Periodic marketing is a unique and imporant socio-economic feature of Chinese ruraltowns, the economic, political, social and cultural centres in rural areas. Through two detailed casestudies in the North China Plain...Periodic marketing is a unique and imporant socio-economic feature of Chinese ruraltowns, the economic, political, social and cultural centres in rural areas. Through two detailed casestudies in the North China Plain in 1990, mis paper examined the temporal and spatialcharacteristics, especially their interrelationship. of regional periodic market systems and theirrelationship with rural development in modern China. The distribution of periodic market-towns isfound to be on consumer convenience, and to have an apparent hierarchical structure and centralplace characteristics. Further, the spatial coordination system of periodic marketing has a reverserelationship of spatio-temporal synchronisation. Finally, this paper notes that periodic marketingimposes significant influence on rural development through conducting and controlling goods flow and population flow in rural economic system.展开更多
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(...Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].展开更多
BACKGROUND Non-erosive reflux disease(NERD),the main gastroesophageal reflux subtype,features reflux symptoms without mucosal damage.Anxiety links to visceral hypersensitivity in NERD,yet mechanisms and animal models ...BACKGROUND Non-erosive reflux disease(NERD),the main gastroesophageal reflux subtype,features reflux symptoms without mucosal damage.Anxiety links to visceral hypersensitivity in NERD,yet mechanisms and animal models are unclear.AIM To establish a translational NERD rat model with anxiety comorbidity via tail clamping and study corticotropin-releasing hormone(CRH)-mediated neuroimmune pathways in visceral hypersensitivity and esophageal injury.METHODS Sprague-Dawley(SD)and Wistar rats were grouped into sham,model,and modified groups(n=10 each).The treatments for the modified groups were as follows:SD rats received ovalbumin/aluminum hydroxide suspension+acid perfusion±tail clamping(40 minutes/day for 7 days),while Wistar rats received fructose water+tail clamping.Esophageal pathology,visceral sensitivity,and behavior were assessed.Serum CRH,calcitonin gene-related peptide(CGRP),5-hydroxytryptamine(5-HT),and mast cell tryptase(MCT)and central amygdala(CeA)CRH mRNA were measured via ELISA and qRT-PCR.RESULTS Tail clamping induced anxiety,worsening visceral hypersensitivity(lower abdominal withdrawal reflex thresholds,P<0.05)and esophageal injury(dilated intercellular spaces and mitochondrial edema).Both models showed raised serum CRH,CGRP,5-HT,and MCT(P<0.01)and CeA CRH mRNA expression(P<0.01).Behavioral tests confirmed anxiety-like phenotypes.NERD-anxiety rats showed clinical-like symptom severity without erosion.CONCLUSION Tail clamping induces anxiety in NERD models,worsening visceral hypersensitivity via CRH neuroimmune dysregulation,offering a translational model and highlighting CRH as a treatment target.展开更多
Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of kn...Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of knowledge about the underlying modes of action and optimal treatment modalities,a thorough translational investigation of noninvasive brain stimulation in preclinical animal models is urgently needed.Thus,we reviewed the current literature on the mechanistic underpinnings of noninvasive brain stimulation in models of central nervous system impairment,with a particular emphasis on traumatic brain injury and stroke.Due to the lack of translational models in most noninvasive brain stimulation techniques proposed,we found this review to the most relevant techniques used in humans,i.e.,transcranial magnetic stimulation and transcranial direct current stimulation.We searched the literature in Pub Med,encompassing the MEDLINE and PMC databases,for studies published between January 1,2020 and September 30,2024.Thirty-five studies were eligible.Transcranial magnetic stimulation and transcranial direct current stimulation demonstrated distinct strengths in augmenting rehabilitation post-stroke and traumatic brain injury,with emerging mechanistic evidence.Overall,we identified neuronal,inflammatory,microvascular,and apoptotic pathways highlighted in the literature.This review also highlights a lack of translational surrogate parameters to bridge the gap between preclinical findings and their clinical translation.展开更多
Electrocardiogram (ECG) analysis is critical for detecting arrhythmias, but traditional methods struggle with large-scale Electrocardiogram data and rare arrhythmia events in imbalanced datasets. These methods fail to...Electrocardiogram (ECG) analysis is critical for detecting arrhythmias, but traditional methods struggle with large-scale Electrocardiogram data and rare arrhythmia events in imbalanced datasets. These methods fail to perform multi-perspective learning of temporal signals and Electrocardiogram images, nor can they fully extract the latent information within the data, falling short of the accuracy required by clinicians. Therefore, this paper proposes an innovative hybrid multimodal spatiotemporal neural network to address these challenges. The model employs a multimodal data augmentation framework integrating visual and signal-based features to enhance the classification performance of rare arrhythmias in imbalanced datasets. Additionally, the spatiotemporal fusion module incorporates a spatiotemporal graph convolutional network to jointly model temporal and spatial features, uncovering complex dependencies within the Electrocardiogram data and improving the model’s ability to represent complex patterns. In experiments conducted on the MIT-BIH arrhythmia dataset, the model achieved 99.95% accuracy, 99.80% recall, and a 99.78% F1 score. The model was further validated for generalization using the clinical INCART arrhythmia dataset, and the results demonstrated its effectiveness in terms of both generalization and robustness.展开更多
Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in ...Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.展开更多
