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Utilizing Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)in hypothesis-driven queries
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作者 Diana Acosta Cankun Wang +1 位作者 Qin Ma Hongjun Fu 《Neural Regeneration Research》 2026年第2期677-678,共2页
Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other... Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis. 展开更多
关键词 sex specific alzheimer s disease ad deciphering molecular mechanisms spatial transcriptomics ssread spatial transcriptomics st Alzheimers disease single cell RNA seq
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Walsh Spectral Characteristics and the Auto-Correlation Function Characteristics of Forming Orthomorphic Permutations of Multi-Output Functions 被引量:4
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作者 ZHAO Yaqun WANG Jue 《Wuhan University Journal of Natural Sciences》 CAS 2006年第6期1895-1898,共4页
Orthomorphic permutations have good characteristics in cryptosystems. In this paper, by using of knowledge about relation between orthomorphic permutations and multi-output functions, and conceptions of the generalize... Orthomorphic permutations have good characteristics in cryptosystems. In this paper, by using of knowledge about relation between orthomorphic permutations and multi-output functions, and conceptions of the generalized Walsh spectrum of multi-output functions and the auto-correlation function of multi-output functions to investigate the Walsh spectral characteristics and the auto-correlation function characteristics of orthormophic permutations, several results are obtained. 展开更多
关键词 orthomorphic permutation multi-output functions walsh spectral auto-correlation function
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Biometric feature extraction using local fractal auto-correlation 被引量:2
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作者 陈熙 张家树 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第9期335-340,共6页
Image texture feature extraction is a classical means for biometric recognition. To extract effective texture feature for matching, we utilize local fractal auto-correlation to construct an effective image texture des... Image texture feature extraction is a classical means for biometric recognition. To extract effective texture feature for matching, we utilize local fractal auto-correlation to construct an effective image texture descriptor. Three main steps are involved in the proposed scheme: (i) using two-dimensional Gabor filter to extract the texture features of biometric images; (ii) calculating the local fractal dimension of Gabor feature under different orientations and scales using fractal auto-correlation algorithm; and (iii) linking the local fractal dimension of Gabor feature under different orientations and scales into a big vector for matching. Experiments and analyses show our proposed scheme is an efficient biometric feature extraction approach. 展开更多
关键词 fractal auto-correlation fractal dimension Gabor filter biometric recognition
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基于spatial PCA降维的卵巢癌空间转录组数据空间域识别
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作者 刘改琴 杨琪 +5 位作者 田雅昕 贾聪聪 房瑞玲 余红梅 张岩波 曹红艳 《中国卫生统计》 北大核心 2025年第6期843-848,855,共7页
目的探讨空间主成分分析(spatial principal component analysis,spatial PCA)在卵巢癌(ovarian cancer,OC)空间转录组学数据空间域识别中的应用,识别在基因表达和组织学上空间一致的区域,检测不同组织区域基因表达的异质性。方法采用sp... 目的探讨空间主成分分析(spatial principal component analysis,spatial PCA)在卵巢癌(ovarian cancer,OC)空间转录组学数据空间域识别中的应用,识别在基因表达和组织学上空间一致的区域,检测不同组织区域基因表达的异质性。方法采用spatial PCA对卵巢癌10x空间转录组学数据进行空间域识别,并与BASS、STAGATE两种空间域识别方法作比较;绘制RGB图可视化降维后的低维成分;筛选空间可变基因(spatially variable genes,SVGs),进行差异表达(differential expression,DE)分析和功能富集分析。结果spatial PCA识别出8个卵巢癌空间域,RGB图像显示空间域识别结果对数据缩放稳定,且相邻区域颜色相似;检测到每个空间域SVGs数量范围为112~2928个,筛选出差异具有统计学意义的1个GO生物学过程和3个蛋白质复合物。结论spatialPCA可以更准确地识别空间域聚类,筛选出的潜在生物标志物及通路,为卵巢癌的异质性研究及针对性治疗提供了依据。 展开更多
关键词 spatial PCA降维 空间转录组 空间域识别 卵巢癌
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SPEECH ENHANCEMENT BASED ON DYNAMIC NOISE ESTIMATION WITHIN AUTO-CORRELATION DOMAIN
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作者 WU Ya-dong(吴亚栋) +1 位作者 WU Xu-hui(吴旭辉) 《Journal of Shanghai Jiaotong university(Science)》 EI 2002年第2期211-214,共4页
