This article outlines the technical specifications of super minimally invasive stepwise full-thickness resection surgery for colorectal cancer(sft-SMIR).sft-SMIR is a super minimally invasive surgery performed through...This article outlines the technical specifications of super minimally invasive stepwise full-thickness resection surgery for colorectal cancer(sft-SMIR).sft-SMIR is a super minimally invasive surgery performed through natural orifices,combining endoscopic submucosal dissection(ESD)and full-thickness resection(EFTR)techniques,aimed at curing the disease while maximizing the preservation of the structure and function of the colorectal organs.The article specifies that this technique is suitable for early colon cancer,early rectal cancer,and locally advanced low rectal cancer after neoadjuvant therapy,detailing its indications and contraindications.It emphasizes the importance of multidisciplinary team(MDT)assessment,meticulous preoperative imaging and endoscopic evaluation,standardized intraoperative procedures(including marking,dissection,traction,full-thickness resection,and wound closure),as well as rigorous postoperative management and follow-up processes.Additionally,the expert consensus highlights the need for a strong focus on infection prevention and the establishment of standardized training and quality control systems to promote the safe and standardized application of this difficult endoscopic technique.展开更多
Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,...Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,a new-type distribution network digital twin topology modeling method based on Common Information Model(CIM)specifications and spectral clustering is proposed.Firstly,according to the specifications of the CIM standard,the digital twin topology models of distributed resources are extended and established.Secondly,based on the digital twin topology models of distributed resources,a digital twin aggregation modelling method for new-type distribution network is proposed based on spectral clustering.Furthermore,an online linked update strategy for the digital twin model of new-type distribution network that integrates real-time topology states is proposed.Finally,a case study is conducted on a distribution network in a certain demonstration area in China,and the results verify the practicability and effectiveness of the method proposed in this paper.This lays the foundation for the application of electrical network twin analysis,such as power flow calculation,optimal power flow,economic dispatch,and safety check,in a new-type distribution network that includes diversified distributed resources.展开更多
Coherence analysis is a powerful tool in seismic interpretation for imaging geological discontinuities such as faults and fractures. However, subtle faults or fractures of one stratum are difficult to be distinguished...Coherence analysis is a powerful tool in seismic interpretation for imaging geological discontinuities such as faults and fractures. However, subtle faults or fractures of one stratum are difficult to be distinguished on coherence sections （time slices or profiles） due to interferences from adjacent strata, especially these with strong reflectivity. In this paper, we propose a coherence enhancement method which applies local histogram specification （LHS） techniques to enhance subtle faults or fractures in the coherence cubes. Unlike the traditional histogram specification （HS） algorithm, our method processes 3D coherence data without discretization. This method partitions a coherence cube into many sub-blocks and self-adaptively specifies the target distribution in each block based on the whole distribution of the coherence cube. Furthermore, the neighboring blocks are partially overlapped to reduce the edge effect. Applications to real datasets show that the new method enhances the details of subtle faults and fractures noticeably.展开更多
s: The farmland shelterbelts in Northeastern Plain of China have formed relatively complete net system. The func-tions of shelterbelt net in omnibearing wind check and prevention of frostbite as well as the field of ...s: The farmland shelterbelts in Northeastern Plain of China have formed relatively complete net system. The func-tions of shelterbelt net in omnibearing wind check and prevention of frostbite as well as the field of integrated climate effect within shelterbelt net were analyzed, through located observation of meteorological factors. Within the shelterbelt net, the area with more than 10% efficiency of omnibearing wind check was determined as benefited area. The analysis of yield and quality of crops indicated that the sheltering range of shelterbelt net was 25 times tree height. The mature heights of the various varieties of poplar composed the shelterbelts were determined according to their height growth. Based on the comprehensive analysis above, the suitable size of farmland shelterbelt net in Northeastern Plain of China was decided to be 400 m×400 m.展开更多
Traditional air conditioner used to be in local control mode. However, with the development of modern information technology, the control of air conditioner will have to support many more functions. As a first step ...Traditional air conditioner used to be in local control mode. However, with the development of modern information technology, the control of air conditioner will have to support many more functions. As a first step in such a development, we have implemented a remote monitoring system of unitary air conditioners, using the manufacturing message specification (MMS). MMS is an OSI application protocol designed for the remote control and monitoring of real devices. The functions supported are those that an operator would do normally at the console of the unitary air conditioner. Due to the accomplishment of UMCS (Unitary air conditioner MMS Control System), there will be a leap of the application of MMS and the control technology of unitary air conditioner.展开更多