The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cereb...The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.展开更多
Marine information has been increasing quickly. The traditional database technologies have disadvantages in manipulating large amounts of marine information which relates to the position in 3-D with the time. Recently...Marine information has been increasing quickly. The traditional database technologies have disadvantages in manipulating large amounts of marine information which relates to the position in 3-D with the time. Recently, greater emphasis has been placed on GIS （geographical information system）to deal with the marine information. The GIS has shown great success for terrestrial applications in the last decades, but its use in marine fields has been far more restricted. One of the main reasons is that most of the GIS systems or their data models are designed for land applications. They cannot do well with the nature of the marine environment and for the marine information. And this becomes a fundamental challenge to the traditional GIS and its data structure. This work designed a data model, the raster-based spatio-temporal hierarchical data model （RSHDM）, for the marine information system, or for the knowledge discovery fi＇om spatio-temporal data, which bases itself on the nature of the marine data and overcomes the shortages of the current spatio-temporal models when they are used in the field. As an experiment, the marine fishery data warehouse （FDW） for marine fishery management was set up, which was based on the RSHDM. The experiment proved that the RSHDM can do well with the data and can extract easily the aggregations that the management needs at different levels.展开更多
Understanding crop patterns and their changes on regional scale is a critical re- quirement for projecting agro-ecosystem dynamics. However, tools and methods for mapping the distribution of crop area and yield are st...Understanding crop patterns and their changes on regional scale is a critical re- quirement for projecting agro-ecosystem dynamics. However, tools and methods for mapping the distribution of crop area and yield are still lacking. Based on the cross-entropy theory, a spatial production allocation model （SPAM） has been developed for presenting spa- tio-temporal dynamics of maize cropping system in Northeast China during 1980-2010. The simulated results indicated that （1） maize sown area expanded northwards to 48~N before 2000, after that the increased sown area mainly occurred in the central and southern parts of Northeast China. Meanwhile, maize also expanded eastwards to 127°E and lower elevation （less than 100 m） as well as higher elevation （mainly distributed between 200 m and 350 m）; （2） maize yield has been greatly promoted for most planted area of Northeast China, espe- cially in the planted zone between 42°N and 48°N, while the yield increase was relatively homogeneous without obvious longitudinal variations for whole region; （3） maize planting density increased gradually to a moderately high level over the investigated period, which reflected the trend of aggregation of maize cultivation driven by market demand.展开更多
The technique of incremental updating,which can better guarantee the real-time situation of navigational map,is the developing orientation of navigational road network updating.The data center of vehicle navigation sy...The technique of incremental updating,which can better guarantee the real-time situation of navigational map,is the developing orientation of navigational road network updating.The data center of vehicle navigation system is in charge of storing incremental data,and the spatio-temporal data model for storing incremental data does affect the efficiency of the response of the data center to the requirements of incremental data from the vehicle terminal.According to the analysis on the shortcomings of several typical spatio-temporal data models used in the data center and based on the base map with overlay model,the reverse map with overlay model (RMOM) was put forward for the data center to make rapid response to incremental data request.RMOM supports the data center to store not only the current complete road network data,but also the overlays of incremental data from the time when each road network changed to the current moment.Moreover,the storage mechanism and index structure of the incremental data were designed,and the implementation algorithm of RMOM was developed.Taking navigational road network in Guangzhou City as an example,the simulation test was conducted to validate the efficiency of RMOM.Results show that the navigation database in the data center can response to the requirements of incremental data by only one query with RMOM,and costs less time.Compared with the base map with overlay model,the data center does not need to temporarily overlay incremental data with RMOM,so time-consuming of response is significantly reduced.RMOM greatly improves the efficiency of response and provides strong support for the real-time situation of navigational road network.展开更多
Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LM...Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LMRB's terrestrial water storage anomaly(TWSA)and its spatio-temporal dynamics during 2002–2020.Considering the effects of natural factors and human activities,the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC)were separated.Results showed that:(1)LMRB's TWSA decreased by 0.3158 cm/a.(2)TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB.TWSA positively changed in Myanmar while slightly changed in Laos and China.It negatively changed in Vietnam,Thailand and Cambodia.(3)TWSA components decreased in a descending order of soil moisture,groundwater and precipitation.(4)Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5)Climate variability contributed 79%of TWSC in the LMRB while human activities contributed 21%with an increasing impact after 2008.The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.展开更多