Most noise suppression algorithms of single channel use the mean of noisy segments to estimate the characteristics of noise spectrum, ignoring the estimation of noise in speech segments. Therefore, when the energy lev... Most noise suppression algorithms of single channel use the mean of noisy segments to estimate the characteristics of noise spectrum, ignoring the estimation of noise in speech segments. Therefore, when the energy level of noise varies with the time, the performance of removing noise will be degraded. To solve this problem, a speech enhancement approach based on dynamic noise estimation within correlation domain was proposed. This method exploits the characteristics that noise energy mainly concentrates on 0 th order correlation coefficients, signal is auto correlated but signal and noise, noise and noise are uncorrelated, then estimates and decomposes the noise, thus helps to solve the above mentioned problem. The results of recognition experiments on speech signals of 15 Chinese cities’ names corrupted by noise of exhibition hall shows, this approach is better than SS (Spectral Subtraction) method, adapts better to the variances of energy levels of speech signal corrupted by noise, has some practicability to improve the robustness of recognition systems under noisy environment. 展开更多
关键词 SPEECH enhancement noise SUPPRESSION auto-correlation DOMAIN SPECTRAL SUBTRACTION
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Chrestenson Spectrum and Auto-Correlation Function of Inverse Permutations of Quick Trickle Permutations
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作者 WANG Jue LI Zhengchao ZHAO Yaqun 《Wuhan University Journal of Natural Sciences》 CAS 2008年第5期587-590,共4页
In this paper, a sufficient and necessary condition of quick trickle permutations is given from the point of inverse permutations. The bridge is built between quick trickle permutations and m-value logic functions. By... In this paper, a sufficient and necessary condition of quick trickle permutations is given from the point of inverse permutations. The bridge is built between quick trickle permutations and m-value logic functions. By the methods of the Chrestenson spectrum of m-value logic functions and the auto-correlation function of m-value logic functions to investigate the Chrestenson spectral characteristics and the auto-correlation function charac- teristics of inverse permutations of quick trickle permutations, a determinant arithmetic of quick trickle permutations is given. Using the results, it becomes easy to judge that a permutation is a quick trickle permutation or not by using computer. This gives a new pathway to study constructions and enumerations of quick trickle permutations. 展开更多
关键词 quick trickle permutation chrestenson spectrum auto-correlation function m-value logic function
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Cyclic-Auto-Correlation Based Timing Estimation Algorithm for Time-Frequency Overlapping Multi-Carrier Signals
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作者 Xing Zhang Jian-Hao Hu 《Journal of Electronic Science and Technology》 CAS CSCD 2020年第3期223-233,共11页
In recent years,the time-frequency overlapping multi-carrier signal has been a novel and valuable topic in blind signal processing,especially in the non-cooperative receiving field.But there is little related research... In recent years,the time-frequency overlapping multi-carrier signal has been a novel and valuable topic in blind signal processing,especially in the non-cooperative receiving field.But there is little related research in public published papers.This paper proposes two timing estimation algorithms,which are non-data-aided and based on the cyclic auto-correlation function.In order to evaluate the performance of the proposed algorithms,the theoretical bound of the timing estimation is derived.According to the analyses and simulation results,the effectiveness of the proposed algorithms has been demonstrated.It shows that MethodⅠhas better performance than MethodⅡ.However,MethodⅡdoes not need prior information,so it has a wider range of applications. 展开更多
关键词 Cyclic auto-correlation orthogonal frequency division multiplexing(OFDM) time-frequency overlapping signal timing estimation
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Monitoring Bridge Deformation Using Auto-Correlation Adjustment Technique for Total Station Observations
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作者 Ashraf Abd El-Wanis Beshr Mosbeh R. Kaloop 《Positioning》 2013年第1期1-7,共7页
Bridges are omnipresent in every society and they affect its human, social, ecological, economical and cultural aspects. This is why a durable and safe usage of bridges is an imperative goal of structural management. ... Bridges are omnipresent in every society and they affect its human, social, ecological, economical and cultural aspects. This is why a durable and safe usage of bridges is an imperative goal of structural management. Measurement and monitoring have an essential role in structural management. The benefits of the information obtained by monitoring are apparent in several domains. In deformation analysis, the functional relationship between the acting forces and the resulting deformations should be established. If time depending observations are given, a regression could be used as a functional model. In case of stochastic model