Hepatic encephalopathy(HE)is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes,particularly in cases of sev...Hepatic encephalopathy(HE)is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes,particularly in cases of severe liver disease or cirrhosis.Previous studies have reported spatially distributed structural and functional abnormalities related to HE,but the exact relationship between the structural and functional alterations with respect to disease progression remains unclear.In this study,we performed surface-based cortical thickness comparisons and functional connectivity(FC)analyses between three cross-sectional groups:healthy controls(HC,N¼51),patients with minimal hepatic en-cephalopathy(MHE,N¼50),patients with overt hepatic encephalopathy(OHE,N¼51).In addition to the distributed cortical thinning that is extensively thought to be associated with cognitive decline in HE,we found significant cortical thickening in the left para-hippocampal gyrus cortex in the OHE group(p<0.001,p¼0.009)as compared to the HC and MHE group respectively,which is further corroborated by the significant correlation between the cortical thickness and digit symbol test(DST)scores.Furthermore,the decreased FC between the right postcentral gyrus and several sensory regions(bilateral somatosensory and visual cortices)was found to be significant in MHE patients as compared to the HC group.Our results revealed cross-sectional structural and functional variations concerning disease progression across different subsystems(e.g.,visual,motor and sensory),providing evidence that can potentially explain the mechanisms underlying the sensorimotor and cognitive deficits related to HE.展开更多
Background:Brain structural alterations of the striatum have been frequently observed in internet gaming disorder(IGD);however,the replicability of the results and the associations with social-affective dysregulations...Background:Brain structural alterations of the striatum have been frequently observed in internet gaming disorder(IGD);however,the replicability of the results and the associations with social-affective dysregulations such as social anxiety remain to be determined.Methods:The present study combined a dimensional neuroimaging approach with both voxel-wise and data-driven multivariate approaches to(i)replicate our previous results on a negative association between IGD symptom load(assessed by the Internet Gaming Disorder Scale-Short Form)and striatal volume,(ii)extend these findings to female individuals,and(iii)employ multivariate and mediation models to determine common brain structural representations of IGD and social anxiety(assessed by the Liebowitz Social Anxiety Scale).Results:In line with the original study,the voxel-wise analyses revealed a negative association between IGD and volumes of the bilateral caudate.Going beyond the earlier study investigating only male participants,the present study demonstrates that the association in the right caudate was comparable in both the male and the female subsamples.Further examination using themultivariate approach revealed regionally different associations between IGD and social anxiety with striatal density representations in the dorsal striatum(caudate)and ventral striatum(nucleus accumbens).Higher levels of IGD were associated with higher social anxiety and the association was critically mediated by the multivariate neurostructural density variations of the striatum.Conclusions:Altered striatal volumes may represent a replicable and generalizable marker of IGD symptoms.However,exploratory multivariate analyses revealed more complex and regional specific associations between striatal density and IGD as well as social anxiety symptoms.Variations in both tendencies may share common structural brain representations,which mediate the association between increased IGD and social anxiety.展开更多
基金the National Natural Scientific Foundation of China(82071994,82202249)Tianjin Health High Level Talent Selection and Training Project(TJSQNYXXR-D2-143)+4 种基金Natural Scientific Foundation of Tianjin(21CYBJC01580,21JCQNJC01480)Tianjin Health Research Project(TJWJ2023QN031,TJWJ2023XK012)Tianjin Health Science and technology project(Specific projects of key disciplines)(TJWJ2022XK019)Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-041A)Tianjin Natural Science Foundation(21JCYBJC01290).
文摘Hepatic encephalopathy(HE)is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes,particularly in cases of severe liver disease or cirrhosis.Previous studies have reported spatially distributed structural and functional abnormalities related to HE,but the exact relationship between the structural and functional alterations with respect to disease progression remains unclear.In this study,we performed surface-based cortical thickness comparisons and functional connectivity(FC)analyses between three cross-sectional groups:healthy controls(HC,N¼51),patients with minimal hepatic en-cephalopathy(MHE,N¼50),patients with overt hepatic encephalopathy(OHE,N¼51).In addition to the distributed cortical thinning that is extensively thought to be associated with cognitive decline in HE,we found significant cortical thickening in the left para-hippocampal gyrus cortex in the OHE group(p<0.001,p¼0.009)as compared to the HC and MHE group respectively,which is further corroborated by the significant correlation between the cortical thickness and digit symbol test(DST)scores.Furthermore,the decreased FC between the right postcentral gyrus and several sensory regions(bilateral somatosensory and visual cortices)was found to be significant in MHE patients as compared to the HC group.Our results revealed cross-sectional structural and functional variations concerning disease progression across different subsystems(e.g.,visual,motor and sensory),providing evidence that can potentially explain the mechanisms underlying the sensorimotor and cognitive deficits related to HE.
基金This work was supported by the National Natural Science Foundation of China(NSFC,no.8221101268,no.82271583,no.32250610208)the National Key Research and Development Program of China(grant no.2018YFA0701400).
文摘Background:Brain structural alterations of the striatum have been frequently observed in internet gaming disorder(IGD);however,the replicability of the results and the associations with social-affective dysregulations such as social anxiety remain to be determined.Methods:The present study combined a dimensional neuroimaging approach with both voxel-wise and data-driven multivariate approaches to(i)replicate our previous results on a negative association between IGD symptom load(assessed by the Internet Gaming Disorder Scale-Short Form)and striatal volume,(ii)extend these findings to female individuals,and(iii)employ multivariate and mediation models to determine common brain structural representations of IGD and social anxiety(assessed by the Liebowitz Social Anxiety Scale).Results:In line with the original study,the voxel-wise analyses revealed a negative association between IGD and volumes of the bilateral caudate.Going beyond the earlier study investigating only male participants,the present study demonstrates that the association in the right caudate was comparable in both the male and the female subsamples.Further examination using themultivariate approach revealed regionally different associations between IGD and social anxiety with striatal density representations in the dorsal striatum(caudate)and ventral striatum(nucleus accumbens).Higher levels of IGD were associated with higher social anxiety and the association was critically mediated by the multivariate neurostructural density variations of the striatum.Conclusions:Altered striatal volumes may represent a replicable and generalizable marker of IGD symptoms.However,exploratory multivariate analyses revealed more complex and regional specific associations between striatal density and IGD as well as social anxiety symptoms.Variations in both tendencies may share common structural brain representations,which mediate the association between increased IGD and social anxiety.
