Objective:To analyze the effect of solution-focused approach on advanced schistosomiasis(AS).Methods:10 cases of patients with AS that were treated with a solution-focused approach were included in our study.The indic...Objective:To analyze the effect of solution-focused approach on advanced schistosomiasis(AS).Methods:10 cases of patients with AS that were treated with a solution-focused approach were included in our study.The indicators before and after the intervention were measured(knowledge mastery,prevention and treatment compliance,personal behavior,self-care ability,management satisfaction,complication rate).Results:After analyzing pre-and post-intervention indicators,statistical significance was found(P<0.05).The intervention received a satisfaction rate of 80.00%,with a complication rate of 10.00%.Conclusion:Using a solution-focused approach for ankylosing spondylitis(AS)patients can enhance their understanding and attitude toward disease prevention and treatment,improve their behaviors and self-care ability,resulting in high satisfaction and reduced complications.展开更多
BACKGROUND Improving mental health is crucial for patients who require wound treatment.AIM To analyze the effects of solution-focused brief therapy(SFBT)combined with vacuum sealing drainage on the psychological healt...BACKGROUND Improving mental health is crucial for patients who require wound treatment.AIM To analyze the effects of solution-focused brief therapy(SFBT)combined with vacuum sealing drainage on the psychological health of patients undergoing wound treatment,providing a basis for selecting wound treatment protocols.METHODS A total of 102 patients undergoing wound treatment were included,with the study period from March 2020 to March 2024.Sex was not a factor,and patients were randomly assigned to two groups of 51 cases each.The control group received negative pressure wound therapy(NPWT),while the experimental group received NPWT plus SFBT.The recovery of wounds,granulation tissue scores,and psychological health levels were compared between the two groups.Statistical analysis was conducted using SPSS Windows software version 26.0 and GraphPad Prism 8.0.RESULTS Post-treatment,the levels of high-sensitivity C-reactive protein,white blood cell count,and lactate dehydrogenase in the experimental group were significantly lower than those in the control group(P<0.05).The two groups had no significant difference in granulation tissue scores(P<0.05).The psychological health level in the experimental group was significantly higher than in the control group(P<0.05).CONCLUSION The combination of SFBT and NPWT accelerates wound healing,promotes granulation tissue growth,and improves psychological well-being,making it a valuable approach for clinical application.展开更多
Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponi...Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponin,and natriuretic peptides play crucial roles in CVD management,yet they are often limited by sensitivity and specificity constraints.This narrative review critically examines the emerging landscape of cardiac biomarkers and advocates for a multiple-marker approach to enhance early detection,prognosis,and risk stratification of CVD.In recent years,several novel biomarkers have shown promise in revolutionizing CVD diagnostics.Gamma-glutamyltransferase,microRNAs,endothelial microparticles,placental growth factor,trimethylamine N-oxide,retinol-binding protein 4,copeptin,heart-type fatty acid-binding protein,galectin-3,growth differentiation factor-15,soluble suppression of tumorigenicity 2,fibroblast growth factor 23,and adrenomedullin have emerged as significant indicators of CV health.These biomarkers provide insights into various pathophysiological processes,such as oxidative stress,endothelial dysfunction,inflammation,metabolic disturbances,and myocardial injury.The integration of these novel biomarkers with traditional ones offers a more comprehensive understanding of CVD mechanisms.This multiple-marker approach can improve diagnostic accuracy,allowing for better risk stratification and more personalized treatment strategies.This review underscores the need for continued research to validate the clinical utility of these biomarkers and their potential incorporation into routine clinical practice.By leveraging the strengths of both traditional and novel biomarkers,precise therapeutic plans can be developed,thereby improving the management and prognosis of patients with CVDs.The ongoing exploration and validation of these biomarkers are crucial for advancing CV care and addressing the limitations of current diagnostic tools.展开更多
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed patho...The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.展开更多
This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal disease...This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.展开更多
Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermato...Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermatology department of a top-three hospital in Jingzhou City from November 2022 to July 2023 were selected and divided into control group and test group with 33 cases in each group by random number table method. The control group received routine health education, and the experimental group received health education based on the HAPA theory. Chronic disease self-efficacy scale, hospital anxiety and depression scale and skin disease quality of life scale were used to evaluate the effect of intervention. Results: After 3 months of intervention, the scores of self-efficacy in experimental group were higher than those in control group (P P Conclusion: Health education based on the theory of HAPA can enhance the self-efficacy of patients with type D personality psoriasis, relieve negative emotions and improve their quality of life.展开更多
BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head cancer.Intra-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of ...BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head cancer.Intra-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic resections.Globally recognized superior mesenteric artery(SMA)first approaches are invariably performed.The mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this study.AIM To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment modalities.METHODS This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and General Surgery of Kathmandu Medical College and Teaching Hospital from January 1,2021 to February 28,2024.Intraop-erative findings and postoperative outcomes were analyzed.RESULTS In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach pancreatoduodenectomy.The mean age was 67.6 years with a male-to-female ratio of 4:5.CL was seen in four patients.With virtue of CL,Clavien-Dindo grade Ⅱ or higher morbidity was observed in four patients.Two patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition requirement.The mean operative time was 330 minutes.Curative resection was achieved in 100%of the patients.The mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,respectively.CONCLUSION Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of CL.After complete curative resection,these were managed with total parenteral nutrition without adversely impacting outcome.展开更多
In response to the common problems in college English writing teaching,such as the separation of learning and application,students’low interest in writing,and difficulties in expression,this paper,based on the theore...In response to the common problems in college English writing teaching,such as the separation of learning and application,students’low interest in writing,and difficulties in expression,this paper,based on the theoretical framework of the production-oriented approach(POA)proposed by Professor Wen Qiufang,designed and implemented a set of IELTS writing teaching plan.This plan takes“motivating,enabling,and assessing”as the core teaching process,and selects typical IELTS argumentative essay topics(such as food diversity)to create real communication scenarios.In the motivating stage,diverse inputs are used to stimulate students’interest and expose their language weaknesses;in the enabling stage,language knowledge,viewpoint generation,and text structure are focused on for targeted input and training;in the assessing stage,a combination of teacher-student cooperation and peer evaluation is adopted to guide students to identify and correct deficiencies in language use.The research results show that the POA model can effectively enhance students’writing interest,active learning awareness,and writing ability,particularly in overcoming vocabulary poverty and material shortages,as well as improving language accuracy and expression richness.This provides an operational theoretical basis and practical path for improving the teaching effect of IELTS writing.展开更多
Background:Dorsal approach is the potentially effective strategy for minimally invasive liver resection.This study aimed to compare the outcomes between robot-assisted and laparoscopic hemihepatectomy through dorsal a...Background:Dorsal approach is the potentially effective strategy for minimally invasive liver resection.This study aimed to compare the outcomes between robot-assisted and laparoscopic hemihepatectomy through dorsal approach.Methods:We compared the patients who underwent robot-assisted hemihepatectomy(Rob-HH)and who had laparoscopic hemihepatectomy(Lap-HH)through dorsal approach between January 2020 and December 2022.A 1:1 propensity score-matching(PSM)analysis was performed to minimize bias and confounding factors.Results:Ninety-six patients were included,41 with Rob-HH and 55 with Lap-HH.Among them,58 underwent left hemihepatectomy(LHH)and 38 underwent right hemihepatectomy(RHH).Compared with LapHH group,patients with Rob-HH had less estimated blood loss(median:100.0 vs.300.0 m L,P=0.016),lower blood transfusion rates(4.9%vs.29.1%,P=0.003)and postoperative complication rates(26.8%vs.54.5%,P=0.016).These significant differences consistently existed after PSM and in the LHH subgroups.Furthermore,robot-assisted LHH was associated with decreased Pringle duration(45 vs.60 min,P=0.047).RHH subgroup analysis showed that compared with Lap-RHH,Rob-RHH was associated with less estimated blood loss(200.0 vs.400.0 m L,P=0.013).No significant differences were found in other perioperative outcomes among pre-and post-PSM cohorts,such as Pringle duration,operative time,and hospital stay.Conclusions:The dorsal approach was a safe and feasible strategy for hemi-hepatectomy with favorable outcomes under robot-assisted system in reducing intraoperative blood loss,transfusion,and postoperative complications.展开更多
Enhancing the mechanical properties is crucial for polyimide films,but the mechanical properties(Young's modulus,tensile strength,and elongation at break)mutually constrain each other,complicating simultaneous enh...Enhancing the mechanical properties is crucial for polyimide films,but the mechanical properties(Young's modulus,tensile strength,and elongation at break)mutually constrain each other,complicating simultaneous enhancement via traditional trial-and-error methods.In this work,we proposed a materials genome approach to design and screen phenylethynyl-terminated polyimides for films with enhanced mechani-cal properties.We first established machine learning models to predict Young's modulus,tensile strength,and elongation at break to explore the chemical space containing thousands of candidate structures.The accuracies of the machine learning models were verified by molecular dynamics simulations on screened polyimides and experimental testing on three representative polyimide films.The performance advantages of the best-selected polyimides were analyzed by comparing well-known polyimides based on molecular dynamics simulations,and the structural rationale was revealed by"gene"analysis and feature importance evaluation.This work provides a cost-effective strategy for designing polyimide films withenhancedmechanical properties.展开更多
In recent years,the production-oriented approach has been applied in the field of teaching Chinese as a foreign language,providing a new perspective for language and cultural instruction.Currently,several issues exist...In recent years,the production-oriented approach has been applied in the field of teaching Chinese as a foreign language,providing a new perspective for language and cultural instruction.Currently,several issues exist in cultural teaching,such as the lack of in-depth cultural input,insufficient training in cross-cultural communication skills,and the over-stylization of cultural teaching in the classroom.The production-oriented approach offers a solution to these challenges.This paper seeks to introduce the production-oriented method into the teaching of Chinese culture as a foreign language,using silk culture as a case study for teaching design.The aim is to implement cultural teaching through a new instructional model and to promote the spread of Chinese silk culture.展开更多