uncorrelated observations with identical variance are assumed. Due to the high sampling rate, a small time difference arises between two observations. Thus the assumed stochastic model is not suitable. The calculation has to be effected by means of auto-correlated observations. This paper investigates an integrated monitoring system for the estimation of the deformation (i.e., static, quasi-static) behavior of bridges from total station observations and studies the effect of autocorrelation technique on the accuracy of the estimated parameters and variances. The results have shown that autocorrelation technique is reduced the standard deviation of X&Y-direction about 6.7% to 29.4% and 6.5% to 15.5% of the original value, respectively, but the situation was differ in Z direction;the standard deviation in vertical component Z was increased. 展开更多
关键词 MONITORING TOTAL STATION auto-correlation BRIDGES DEFORMATION
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Spatial Evolution Characteristics and Influencing Factors of Urban Green Innovation in China 被引量:3
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作者 PENG Wenbin SU Xinyi TANG Yueliang 《Chinese Geographical Science》 2025年第2期234-249,共16页
Cities are important carriers of green innovation.The foundation for accelerating China's ecological civilization construction and fostering regionally coordinated and sustainable development is quantitative analy... Cities are important carriers of green innovation.The foundation for accelerating China's ecological civilization construction and fostering regionally coordinated and sustainable development is quantitative analysis of the spatial evolution pattern and influencing factors of urban green innovation,as well as revealing the development differences between regions.This study's research object includes 284 Chinese cities that are at the prefecture level or above,excluding Xizang,Hong Kong,Macao,and Taiwan of China due to incomplete data.The spatial evolution characteristics of urban green innovation in China between 2005 and 2021 are comprehensively described using the gravity center model and boxplot analysis.The factors that affect urban green innovation are examined using the spatial Durbin model(SDM).The findings indicate that:1)over the period of the study,the gravity center of urban green innovation in China has always been distributed in the Henan-Anhui border region,showing a migration characteristic of‘initially shifting northeast,subsequently southeast',and the migration speed has gradually increased.2)Although there are also noticeable disparities in east-west,the north-south gap is the main cause of the shift in China's urban green innovation gravity center.The primary areas of urban green innovation in China are the cities with green innovation levels higher than the median.3)The main influencing factor of urban green innovation is the industrial structure level.The effect of the financial development level,the government intervention level,and the openness to the outside world degree on urban green innovation is weakened in turn.The environmental regulation degree is not truly influencing urban green innovation.The impact of various factors on green innovation across cities of different sizes,exhibiting heterogeneity.This study is conducive to broadening the academic community's comprehension of the spatial evolution characteristics of urban green innovation and offering a theoretical framework for developing policies for the all-encompassing green transformation of social and economic growth. 展开更多
关键词 urban green innovation spatial evolution spatial Durbin model China
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Fingerspelling Recognition by Hand Shape Using Higher-Order Local Auto-Correlation Features
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作者 Yoshihiro Mitani Takuya Kanemura +1 位作者 Yusuke Fujita Yoshihiko Hamamoto 《Computer Technology and Application》 2012年第12期784-788,共5页
The fingerspelling recognition by hand shape is an important step for developing a human-computer interaction system. A method of fingerspelling recognition by hand shape using HLAC (higher-order local auto-correlat... The fingerspelling recognition by hand shape is an important step for developing a human-computer interaction system. A method of fingerspelling recognition by hand shape using HLAC (higher-order local auto-correlation) features is proposed. Furthermore, in order to use HLAC features more effectively, the use of image processing techniques: reducing an image resolution, dividing an image, and image pre-processing techniques, is also proposed. The experimental results show that the proposed method is promising. 展开更多
关键词 Image processing techniques fingerspelling recognition HLAC (higher-order local auto-correlation features.
