Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as ...Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct target.In addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon exposure.To investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with kanamycin.We found that the mice exhibited auditory deficits following the acute loss of outer hair cells.Spiral ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over time.Transcriptomic profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 inflammasome.Activation of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory cytokines.Pharmacological intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury model.These findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron degeneration.Inhibition of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.展开更多
Spiral pile foundations,as a promising type of foundation,are of significant importance for the development of offshore wind energy,particularly as it moves toward deeper waters.This study conducted a physical experim...Spiral pile foundations,as a promising type of foundation,are of significant importance for the development of offshore wind energy,particularly as it moves toward deeper waters.This study conducted a physical experiment on a three-spiral-pile jacket foundation under deep-buried sandy soil conditions.During the experiment,horizontal displacement was applied to the structure to thoroughly investigate the bearing characteristics of the three-spiral-pile jacket foundation.This study also focused on analyzing the bearing mechanisms of conventional piles compared with spiral piles with different numbers of blades.Three different working conditions were set up and compared,and key data,such as the horizontal bearing capacity,pile shaft axial force,and spiral blade soil pressure,were measured and analyzed.The results show the distinct impacts of the spiral blades on the compressed and tensioned sides of the foundation.Specifically,on the compressed side,the spiral blades effectively enhance the restraint of the soil on the pile foundation,whereas on the tensioned side,an excessive number of spiral blades can negatively affect the structural tensile performance to some extent.This study also emphasizes that the addition of blades to the side of a single pile is the most effective method for increasing the bearing capacity of the foundation.This research aims to provide design insights into improving the bearing capacity of the foundation.展开更多
Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF ...Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF envelope forming principle of spiral bevel gears is proposed.Secondly,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement relationships.Thirdly,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel gear.Fourthly,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their interference.Finally,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming equipment.The simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods.展开更多
Photoinduced[2+2]cycloaddition of biomass-derived cycloolefin is a promising approach to synthesize high-energy bio-fuels,however,the conversion efficiency and selectivity are still low.Herein,we provide an acid-promo...Photoinduced[2+2]cycloaddition of biomass-derived cycloolefin is a promising approach to synthesize high-energy bio-fuels,however,the conversion efficiency and selectivity are still low.Herein,we provide an acid-promoted photocycloaddition approach to synthesize a new kind of spiral fuel from biomass-derived cyclohexanone (CHOE) and camphene (CPE).BrΦnsted acids show higher catalytic activity than Lewis acids,and acetic acid (HOAc) possesses the best catalytic performance,with CHOE conversion up to 99.1%.Meanwhile,the HOAc-catalytic effect has been confirmed for[2+2]photocycloaddition of other biomass-derived ketenes and olefins.The catalytic mechanism and dynamics have been investigated,and show that HOAc can bond with C=O groups of CHOE to form H–CHOE complex,which leads to higher light adsorption and longer triplet lifetime.Meanwhile,H–CHOE complex reduces the energy gap between CHOE LUMO and CPE HOMO,shortens the distance of ring-forming atoms,and then decreases the energy barrier (from 103.3 kcal mol^(-1)to 95.8 kcal mol^(-1)) of rate-limiting step.After hydrodeoxygenation,the targeted bio-spiral fuel shows high density of 0.992 g cm^(-3),high neat heat of combustion of 41.89 MJ L^(-1),low kinetic viscosity of 5.69 mm^(2)s^(-1)at 20℃,which is very promising to serve as high-performance aerospace fuel.展开更多
During high-speed rotation,the surface of aeronautic spiral bevel gears will generate significant pressure and viscous forces,which will cause a certain amount of windage power loss and reduce the efficiency of the tr...During high-speed rotation,the surface of aeronautic spiral bevel gears will generate significant pressure and viscous forces,which will cause a certain amount of windage power loss and reduce the efficiency of the transmission system.Based on the computational fluid dynamics,this paper analyzes the windage power loss of a single spiral bevel gear and a spiral bevel gear pair under oil injection lubrication.In addition,the shroud is used to suppress gear windage loss,and the clearance size and opening angle of the designed shroud are optimized.Finally,by comparing and analyzing the experimental results,the following conclusions were obtained:(1)For a single gear,the speed is the most important factor affecting windage loss,followed by the hand of spiral,and rotation direction;(2)For gear pairs,under oil injection lubrication,the input speed has the greatest impact on windage power loss,followed by the influence of oil injection port speed,temperature and oil injection port pressure;(3)Installing a shroud is an effective method to reduce windage power loss;(4)In the pure air phase,the smaller the clearance between the shroud and the gear surface,and the smaller the radial direction between the shroud and the shaft,the better the effect of reducing windage;(5)In the two-phase flow of oil and gas,it is necessary to design oil drainage holes on the shroud to ensure the smooth discharge of lubricating oil and improve the drag reduction effect.展开更多
1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出...1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出。行为测听:左侧听力正常,右侧极重度感音神经性听力下降。耳声发射(OAE):左侧正常,右侧全频未引出。展开更多
Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of curr...Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.展开更多