Rice is one of the most important grain crops in Northeast China （NEC） and its cultivation is sensitive to climate change. This study aimed to explore the spatio-temporal changes in the NEC rice planting area over t...Rice is one of the most important grain crops in Northeast China （NEC） and its cultivation is sensitive to climate change. This study aimed to explore the spatio-temporal changes in the NEC rice planting area over the period of 1980-2010 and to analyze their relationship to climate change. To do so, the CLUE-S （conversion of land use and its effects at small region extent） model was ifrst updated and used to simulate dynamic changes in the rice planting area in NEC to understand spatio-temporal change trends during three periods： 1980-1990, 1990-2000 and 2000-2010. The changing results in individual periods were then linked to climatic variables to investigate the climatic drivers of these changes. Results showed that the NEC rice planting area expanded quickly and increased by nearly 4.5 times during 1980-2010. The concentration of newly planted rice areas in NEC constantly moved northward and the changes were strongly dependent on latitude. This conifrmed that climate change, increases in temperature in particular, greatly inlfuenced the shift in the rice planting area. The shift in the north limit of the NEC rice planting area generally followed a 1＆#176;C isoline migration pattern, but with an obvious time-lag effect. These ifndings can help policy makers and crop producers take proper adaptation measures even when exposed to the global warming situation in NEC.展开更多
This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble lear...This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.展开更多
Objective To investigate the spatiotemporal patterns and socioeconomic factors influencing the incidence of tuberculosis(TB)in the Guangdong Province between 2010 and 2019.Method Spatial and temporal variations in TB ...Objective To investigate the spatiotemporal patterns and socioeconomic factors influencing the incidence of tuberculosis(TB)in the Guangdong Province between 2010 and 2019.Method Spatial and temporal variations in TB incidence were mapped using heat maps and hierarchical clustering.Socioenvironmental influencing factors were evaluated using a Bayesian spatiotemporal conditional autoregressive(ST-CAR)model.Results Annual incidence of TB in Guangdong decreased from 91.85/100,000 in 2010 to 53.06/100,000in 2019.Spatial hotspots were found in northeastern Guangdong,particularly in Heyuan,Shanwei,and Shantou,while Shenzhen,Dongguan,and Foshan had the lowest rates in the Pearl River Delta.The STCAR model showed that the TB risk was lower with higher per capita Gross Domestic Product(GDP)[Relative Risk(RR),0.91;95%Confidence Interval(CI):0.86–0.98],more the ratio of licensed physicians and physician(RR,0.94;95%CI:0.90-0.98),and higher per capita public expenditure(RR,0.94;95%CI:0.90–0.97),with a marginal effect of population density(RR,0.86;95%CI:0.86–1.00).Conclusion The incidence of TB in Guangdong varies spatially and temporally.Areas with poor economic conditions and insufficient healthcare resources are at an increased risk of TB infection.Strategies focusing on equitable health resource distribution and economic development are the key to TB control.展开更多
Conducting predictability studies is essential for tracing the source of forecast errors,which not only leads to the improvement of observation and forecasting systems,but also enhances the understanding of weather an...Conducting predictability studies is essential for tracing the source of forecast errors,which not only leads to the improvement of observation and forecasting systems,but also enhances the understanding of weather and climate phenomena.In the past few decades,dynamical numerical models have been the primary tools for predictability studies,achieving significant progress.Nowadays,with the advances in artificial intelligence(AI)techniques and accumulations of vast meteorological data,modeling weather and climate events using modern data-driven approaches is becoming trendy,where FourCastNet,Pangu-Weather,and GraphCast are successful pioneers.In this perspective article,we suggest AI models should not be limited to forecasting but be expanded to predictability studies,leveraging AI's advantages of high efficiency and self-contained optimization modules.To this end,we first remark that AI models should possess high simulation capability with fine spatiotemporal resolution for two kinds of predictability studies.AI models with high simulation capabilities comparable to numerical models can be considered to provide solutions to partial differential equations in a data-driven way.Then,we highlight several specific predictability issues with well-determined nonlinear optimization formulizations,which can be well-studied using AI models,holding significant scientific value.In addition,we advocate for the incorporation of AI models into the synergistic cycle of the cognition–observation–model paradigm.Comprehensive predictability studies have the potential to transform“big data”to“big and better data”and shift the focus from“AI for forecasts”to“AI for science”,ultimately advancing the development of the atmospheric and oceanic sciences.展开更多
Land use and its dynamics have attracted considerable scientific attention for their significant ecological and socioeconomic implications.Many studies have investigated the past changes in land use,but efforts explor...Land use and its dynamics have attracted considerable scientific attention for their significant ecological and socioeconomic implications.Many studies have investigated the past changes in land use,but efforts exploring the potential changes in land use and implications under future scenarios are still lacking.Here we simulate the future land use changes and their impacts on ecosystem services in Northeast China(NEC) over the period of 2000–2050 using the CLUE–S(Conversion of Land Use and its Effects at Small regional extent) model under the scenarios of ecological security(ESS),food security(FSS) and comprehensive development(CDS).The model was validated against remote sensing data in 2005.Overall,the accuracy of the CLUE–S model was evaluated at 82.5%.Obtained results show that future cropland changes mainly occur in the Songnen Plain and the Liaohe Plain,forest and grassland changes are concentrated in the southern Lesser Khingan Mountains and the western Changbai Mountains,while the Sanjiang Plain will witness major changes of the wetlands.Our results also show that even though CDS is defined based on the goals of the regional development plan,the ecological service value(ESV) under CDS is RMB 2656.18 billion in 2050.The ESV of CDS is lower compared with the other scenarios.Thus,CDS is not an optimum scenario for eco-environmental protection,especially for the wetlands,which should be given higher priority for future development.The issue of coordination is also critical in future development.The results can help to assist structural adjustments for agriculture and to guide policy interventions in NEC.展开更多
