Fruit lignification is of significant economic importance because it affects the quality of fruit and the production of seed oil.The specified lignification pattern in Camellia chekiangoleosa fruits plays critical rol...Fruit lignification is of significant economic importance because it affects the quality of fruit and the production of seed oil.The specified lignification pattern in Camellia chekiangoleosa fruits plays critical roles in its seed oil yield,but little is known about how this lignification process is regulated.Here,we report on a comprehensive tissue-specific transcriptomics analysis conducted for C.chekiangoleosa fruit.By mining the differentially expressed genes,we found that lignin biosynthesis and transcriptional regulation pathways were significantly enriched in the lignified tissues.The homolog of NST-like transcription factor,CcNST1,was highly expressed in lignified seed coat and endocarp tissues;transgenic analyses of CcNST1 in Arabidopsis and hybrid poplar revealed the enhanced lignification levels of various tissues.Gene expression analysis of the transgenic lines uncovered potential downstream genes involved in the regulation of lignin biosynthesis.This work provides a valuable gene expression resource and identified the pivotal role of CcNST1 in regulating the lignin biosynthesis underlying fruit lignification.展开更多
In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabiliti...In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabilities of simulating instability flow and lock-in phenomenon are verified on a transonic rotor and a NACA0012 airfoil by comparing with the test data,respectively.The lock-in phenomenon is first numerically confirmed that may occur to TCF instabilities when its frequency is close to the blade vibration frequency.The lock-in region becomes wider with the vibration amplitude increasing,and it is also affected by modal shapes.For the rotor at the simulation conditions in this study,the bending mode results in a wider lock-in region than the torsional mode.In the lock-in region,the phase difference between the Tip Clearance Vortex(TCV)and the blade vibration changes with the flow condition and the frequency ratio of the blade vibration and the TCV instabilities.The frequency of the TCV instabilities reduces with the mass flow decreasing.Therefore,reducing mass flow and increasing frequency ratio have similar effects on the TCV phase,which causes a significant variation on the unsteady pressure amplitude in the blade tip area.Thus,the aerodynamic damping changes significantly with the TCV phase.The aerodynamic damping displays a nonlinear relationship with the vibration amplitude,and it changes from negative to positive with the vibration amplitude increasing at the same frequency ratio.The negative damping is mainly provided by the tip area of the blade.For unlocked conditions,the period of the TCF instabilities fluctuates over time,and it cannot be directly separated by their frequency features.Inter Blade Phase Angle(IBPA)also has an important influence on the feature of the TCV instabilities.The occurrence of frequency lock-in also requires“appropriate”IBPA.For the examined working conditions,the frequency lock-in occurs under 0 ND(Nodal Diameter),but not under 8 ND.However,no matter 0 ND or 8 ND,the phase of TCV always locks onto the IBPA at the examined conditions.展开更多
Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the pancreas.Despite the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type no...Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the pancreas.Despite the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type not otherwise specified(NOS)and therefore very little is known about clinical features and long-term outcomes of these patients.The aim of this study was to investigate clinical and radiological features of AIP type NOS-patients.Methods:Patients classified as AIP type NOS at clinical onset included in our database prospectively maintained since 1995 were evaluated.Epidemiological,clinical data were collected and analyzed.Results:Forty-six patients were included in the study.The clinical onset was mainly characterized by weight loss,jaundice and acute pancreatitis.Eight patients(17.4%)were reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.Seven patients(15.2%)experienced relapse after steroid treatment but only one(2.2%)needed immunosuppressive drugs because of recurrent relapses.Conclusions:AIP type NOS shares clinical features similar to AIP type 2 and a relevant proportion of patients was reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.The risk of relapse is low but not irrelevant.展开更多