In this paper,a 4×4 wideband linearly po-larization(LP)antenna array is proposed by using pla-nar dual-arm spiral structures.Wideband balun struc-tures,composed of microstrip line-fed coupling slots,are adopted t...In this paper,a 4×4 wideband linearly po-larization(LP)antenna array is proposed by using pla-nar dual-arm spiral structures.Wideband balun struc-tures,composed of microstrip line-fed coupling slots,are adopted to feed two dual-arms spiral structures with opposite phases.Then,by combining the left-and right-hand circular polarizations,a linearly polar-ization is achieved.The proposed antenna has a wide operating bandwidth due to the wideband nature of the spiral structure.Simulated results show that the an-tenna element can achieve a 68.73%impedance band-width and a maximum gain of 6.64 dBi within 19.44–38.83 GHz.A 4×4 array prototype is designed to verify the concept.Measured results show that an impedance bandwidth of 63.73%is obtained.The pro-posed array has the merits of a wide bandwidth,a low profile,a low cost,and a small size,which is promis-ing for the application in millimeter wave wireless sys-tems.展开更多
BACKGROUND In postsurgical upper gastrointestinal anatomy,motorized spiral enteroscopy(MSE)assisted endoscopic retrograde cholangiopancreaticography(ERCP)was shown feasible and has the advantage that standard ERCP ins...BACKGROUND In postsurgical upper gastrointestinal anatomy,motorized spiral enteroscopy(MSE)assisted endoscopic retrograde cholangiopancreaticography(ERCP)was shown feasible and has the advantage that standard ERCP instruments can be used.Therefore,MSE-ERCP appears to be the optimal solution for postsurgical patients,especially with Roux-en-Y anatomy.AIM To show feasibility and safety of MSE-ERCP in patients with Roux-en-Y anatomy.METHODS We retrospectively analyzed all consecutive MSE-ERCP procedures in patients with Roux-en-Y anatomy between September 2021 and May 2023 in an endoscopic tertiary referral center.RESULTS We identified 26 MSE-ERCPs:(1)18 MSE-ERCPs in 13 patients with Roux-en-Y anatomy after liver transplantation(n=11)or gastrectomy(n=2);and(2)Another 8 MSE-ERCP interventions in 5 patients with very long Roux-en-Y situation after gastric bypass.Overall success of reaching the biliary entry was 88%and further interventions were successful in 83%of patients.In very long alimentary limb situations,success of reaching the biliary entry was not-significantly lower compared to“standard”Roux-en-Y(75%vs 94%,P=0.215).ERCP-interventions were not-significantly less successful in patients with native papilla compared to hepaticojejunostomy(63%vs 93%,P=0.103).Mean intervention time was 105 minutes.Intervention times were longer in very long limb situations(133 minutes vs 91 minutes;P=0.032).Overall,we observed three adverse events(n=1 caused by enteroscopy,n=1 caused by the biliary intervention,n=1 unrelated to the procedure).In 15/26 cases(58%)MSE-ERCP was carried out on an outpatient basis.CONCLUSION MSE-ERCP has been a promising technique for patients with Roux-en-Y reconstruction requiring biliary interventions.However,MSE was recently withdrawn from the market due to severe safety concerns,which were not observed in this study.展开更多
Objective:This study aims to establish an economically viable and easily accessible adult animal model for optogenetic activation of auditory neurons using adeno-associated viruses(AAVs)carrying Ch R2(H134R)to explore...Objective:This study aims to establish an economically viable and easily accessible adult animal model for optogenetic activation of auditory neurons using adeno-associated viruses(AAVs)carrying Ch R2(H134R)to explore the potential of cochlear optogenetics as a hearing restoration technology.Methods:Healthy adult guinea pigs were used in the experiments.The viral vector AAV2/8-Ch R2(H134R)-h Syn-e YFP was administered to the right cochlea via the round window membrane.The confocal microscopy and reverse transcription polymerase chain reaction(RT-PCR)were utilized to analyze the Ch R2(H134R)expression localized to spiral ganglion neurons(SGNs).The auditory pathway activation was assessed by recording the optical compound action potential(oCAP)and acoustic compound action potential(a CAP)at various laser intensities.Results:The Ch R2(H134R)-e YFP expression was confirmed in 90%of the tested animals,localized to the SGNs of the injected ear.Higher m RNA levels of Ch R2(H134R)and e YFP were observed in the injected ear compared to the non-injected ear,while actin(Actb)m RNA levels were not significantly different.The o CAP was successfully elicited by a 470 nm blue light laser stimulus,with similar amplitudes and latency periods to those of a CAPs when the o CAP was evoked by 5.80 m W blue light and the a CAP was evoked by a 40 d B SPL click.The amplitudes of o CAPs increased with increasing laser intensity.Conclusion:This study demonstrates the viability of optogenetic activation of the auditory system in adult guinea pigs through the transduction of AAV-Ch R2(H134R)in SGNs.Cochlear optogenetics demonstrates potential as a hearing restoration technology,providing a basis for further clinical research and opening new avenues for investigation.展开更多
To achieve high-precision trajectory following during helicopter maneuver tasks and reduce the disruptive influences of unknown variabilities,this study introduces a cascaded-loop helicopter trajectory tracking contro...To achieve high-precision trajectory following during helicopter maneuver tasks and reduce the disruptive influences of unknown variabilities,this study introduces a cascaded-loop helicopter trajectory tracking controller,whose parameters are set using an Ant Colony OptimizationSlime Mould Algorithm(ACO-SMA).Initially,a nonlinear flight dynamics model of the helicopter is constructed.Observer gain functions and nonlinear feedback from a vibrational suppression function to improve the tracking performance of the controller,addressing issues in disturbance estimation and compensation of the Active Disturbance Rejection Control(ADRC).Simultaneously,a cascaded loop system,comprising an internal attitude loop and an external position loop,is created,and the ant colony-slime mold hybrid algorithm optimizes the system parameters of the trajectory tracking controller.Finally,helicopter trajectory tracking simulation experiments are conducted,including spiral ascending and“8”shape climbing maneuvers.The findings indicate that the ADRC employed for helicopter trajectory tracking exhibits outstanding performance in rejecting disturbances caused by gusts and accurately tracking trajectories.The trajectory tracking controller,whose parameters are optimized by the ACO-SMA,shows higher tracking precision compared to the conventional PID and ADRC,thereby substantially improving the precision of maneuver tasks.展开更多