According to calculation results of ocean chlorophyll concentration based on SeaWiFS data by SeaBAM model and synchronous ship-measured data, this research set up an improved model for CaseⅠand CaseⅡwater bodies...According to calculation results of ocean chlorophyll concentration based on SeaWiFS data by SeaBAM model and synchronous ship-measured data, this research set up an improved model for CaseⅠand CaseⅡwater bodies respectively. The monthly chlorophyll distribution in the East China Sea in 1998 was obtained from this improved model on calculation results of SeaBAM. The euphotic depth distribution in 1998 in the East China Sea is calculated by using remote sensing data of K 490 from SeaWiFS according to the relation between the euphotic depth and the oceanic diffuse attenuation coefficient. With data of ocean chlorophyll concentration, euphotic depth, ocean surface photosynthetic available radiation (PAR), daily photoperiod and optimal rate of daily carbon fixation within a water column, the monthly and annual primary productivity spatio-temporal distributions in the East China Sea in 1998 were obtained based on VGPM model. Based on analysis of those distributions, the conclusion can be drawn that there is a clear bimodality character of primary productivity in the monthly distribution in the East China Sea. In detail, the monthly distribution of primary productivity stays the lowest level in winter and rises rapidly to the peak in spring. It gets down a little in summer, and gets up a little in autumn. The daily average of primary productivity in the whole East China Sea is 560.03 mg/m 2 /d, which is far higher than the average of subtropical ocean areas. The annual average of primary productivity is 236.95 g/m 2 /a. The research on the seasonal variety mechanism of primary productivity shows that several factors that affect the spatio-temporal distribution may include the chlorophyll concentration distribution, temperature condition, the Yangtze River diluted water variety, the euphotic depth, ocean current variety, etc. But the main influencing factors may be different in each local sea area.展开更多
This paper deals mainly with the existence and asymptotic behavior of traveling waves in a SIRH model with spatio-temporal delay and nonlocal dispersal based on Schauder’s fixed-point theorem and analysis techniques,...This paper deals mainly with the existence and asymptotic behavior of traveling waves in a SIRH model with spatio-temporal delay and nonlocal dispersal based on Schauder’s fixed-point theorem and analysis techniques,which generalize the results of nonlocal SIRH models without relapse and delay.In particular,the difficulty of obtaining the asymptotic behavior of traveling waves for the appearance of spatio-temporal delay is overcome by the use of integral techniques and analysis techniques.Finally,the more general nonexistence result of traveling waves is also included.展开更多
Based on the theoretical expression of the three-dimension rheologic inclusion model, we analyze in detail the spatio-temporal changes on the ground of the bulk-strain produced by a spherical rheologic inclusion in a ...Based on the theoretical expression of the three-dimension rheologic inclusion model, we analyze in detail the spatio-temporal changes on the ground of the bulk-strain produced by a spherical rheologic inclusion in a semi-infinite rheologic medium. The results show that the spatio-temporal change of bulk-strain produced by the hard inclusion has three stages of different characteristics, which are similar to most of those geodetic deformation curves, but those by a soft inclusion do not. The α-stage is a long stage in which the precursors in both the near source region and the far field develop from the focal region to the periphery. The β-stage indicates a very rapid propagation of the precursors, so that they almost appear everywhere. During the γ-stage, the precursors in the far-field converge from the periphery, and the precursors in the near source region develop outwards. The theoretical results have been used to explain tentatively the stage characteristics of the spatio-temporal change of earthquake precursors.展开更多
Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experienci...Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.展开更多
文摘Periodic marketing is a unique and imporant socio-economic feature of Chinese ruraltowns, the economic, political, social and cultural centres in rural areas. Through two detailed casestudies in the North China Plain in 1990, mis paper examined the temporal and spatialcharacteristics, especially their interrelationship. of regional periodic market systems and theirrelationship with rural development in modern China. The distribution of periodic market-towns isfound to be on consumer convenience, and to have an apparent hierarchical structure and centralplace characteristics. Further, the spatial coordination system of periodic marketing has a reverserelationship of spatio-temporal synchronisation. Finally, this paper notes that periodic marketingimposes significant influence on rural development through conducting and controlling goods flow and population flow in rural economic system.
文摘Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].
