A new type of C2-symmetric chiral spirobiindole structure is developed,and excellent diastereoselectivities and enantioselectivities(>20:1 dr&>99%ee for all examples)were obtained via an asymmetric rhodium c...A new type of C2-symmetric chiral spirobiindole structure is developed,and excellent diastereoselectivities and enantioselectivities(>20:1 dr&>99%ee for all examples)were obtained via an asymmetric rhodium catalysis-intramolecular spirocyclization sequence.Selective synthesis of both spirobiindole enantiomers could be achieved using the same catalyst by simply switching the substrate combination.展开更多
基金the financial support from the National Natural Science Foundation of China(No.22207094)the financial support from the National Natural Science Foundation of China(Nos.22077110,22377103)+2 种基金the financial support from the Fundamental Research Funds for the Central Universities(No.2632024ZD03)the National Natural Science Foundation of China(No.22471290)the Jiangsu Outstanding Youth Fund(No.BK20240051)。
文摘A new type of C2-symmetric chiral spirobiindole structure is developed,and excellent diastereoselectivities and enantioselectivities(>20:1 dr&>99%ee for all examples)were obtained via an asymmetric rhodium catalysis-intramolecular spirocyclization sequence.Selective synthesis of both spirobiindole enantiomers could be achieved using the same catalyst by simply switching the substrate combination.