Under the dual-carbon background,the technological updating of traditional high-energy-consuming equipment should not be delayed,and the problem of reactor energy consumption should not be ignored.Therefore,this study...Under the dual-carbon background,the technological updating of traditional high-energy-consuming equipment should not be delayed,and the problem of reactor energy consumption should not be ignored.Therefore,this study is based on computational fluid dynamics(CFD)theory to simulate the spiral stirred reactor with different design parameters(distance of paddle from bottom surface to reactor height ratio h1/H,diameter of stirring paddle to reactor diameter ratio Ds/D,length of blade section to reactor height ratio Ls/H).It was found that the reactor designed with lower Ls/H values and higher h1/H,Ds/D values would have smaller power number(Np)values and smaller flow field average velocity.In addition,this study also fitted the correlation equation of Np concerning Reynolds number and h1/H,Ds/D,and Ls/H,and the conclusions of the study can be used as a reference for the design of industrial equipment.展开更多
Organisms have evolved a strain limiting mechanism,reflected as a non-linear elastic constitutive,to prevent large deformations from threatening soft tissue integrity.Compared with linear elastic substrates,the wrinkl...Organisms have evolved a strain limiting mechanism,reflected as a non-linear elastic constitutive,to prevent large deformations from threatening soft tissue integrity.Compared with linear elastic substrates,the wrinkle of films on non-linear elastic substrates has received less attention.In this article,a unique wrinkle evolution of the film-substrate system with a J-shaped non-linear stress-strain relation is reported.The result shows that a concave hexagonal array pattern is formed with the shrinkage strain of the film-substrate systems developing.As the interconnection of hexagonal arrays,a unit cell ridge network appears with properties such as chirality and helix.The subparagraph maze pattern formed with high compression is mainly composed of special single-cell ridge networks such as spiral single cores,chiral double cores,and combined multi-cores.This evolutionary model is highly consistent with the results of experiments,and it also predicts wrinkle morphology that has not yet been reported.These findings can serve as a novel explanation for the surface wrinkle of biological soft tissue,as well as provide references for the preparation of artificial biomaterials and programmable soft matter.展开更多
Spiral patterns widely exist in both macroscopic and microscopic systems such as hearts,bacteria,and active matters but have never been reported at molecular length scale.The emergence of spiral patterns has considera...Spiral patterns widely exist in both macroscopic and microscopic systems such as hearts,bacteria,and active matters but have never been reported at molecular length scale.The emergence of spiral patterns has considerable impacts on the trajectories of the objects and thus usually relates to various physical,chemical,biological and physiological processes.In this paper,we show that,down to the length scale of only several Angstroms,asymmetric molecules exhibit spiral patterns in their trajectories within finite time based on the under-damped Langevin equation and demonstrated by molecular dynamics simulation.The key to this observation lies in the asymmetric molecular architecture that leads to a translation-rotation coupling.This finding enriches the knowledge of spiral patterns to the molecular length scale,provides a new insight into the understanding of various processes at the molecular level,and may evoke new ideas on the understanding of the vortices in turbulence.展开更多
Objective:In the Radiology Department of Mzuzu Central Hospital(MCH),daily training for radiographers now includes content on Computed Tomography(CT)image quality control and equipment maintenance to ensure the normal...Objective:In the Radiology Department of Mzuzu Central Hospital(MCH),daily training for radiographers now includes content on Computed Tomography(CT)image quality control and equipment maintenance to ensure the normal,continuous,and stable operation of the 16-slice spiral CT scanner.Methods:Through comprehensive analysis of relevant equipment,we have identified key parameters that significantly impact CT image quality.Innovative optimization strategies and solutions targeting these parameters have been developed and integrated into daily training programs.Furthermore,starting from an examination of prevalent failure modes observed in CT equipment,we delve into essential maintenance and preservation techniques that CT technologists must master to ensure optimal system performance.Results:(1)Crucial factors affecting CT image quality include artifacts,noise,partial volume effects,and surrounding gap phenomena,alongside spatial and density resolutions,CT dose,reconstruction algorithms,and human factors during the scanning process.In the daily training for radiographers,emphasis is placed on strictly implementing image quality control measures at every stage of the CT scanning process and skillfully applying advanced scanning and image processing techniques.By doing so,we can provide clinicians with accurate and reliable imaging references for diagnosis and treatment.(2)Strategies for CT equipment maintenance:①Environmental inspection of the CT room to ensure cleanliness and hygiene.②Rational and accurate operation,including calibration software proficiency.③Regular maintenance and servicing for minimizing machine downtime.④Maintenance of the CT X-ray tube.CT technicians can become proficient in equipment maintenance and upkeep techniques through training,which can significantly extend the service life of CT systems and reduce the occurrence of malfunctions.Conclusion:Through the regular implementation of rigorous CT image quality control training for radiology technicians,coupled with diligent and proactive CT equipment maintenance,we have observed profound and beneficial impacts on improving image quality.The accuracy and fidelity of radiological data ultimately leads to more accurate diagnoses and effective treatments.展开更多