Aims In the HORIZONS trial, in-hospital treatment with bivalirudin reduced bleeding and mortality in primary percutaneous coronary intervention（PCI） compared with heparin and routine glycoprotein Ⅱb / Ⅲa inhibitor...Aims In the HORIZONS trial, in-hospital treatment with bivalirudin reduced bleeding and mortality in primary percutaneous coronary intervention（PCI） compared with heparin and routine glycoprotein Ⅱb / Ⅲa inhibitors（GPI）. It is unknown whether this advantage of bivalirudin is observed in comparison with heparins only with GPI used as bailout. Methods and results In the EUROMAX study, 2198 patients with ST-segment elevation myocardial infarction（STEMI） were randomized during transport for primary PCI to bivalirudin or to heparins with optional GPI. Primary and principal outcome was the composites of death or nonCABG-related major bleeding at 30 days. This pre-specified analysis compared patients receiving bivalirudin（n = 1089） with those receiving heparins with routine upstream GPI（n = 649） and those receiving heparins only with GPI use restricted to bailout（n = 460）. The primary outcome death and major bleeding occurred in5.1% with bivalirudin, 7.6% with heparin plus routine GPI（HR 0.67 and 95% CI 0.46-0.97, P = 0.034）,and 9.8% with heparins plus bailout GPI（HR 0.52 and 95% CI 0.35-0.75, P = 0.006）. Following adjustment by logistic regression, bivalirudin was still associated with significantly lower rates of the primary outcome（odds ratio 0.53, 95% CI 0.33-0.87） and major bleeding（odds ratio 0.44, 95% CI 0.24 – 0.82） compared with heparins alone with bailout GPI. Rates of stent thrombosis were higher with bivalirudin（1.6 vs. 0.6 vs.0.4%, P = 0.09 and 0.09）. Conclusion Bivalirudin, started during transport for primary PCI, reduces major bleeding compared with both patients treated with heparin only plus bailout GPI and patients treated with heparin and routine GPI, but increased stent thrombosis.展开更多
Theoretical argumentation for so-called suitable spatial condition is conducted by the aid of homotopy framework to demonstrate that the proposed boundary condition does guarantee that the over-specification boundary ...Theoretical argumentation for so-called suitable spatial condition is conducted by the aid of homotopy framework to demonstrate that the proposed boundary condition does guarantee that the over-specification boundary condition resulting from an adjoint model on a limited-area is no longer an issue, and yet preserve its well-poseness and optimal character in the boundary setting. The ill-poseness of over-specified spatial boundary condition is in a sense, inevitable from an adjoint model since data assimilation processes have to adapt prescribed observations that used to be over-specified at the spatial boundaries of the modeling domain. In the view of pragmatic implement, the theoretical framework of our proposed condition for spatial boundaries indeed can be reduced to the hybrid formulation of nudging filter, radiation condition taking account of ambient forcing, together with Dirichlet kind of compatible boundary condition to the observations prescribed in data assimilation procedure. All of these treatments, no doubt, are very familiar to mesoscale modelers. Key words Variational data assimilation - Adjoint model - Over-specified partial boundary condition This research work is sponsored by the National Key Programme for Developing Basic Sciences (G1998040907), the Project of Natural Science Foundation of Jiangsu Province (BK99020), the President Foundation of Nanjing University (985) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.展开更多
BACKGROUND Gastrointestinal lymphoma typically arises in the stomach,small bowel,or colorectum and is usually a B-cell lymphoma.However,primary T-cell lymp-homas originating in the stomach are particularly rare.Gastri...BACKGROUND Gastrointestinal lymphoma typically arises in the stomach,small bowel,or colorectum and is usually a B-cell lymphoma.However,primary T-cell lymp-homas originating in the stomach are particularly rare.Gastric peripheral T-cell lymphoma-not otherwise specified(PTCL-NOS)is an extremely rare subtype.CASE SUMMARY We report a 63-year-old male presenting with epigastric pain.Esophagogastro-duodenoscopy revealed a large ulcerative lesion in the gastric cardia.Biopsy and immunohistochemical profiling confirmed PTCL-NOS.Imaging indicated stage II disease involving the stomach and intra-abdominal lymph nodes.The patient is planned to undergo cyclophosphamide,doxorubicin,vincristine,and prednisone or cyclophosphamide,doxorubicin,vincristine,prednisone,and etoposide chemo-therapy.CONCLUSION This case highlights the necessity of considering PTCL-NOS in differential diag-noses of gastric lesions.Comprehensive histopathological and immunohistoche-mical analysis is crucial for accurate diagnosis and guiding treatment.展开更多
Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the fo...Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.展开更多
In multisignature schemes signers can sign either in a linear order or not in any specified order, but neither of them is adequate in some scenarios where require mixture using of orderless and ordered multisignature....In multisignature schemes signers can sign either in a linear order or not in any specified order, but neither of them is adequate in some scenarios where require mixture using of orderless and ordered multisignature. Most order-specified multisignatures specified the orders as linear ones. In this paper, we proposed an order-specified multisignature scheme based on DSA secure against active insider attack. To our knowledge, it is the first order-specified multisignature scheme based on DSA signature scheme, in which signers can sign in flexible order represented by series-parallel graphs. In the multisignature scheme verification to both signers and signing order are available. The security of the scheme is proved by reduce to an identification scheme that is proved have some concrete security. The running time of verifying a signature is comparable to previous schemes while the running time of multisignature generation and the space needed is less than those schemes.展开更多