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Spatial Grasp Model for Distributed Management and Its Comparison With Traditional Algorithms 被引量:1
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作者 Peter Simon Sapaty 《International Relations and Diplomacy》 2025年第3期164-179,共16页
The word“spatial”fundamentally relates to human existence,evolution,and activity in terrestrial and even celestial spaces.After reviewing the spatial features of many areas,the paper describes basics of high level m... The word“spatial”fundamentally relates to human existence,evolution,and activity in terrestrial and even celestial spaces.After reviewing the spatial features of many areas,the paper describes basics of high level model and technology called Spatial Grasp for dealing with large distributed systems,which can provide spatial vision,awareness,management,control,and even consciousness.The technology description includes its key Spatial Grasp Language(SGL),self-evolution of recursive SGL scenarios,and implementation of SGL interpreter converting distributed networked systems into powerful spatial engines.Examples of typical spatial scenarios in SGL include finding shortest path tree and shortest path between network nodes,collecting proper information throughout the whole world,elimination of multiple targets by intelligent teams of chasers,and withstanding cyber attacks in distributed networked systems.Also this paper compares Spatial Grasp model with traditional algorithms,confirming universality of the former for any spatial systems,while the latter just tools for concrete applications. 展开更多
关键词 spatial awareness spatial control spatial consciousness spatial Grasp Technology spatial Grasp Language spatial scenarios cyber attacks distributed algorithms mobile agents
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Phase distortion correction of fringe patterns in spaceborne Doppler asymmetric spatial heterodyne interferometry 被引量:1
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作者 PEI Hui-yi JIANG Lun +4 位作者 WANG Jin-jiang CUI Yong FANG Yuan-xiang ZHANG Jia-ming CHEN Ci 《中国光学(中英文)》 北大核心 2025年第2期382-392,共11页
As an advanced device for observing atmospheric winds,the spaceborne Doppler Asymmetric Spatial Heterodyne(DASH)interferometer also encounters challenges associated with phase distortion,par-ticularly in limb sounding... As an advanced device for observing atmospheric winds,the spaceborne Doppler Asymmetric Spatial Heterodyne(DASH)interferometer also encounters challenges associated with phase distortion,par-ticularly in limb sounding scenarios.This paper discusses interferogram modeling and phase distortion cor-rection techniques for spaceborne DASH interferometers.The modeling of phase distortion interferograms with and without Doppler shift for limb observation was conducted,and the effectiveness of the analytical expression was verified through numerical simulation.The simulation results indicate that errors propagate layer by layer while using the onion-peeling inversion algorithm to handle phase-distorted interferograms.In contrast,the phase distortion correction algorithm can achieve effective correction.This phase correction method can be successfully applied to correct phase distortions in the interferograms of the spaceborne DASH interferometer,providing a feasible solution to enhance its measurement accuracy. 展开更多
关键词 Doppler asymmetric spatial heterodyne spectroscopy phase distortion phase inversion atmospheric wind measurement
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Spatial differentiation of carbon emissions from energy consumption based on machine learning algorithm:A case study during 2015–2020 in Shaanxi,China 被引量:2
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作者 Hongye Cao Ling Han +1 位作者 Ming Liu Liangzhi Li 《Journal of Environmental Sciences》 2025年第3期358-373,共16页
Carbon emissions resulting from energy consumption have become a pressing issue for governments worldwide.Accurate estimation of carbon emissions using satellite remote sensing data has become a crucial research probl... Carbon emissions resulting from energy consumption have become a pressing issue for governments worldwide.Accurate estimation of carbon emissions using satellite remote sensing data has become a crucial research problem.Previous studies relied on statistical regression models that failed to capture the complex nonlinear relationships between carbon emissions and characteristic variables.In this study,we propose a machine learning algorithm for carbon emissions,a Bayesian optimized XGboost regression model,using multi-year energy carbon