To mill fine and well-defined micro-dimpled structures,a machining manner of spiral trajectory tool reciprocating motion,where the tool repeats the process of‘feed milling–retract–cutting feed–feed milling again’...To mill fine and well-defined micro-dimpled structures,a machining manner of spiral trajectory tool reciprocating motion,where the tool repeats the process of‘feed milling–retract–cutting feed–feed milling again’along the spiral trajectory,was proposed.From the kinematics analysis,it is found that the machining quality of micro-dimpled structures is highly dependent on the machining trajectory using spiral trajectory tool reciprocating motion.To reveal this causation,simulation modelling and experimental studies were carried out.A simulation model was developed to quantitatively and qualitatively investigate the influence of the trajectory discretization strategies(constant-angle and constant-arc length)and parameters(discrete angle,discrete arc length,and pitch)on surface texture and residual height of micro-dimpled structures.Subsequently,micro-dimpled structures were milled under different trajectory discretization strategies and parameters with spiral trajectory tool reciprocating motion.A comprehensive comparison between the milled results and simulation analysis was made based on geometry accuracy,surface morphology and surface roughness of milled dimples.Meanwhile,the errors and factors affecting the above three aspects were analyzed.The results demonstrate both the feasibility of the established simulation model and the machining capability of this machining way in milling high-quality micro-dimpled structures.Spiral trajectory tool reciprocating motion provides a new machining way for milling micro-dimpled structures and micro-dimpled functional surfaces.And an appropriate machining trajectory can be generated based on the optimized trajectory parameters,thus contributing to the improvement of machining quality and efficiency.展开更多
Objective:To investigate the diagnostic value of multi-slice spiral CT(MSCT)for patients with acute appendicitis(AA).Methods:Fifty patients with suspected AA who visited the hospital from January 2023 to January 2025 ...Objective:To investigate the diagnostic value of multi-slice spiral CT(MSCT)for patients with acute appendicitis(AA).Methods:Fifty patients with suspected AA who visited the hospital from January 2023 to January 2025 were selected as samples.All patients underwent MSCT and ultrasound diagnosis,and the diagnostic efficacy of MSCT was analyzed in comparison with pathology.Results:Pathology indicated 40 positive and 10 negative cases,ultrasound indicated 30 positive and 20 negative cases,and MSCT indicated 39 positive and 11 negative cases.The diagnostic efficacy of MSCT was higher than that of ultrasound(P<0.05).The accuracy of pathological classification of MSCT was higher than that of ultrasound(P<0.05).The detection rate of MSCT imaging indicators in AA patients was higher than that in non-AA patients(P<0.05).Conclusion:MSCT has high diagnostic efficacy in AA patients and can assist physicians in determining pathological classification.展开更多
To address the current issues with the conventional slide gate system utilized in the steel teeming process,a unique electromagnetic induction controlled automated steel teeming(EICAST)technology has been developed.Co...To address the current issues with the conventional slide gate system utilized in the steel teeming process,a unique electromagnetic induction controlled automated steel teeming(EICAST)technology has been developed.Cooling means of spiral coil in this technology is directly related to its service life.Firstly,heat transfer processes of air cooling and spray cooling were compared and analyzed.Secondly,the impacts of water temperature,water flow rate and air flow rate were examined in order to maximize the spray cooling effect.To maintain coil temperature at a low value consistently throughout the entire thermal cycle process of the ladle,a combined cooling mode was finally employed.Numerical simulation was applied to examine the coil temperature variation with different cooling systems and characteristics.Before coil operation,spray cooling is said to be more effective.By controlling the water flow rate and air flow rate,the spray cooling effect is enhanced.However,water temperature has little or no impact when using spray cooling.Air cooling during the secondary refining process and spray cooling prior to coil operation are combined to further lower coil temperature.When the direction of the spray cooling is from bottom to top,the coil temperature is lowered below 165℃.A practical induction coil cooling plan was provided for the EICAST technology’s production process.展开更多
Two-dimensional(2D)heterostructures compris-ing of differently stacking atomic layers are attrac-tive owing to its flexible composition as well as the emerging new physicochemical properties.Howev-er,so far many 2D ve...Two-dimensional(2D)heterostructures compris-ing of differently stacking atomic layers are attrac-tive owing to its flexible composition as well as the emerging new physicochemical properties.Howev-er,so far many 2D vertical heterojunctions are constructed through transfer methods,inevitably introducing interfacial impurities and thus hindering detailed atomic-level studies.In this work,we have developed a clean two-step fabrication strat-egy by combining ultrahigh vacuum(UHV)molecular beam epitaxy(MBE)growth with am-bient chemical vapor deposition(CVD).We first-ly grew single crystalline graphene film on a SiC substrate under UHV condition,and then synthesized MoS_(2)films on the graphene-SiC sur-face through CVD under inert atmosphere,thus successfully realized the construction of a well-defined MoS_(2)-graphene/SiC heterojunction with clean surface.Particularly,we observed the MoS_(2)can not only grow into monolayer flakes but also form spiral structures,the latter showing layer-by-layer stacks with reduced bandgap down to~1.0 eV.展开更多
Congenital aorta-right atrial tunnel(ARAT)is a rare congenital cardiovascular malformation characterized by an abnormal tunnel-like connection between the aorta and the right atrium.Patients with ARAT frequently have ...Congenital aorta-right atrial tunnel(ARAT)is a rare congenital cardiovascular malformation characterized by an abnormal tunnel-like connection between the aorta and the right atrium.Patients with ARAT frequently have other congenital heart malformations and require diagnosis through a variety of imaging examinations.We report a 1-month-old female infant with multiple congenital cardiac malformations who was diagnosed with ARAT using low-dose multislice spiral computed to-mography because echocardiography was unclear.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW)the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY).