基金Supported by the National Key Specialty of Traditional Chinese Medicine(Spleen and Stomach Diseases),No.0500004National Natural Science Foundation of China,No.82205104 and No.82104850+1 种基金Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0303-07the Fundamental Research Funds for the Central Public Welfare Research Institutes,Excellent Young Scientists Training Program of China Academy of Chinese Medical Sciences,No.ZZ16-YQ-002.
文摘BACKGROUND Non-erosive reflux disease(NERD),the main gastroesophageal reflux subtype,features reflux symptoms without mucosal damage.Anxiety links to visceral hypersensitivity in NERD,yet mechanisms and animal models are unclear.AIM To establish a translational NERD rat model with anxiety comorbidity via tail clamping and study corticotropin-releasing hormone(CRH)-mediated neuroimmune pathways in visceral hypersensitivity and esophageal injury.METHODS Sprague-Dawley(SD)and Wistar rats were grouped into sham,model,and modified groups(n=10 each).The treatments for the modified groups were as follows:SD rats received ovalbumin/aluminum hydroxide suspension+acid perfusion±tail clamping(40 minutes/day for 7 days),while Wistar rats received fructose water+tail clamping.Esophageal pathology,visceral sensitivity,and behavior were assessed.Serum CRH,calcitonin gene-related peptide(CGRP),5-hydroxytryptamine(5-HT),and mast cell tryptase(MCT)and central amygdala(CeA)CRH mRNA were measured via ELISA and qRT-PCR.RESULTS Tail clamping induced anxiety,worsening visceral hypersensitivity(lower abdominal withdrawal reflex thresholds,P<0.05)and esophageal injury(dilated intercellular spaces and mitochondrial edema).Both models showed raised serum CRH,CGRP,5-HT,and MCT(P<0.01)and CeA CRH mRNA expression(P<0.01).Behavioral tests confirmed anxiety-like phenotypes.NERD-anxiety rats showed clinical-like symptom severity without erosion.CONCLUSION Tail clamping induces anxiety in NERD models,worsening visceral hypersensitivity via CRH neuroimmune dysregulation,offering a translational model and highlighting CRH as a treatment target.
基金funded by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation):project ID 431549029-SFB 1451the Marga-und-Walter-Boll-Stiftung(#210-10-15)(to MAR)a stipend from the'Gerok Program'(Faculty of Medicine,University of Cologne,Germany)。
文摘Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of knowledge about the underlying modes of action and optimal treatment modalities,a thorough translational investigation of noninvasive brain stimulation in preclinical animal models is urgently needed.Thus,we reviewed the current literature on the mechanistic underpinnings of noninvasive brain stimulation in models of central nervous system impairment,with a particular emphasis on traumatic brain injury and stroke.Due to the lack of translational models in most noninvasive brain stimulation techniques proposed,we found this review to the most relevant techniques used in humans,i.e.,transcranial magnetic stimulation and transcranial direct current stimulation.We searched the literature in Pub Med,encompassing the MEDLINE and PMC databases,for studies published between January 1,2020 and September 30,2024.Thirty-five studies were eligible.Transcranial magnetic stimulation and transcranial direct current stimulation demonstrated distinct strengths in augmenting rehabilitation post-stroke and traumatic brain injury,with emerging mechanistic evidence.Overall,we identified neuronal,inflammatory,microvascular,and apoptotic pathways highlighted in the literature.This review also highlights a lack of translational surrogate parameters to bridge the gap between preclinical findings and their clinical translation.
基金supported by The Henan Province Science and Technology Research Project(242102211046)the Key Scientific Research Project of Higher Education Institutions in Henan Province(25A520039)+1 种基金theNatural Science Foundation project of Zhongyuan Institute of Technology(K2025YB011)the Zhongyuan University of Technology Graduate Education and Teaching Reform Research Project(JG202424).
文摘Electrocardiogram (ECG) analysis is critical for detecting arrhythmias, but traditional methods struggle with large-scale Electrocardiogram data and rare arrhythmia events in imbalanced datasets. These methods fail to perform multi-perspective learning of temporal signals and Electrocardiogram images, nor can they fully extract the latent information within the data, falling short of the accuracy required by clinicians. Therefore, this paper proposes an innovative hybrid multimodal spatiotemporal neural network to address these challenges. The model employs a multimodal data augmentation framework integrating visual and signal-based features to enhance the classification performance of rare arrhythmias in imbalanced datasets. Additionally, the spatiotemporal fusion module incorporates a spatiotemporal graph convolutional network to jointly model temporal and spatial features, uncovering complex dependencies within the Electrocardiogram data and improving the model’s ability to represent complex patterns. In experiments conducted on the MIT-BIH arrhythmia dataset, the model achieved 99.95% accuracy, 99.80% recall, and a 99.78% F1 score. The model was further validated for generalization using the clinical INCART arrhythmia dataset, and the results demonstrated its effectiveness in terms of both generalization and robustness.
文摘Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.