On the software module, this paper proposes a visual specification language(VSL). Based on decomposition, the language imitates men's thinking procedure that decomposes aproblem into smaller ones, then independent...On the software module, this paper proposes a visual specification language(VSL). Based on decomposition, the language imitates men's thinking procedure that decomposes aproblem into smaller ones, then independently solves the results of every small problem to get theresult of original problem (decomposition and synthesis). Besides, the language mixes visual withspecification. With computer supporting, we can implement the software module automatically. It willgreatly improve the quality of software and raise the efficiency of software development. Thesimple definition of VSL, the principle of auto-generation, an example and the future research areintroduced.展开更多
This paper analyzes the applications of four air terminal device（ATD）models（i.e.,the basic model,the box model,the N-point momentum model,the jet main region specification model）in computational fluid dynamics（CF...This paper analyzes the applications of four air terminal device（ATD）models（i.e.,the basic model,the box model,the N-point momentum model,the jet main region specification model）in computational fluid dynamics（CFD）simulation and their performance in case study.A full-scale experiment is performed in an environment chamber,and the measured air velocity and temperature fields are compared with the simulation results by using four ATD models.The velocity and temperature fields are measured by an omni-directional thermo-anemometer system.It demonstrates that the basic model and the box model are not applicable to complicated air terminal devices.At the occupant area,the relative errors between simulated and measured air velocities are less than 20% based on the N-point momentum model and the jet main region specification model.Around the ATD zone,the relative error between the numerical and measured air velocity based on the jet main region specification model is less than 15%.The jet main region specification model is proved to be an applicable approach and a more accurate way to study the airflow pattern around the ATD with complicated geometry.展开更多
Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrins...Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrinsic mechanisms underlying the decision of a stem cell to proliferate,enter a dormant quiescent state or differentiate into a specific cell type remains incompletely understood.展开更多
Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.展开更多
基金National Key Research and Development Program of China(Project No.:2022YFC2503600)。
文摘This article outlines the technical specifications of super minimally invasive stepwise full-thickness resection surgery for colorectal cancer(sft-SMIR).sft-SMIR is a super minimally invasive surgery performed through natural orifices,combining endoscopic submucosal dissection(ESD)and full-thickness resection(EFTR)techniques,aimed at curing the disease while maximizing the preservation of the structure and function of the colorectal organs.The article specifies that this technique is suitable for early colon cancer,early rectal cancer,and locally advanced low rectal cancer after neoadjuvant therapy,detailing its indications and contraindications.It emphasizes the importance of multidisciplinary team(MDT)assessment,meticulous preoperative imaging and endoscopic evaluation,standardized intraoperative procedures(including marking,dissection,traction,full-thickness resection,and wound closure),as well as rigorous postoperative management and follow-up processes.Additionally,the expert consensus highlights the need for a strong focus on infection prevention and the establishment of standardized training and quality control systems to promote the safe and standardized application of this difficult endoscopic technique.
基金Supported by Science and Technology Project of State Grid Corporation of China(5108-202218280A-2-396-XG).
文摘Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,a new-type distribution network digital twin topology modeling method based on Common Information Model(CIM)specifications and spectral clustering is proposed.Firstly,according to the specifications of the CIM standard,the digital twin topology models of distributed resources are extended and established.Secondly,based on the digital twin topology models of distributed resources,a digital twin aggregation modelling method for new-type distribution network is proposed based on spectral clustering.Furthermore,an online linked update strategy for the digital twin model of new-type distribution network that integrates real-time topology states is proposed.Finally,a case study is conducted on a distribution network in a certain demonstration area in China,and the results verify the practicability and effectiveness of the method proposed in this paper.This lays the foundation for the application of electrical network twin analysis,such as power flow calculation,optimal power flow,economic dispatch,and safety check,in a new-type distribution network that includes diversified distributed resources.