文摘Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct target.In addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon exposure.To investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with kanamycin.We found that the mice exhibited auditory deficits following the acute loss of outer hair cells.Spiral ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over time.Transcriptomic profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 inflammasome.Activation of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory cytokines.Pharmacological intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury model.These findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron degeneration.Inhibition of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.
基金The National Natural Science Foundation of China(No.52171274).
文摘Spiral pile foundations,as a promising type of foundation,are of significant importance for the development of offshore wind energy,particularly as it moves toward deeper waters.This study conducted a physical experiment on a three-spiral-pile jacket foundation under deep-buried sandy soil conditions.During the experiment,horizontal displacement was applied to the structure to thoroughly investigate the bearing characteristics of the three-spiral-pile jacket foundation.This study also focused on analyzing the bearing mechanisms of conventional piles compared with spiral piles with different numbers of blades.Three different working conditions were set up and compared,and key data,such as the horizontal bearing capacity,pile shaft axial force,and spiral blade soil pressure,were measured and analyzed.The results show the distinct impacts of the spiral blades on the compressed and tensioned sides of the foundation.Specifically,on the compressed side,the spiral blades effectively enhance the restraint of the soil on the pile foundation,whereas on the tensioned side,an excessive number of spiral blades can negatively affect the structural tensile performance to some extent.This study also emphasizes that the addition of blades to the side of a single pile is the most effective method for increasing the bearing capacity of the foundation.This research aims to provide design insights into improving the bearing capacity of the foundation.
基金the National Science and Technology Major Project of China(No.2019-VII0017e0158)the National Natural Science Foundation of China(No.U21A20131)+1 种基金the Industry-University Research Cooperation Project,China(No.HFZL2020CXY025)the National Key Laboratory of Science and Technology on Helicopter Transmission,China(No.HTL-O-21G05).
文摘Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF envelope forming principle of spiral bevel gears is proposed.Secondly,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement relationships.Thirdly,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel gear.Fourthly,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their interference.Finally,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming equipment.The simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods.
基金the support from National Key R&D Program of China (2021YFC2103704)the National Natural Science Foundation of China (22222808)+4 种基金the Natural Science Foundation of Shandong Province (ZR2023QB152)the Youth Innovation Team Plan of Shandong Province (2022KJ270)the China National Postdoctoral Program for Innovative Talents (BX20240251)the Aeronautical Science Foundation of China (2023Z073048003)the Haihe Laboratory of Sustainable Chemical Transformations。
文摘Photoinduced[2+2]cycloaddition of biomass-derived cycloolefin is a promising approach to synthesize high-energy bio-fuels,however,the conversion efficiency and selectivity are still low.Herein,we provide an acid-promoted photocycloaddition approach to synthesize a new kind of spiral fuel from biomass-derived cyclohexanone (CHOE) and camphene (CPE).BrΦnsted acids show higher catalytic activity than Lewis acids,and acetic acid (HOAc) possesses the best catalytic performance,with CHOE conversion up to 99.1%.Meanwhile,the HOAc-catalytic effect has been confirmed for[2+2]photocycloaddition of other biomass-derived ketenes and olefins.The catalytic mechanism and dynamics have been investigated,and show that HOAc can bond with C=O groups of CHOE to form H–CHOE complex,which leads to higher light adsorption and longer triplet lifetime.Meanwhile,H–CHOE complex reduces the energy gap between CHOE LUMO and CPE HOMO,shortens the distance of ring-forming atoms,and then decreases the energy barrier (from 103.3 kcal mol^(-1)to 95.8 kcal mol^(-1)) of rate-limiting step.After hydrodeoxygenation,the targeted bio-spiral fuel shows high density of 0.992 g cm^(-3),high neat heat of combustion of 41.89 MJ L^(-1),low kinetic viscosity of 5.69 mm^(2)s^(-1)at 20℃,which is very promising to serve as high-performance aerospace fuel.
基金Supported by National Natural Science Foundation of China(Grant Nos.51175422,61973011)Shaanxi Provincial Natural Science Basic Research Plan of China(Grant No.2022JM-195)+1 种基金Fundamental Research Funds for the Central Universities of Chinathe Research Start-up Funds of Hangzhou International Innovation Institute of Beihang University(Grant No.2024KQ036)。
文摘During high-speed rotation,the surface of aeronautic spiral bevel gears will generate significant pressure and viscous forces,which will cause a certain amount of windage power loss and reduce the efficiency of the transmission system.Based on the computational fluid dynamics,this paper analyzes the windage power loss of a single spiral bevel gear and a spiral bevel gear pair under oil injection lubrication.In addition,the shroud is used to suppress gear windage loss,and the clearance size and opening angle of the designed shroud are optimized.Finally,by comparing and analyzing the experimental results,the following conclusions were obtained:(1)For a single gear,the speed is the most important factor affecting windage loss,followed by the hand of spiral,and rotation direction;(2)For gear pairs,under oil injection lubrication,the input speed has the greatest impact on windage power loss,followed by the influence of oil injection port speed,temperature and oil injection port pressure;(3)Installing a shroud is an effective method to reduce windage power loss;(4)In the pure air phase,the smaller the clearance between the shroud and the gear surface,and the smaller the radial direction between the shroud and the shaft,the better the effect of reducing windage;(5)In the two-phase flow of oil and gas,it is necessary to design oil drainage holes on the shroud to ensure the smooth discharge of lubricating oil and improve the drag reduction effect.
文摘1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出。行为测听:左侧听力正常,右侧极重度感音神经性听力下降。耳声发射(OAE):左侧正常,右侧全频未引出。
文摘Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.
基金supported in part by the National Natural Science Foundation of China under Grant 62131008the Fundamental Research Funds for the Central Universities 2242022k60003.