基金supported by the Grant PID2021-126715OB-IOO financed by MCIN/AEI/10.13039/501100011033 and"ERDFA way of making Europe"by the Grant PI22CⅢ/00055 funded by Instituto de Salud CarlosⅢ(ISCⅢ)+6 种基金the UFIECPY 398/19(PEJ2018-004965) grant to RGS funded by AEI(Spain)the UFIECPY-396/19(PEJ2018-004961)grant financed by MCIN (Spain)FI23CⅢ/00003 grant funded by ISCⅢ-PFIS Spain) to PMMthe UFIECPY 328/22 (PEJ-2021-TL/BMD-21001) grant to LM financed by CAM (Spain)the grant by CAPES (Coordination for the Improvement of Higher Education Personnel)through the PDSE program (Programa de Doutorado Sanduiche no Exterior)to VSCG financed by MEC (Brazil)
文摘The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.
基金supported by the National Key Basic Research and Development Program of China under contract No.2006CB701305the National Natural Science Foundation of China under coutract No.40571129the National High-Technology Program of China under contract Nos 2002AA639400,2003AA604040 and 2003AA637030.
文摘Marine information has been increasing quickly. The traditional database technologies have disadvantages in manipulating large amounts of marine information which relates to the position in 3-D with the time. Recently, greater emphasis has been placed on GIS （geographical information system）to deal with the marine information. The GIS has shown great success for terrestrial applications in the last decades, but its use in marine fields has been far more restricted. One of the main reasons is that most of the GIS systems or their data models are designed for land applications. They cannot do well with the nature of the marine environment and for the marine information. And this becomes a fundamental challenge to the traditional GIS and its data structure. This work designed a data model, the raster-based spatio-temporal hierarchical data model （RSHDM）, for the marine information system, or for the knowledge discovery fi＇om spatio-temporal data, which bases itself on the nature of the marine data and overcomes the shortages of the current spatio-temporal models when they are used in the field. As an experiment, the marine fishery data warehouse （FDW） for marine fishery management was set up, which was based on the RSHDM. The experiment proved that the RSHDM can do well with the data and can extract easily the aggregations that the management needs at different levels.
基金Foundation： National Natural Science Foundation of China, No.41171328, No.41201184, No.41101537 National Basic Program of China, No.2010CB951502
文摘Understanding crop patterns and their changes on regional scale is a critical re- quirement for projecting agro-ecosystem dynamics. However, tools and methods for mapping the distribution of crop area and yield are still lacking. Based on the cross-entropy theory, a spatial production allocation model （SPAM） has been developed for presenting spa- tio-temporal dynamics of maize cropping system in Northeast China during 1980-2010. The simulated results indicated that （1） maize sown area expanded northwards to 48~N before 2000, after that the increased sown area mainly occurred in the central and southern parts of Northeast China. Meanwhile, maize also expanded eastwards to 127°E and lower elevation （less than 100 m） as well as higher elevation （mainly distributed between 200 m and 350 m）; （2） maize yield has been greatly promoted for most planted area of Northeast China, espe- cially in the planted zone between 42°N and 48°N, while the yield increase was relatively homogeneous without obvious longitudinal variations for whole region; （3） maize planting density increased gradually to a moderately high level over the investigated period, which reflected the trend of aggregation of maize cultivation driven by market demand.
基金Under the auspices of National High Technology Research and Development Program of China (No.2007AA12Z242)
文摘The technique of incremental updating,which can better guarantee the real-time situation of navigational map,is the developing orientation of navigational road network updating.The data center of vehicle navigation system is in charge of storing incremental data,and the spatio-temporal data model for storing incremental data does affect the efficiency of the response of the data center to the requirements of incremental data from the vehicle terminal.According to the analysis on the shortcomings of several typical spatio-temporal data models used in the data center and based on the base map with overlay model,the reverse map with overlay model (RMOM) was put forward for the data center to make rapid response to incremental data request.RMOM supports the data center to store not only the current complete road network data,but also the overlays of incremental data from the time when each road network changed to the current moment.Moreover,the storage mechanism and index structure of the incremental data were designed,and the implementation algorithm of RMOM was developed.Taking navigational road network in Guangzhou City as an example,the simulation test was conducted to validate the efficiency of RMOM.Results show that the navigation database in the data center can response to the requirements of incremental data by only one query with RMOM,and costs less time.Compared with the base map with overlay model,the data center does not need to temporarily overlay incremental data with RMOM,so time-consuming of response is significantly reduced.RMOM greatly improves the efficiency of response and provides strong support for the real-time situation of navigational road network.