Comprehensive river regulation in the new era is a series of construction procedures from planning,scheme generation and engineering design to commercial pattern,construction and operation,etc.,which is a comprehensiv...Comprehensive river regulation in the new era is a series of construction procedures from planning,scheme generation and engineering design to commercial pattern,construction and operation,etc.,which is a comprehensive project coordinated and managed by multiple departments.Different industry departments measure the feasibility of scheme design according to the standards of their own departments in the examination of river regulation,but due to the lack of understanding of other industry standards,some unnecessary scheme contradictions are often caused in the cross-industry cooperation.The study integrates and sorts out specifi cations of various departments involved in river regulation,and performs analogy study of standards of various contents in multi-industry cooperation with contents of comprehensive river regulation as the scale,so as to promote cross-industry communication of comprehensive river regulation and promote construction of integrated river regulation platform.展开更多
A practical transportation problem for finding the “departure” time at “all source nodes” in order to arrive at “some destination nodes” at specified time for both FIFO (i.e., First In First Out) and Non-FIFO “...A practical transportation problem for finding the “departure” time at “all source nodes” in order to arrive at “some destination nodes” at specified time for both FIFO (i.e., First In First Out) and Non-FIFO “Dynamic ” Networks is considered in this study. Although shortest path (SP) for dynamic networks have been studied/documented by various researchers, contributions from this present work consists of a sparse matrix storage scheme for efficiently storing large scale sparse network’s connectivity, a concept of Time Delay Factor (TDF) combining with a “general piece- wise linear function” to describe the link cost as a function of time for Non-FIFO links’ costs, and Backward Dijkstra SP Algorithm with simple heuristic rules for rejecting unwanted solutions during the backward search algorithm. Both small-scale (academic) networks as well as large- scale (real-life) networks are investigated in this work to explain and validate the proposed dynamic algorithms. Numerical results obtained from this research work have indicated that the newly proposed dynamic algorithm is reliable, and efficient. Based on the numerical results, the calculated departure time at the source node(s), for a given/specified arrival time at the destination node(s), can be non-unique, for some Non-FIFO networks’ connectivity.展开更多
This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed t...This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed to find a suitable controller that minimizes the performance index of error signal subject to an unequal constraint on the norm of the closed-loop system. Although the mixed H2/H∞ for the output feedback approach control is considered as a robust and optimal control technique, the design process normally comes up with a complex and non-convex optimization problem, which is difficult to solve by the conventional optimization methods. The PSO can efficiently solve design problems of multi-input-multi-output (MIMO) optimal control systems, which is very suitable for practical engineering designs. It is used to search for parameters of a structure-specified controller, which satisfies mixed performance index. The simulation and experimental results show high feasibility, robustness and practical value compared with the conventional proportional-integral-derivative (PID) and proportional-Integral (PI) controller, and the proposed algorithm is also more efficient compared with the genetic algorithm (GA).展开更多
Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndr...Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndrome (HES) by the presence of eosinophilic clonality. Chronic eosinophilic leukemia not otherwise specified (CEL-NOS) diagnosis is made when no fusion genes are detected by most modern molecular testing, particularly the most common fusion gene FIP1L-1/PDGFRA (Factor Interacting with PAP like-1/Platelet-Derived Growth Factor Receptor Alpha). This disease is very rare, and its description in the literature is not well characterized. We report a fetal case of severe CEL-NOS in a 19-year-old male who presented with a plethora of clinical features consists of constitutional symptoms, pancytopenia, intravascular thrombosis, acute stroke and endomyocardial infiltrates. The course of his disease was aggressive and resistant to conventional treatment. After a short period of improvement, an acute transformation into blast crisis (BC) had occurred. The diagnosis was confirmed by morphology and immunophenotyping of bone marrow biopsy. The patient eventually died of heart failure and sepsis. To our knowledge this is the first case report of fatal CEL-NOS transforming into severe blast crisis.展开更多