文摘In this paper,a 4×4 wideband linearly po-larization(LP)antenna array is proposed by using pla-nar dual-arm spiral structures.Wideband balun struc-tures,composed of microstrip line-fed coupling slots,are adopted to feed two dual-arms spiral structures with opposite phases.Then,by combining the left-and right-hand circular polarizations,a linearly polar-ization is achieved.The proposed antenna has a wide operating bandwidth due to the wideband nature of the spiral structure.Simulated results show that the an-tenna element can achieve a 68.73%impedance band-width and a maximum gain of 6.64 dBi within 19.44–38.83 GHz.A 4×4 array prototype is designed to verify the concept.Measured results show that an impedance bandwidth of 63.73%is obtained.The pro-posed array has the merits of a wide bandwidth,a low profile,a low cost,and a small size,which is promis-ing for the application in millimeter wave wireless sys-tems.
文摘BACKGROUND In postsurgical upper gastrointestinal anatomy,motorized spiral enteroscopy(MSE)assisted endoscopic retrograde cholangiopancreaticography(ERCP)was shown feasible and has the advantage that standard ERCP instruments can be used.Therefore,MSE-ERCP appears to be the optimal solution for postsurgical patients,especially with Roux-en-Y anatomy.AIM To show feasibility and safety of MSE-ERCP in patients with Roux-en-Y anatomy.METHODS We retrospectively analyzed all consecutive MSE-ERCP procedures in patients with Roux-en-Y anatomy between September 2021 and May 2023 in an endoscopic tertiary referral center.RESULTS We identified 26 MSE-ERCPs:(1)18 MSE-ERCPs in 13 patients with Roux-en-Y anatomy after liver transplantation(n=11)or gastrectomy(n=2);and(2)Another 8 MSE-ERCP interventions in 5 patients with very long Roux-en-Y situation after gastric bypass.Overall success of reaching the biliary entry was 88%and further interventions were successful in 83%of patients.In very long alimentary limb situations,success of reaching the biliary entry was not-significantly lower compared to“standard”Roux-en-Y(75%vs 94%,P=0.215).ERCP-interventions were not-significantly less successful in patients with native papilla compared to hepaticojejunostomy(63%vs 93%,P=0.103).Mean intervention time was 105 minutes.Intervention times were longer in very long limb situations(133 minutes vs 91 minutes;P=0.032).Overall,we observed three adverse events(n=1 caused by enteroscopy,n=1 caused by the biliary intervention,n=1 unrelated to the procedure).In 15/26 cases(58%)MSE-ERCP was carried out on an outpatient basis.CONCLUSION MSE-ERCP has been a promising technique for patients with Roux-en-Y reconstruction requiring biliary interventions.However,MSE was recently withdrawn from the market due to severe safety concerns,which were not observed in this study.
基金supported by the Beijing Natural Science Foundation of China under Grant 7222185。
文摘Objective:This study aims to establish an economically viable and easily accessible adult animal model for optogenetic activation of auditory neurons using adeno-associated viruses(AAVs)carrying Ch R2(H134R)to explore the potential of cochlear optogenetics as a hearing restoration technology.Methods:Healthy adult guinea pigs were used in the experiments.The viral vector AAV2/8-Ch R2(H134R)-h Syn-e YFP was administered to the right cochlea via the round window membrane.The confocal microscopy and reverse transcription polymerase chain reaction(RT-PCR)were utilized to analyze the Ch R2(H134R)expression localized to spiral ganglion neurons(SGNs).The auditory pathway activation was assessed by recording the optical compound action potential(oCAP)and acoustic compound action potential(a CAP)at various laser intensities.Results:The Ch R2(H134R)-e YFP expression was confirmed in 90%of the tested animals,localized to the SGNs of the injected ear.Higher m RNA levels of Ch R2(H134R)and e YFP were observed in the injected ear compared to the non-injected ear,while actin(Actb)m RNA levels were not significantly different.The o CAP was successfully elicited by a 470 nm blue light laser stimulus,with similar amplitudes and latency periods to those of a CAPs when the o CAP was evoked by 5.80 m W blue light and the a CAP was evoked by a 40 d B SPL click.The amplitudes of o CAPs increased with increasing laser intensity.Conclusion:This study demonstrates the viability of optogenetic activation of the auditory system in adult guinea pigs through the transduction of AAV-Ch R2(H134R)in SGNs.Cochlear optogenetics demonstrates potential as a hearing restoration technology,providing a basis for further clinical research and opening new avenues for investigation.
基金support of the National Natural Science Foundation of China(No.12032012)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China。
文摘To achieve high-precision trajectory following during helicopter maneuver tasks and reduce the disruptive influences of unknown variabilities,this study introduces a cascaded-loop helicopter trajectory tracking controller,whose parameters are set using an Ant Colony OptimizationSlime Mould Algorithm(ACO-SMA).Initially,a nonlinear flight dynamics model of the helicopter is constructed.Observer gain functions and nonlinear feedback from a vibrational suppression function to improve the tracking performance of the controller,addressing issues in disturbance estimation and compensation of the Active Disturbance Rejection Control(ADRC).Simultaneously,a cascaded loop system,comprising an internal attitude loop and an external position loop,is created,and the ant colony-slime mold hybrid algorithm optimizes the system parameters of the trajectory tracking controller.Finally,helicopter trajectory tracking simulation experiments are conducted,including spiral ascending and“8”shape climbing maneuvers.The findings indicate that the ADRC employed for helicopter trajectory tracking exhibits outstanding performance in rejecting disturbances caused by gusts and accurately tracking trajectories.The trajectory tracking controller,whose parameters are optimized by the ACO-SMA,shows higher tracking precision compared to the conventional PID and ADRC,thereby substantially improving the precision of maneuver tasks.