emission data and nighttime lights(NTL)remote sensing data from Shaanxi Province,China.Our results demonstrate that the XGboost algorithm outperforms linear regression and four other machine learning models,with an R^(2)of 0.906 and RMSE of 5.687.We observe an annual increase in carbon emissions,with high-emission counties primarily concentrated in northern and central Shaanxi Province,displaying a shift from discrete,sporadic points to contiguous,extended spatial distribution.Spatial autocorrelation clustering reveals predominantly high-high and low-low clustering patterns,with economically developed counties showing high-emission clustering and economically relatively backward counties displaying low-emission clustering.Our findings show that the use of NTL data and the XGboost algorithm can estimate and predict carbon emissionsmore accurately and provide a complementary reference for satellite remote sensing image data to serve carbon emission monitoring and assessment.This research provides an important theoretical basis for formulating practical carbon emission reduction policies and contributes to the development of techniques for accurate carbon emission estimation using remote sensing data. 展开更多
关键词 Machine learning Energy carbon emissions Nighttime light spatial distribution
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Customizing solid electrolyte interphase with bilayer spatial structure to mitigate swelling towards long-term life lithium battery 被引量:1
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作者 Dongni Zhao Hongcheng Liang +6 位作者 Shumin Wu Yin Quan Xinyi Hu Jingni Li Peng Wang Xiaoling Cui Shiyou Li 《Journal of Energy Chemistry》 2025年第6期702-712,I0015,共12页
The swelling behavior and stability in solid electrolyte interphase(SEI)have been proved to determine the battery cycle life.A high swollen,unstable SEI shows a high permeability to electrolyte,which results in the ra... The swelling behavior and stability in solid electrolyte interphase(SEI)have been proved to determine the battery cycle life.A high swollen,unstable SEI shows a high permeability to electrolyte,which results in the rapid battery performance degradation.Here,we customize two SEIs with different spatial structures(bilayer and mosaic)by simply regulating the proportion of additive fluoroethylene carbonate.Surprisingly,due to the uniform distribution of dense inorganic nano-crystals in the inner,the bilayer SEI exhibits low-swelling and excellent mechanical properties,so the undesirable side reactions of the electrolyte are effectively suppressed.In addition,we put forward the growth rate of swelling ratio(GSR)as a key indicator to reveal the swelling change in SEI.The GSR of bilayer SEI merely increases from1.73 to 3.16 after the 300th cycle,which enables the corresponding graphite‖Li battery to achieve longer cycle stability.The capacity retention is improved by 47.5% after 300 cycles at 0.5 C.The correlation among SEI spatial structure,swelling behavior,and battery performance provides a new direction for electrolyte optimization and interphase structure design of high energy density batteries. 展开更多
关键词 Lithium battery SEI film spatial structure Swelling behavior Cycle-stable
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Single-cell and spatial omics:exploring hypothalamic heterogeneity
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作者 Muhammad Junaid Eun Jeong Lee Su Bin Lim 《Neural Regeneration Research》 SCIE CAS 2025年第6期1525-1540,共16页
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technolo... Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements. 展开更多
关键词 cellular diversity HYPOTHALAMUS multi-omics single-cell transcriptomics spatial transcriptomics
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Concentrations, spatial distribution, and human exposure of synthetic phenolic antioxidants in indoor dust from ten provinces in China 被引量:1
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作者 Xueyu Weng Wanyi Wang +2 位作者 Qingqing Zhu Chunyang Liao Guibin Jiang 《Journal of Environmental Sciences》 2025年第6期584-593,共10页