The problem of guidance law is investigated for multiple interceptors to attack a target cooperatively.A leader-following cooperative guidance strategy is presented to render the leader and the followers reach the tar...The problem of guidance law is investigated for multiple interceptors to attack a target cooperatively.A leader-following cooperative guidance strategy is presented to render the leader and the followers reach the target at specified impact time.The guidance law of leader is given to meet the demand of specified impact time.The arrival time is synchronized by enforcing the ranges-to-go of followers keep consensus with that of leader.The convergence time bound is estimated without dependence on the initial states,since the proposed leader-following cooperative guidance law is fixed-time convergent.The simulation is developed to validate the availability of proposed cooperative guidance law.展开更多
As huge volumes of data are organized or exported in tree-structured form, it is quite necessary to extract useful information from these data collections using effective and efficient query processing methods. A natu...As huge volumes of data are organized or exported in tree-structured form, it is quite necessary to extract useful information from these data collections using effective and efficient query processing methods. A natural way of retrieving desired information from XML documents is using twig pattern （TP）, which is, actually, the core component of existing XML query languages. Twig pattern possesses the inherent feature that query nodes on the same path have concrete precedence relationships. It is this feature that makes it infeasible in many actual scenarios. This has driven the requirement of relaxing the complete specification of a twig pattern to express more flexible semantic constraints in a single query expression. In this paper, we focus on query evaluation of partially specified twig pattern （PSTP） queries, through which we can reap the most flexibility of specifying partial semantic constraints in a query expression. We propose an extension to XPath through introducing two Samepath axes to support partial semantic constraints in a concise but effective way. Then we propose a stack based algorithm, pTwigStack, to process a PSTP holistically without deriving the concrete twig patterns and then processing them one by one. Further, we propose two DTD schema based optimization methods to improve the performance of pTwigStack algorithm. Our experimental results on various datasets indicate that our method performs significantly better than existing ones when processing PSTPs.展开更多
Soft errors have become a critical challenge as a result of technology scaling. Existing circuit-hardening techniques are commonly associated with prohibitive overhead of performance, area, and power. However,evaluati...Soft errors have become a critical challenge as a result of technology scaling. Existing circuit-hardening techniques are commonly associated with prohibitive overhead of performance, area, and power. However,evaluating the influence of soft errors in Flip-Flops(FFs) on the failure of circuit is a difficult verification problem.Here, we proposed a novel flip-flop soft-error failure rate analysis methodology using a formal method with respect to application behaviors. Approach and optimization techniques to implement the proposed methodology based on the given formula using Sequential Equivalence Checking(SEC) are introduced. The proposed method combines the advantage of formal technique-based approaches in completeness and the advantage of application behaviors in accuracy to differentiate vulnerability of components. As a result, the FFs in a circuit are sorted by their failure rates, and designers can use this information to perform optimal hardening of selected sequential components against soft errors. Experimental results of an implementation of a SpaceWire end node and the largest ISCAS’89 benchmark sequential circuits indicate the feasibility and potential scalability of our approach. A case study on an instruction decoder of a practical 32-bit microprocessor demonstrates the applicability of our method.展开更多
A k-tree is a tree with maximum degree at most k. In this paper, we give a sharp degree sum condition for a graph to have a spanning k-tree in which specified vertices have degree less than t, where 1≤t≤k.We denote ...A k-tree is a tree with maximum degree at most k. In this paper, we give a sharp degree sum condition for a graph to have a spanning k-tree in which specified vertices have degree less than t, where 1≤t≤k.We denote by σ_k(G) the minimum value of the degree sum of k independent vertices in a graph G. Let k≥2,s≥0 and 1≤t≤k be integers, and suppose G is an(s + 1)-connected graph with σ_k(G)≥|G|+(k-t)s-1.Then for any s specified vertices, G contains a spanning k-tree in which every specified vertex has degree at most t. This improves a result obtained by Matsuda and Matsumura.展开更多
This specification is mainly drafted by Beijing Sport University(BSU),Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine in accordance with the drafting procedure specified in The General Rules ...This specification is mainly drafted by Beijing Sport University(BSU),Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine in accordance with the drafting procedure specified in The General Rules for the Compilation of International Traditional Chinese Medicine(TCM)Technical Specifications and The Common Standards for the Compilation of International Standards for TCM Technology.展开更多
