and R&D intensity.Our study provides direct empirical evidence of the importance of CEO compensation structure and corporate governance in understanding firm value in a knowledge economy.
文摘Objective To explore the current state of biopharmaceutical innovation in Africa by analyzing patent data related to biopharmaceutical products in African countries.Methods Based on patent data,simple descriptive statistical methods were used to analyze the trend of patent applications,the geographical distribution of patents,and the distribution of applicants in the pharmaceutical field in Africa.Besides,Excel software was used to draw charts to visualize statistical information.Results and Conclusion According to the result,a large number of patents has been granted in these countries and the number is steadily rising each year.From the figure below,we can see that the largest number of patents was granted to Morocco in 2014 with a total number of 613 patents followed by Tunisia with 315 patents,the African Intellectual Property Organization(OAPI)with 124 patents,South Africa with 106 and Mozambique with 1 patent based on data availability(IncoPat Global Patent Search Database).It was observed that,as patents were granted,the number of applications filed on this continent increased.The largest number of patents has been recorded by Morocco,Tunisia and South Africa.Patent applications in Morocco increased fast with an average annual growth of 7.3%.The increase in patent applications is due to improved research infrastructure and enhanced research activities,which shows the importance of biopharmaceutical innovation in the continent.
基金Ministry of Justice of China Funding 22SFB5044:Research on the optimization and governance strategies of intellectual property ecosystem empowered by blockchain technology。
文摘Embodied intelligence represents a new paradigm for the cross-integration development of artificial intelli⁃gence.By endowing AI with a"physical body",it enables interaction with the real world,allowing AI to move beyond digital environments into the physical realm and demonstrate intelligence that simulates or even surpasses human capa⁃bilities.Although embodied artificial intelligence demonstrates substantial potential in the realm of invention and cre⁃ation,there remain challenges in obtaining patent authorization for its generated technical solutions,specifically con⁃cerning subject,object,and market aspects.To address these issues,the feasibility of the subject should be demon⁃strated from the perspective of embodied cognition theory,while the object should be justified from a techno-centric standpoint.Subsequently,a regulatory framework for the patentability of technical solutions generated by embodied in⁃telligence should be proposed.First,a more inclusive subject framework should be established,recognizing embodied artificial intelligence as an inventor alongside humans,thereby affirming a coexistent"inventor"identity.Second,pat⁃ent rights should be assigned to developers of embodied artificial intelligence,referencing the rights distribution para⁃digm under employment relationships.Third,the criteria for patent eligibility and the"three-aspect"examination stan⁃dards should be refined.Finally,mechanisms for optimizing the implementation of rights and risk prevention should be developed.
基金funded by the Beijing Natural Science Foundation(grant number 9232010)Capital's Funds for Health Improvement and Research(grant number 2022-2-4079).
文摘Background:Atherosclerotic cardiovascular disease remains the leading cause of death worldwide.This study aims to explore the impact of national volume-based procurement(NVBP)on Chinese patent medicines and provide evidence for improving policies and promoting rational drug use.Methods:The study was based on data from the China National Health Insurance Agency that spanned January 2019 to December 2020.Descriptive analysis was conducted using volume and expenditure as variables.Interrupted time series analysis was applied to further analyze Chinese patent medicines.Results:The unit prices of atorvastatin and rosuvastatin decreased by 25%-96%,whereas the prices of Zhibitai and Xuezhikang fluctuated slightly.The affordability is measured as the monthly expenditure on treatment divided by the daily wage.After policy implementation,the affordability of atorvastatin and rosuvastatin improved from 0.242 to 0.014 and from 0.247 to 0.019,respectively.The defined daily doses(DDDs)for atorvastatin and rosuvastatin also increased,whereas total expenditures decreased in hospitals of all levels.Both at the national level and at all levels of hospital,the policy had no significant impact on expenditures for Zhibitai and Xuezhikang and their defined daily doses.Conclusions:The NVBP saved costs in the short term by incorporating high-quality,widely used lipid-lowering drugs.Notably,the policy impacted lipid-lowering chemical drugs,whereas Chinese patent medicines remained largely unaffected.Doctors'use of Chinese patent medicines did not decline,highlighting the clinical specificity of these medicines.
