目的探讨比较肝脏局灶性病变Sonazoid超声造影(Sonazoid contrast-enhanced ultrasound,SE-CEUS)增强模式及造影定量参数的区别。方法选取2022年1~9月笔者医院诊治的56例肝脏局灶性病变患者,对其行SE-CEUS检查,根据病理或结合增强磁共...目的探讨比较肝脏局灶性病变Sonazoid超声造影(Sonazoid contrast-enhanced ultrasound,SE-CEUS)增强模式及造影定量参数的区别。方法选取2022年1~9月笔者医院诊治的56例肝脏局灶性病变患者,对其行SE-CEUS检查,根据病理或结合增强磁共振及增强CT检查结果分为恶性组和良性组,对比两组间超声造影特征及超声造影定量参数。结果恶性组病灶增强模式以“快进快出”为主,库普弗期均有不同程度的廓清。良性组增强模式以“同进同出”为主,绝大多数病灶库普弗期未见廓清。恶性组较良性组到达峰值的时间点(time to peak,TTP)、上升时间(rise time,RT)均低(P<0.05),两组间开始出现的时间点(arrival time,AT)、峰值强度(perk in tensity,PI)、曲线下面积(area under curve,AUC)差异无统计学意义。恶性组病灶与周边实质比较,AT、TTP较短,PI、AUC较大(P均<0.05)。结论SE-CEUS在肝脏局灶性病变血管相的表现与既往Sonovue超声造影表现一致,特有的库普弗期可以帮助医生做出诊断。对于增强不典型的病灶还可参考超声造影定量参数进行判断。展开更多
AIM: To find occult metastases during hepatectomy in patients with colorectal cancer liver metastases (CRCLM), contrast-enhanced intraoperative ultrasonography (CE-IOUS) was performed using a new microbubble agent, so...AIM: To find occult metastases during hepatectomy in patients with colorectal cancer liver metastases (CRCLM), contrast-enhanced intraoperative ultrasonography (CE-IOUS) was performed using a new microbubble agent, sonazoid, which provides a parenchyma-specific contrast image based on its accumulation in the Kupffer cells. METHODS: Eight patients with CRCLM underwent CE- IOUS using sonazoid before hepatectomy. The liver was investigated during a late Kupffer-phase imaging, which is a valuable characteristic of sonazoid. RESULTS: CE-IOUS using sonazoid provided the early vascular- and sinusoidal-phase images for 10 min followed by the late Kupffer-phase image up to 30 min after the injection of sonazoid. IOUS did not provide new findings of metastatic lesion in the 8 patients. However, during the late Kupffer-phase image of sonazoid, a metastatic lesion was newly found in two of the 8 patients. These newly detected lesions were removed by an additional hepatectomy and histopathologically diagnosed as a metastasis. CONCLUSION: CE-IOUS using sonazoid can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively.展开更多
文摘目的探讨比较肝脏局灶性病变Sonazoid超声造影(Sonazoid contrast-enhanced ultrasound,SE-CEUS)增强模式及造影定量参数的区别。方法选取2022年1~9月笔者医院诊治的56例肝脏局灶性病变患者,对其行SE-CEUS检查,根据病理或结合增强磁共振及增强CT检查结果分为恶性组和良性组,对比两组间超声造影特征及超声造影定量参数。结果恶性组病灶增强模式以“快进快出”为主,库普弗期均有不同程度的廓清。良性组增强模式以“同进同出”为主,绝大多数病灶库普弗期未见廓清。恶性组较良性组到达峰值的时间点(time to peak,TTP)、上升时间(rise time,RT)均低(P<0.05),两组间开始出现的时间点(arrival time,AT)、峰值强度(perk in tensity,PI)、曲线下面积(area under curve,AUC)差异无统计学意义。恶性组病灶与周边实质比较,AT、TTP较短,PI、AUC较大(P均<0.05)。结论SE-CEUS在肝脏局灶性病变血管相的表现与既往Sonovue超声造影表现一致,特有的库普弗期可以帮助医生做出诊断。对于增强不典型的病灶还可参考超声造影定量参数进行判断。
文摘AIM: To find occult metastases during hepatectomy in patients with colorectal cancer liver metastases (CRCLM), contrast-enhanced intraoperative ultrasonography (CE-IOUS) was performed using a new microbubble agent, sonazoid, which provides a parenchyma-specific contrast image based on its accumulation in the Kupffer cells. METHODS: Eight patients with CRCLM underwent CE- IOUS using sonazoid before hepatectomy. The liver was investigated during a late Kupffer-phase imaging, which is a valuable characteristic of sonazoid. RESULTS: CE-IOUS using sonazoid provided the early vascular- and sinusoidal-phase images for 10 min followed by the late Kupffer-phase image up to 30 min after the injection of sonazoid. IOUS did not provide new findings of metastatic lesion in the 8 patients. However, during the late Kupffer-phase image of sonazoid, a metastatic lesion was newly found in two of the 8 patients. These newly detected lesions were removed by an additional hepatectomy and histopathologically diagnosed as a metastasis. CONCLUSION: CE-IOUS using sonazoid can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively.
