The metal-free S–S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is described. This novel protocol provides a facile and efficient approach to accessing important unsymmetrical disulfides.Further...The metal-free S–S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is described. This novel protocol provides a facile and efficient approach to accessing important unsymmetrical disulfides.Furthermore, this strategy could also be utilized in the late-stage functionalization of amino acids, drugs,and natural products. The broad substrate scope, good functional group tolerance and easy accessibility of catalyst indicate that this strategy affords a green and practical complementary method to various unsymmetrical disulfides.展开更多
基金the financial support from the National Natural Science Foundation of China (Nos. 21572026, 21702019)Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. SJCX20_0952)Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University
文摘The metal-free S–S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is described. This novel protocol provides a facile and efficient approach to accessing important unsymmetrical disulfides.Furthermore, this strategy could also be utilized in the late-stage functionalization of amino acids, drugs,and natural products. The broad substrate scope, good functional group tolerance and easy accessibility of catalyst indicate that this strategy affords a green and practical complementary method to various unsymmetrical disulfides.