This paper presents a method for state simplification in incompletely specified sequential machines. The new method adopts Inclusive-OR operation of column vectors for multi-level output matrix E_k! Compared with othe...This paper presents a method for state simplification in incompletely specified sequential machines. The new method adopts Inclusive-OR operation of column vectors for multi-level output matrix E_k! Compared with other algorithms in use, this method is theoretically more strict, while its structure is simple and the results obtained are accurate.展开更多
基金supported by Nonprofit Research Projects(CAFYBB2021QD001)of Chinese Academy of ForestryNational Key R&D Program of China(2019YFD1001602)。
文摘Fruit lignification is of significant economic importance because it affects the quality of fruit and the production of seed oil.The specified lignification pattern in Camellia chekiangoleosa fruits plays critical roles in its seed oil yield,but little is known about how this lignification process is regulated.Here,we report on a comprehensive tissue-specific transcriptomics analysis conducted for C.chekiangoleosa fruit.By mining the differentially expressed genes,we found that lignin biosynthesis and transcriptional regulation pathways were significantly enriched in the lignified tissues.The homolog of NST-like transcription factor,CcNST1,was highly expressed in lignified seed coat and endocarp tissues;transgenic analyses of CcNST1 in Arabidopsis and hybrid poplar revealed the enhanced lignification levels of various tissues.Gene expression analysis of the transgenic lines uncovered potential downstream genes involved in the regulation of lignin biosynthesis.This work provides a valuable gene expression resource and identified the pivotal role of CcNST1 in regulating the lignin biosynthesis underlying fruit lignification.
基金supported by the National Natural Science Foundation of China(No.51475022)。
文摘In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabilities of simulating instability flow and lock-in phenomenon are verified on a transonic rotor and a NACA0012 airfoil by comparing with the test data,respectively.The lock-in phenomenon is first numerically confirmed that may occur to TCF instabilities when its frequency is close to the blade vibration frequency.The lock-in region becomes wider with the vibration amplitude increasing,and it is also affected by modal shapes.For the rotor at the simulation conditions in this study,the bending mode results in a wider lock-in region than the torsional mode.In the lock-in region,the phase difference between the Tip Clearance Vortex(TCV)and the blade vibration changes with the flow condition and the frequency ratio of the blade vibration and the TCV instabilities.The frequency of the TCV instabilities reduces with the mass flow decreasing.Therefore,reducing mass flow and increasing frequency ratio have similar effects on the TCV phase,which causes a significant variation on the unsteady pressure amplitude in the blade tip area.Thus,the aerodynamic damping changes significantly with the TCV phase.The aerodynamic damping displays a nonlinear relationship with the vibration amplitude,and it changes from negative to positive with the vibration amplitude increasing at the same frequency ratio.The negative damping is mainly provided by the tip area of the blade.For unlocked conditions,the period of the TCF instabilities fluctuates over time,and it cannot be directly separated by their frequency features.Inter Blade Phase Angle(IBPA)also has an important influence on the feature of the TCV instabilities.The occurrence of frequency lock-in also requires“appropriate”IBPA.For the examined working conditions,the frequency lock-in occurs under 0 ND(Nodal Diameter),but not under 8 ND.However,no matter 0 ND or 8 ND,the phase of TCV always locks onto the IBPA at the examined conditions.
文摘Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the pancreas.Despite the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type not otherwise specified(NOS)and therefore very little is known about clinical features and long-term outcomes of these patients.The aim of this study was to investigate clinical and radiological features of AIP type NOS-patients.Methods:Patients classified as AIP type NOS at clinical onset included in our database prospectively maintained since 1995 were evaluated.Epidemiological,clinical data were collected and analyzed.Results:Forty-six patients were included in the study.The clinical onset was mainly characterized by weight loss,jaundice and acute pancreatitis.Eight patients(17.4%)were reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.Seven patients(15.2%)experienced relapse after steroid treatment but only one(2.2%)needed immunosuppressive drugs because of recurrent relapses.Conclusions:AIP type NOS shares clinical features similar to AIP type 2 and a relevant proportion of patients was reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.The risk of relapse is low but not irrelevant.