Synthetic phenolic antioxidants(SPAs)are widely used in diverse industries due to their exceptional antioxidant characteristics.However,human exposure to SPAs may cause health problems.In this study,226 dust samples w... Synthetic phenolic antioxidants(SPAs)are widely used in diverse industries due to their exceptional antioxidant characteristics.However,human exposure to SPAs may cause health problems.In this study,226 dust samples were collected from 10 provinces in China,and six SPAs(three parent SPAs and their three transformation products)were analyzed.The concentrations of6SPAs(the sum of six target compounds)ranged from 15.4 to 3210 ng/g(geometric mean(GM):169 ng/g).The highest concentration of6SPAswas found in Sichuan Province(GM:349 ng/g),which was approximately 4 times higher than that in Hubei Province(81.6 ng/g)(p<0.05).The concentrations of butylated hydroxytoluene(BHT),2,2'-methylene bis(4-methyl-6–tert-butylphenol)(AO2246),2,6-di–tert–butyl–1,4-benzoquinone(BHT-Q),2,6-di–tert–butyl–4-(hydroxymethyl)phenol(BHT-OH),and ∑_(p)-SPAs were substantially higher in dust from urban areas than rural areas(p<0.05).AO2246 concentration in dust from homes(GM:0.400 ng/g)was about 4 times higher than that in workplaces(0.116 ng/g)(p<0.01).Significantly higherp-SPAs concentrations were found in dust from homes(GM:17.5 ng/g)than workplaces(11.4 ng/g)(p<0.01).The estimated daily intakes(EDIs)of ∑_(6)SPAs exposed through dust ingestion were 0.582,0.342,0.197,0.076,and 0.080 ng/kg bw/day in different age groups,and exposed through dermal contact was 0.358,0.252,0.174,0.167,and 0.177 ng/kg bw/day.EDIs showed that the exposure risks of SPAs decreased with age.This is the first work to determine SPAs in dust from10 provinces in China and investigate the spatial distribution of SPAs in those regions. 展开更多
关键词 Indoor dust Synthetic phenolic antioxidants spatial distribution Composition profile Human exposure
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Impact of coking plant to heavy metal characteristics in groundwater of surrounding areas:Spatial distribution,source apportionment and risk assessments 被引量:1
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作者 Congqing Wang Wanjun Wang +5 位作者 ChaoWang Shixing Ren Yingjun Wu Meicheng Wen Guiying Li Taicheng An 《Journal of Environmental Sciences》 2025年第3期688-698,共11页
Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution character... Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution characteristics and health risks of HMs in groundwater nearby a typical coking plant.Nine HMs including Fe,Zn,Mo,As,Cu,Ni,Cr,Pb and Cd were analyzed.The average concentration of total HMswas higher in the nearby area(244.27μg/L)than that of remote area away the coking plant(89.15μg/L).The spatial distribution of pollution indices including heavy metal pollution index(HPI),Nemerow index(NI)and contamination degree(CD),all demonstrated higher values at the nearby residential areas,suggesting coking activity could significantly impact the HMs distribution characteristics.Four sources of HMs were identified by Positive Matrix Factorization(PMF)model,which indicated coal washing and coking emission were the dominant sources,accounted for 40.4%,and 31.0%,respectively.Oral ingestionwas found to be the dominant exposure pathway with higher exposure dose to children than adults.Hazard quotient(HQ)values were below 1.0,suggesting negligible non-carcinogenic health risks,while potential carcinogenic risks were from Pb and Ni with cancer risk(CR)values>10−6.Monte Carlo simulation matched well with the calculated results with HMs concentrations to be the most sensitive parameters.This study provides insights into understanding how the industrial coking activities can impact the HMs pollution characteristics in groundwater,thus facilitating the implement of HMs regulation in coking industries. 展开更多
关键词 Coking industry Heavy metal GROUNDWATER spatial distribution Source apportionment Monte Carlo simulation
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A Framework for Analyzing Spatial Heterogeneity and Influencing Factors of Campus Green Space in Xi’an,China 被引量:2
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作者 ZANG Zexuan ZHANG Liwei +5 位作者 LIU Yu YANG Xiping WANG Zhuangzhuang JIAO Lei WANG Hao LUO Ying 《Chinese Geographical Science》 2025年第4期786-801,共16页
Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different educ... Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different education stages is still limited.A new framework was established to evaluate the spatial heterogeneity and its influencing factors across all education stages(kindergarten,primary school,middle school,college)in 1100 schools at the urban scale of Xi’an,China.The research results show that:1)CGS is lower in the Baqiao district and higher in the Yanta and Xincheng districts of Xi’an City.‘Green wealthy schools are mainly concentrated in the Weiyang,Chang’an and Yanta districts.2)CGS of these schools in descending order is college(31.40%)>kindergarten(18.32%)>middle school(13.56%)>primary school(10.70%).3)Colleges have the most recreation sites(n(number)=2),the best education levels(11.93 yr),and the lowest housing prices(1.18×10^(4) yuan(RMB)/m^(2));middle schools have the highest public expenditures(3.97×10^(9) yuan/yr);primary schools have the highest CGS accessibility(travel time gap(TTG)=31.33).4)Multiscale Geographically Weighted Regression model and Spearman’s test prove that recreation sites have a significant positive impact on college green spaces(0.28–0.35),and education level has a significant positive impact on kindergarten green spaces(0.16–0.24).This research framework provides important insights for the assessment of school greening initiatives aimed at fostering healthier learning environments for future generations. 展开更多