基金National Natural Science Foundation of China,No.42161006Yunnan Fundamental Research Projects No.202201AT070094,No.202301BF070001-004+1 种基金Special Project for High-level Talents of Yunnan Province for Young Top Talents,No.C6213001159European Research Council(ERC)Starting-Grant STORIES,No.101040939。
文摘Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LMRB's terrestrial water storage anomaly(TWSA)and its spatio-temporal dynamics during 2002–2020.Considering the effects of natural factors and human activities,the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC)were separated.Results showed that:(1)LMRB's TWSA decreased by 0.3158 cm/a.(2)TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB.TWSA positively changed in Myanmar while slightly changed in Laos and China.It negatively changed in Vietnam,Thailand and Cambodia.(3)TWSA components decreased in a descending order of soil moisture,groundwater and precipitation.(4)Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5)Climate variability contributed 79%of TWSC in the LMRB while human activities contributed 21%with an increasing impact after 2008.The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.
基金supported and financed by the National Basic Research Program of China(973 Program,2010CB951504)the National Natural Science Foundation of China(41201089 and 41271112)
文摘Rice is one of the most important grain crops in Northeast China （NEC） and its cultivation is sensitive to climate change. This study aimed to explore the spatio-temporal changes in the NEC rice planting area over the period of 1980-2010 and to analyze their relationship to climate change. To do so, the CLUE-S （conversion of land use and its effects at small region extent） model was ifrst updated and used to simulate dynamic changes in the rice planting area in NEC to understand spatio-temporal change trends during three periods： 1980-1990, 1990-2000 and 2000-2010. The changing results in individual periods were then linked to climatic variables to investigate the climatic drivers of these changes. Results showed that the NEC rice planting area expanded quickly and increased by nearly 4.5 times during 1980-2010. The concentration of newly planted rice areas in NEC constantly moved northward and the changes were strongly dependent on latitude. This conifrmed that climate change, increases in temperature in particular, greatly inlfuenced the shift in the rice planting area. The shift in the north limit of the NEC rice planting area generally followed a 1＆#176;C isoline migration pattern, but with an obvious time-lag effect. These ifndings can help policy makers and crop producers take proper adaptation measures even when exposed to the global warming situation in NEC.
基金the University of Transport Technology under the project entitled“Application of Machine Learning Algorithms in Landslide Susceptibility Mapping in Mountainous Areas”with grant number DTTD2022-16.
文摘This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.
基金supported by the Guangdong Provincial Clinical Research Center for Tuberculosis(No.2020B1111170014)。
文摘Objective To investigate the spatiotemporal patterns and socioeconomic factors influencing the incidence of tuberculosis(TB)in the Guangdong Province between 2010 and 2019.Method Spatial and temporal variations in TB incidence were mapped using heat maps and hierarchical clustering.Socioenvironmental influencing factors were evaluated using a Bayesian spatiotemporal conditional autoregressive(ST-CAR)model.Results Annual incidence of TB in Guangdong decreased from 91.85/100,000 in 2010 to 53.06/100,000in 2019.Spatial hotspots were found in northeastern Guangdong,particularly in Heyuan,Shanwei,and Shantou,while Shenzhen,Dongguan,and Foshan had the lowest rates in the Pearl River Delta.The STCAR model showed that the TB risk was lower with higher per capita Gross Domestic Product(GDP)[Relative Risk(RR),0.91;95%Confidence Interval(CI):0.86–0.98],more the ratio of licensed physicians and physician(RR,0.94;95%CI:0.90-0.98),and higher per capita public expenditure(RR,0.94;95%CI:0.90–0.97),with a marginal effect of population density(RR,0.86;95%CI:0.86–1.00).Conclusion The incidence of TB in Guangdong varies spatially and temporally.Areas with poor economic conditions and insufficient healthcare resources are at an increased risk of TB infection.Strategies focusing on equitable health resource distribution and economic development are the key to TB control.
基金in part supported by the National Natural Science Foundation of China(Grant Nos.42288101,42405147 and 42475054)in part by the China National Postdoctoral Program for Innovative Talents(Grant No.BX20230071)。
文摘Conducting predictability studies is essential for tracing the source of forecast errors,which not only leads to the improvement of observation and forecasting systems,but also enhances the understanding of weather and climate phenomena.In the past few decades,dynamical numerical models have been the primary tools for predictability studies,achieving significant progress.Nowadays,with the advances in artificial intelligence(AI)techniques and accumulations of vast meteorological data,modeling weather and climate events using modern data-driven approaches is becoming trendy,where FourCastNet,Pangu-Weather,and GraphCast are successful pioneers.In this perspective article,we suggest AI models should not be limited to forecasting but be expanded to predictability studies,leveraging AI's advantages of high efficiency and self-contained optimization modules.To this end,we first remark that AI models should possess high simulation capability with fine spatiotemporal resolution for two kinds of predictability studies.AI models with high simulation capabilities comparable to numerical models can be considered to provide solutions to partial differential equations in a data-driven way.Then,we highlight several specific predictability issues with well-determined nonlinear optimization formulizations,which can be well-studied using AI models,holding significant scientific value.In addition,we advocate for the incorporation of AI models into the synergistic cycle of the cognition–observation–model paradigm.Comprehensive predictability studies have the potential to transform“big data”to“big and better data”and shift the focus from“AI for forecasts”to“AI for science”,ultimately advancing the development of the atmospheric and oceanic sciences.