基金supported by grants from National High-Level Hospital Clinical Research Funding(2023-GSP-RC-04).
文摘This study aimed to evaluate the feasibility,safety,and efficacy of a noveltranscatheter suture closure system(HaloStitch^(®))for patent foramen ovale(PFO)closure in a swine model.Methods:Thirteen swine underwentexperimental PF0 model creation.All animals received implantationof the transcatheter suture closure system to evaluate procedural success.Comprehensive follow-up over sixmonths included serial ultrasound imaging,histopathological analysis,and gross anatomical exaninationof cardiac specimens.Results:Successful HaloStitch^(®)device implantation was adhieved in 11 of 13 swine.Gross anatomical examination confirrned secure positioning of all sutures in the atrial septum,with noredundancy or thrombus formation.Postoperative ultrasound demonstrated stable suture and staplepositions throughout follow-up,with no evidence of suture breakage,displacement,or thrombus.Stapleswere clearly visualized under ultrasound imaging,Both the atrial septal defect orifice diameter and residualseptal shunt flow velocity decreased significantly during the observation period.Histopathological analysisrevealed partially organized thrombi at the implant head and fibrous connective tissue encapsulation withlocalized inflammatory cell infiltration surrounding the polymer material.Conclsions:The transcathetersuture closure system(HaloStitch^(®))demonstrated feasibility,safety,and biocompatib ility for PFO closure ina swine model,supporting its potential for clinical translation.
基金Special Fund for Basic Scientific Research Business Expenses of Central Public Welfare Scientific Research Institutions(S201947)。
文摘This study takes the patent information of China's electric agricultural machinery technology as the research object,and uses patent measurement analysis method and visual analysis tools to carry out statistical analysis and comparative research on the relevant patent information from the perspectives of annual patent applications,patent structure,technological key,main applicants,patent layout,technology lifecycle and so on.The research results show that China's electric agricultural machinery technology innovation is developing rapidly,and the patent categories are mainly utility model and invention patents,and the proportion of invention patents is lower than utility model patents.Universities are the most important innovation subjects in this field,and technology research and development focuses on IPC(international patent classification)subcategories such as A01C(seeding,fertilization),B60K(power,transmission),and A01D(harvesting.mowing).Jiangsu Province and Shandong Province rank the top 2 in the number of domestic patent applications,and the United States and Japan are the two countries with the most layout in China.At present,the growth of electric agricultural machinery technology is weak,but the new technology has strong features,there is no sign of maturity,and it does not have signs of technological aging and still has greater development potential.The results of the study can provide information reference for clarifying the status quo,characteristics and development trend of China's electric agricultural machinery technology innovation.
文摘Nucleic acid drugs represent the third wave of innovation in drug research and development,succeeding small-molecule and antibody drugs.These drugs,particularly RNA interference(RNAi)therapies,have become a pivotal focus in the pharmaceutical industry.RNAi drugs are extensively utilized in the treatment of chronic and rare diseases due to their exceptional gene-silencing efficiency,manageable side effects,and straightforward synthesis process.This study undertook a thorough analysis of the global landscape of RNAi drug patents,highlighting the latest technological advancements and trends.We meticulously identified and cataloged the key technologies that dominated this patent landscape.The goal was to provide valuable insights and references for researchers involved in the development of RNAi drugs within the domestic pharmaceutical sector.
文摘Patent foramen ovale(PFO)is a common congenital heart disorder associated with stroke,decompression sickness and migraine.Combining synchronized contrast transcranial Doppler with contrast transthoracic echocardiography has important clinical significance and can improve the accuracy of detecting right-left shunts(RLSs)in patients with PFO.In this letter,regarding an original study presented by Yao et al,we present our insights and discuss how to better help clinicians evaluate changes in PFO-related RLS.
基金National Multidisciplinary Innovation Team of Traditional Chinese Medicine (ZYYCXTD-D-202204)Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00013)。
文摘Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.