基金supported by the Natural Science Foundation of Shandong Province(ZR2023ZD22)the Major Research and Development Program of Shandong Province(2023CXGC010601).
文摘Under the dual-carbon background,the technological updating of traditional high-energy-consuming equipment should not be delayed,and the problem of reactor energy consumption should not be ignored.Therefore,this study is based on computational fluid dynamics(CFD)theory to simulate the spiral stirred reactor with different design parameters(distance of paddle from bottom surface to reactor height ratio h1/H,diameter of stirring paddle to reactor diameter ratio Ds/D,length of blade section to reactor height ratio Ls/H).It was found that the reactor designed with lower Ls/H values and higher h1/H,Ds/D values would have smaller power number(Np)values and smaller flow field average velocity.In addition,this study also fitted the correlation equation of Np concerning Reynolds number and h1/H,Ds/D,and Ls/H,and the conclusions of the study can be used as a reference for the design of industrial equipment.
基金This work was supported by the Youth Project of Hunan Provincial Department of Education(Grant No.22B0334)the Bridge and Tunnel Engineering Innovation Project of Changsha University of Science&Technology(Grant No.11ZDXK11)and the Practical Innovation and Entrepreneurship Capacity Improvement Plan of Changsha University of Science and Technology(Grant No.CLSJCX23029).
文摘Organisms have evolved a strain limiting mechanism,reflected as a non-linear elastic constitutive,to prevent large deformations from threatening soft tissue integrity.Compared with linear elastic substrates,the wrinkle of films on non-linear elastic substrates has received less attention.In this article,a unique wrinkle evolution of the film-substrate system with a J-shaped non-linear stress-strain relation is reported.The result shows that a concave hexagonal array pattern is formed with the shrinkage strain of the film-substrate systems developing.As the interconnection of hexagonal arrays,a unit cell ridge network appears with properties such as chirality and helix.The subparagraph maze pattern formed with high compression is mainly composed of special single-cell ridge networks such as spiral single cores,chiral double cores,and combined multi-cores.This evolutionary model is highly consistent with the results of experiments,and it also predicts wrinkle morphology that has not yet been reported.These findings can serve as a novel explanation for the surface wrinkle of biological soft tissue,as well as provide references for the preparation of artificial biomaterials and programmable soft matter.
基金supported by the National Natural Science Foun-dation of China(Grant Nos.12475032 and 12005062)the Supercomputing Center of the Chinese Academy of Sciences,Shanghai Snowlake Technology Co.,Ltd.,and the Shanghai Super-Computer Center of China。
文摘Spiral patterns widely exist in both macroscopic and microscopic systems such as hearts,bacteria,and active matters but have never been reported at molecular length scale.The emergence of spiral patterns has considerable impacts on the trajectories of the objects and thus usually relates to various physical,chemical,biological and physiological processes.In this paper,we show that,down to the length scale of only several Angstroms,asymmetric molecules exhibit spiral patterns in their trajectories within finite time based on the under-damped Langevin equation and demonstrated by molecular dynamics simulation.The key to this observation lies in the asymmetric molecular architecture that leads to a translation-rotation coupling.This finding enriches the knowledge of spiral patterns to the molecular length scale,provides a new insight into the understanding of various processes at the molecular level,and may evoke new ideas on the understanding of the vortices in turbulence.
基金supported by the First Affiliated Hospital of Xi’an Jiaotong University Teaching Reform Project(Grant No.JG2023-0206 and JG2022-0324).
文摘Objective:In the Radiology Department of Mzuzu Central Hospital(MCH),daily training for radiographers now includes content on Computed Tomography(CT)image quality control and equipment maintenance to ensure the normal,continuous,and stable operation of the 16-slice spiral CT scanner.Methods:Through comprehensive analysis of relevant equipment,we have identified key parameters that significantly impact CT image quality.Innovative optimization strategies and solutions targeting these parameters have been developed and integrated into daily training programs.Furthermore,starting from an examination of prevalent failure modes observed in CT equipment,we delve into essential maintenance and preservation techniques that CT technologists must master to ensure optimal system performance.Results:(1)Crucial factors affecting CT image quality include artifacts,noise,partial volume effects,and surrounding gap phenomena,alongside spatial and density resolutions,CT dose,reconstruction algorithms,and human factors during the scanning process.In the daily training for radiographers,emphasis is placed on strictly implementing image quality control measures at every stage of the CT scanning process and skillfully applying advanced scanning and image processing techniques.By doing so,we can provide clinicians with accurate and reliable imaging references for diagnosis and treatment.(2)Strategies for CT equipment maintenance:①Environmental inspection of the CT room to ensure cleanliness and hygiene.②Rational and accurate operation,including calibration software proficiency.③Regular maintenance and servicing for minimizing machine downtime.④Maintenance of the CT X-ray tube.CT technicians can become proficient in equipment maintenance and upkeep techniques through training,which can significantly extend the service life of CT systems and reduce the occurrence of malfunctions.Conclusion:Through the regular implementation of rigorous CT image quality control training for radiology technicians,coupled with diligent and proactive CT equipment maintenance,we have observed profound and beneficial impacts on improving image quality.The accuracy and fidelity of radiological data ultimately leads to more accurate diagnoses and effective treatments.
基金co-supported the National Natural Science Foundation of China(No.52235010)the Heilongjiang Postdoctoral Fund(No.LBH-Z22136)the New Era Longjiang Excellent Master and Doctoral Dissertation Fund(No.LJYXL2022-057).