基金Agricultural Outstanding Talents Research Foundation of Ministry of Agriculture(MOA)Key Laboratory of Agri–Informatics Foundation of MOA No.2015001+1 种基金Natural Science Foundation of Hubei Province No.2016CFB558The Fundamental Research Funds for the Central Universities,No.CCNU15A05058
文摘Land use and its dynamics have attracted considerable scientific attention for their significant ecological and socioeconomic implications.Many studies have investigated the past changes in land use,but efforts exploring the potential changes in land use and implications under future scenarios are still lacking.Here we simulate the future land use changes and their impacts on ecosystem services in Northeast China(NEC) over the period of 2000–2050 using the CLUE–S(Conversion of Land Use and its Effects at Small regional extent) model under the scenarios of ecological security(ESS),food security(FSS) and comprehensive development(CDS).The model was validated against remote sensing data in 2005.Overall,the accuracy of the CLUE–S model was evaluated at 82.5%.Obtained results show that future cropland changes mainly occur in the Songnen Plain and the Liaohe Plain,forest and grassland changes are concentrated in the southern Lesser Khingan Mountains and the western Changbai Mountains,while the Sanjiang Plain will witness major changes of the wetlands.Our results also show that even though CDS is defined based on the goals of the regional development plan,the ecological service value(ESV) under CDS is RMB 2656.18 billion in 2050.The ESV of CDS is lower compared with the other scenarios.Thus,CDS is not an optimum scenario for eco-environmental protection,especially for the wetlands,which should be given higher priority for future development.The issue of coordination is also critical in future development.The results can help to assist structural adjustments for agriculture and to guide policy interventions in NEC.
基金The Key National Project for the Ninth Five-Year PlanNo.HY126-06-04-04
文摘According to calculation results of ocean chlorophyll concentration based on SeaWiFS data by SeaBAM model and synchronous ship-measured data, this research set up an improved model for CaseⅠand CaseⅡwater bodies respectively. The monthly chlorophyll distribution in the East China Sea in 1998 was obtained from this improved model on calculation results of SeaBAM. The euphotic depth distribution in 1998 in the East China Sea is calculated by using remote sensing data of K 490 from SeaWiFS according to the relation between the euphotic depth and the oceanic diffuse attenuation coefficient. With data of ocean chlorophyll concentration, euphotic depth, ocean surface photosynthetic available radiation (PAR), daily photoperiod and optimal rate of daily carbon fixation within a water column, the monthly and annual primary productivity spatio-temporal distributions in the East China Sea in 1998 were obtained based on VGPM model. Based on analysis of those distributions, the conclusion can be drawn that there is a clear bimodality character of primary productivity in the monthly distribution in the East China Sea. In detail, the monthly distribution of primary productivity stays the lowest level in winter and rises rapidly to the peak in spring. It gets down a little in summer, and gets up a little in autumn. The daily average of primary productivity in the whole East China Sea is 560.03 mg/m 2 /d, which is far higher than the average of subtropical ocean areas. The annual average of primary productivity is 236.95 g/m 2 /a. The research on the seasonal variety mechanism of primary productivity shows that several factors that affect the spatio-temporal distribution may include the chlorophyll concentration distribution, temperature condition, the Yangtze River diluted water variety, the euphotic depth, ocean current variety, etc. But the main influencing factors may be different in each local sea area.
基金supported by the NSF of China(11761046)Science and Technology Plan Foundation of Gansu Province of China(20JR5RA411)Foundation of A Hundred Youth Talents Training Program of Lanzhou Jiaotong University。
文摘This paper deals mainly with the existence and asymptotic behavior of traveling waves in a SIRH model with spatio-temporal delay and nonlocal dispersal based on Schauder’s fixed-point theorem and analysis techniques,which generalize the results of nonlocal SIRH models without relapse and delay.In particular,the difficulty of obtaining the asymptotic behavior of traveling waves for the appearance of spatio-temporal delay is overcome by the use of integral techniques and analysis techniques.Finally,the more general nonexistence result of traveling waves is also included.
文摘Based on the theoretical expression of the three-dimension rheologic inclusion model, we analyze in detail the spatio-temporal changes on the ground of the bulk-strain produced by a spherical rheologic inclusion in a semi-infinite rheologic medium. The results show that the spatio-temporal change of bulk-strain produced by the hard inclusion has three stages of different characteristics, which are similar to most of those geodetic deformation curves, but those by a soft inclusion do not. The α-stage is a long stage in which the precursors in both the near source region and the far field develop from the focal region to the periphery. The β-stage indicates a very rapid propagation of the precursors, so that they almost appear everywhere. During the γ-stage, the precursors in the far-field converge from the periphery, and the precursors in the near source region develop outwards. The theoretical results have been used to explain tentatively the stage characteristics of the spatio-temporal change of earthquake precursors.
基金supported by the Brain&Behavior Research Foundation(30233).
文摘Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.