文摘Aims In the HORIZONS trial, in-hospital treatment with bivalirudin reduced bleeding and mortality in primary percutaneous coronary intervention（PCI） compared with heparin and routine glycoprotein Ⅱb / Ⅲa inhibitors（GPI）. It is unknown whether this advantage of bivalirudin is observed in comparison with heparins only with GPI used as bailout. Methods and results In the EUROMAX study, 2198 patients with ST-segment elevation myocardial infarction（STEMI） were randomized during transport for primary PCI to bivalirudin or to heparins with optional GPI. Primary and principal outcome was the composites of death or nonCABG-related major bleeding at 30 days. This pre-specified analysis compared patients receiving bivalirudin（n = 1089） with those receiving heparins with routine upstream GPI（n = 649） and those receiving heparins only with GPI use restricted to bailout（n = 460）. The primary outcome death and major bleeding occurred in5.1% with bivalirudin, 7.6% with heparin plus routine GPI（HR 0.67 and 95% CI 0.46-0.97, P = 0.034）,and 9.8% with heparins plus bailout GPI（HR 0.52 and 95% CI 0.35-0.75, P = 0.006）. Following adjustment by logistic regression, bivalirudin was still associated with significantly lower rates of the primary outcome（odds ratio 0.53, 95% CI 0.33-0.87） and major bleeding（odds ratio 0.44, 95% CI 0.24 – 0.82） compared with heparins alone with bailout GPI. Rates of stent thrombosis were higher with bivalirudin（1.6 vs. 0.6 vs.0.4%, P = 0.09 and 0.09）. Conclusion Bivalirudin, started during transport for primary PCI, reduces major bleeding compared with both patients treated with heparin only plus bailout GPI and patients treated with heparin and routine GPI, but increased stent thrombosis.
基金the National Key Programme for Developing Basic Sciences(G1998040907)the Project of Natural Science Foundation of Jiangsu Pr
文摘Theoretical argumentation for so-called suitable spatial condition is conducted by the aid of homotopy framework to demonstrate that the proposed boundary condition does guarantee that the over-specification boundary condition resulting from an adjoint model on a limited-area is no longer an issue, and yet preserve its well-poseness and optimal character in the boundary setting. The ill-poseness of over-specified spatial boundary condition is in a sense, inevitable from an adjoint model since data assimilation processes have to adapt prescribed observations that used to be over-specified at the spatial boundaries of the modeling domain. In the view of pragmatic implement, the theoretical framework of our proposed condition for spatial boundaries indeed can be reduced to the hybrid formulation of nudging filter, radiation condition taking account of ambient forcing, together with Dirichlet kind of compatible boundary condition to the observations prescribed in data assimilation procedure. All of these treatments, no doubt, are very familiar to mesoscale modelers. Key words Variational data assimilation - Adjoint model - Over-specified partial boundary condition This research work is sponsored by the National Key Programme for Developing Basic Sciences (G1998040907), the Project of Natural Science Foundation of Jiangsu Province (BK99020), the President Foundation of Nanjing University (985) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.
基金Supported by 2024 Kangwon National University Hospital Grant,No.KNUH_2024_02_06.
文摘BACKGROUND Gastrointestinal lymphoma typically arises in the stomach,small bowel,or colorectum and is usually a B-cell lymphoma.However,primary T-cell lymp-homas originating in the stomach are particularly rare.Gastric peripheral T-cell lymphoma-not otherwise specified(PTCL-NOS)is an extremely rare subtype.CASE SUMMARY We report a 63-year-old male presenting with epigastric pain.Esophagogastro-duodenoscopy revealed a large ulcerative lesion in the gastric cardia.Biopsy and immunohistochemical profiling confirmed PTCL-NOS.Imaging indicated stage II disease involving the stomach and intra-abdominal lymph nodes.The patient is planned to undergo cyclophosphamide,doxorubicin,vincristine,and prednisone or cyclophosphamide,doxorubicin,vincristine,prednisone,and etoposide chemo-therapy.CONCLUSION This case highlights the necessity of considering PTCL-NOS in differential diag-noses of gastric lesions.Comprehensive histopathological and immunohistoche-mical analysis is crucial for accurate diagnosis and guiding treatment.
基金supported by grants from the Ministry of Education,Culture,Sports,Science and Technology in Japan and Naito Foundation to TCthe Japan Society for the Promotion of Science to MO and TC
文摘Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.