文摘To mill fine and well-defined micro-dimpled structures,a machining manner of spiral trajectory tool reciprocating motion,where the tool repeats the process of‘feed milling–retract–cutting feed–feed milling again’along the spiral trajectory,was proposed.From the kinematics analysis,it is found that the machining quality of micro-dimpled structures is highly dependent on the machining trajectory using spiral trajectory tool reciprocating motion.To reveal this causation,simulation modelling and experimental studies were carried out.A simulation model was developed to quantitatively and qualitatively investigate the influence of the trajectory discretization strategies(constant-angle and constant-arc length)and parameters(discrete angle,discrete arc length,and pitch)on surface texture and residual height of micro-dimpled structures.Subsequently,micro-dimpled structures were milled under different trajectory discretization strategies and parameters with spiral trajectory tool reciprocating motion.A comprehensive comparison between the milled results and simulation analysis was made based on geometry accuracy,surface morphology and surface roughness of milled dimples.Meanwhile,the errors and factors affecting the above three aspects were analyzed.The results demonstrate both the feasibility of the established simulation model and the machining capability of this machining way in milling high-quality micro-dimpled structures.Spiral trajectory tool reciprocating motion provides a new machining way for milling micro-dimpled structures and micro-dimpled functional surfaces.And an appropriate machining trajectory can be generated based on the optimized trajectory parameters,thus contributing to the improvement of machining quality and efficiency.
文摘Objective:To investigate the diagnostic value of multi-slice spiral CT(MSCT)for patients with acute appendicitis(AA).Methods:Fifty patients with suspected AA who visited the hospital from January 2023 to January 2025 were selected as samples.All patients underwent MSCT and ultrasound diagnosis,and the diagnostic efficacy of MSCT was analyzed in comparison with pathology.Results:Pathology indicated 40 positive and 10 negative cases,ultrasound indicated 30 positive and 20 negative cases,and MSCT indicated 39 positive and 11 negative cases.The diagnostic efficacy of MSCT was higher than that of ultrasound(P<0.05).The accuracy of pathological classification of MSCT was higher than that of ultrasound(P<0.05).The detection rate of MSCT imaging indicators in AA patients was higher than that in non-AA patients(P<0.05).Conclusion:MSCT has high diagnostic efficacy in AA patients and can assist physicians in determining pathological classification.
基金supported by the Startup Foundation of Shenyang Agriculture University(No.X2023050)the Fundamental Research Funds for the Central Universities(No.N2209006)the National Natural Science Foundation of China(No.U22A20173).
文摘To address the current issues with the conventional slide gate system utilized in the steel teeming process,a unique electromagnetic induction controlled automated steel teeming(EICAST)technology has been developed.Cooling means of spiral coil in this technology is directly related to its service life.Firstly,heat transfer processes of air cooling and spray cooling were compared and analyzed.Secondly,the impacts of water temperature,water flow rate and air flow rate were examined in order to maximize the spray cooling effect.To maintain coil temperature at a low value consistently throughout the entire thermal cycle process of the ladle,a combined cooling mode was finally employed.Numerical simulation was applied to examine the coil temperature variation with different cooling systems and characteristics.Before coil operation,spray cooling is said to be more effective.By controlling the water flow rate and air flow rate,the spray cooling effect is enhanced.However,water temperature has little or no impact when using spray cooling.Air cooling during the secondary refining process and spray cooling prior to coil operation are combined to further lower coil temperature.When the direction of the spray cooling is from bottom to top,the coil temperature is lowered below 165℃.A practical induction coil cooling plan was provided for the EICAST technology’s production process.
基金support from the Natural Science Foundation of Jiangsu Province(No.BK20210124)the National Natural Science Foun-dation of China(No.12204512,No.22172152,No.21872130,No.22372193)+3 种基金the National Key Re-search and Development Program of China(No.2021YFA1502801)the joint funds from the Hefei National Synchrotron Radiation Laboratory(No.KY2060000202)We also acknowledge financial support from the CAS Project for Young Scientists in Basic Research(No.YSBR-049)the Fundamental Re-search Funds for the Central Universities(No.WK3510000013,WK2060000066).
文摘Two-dimensional(2D)heterostructures compris-ing of differently stacking atomic layers are attrac-tive owing to its flexible composition as well as the emerging new physicochemical properties.Howev-er,so far many 2D vertical heterojunctions are constructed through transfer methods,inevitably introducing interfacial impurities and thus hindering detailed atomic-level studies.In this work,we have developed a clean two-step fabrication strat-egy by combining ultrahigh vacuum(UHV)molecular beam epitaxy(MBE)growth with am-bient chemical vapor deposition(CVD).We first-ly grew single crystalline graphene film on a SiC substrate under UHV condition,and then synthesized MoS_(2)films on the graphene-SiC sur-face through CVD under inert atmosphere,thus successfully realized the construction of a well-defined MoS_(2)-graphene/SiC heterojunction with clean surface.Particularly,we observed the MoS_(2)can not only grow into monolayer flakes but also form spiral structures,the latter showing layer-by-layer stacks with reduced bandgap down to~1.0 eV.
文摘Congenital aorta-right atrial tunnel(ARAT)is a rare congenital cardiovascular malformation characterized by an abnormal tunnel-like connection between the aorta and the right atrium.Patients with ARAT frequently have other congenital heart malformations and require diagnosis through a variety of imaging examinations.We report a 1-month-old female infant with multiple congenital cardiac malformations who was diagnosed with ARAT using low-dose multislice spiral computed to-mography because echocardiography was unclear.