基金sponsored by Important National Science and Technology Specific Projects of China (Grant No.2008ZX05023-005-011 and No. 2008ZX05040-003)the National 973 Program of China (Grant No. 2006CB202208)
文摘Coherence analysis is a powerful tool in seismic interpretation for imaging geological discontinuities such as faults and fractures. However, subtle faults or fractures of one stratum are difficult to be distinguished on coherence sections （time slices or profiles） due to interferences from adjacent strata, especially these with strong reflectivity. In this paper, we propose a coherence enhancement method which applies local histogram specification （LHS） techniques to enhance subtle faults or fractures in the coherence cubes. Unlike the traditional histogram specification （HS） algorithm, our method processes 3D coherence data without discretization. This method partitions a coherence cube into many sub-blocks and self-adaptively specifies the target distribution in each block based on the whole distribution of the coherence cube. Furthermore, the neighboring blocks are partially overlapped to reduce the edge effect. Applications to real datasets show that the new method enhances the details of subtle faults and fractures noticeably.
文摘s: The farmland shelterbelts in Northeastern Plain of China have formed relatively complete net system. The func-tions of shelterbelt net in omnibearing wind check and prevention of frostbite as well as the field of integrated climate effect within shelterbelt net were analyzed, through located observation of meteorological factors. Within the shelterbelt net, the area with more than 10% efficiency of omnibearing wind check was determined as benefited area. The analysis of yield and quality of crops indicated that the sheltering range of shelterbelt net was 25 times tree height. The mature heights of the various varieties of poplar composed the shelterbelts were determined according to their height growth. Based on the comprehensive analysis above, the suitable size of farmland shelterbelt net in Northeastern Plain of China was decided to be 400 m×400 m.
文摘Traditional air conditioner used to be in local control mode. However, with the development of modern information technology, the control of air conditioner will have to support many more functions. As a first step in such a development, we have implemented a remote monitoring system of unitary air conditioners, using the manufacturing message specification (MMS). MMS is an OSI application protocol designed for the remote control and monitoring of real devices. The functions supported are those that an operator would do normally at the console of the unitary air conditioner. Due to the accomplishment of UMCS (Unitary air conditioner MMS Control System), there will be a leap of the application of MMS and the control technology of unitary air conditioner.
文摘On the software module, this paper proposes a visual specification language(VSL). Based on decomposition, the language imitates men's thinking procedure that decomposes aproblem into smaller ones, then independently solves the results of every small problem to get theresult of original problem (decomposition and synthesis). Besides, the language mixes visual withspecification. With computer supporting, we can implement the software module automatically. It willgreatly improve the quality of software and raise the efficiency of software development. Thesimple definition of VSL, the principle of auto-generation, an example and the future research areintroduced.
文摘This paper analyzes the applications of four air terminal device（ATD）models（i.e.,the basic model,the box model,the N-point momentum model,the jet main region specification model）in computational fluid dynamics（CFD）simulation and their performance in case study.A full-scale experiment is performed in an environment chamber,and the measured air velocity and temperature fields are compared with the simulation results by using four ATD models.The velocity and temperature fields are measured by an omni-directional thermo-anemometer system.It demonstrates that the basic model and the box model are not applicable to complicated air terminal devices.At the occupant area,the relative errors between simulated and measured air velocities are less than 20% based on the N-point momentum model and the jet main region specification model.Around the ATD zone,the relative error between the numerical and measured air velocity based on the jet main region specification model is less than 15%.The jet main region specification model is proved to be an applicable approach and a more accurate way to study the airflow pattern around the ATD with complicated geometry.
基金supported by the Argentine Agency for the Promotion of Science and Technology ANPCyT(PICT2019-1472 to GP,PICT2019-4597 to FL,PICT2020-1524 to GP,and PICT2021-00627 to FL)supported by an Independent Career Position from CONICETsupported by a postdoctoral fellowship from ANPCyT。
文摘Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrinsic mechanisms underlying the decision of a stem cell to proliferate,enter a dormant quiescent state or differentiate into a specific cell type remains incompletely understood.
文摘Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.