关键词 campus green space(CGS) spatial heterogeneity multiscale geographically weighted regression Xi’an China
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Spatial and Temporal Evolution of Lithospheric Mantle beneath the Eastern North China Craton:Constraints from Mineral Chemistry of Peridotite Xenoliths from the Miocene Qingyuan Basalts and a Regional Synthesis 被引量:1
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作者 Jian-Fang Guo Qiang Ma +1 位作者 Jian-Ping Zheng Yu-Ping Su 《Journal of Earth Science》 2025年第2期474-484,共11页
Mineralogical data are presented for the peridotite xenoliths from Miocene(~19 Ma)Qingyuan basalts in the eastern North China Craton(NCC),with the aim of constraining on property of the sub-continental lithospheric ma... Mineralogical data are presented for the peridotite xenoliths from Miocene(~19 Ma)Qingyuan basalts in the eastern North China Craton(NCC),with the aim of constraining on property of the sub-continental lithospheric mantle(SCLM)beneath the northern Tan-Lu fault zone(TLFZ)during the Cenozoic.The Qingyuan peridotites are dominated by spinel lherzolites with moderate-Mg^(#)olivines(89.4 to 91.2),suggesting that the regional SCLM is mainly transitional and fertile.Light rare earth element(LREE)-depleted,slightly depleted and enriched clinopyroxenes(Cpx)are identified in different peridotites.Chemical compositions of the LREE-enriched Cpx and the presence of phlogopite suggest that the Qingyuan SCLM has experienced silicate-related metasomatism.The synthesis of available mineral chemical data of the mantle xenoliths across the NCC confirms the SCLM beneath the NCC is highly heterogeneous in time and space.The Mesozoic–Cenozoic SCLM beneath the TLFZ and neighboring regions are more fertile and thinner than that beneath the region away from the fault zone.The fertile and refractory peridotite xenoliths experienced varying degrees of silicate and carbonatite metasomatism,respectively.The spatial-temporal lithospheric mantle heterogeneity in composition,age and thickness suggest that the trans-lithosphere fault zone played an important role in heterogeneous replacement of refractory cratonic lithospheric mantle. 展开更多
关键词 lithospheric mantle peridotite xenoliths temporal and spatial variations Tan-Lu fault zone North China craton PETROLOGY GEOCHEMISTRY
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Spatial metabolomics combined with machine learning in colon cancer diagnosis research 被引量:1
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作者 Ling Weng Huanhuan Wang +5 位作者 Chunxiang Zhai Qi Wang Yanyan Guo Ziyi Zhong Chenying Ma Jing Wang 《Journal of Pharmaceutical Analysis》 2025年第8期1937-1938,共2页
Colon cancer is one of the malignant tumors with high morbidity and mortality worldwide[1],and its early diagnosis is crucial for improving patient survival.However,due to the lack of obvious early symptoms of colon c... Colon cancer is one of the malignant tumors with high morbidity and mortality worldwide[1],and its early diagnosis is crucial for improving patient survival.However,due to the lack of obvious early symptoms of colon cancer,many patients are in the middle to late stage when diagnosed and miss the best time for treatment.Therefore,developing an efficient and accurate diagnostic method for colon cancer is of great clinical significance and scientific value.Currently,the current colon cancer biomarkers carcinoembryonic antigen and carbohydrate antigen 19-9[2]have low sensitivity and specificity,the emerging markers circulating tumor DNA(ctDNA)and miRNA face high cost and standardization challenges,and the existing methods lack spatial resolution,prompting the incorporation of spatial metabolomics technologies to enhance diagnostic capabilities. 展开更多
关键词 machine learning colon cancer diagnosis miRNA colon cancer spatial metabolomics malignant tumors circulating tumor DNA biomarkers
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