基金Supported by the National Natural Science Foundation ofChina (60403027)
文摘In multisignature schemes signers can sign either in a linear order or not in any specified order, but neither of them is adequate in some scenarios where require mixture using of orderless and ordered multisignature. Most order-specified multisignatures specified the orders as linear ones. In this paper, we proposed an order-specified multisignature scheme based on DSA secure against active insider attack. To our knowledge, it is the first order-specified multisignature scheme based on DSA signature scheme, in which signers can sign in flexible order represented by series-parallel graphs. In the multisignature scheme verification to both signers and signing order are available. The security of the scheme is proved by reduce to an identification scheme that is proved have some concrete security. The running time of verifying a signature is comparable to previous schemes while the running time of multisignature generation and the space needed is less than those schemes.
基金Interdisciplinary Research Projects of the Fundamental Research Funds for the Central Universities(DUT19JC55)High-level Talents Innovation Support Project of Dalian City(2017RQ076).
文摘Comprehensive river regulation in the new era is a series of construction procedures from planning,scheme generation and engineering design to commercial pattern,construction and operation,etc.,which is a comprehensive project coordinated and managed by multiple departments.Different industry departments measure the feasibility of scheme design according to the standards of their own departments in the examination of river regulation,but due to the lack of understanding of other industry standards,some unnecessary scheme contradictions are often caused in the cross-industry cooperation.The study integrates and sorts out specifi cations of various departments involved in river regulation,and performs analogy study of standards of various contents in multi-industry cooperation with contents of comprehensive river regulation as the scale,so as to promote cross-industry communication of comprehensive river regulation and promote construction of integrated river regulation platform.
文摘A practical transportation problem for finding the “departure” time at “all source nodes” in order to arrive at “some destination nodes” at specified time for both FIFO (i.e., First In First Out) and Non-FIFO “Dynamic ” Networks is considered in this study. Although shortest path (SP) for dynamic networks have been studied/documented by various researchers, contributions from this present work consists of a sparse matrix storage scheme for efficiently storing large scale sparse network’s connectivity, a concept of Time Delay Factor (TDF) combining with a “general piece- wise linear function” to describe the link cost as a function of time for Non-FIFO links’ costs, and Backward Dijkstra SP Algorithm with simple heuristic rules for rejecting unwanted solutions during the backward search algorithm. Both small-scale (academic) networks as well as large- scale (real-life) networks are investigated in this work to explain and validate the proposed dynamic algorithms. Numerical results obtained from this research work have indicated that the newly proposed dynamic algorithm is reliable, and efficient. Based on the numerical results, the calculated departure time at the source node(s), for a given/specified arrival time at the destination node(s), can be non-unique, for some Non-FIFO networks’ connectivity.
文摘This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed to find a suitable controller that minimizes the performance index of error signal subject to an unequal constraint on the norm of the closed-loop system. Although the mixed H2/H∞ for the output feedback approach control is considered as a robust and optimal control technique, the design process normally comes up with a complex and non-convex optimization problem, which is difficult to solve by the conventional optimization methods. The PSO can efficiently solve design problems of multi-input-multi-output (MIMO) optimal control systems, which is very suitable for practical engineering designs. It is used to search for parameters of a structure-specified controller, which satisfies mixed performance index. The simulation and experimental results show high feasibility, robustness and practical value compared with the conventional proportional-integral-derivative (PID) and proportional-Integral (PI) controller, and the proposed algorithm is also more efficient compared with the genetic algorithm (GA).
文摘Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndrome (HES) by the presence of eosinophilic clonality. Chronic eosinophilic leukemia not otherwise specified (CEL-NOS) diagnosis is made when no fusion genes are detected by most modern molecular testing, particularly the most common fusion gene FIP1L-1/PDGFRA (Factor Interacting with PAP like-1/Platelet-Derived Growth Factor Receptor Alpha). This disease is very rare, and its description in the literature is not well characterized. We report a fetal case of severe CEL-NOS in a 19-year-old male who presented with a plethora of clinical features consists of constitutional symptoms, pancytopenia, intravascular thrombosis, acute stroke and endomyocardial infiltrates. The course of his disease was aggressive and resistant to conventional treatment. After a short period of improvement, an acute transformation into blast crisis (BC) had occurred. The diagnosis was confirmed by morphology and immunophenotyping of bone marrow biopsy. The patient eventually died of heart failure and sepsis. To our knowledge this is the first case report of fatal CEL-NOS transforming into severe blast crisis.
基金This work was supported by the National Key Research and Development Program of China(Grant No.2017YFB1400702)and the National Natural Science Foundation of China(Grant Nos.61932014,61972018 and 61803357).
文摘The problem of guidance law is investigated for multiple interceptors to attack a target cooperatively.A leader-following cooperative guidance strategy is presented to render the leader and the followers reach the target at specified impact time.The guidance law of leader is given to meet the demand of specified impact time.The arrival time is synchronized by enforcing the ranges-to-go of followers keep consensus with that of leader.The convergence time bound is estimated without dependence on the initial states,since the proposed leader-following cooperative guidance law is fixed-time convergent.The simulation is developed to validate the availability of proposed cooperative guidance law.
基金Supported partially by the National Natural Science Foundation of China (Grant No. 60833005)the National High-Tech Research & Development Program of China (Grant Nos. 2007AA01Z155, 2009AA011904)the National Basic Research Program of China (Grant No.2003CB317000)
文摘As huge volumes of data are organized or exported in tree-structured form, it is quite necessary to extract useful information from these data collections using effective and efficient query processing methods. A natural way of retrieving desired information from XML documents is using twig pattern （TP）, which is, actually, the core component of existing XML query languages. Twig pattern possesses the inherent feature that query nodes on the same path have concrete precedence relationships. It is this feature that makes it infeasible in many actual scenarios. This has driven the requirement of relaxing the complete specification of a twig pattern to express more flexible semantic constraints in a single query expression. In this paper, we focus on query evaluation of partially specified twig pattern （PSTP） queries, through which we can reap the most flexibility of specifying partial semantic constraints in a query expression. We propose an extension to XPath through introducing two Samepath axes to support partial semantic constraints in a concise but effective way. Then we propose a stack based algorithm, pTwigStack, to process a PSTP holistically without deriving the concrete twig patterns and then processing them one by one. Further, we propose two DTD schema based optimization methods to improve the performance of pTwigStack algorithm. Our experimental results on various datasets indicate that our method performs significantly better than existing ones when processing PSTPs.
基金supported by the National Key Basic R&D Program (973) of China (No. 2017YFB1001802)
文摘Soft errors have become a critical challenge as a result of technology scaling. Existing circuit-hardening techniques are commonly associated with prohibitive overhead of performance, area, and power. However,evaluating the influence of soft errors in Flip-Flops(FFs) on the failure of circuit is a difficult verification problem.Here, we proposed a novel flip-flop soft-error failure rate analysis methodology using a formal method with respect to application behaviors. Approach and optimization techniques to implement the proposed methodology based on the given formula using Sequential Equivalence Checking(SEC) are introduced. The proposed method combines the advantage of formal technique-based approaches in completeness and the advantage of application behaviors in accuracy to differentiate vulnerability of components. As a result, the FFs in a circuit are sorted by their failure rates, and designers can use this information to perform optimal hardening of selected sequential components against soft errors. Experimental results of an implementation of a SpaceWire end node and the largest ISCAS’89 benchmark sequential circuits indicate the feasibility and potential scalability of our approach. A case study on an instruction decoder of a practical 32-bit microprocessor demonstrates the applicability of our method.
基金Partially supported by National Natural Science Foundation of China(No.11771172)key scientific and technological project of higher education of Henan Province(No.19A110019)+1 种基金Science and technology innovation fund of Henan Agricultural University(No.KJCX2019A15)Partially supported by the Ph D Research Foundation of Henan Agricultural University(No.30500614)
文摘A k-tree is a tree with maximum degree at most k. In this paper, we give a sharp degree sum condition for a graph to have a spanning k-tree in which specified vertices have degree less than t, where 1≤t≤k.We denote by σ_k(G) the minimum value of the degree sum of k independent vertices in a graph G. Let k≥2,s≥0 and 1≤t≤k be integers, and suppose G is an(s + 1)-connected graph with σ_k(G)≥|G|+(k-t)s-1.Then for any s specified vertices, G contains a spanning k-tree in which every specified vertex has degree at most t. This improves a result obtained by Matsuda and Matsumura.
文摘This specification is mainly drafted by Beijing Sport University(BSU),Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine in accordance with the drafting procedure specified in The General Rules for the Compilation of International Traditional Chinese Medicine(TCM)Technical Specifications and The Common Standards for the Compilation of International Standards for TCM Technology.
文摘This paper presents a method for state simplification in incompletely specified sequential machines. The new method adopts Inclusive-OR operation of column vectors for multi-level output matrix E_k! Compared with other algorithms in use, this method is theoretically more strict, while its structure is simple and the results obtained are accurate.