Pelvic fractures are rare but severe injuries that severely affect patients’quality of life.Treatment of these fractures often involves invasive approaches with high risk of injuries to nervous structures,particularl...Pelvic fractures are rare but severe injuries that severely affect patients’quality of life.Treatment of these fractures often involves invasive approaches with high risk of injuries to nervous structures,particularly lumbosacral plexus.The introduction of minimally invasive surgical approaches,such as the lateral rectus approach,not only contributes to preserving lumbar plexus integrity in operated patients but also positively impacts their psychological well-being.Patients treated by surgical reduction of pelvic fractures with lumbosacral plexus injury often experience states of anxiety and depression.The lateral rectus approach is associated with lower levels of anxiety and depression compared to more invasive surgical techniques used for similar fractures.展开更多
This study explores the application of Production-Oriented Approach(POA)in teaching German to nursing students in colleges and universities.Focusing on the requirements of the German B1 exam,the study takes the themat...This study explores the application of Production-Oriented Approach(POA)in teaching German to nursing students in colleges and universities.Focusing on the requirements of the German B1 exam,the study takes the thematic unit of“Movement”as an example,and designs the teaching through the links of“drive-enable-evaluate”.The results show that POA effectively improves students’speaking and writing output,but there are still deficiencies in reading and listening.Accordingly,this study has proposed the strategies of“vocabulary in-depth facilitation”and“accurate matching of listening and writing”to optimize the input materials and skills training,achieve the goal of“learning and using”,and provide a practical path for teaching German for Special Purposes.This provides a practical path for the teaching of German for special purposes.展开更多
This paper focuses on the numerical solution of a tumor growth model under a data-driven approach.Based on the inherent laws of the data and reasonable assumptions,an ordinary differential equation model for tumor gro...This paper focuses on the numerical solution of a tumor growth model under a data-driven approach.Based on the inherent laws of the data and reasonable assumptions,an ordinary differential equation model for tumor growth is established.Nonlinear fitting is employed to obtain the optimal parameter estimation of the mathematical model,and the numerical solution is carried out using the Matlab software.By comparing the clinical data with the simulation results,a good agreement is achieved,which verifies the rationality and feasibility of the model.展开更多
A structured method to generate conformal finite element(FE)mesh for realistic 3D woven textile reinforced composite is proposed.It is based on a voxel structure mesh reconstruction framework and aims to provide accur...A structured method to generate conformal finite element(FE)mesh for realistic 3D woven textile reinforced composite is proposed.It is based on a voxel structure mesh reconstruction framework and aims to provide accurate composite model at yarn level with material properties ready for use in commercial FE software.The textile representative volume element(RVE)is generated at filament level implementing the digital element method.Yarn structure is determined by filament bundle with variant cross-section shapes along its path.Yarn surface is then extracted using the Delaunay triangulation algorithm and a surface mesh is initiated.Then,the mesh domain is defined and constructed by voxel structure.Periodic boundary conditions,inter-yarn,and yarnmatrix interfaces are eliminated by re-mesh and mesh optimization.An element splitting rule is established to split the voxel unit into sub-elements to create smooth interface.A 3D orthogonal weave fabric reinforced composite is generated and simulated under compressive load.The composite structure and damage morphology are in good agreement with those of the experiment.展开更多
Objective:To investigate the therapeutic effect of trans-tarsal sinus approach surgery combined with dalteparin sodium and furosemide in the treatment of heel bone fracture.Methods:A hundred patients with heel bone fr...Objective:To investigate the therapeutic effect of trans-tarsal sinus approach surgery combined with dalteparin sodium and furosemide in the treatment of heel bone fracture.Methods:A hundred patients with heel bone fracture who were hospitalized from August 2023 to January 2025 were selected and randomly divided into two groups of 50 cases each.The control group was operated by purely trans-tarsal sinus approach,and the observation group added dalteparin sodium and furosemide on this basis.Postoperative limb swelling,pain,coagulation and inflammation indexes,fracture healing time,foot function and complications were compared between the two groups.Results:In the observation group,postoperative limb swelling subsided faster,pain score was lower,coagulation and inflammation indexes improved more significantly,fracture healing time was shorter,foot function recovery was better,and complication rate was lower,P<0.05.Conclusion:The treatment of heel fracture by trans-tarsal sinus approach combined with sodium heparin and furosemide can significantly accelerate the patient’s recovery and reduce the occurrence of complications,which has high clinical application value.展开更多
Social development puts forward higher requirements for students’English application ability and cultural literacy.This study proposes an innovative“3+2+1”blended teaching model integrating the production-oriented ...Social development puts forward higher requirements for students’English application ability and cultural literacy.This study proposes an innovative“3+2+1”blended teaching model integrating the production-oriented approach(POA)to address key challenges in college English cultural courses at application-oriented universities.The model combines three phases(pre-class,in-class,and post-class),two dimensions(online resources and offline interaction),and one overarching goal(all-round education).Through experimental implementation at three universities,results demonstrated significant improvements in student satisfaction,autonomous learning engagement,and crosscultural competence.This research provides a replicable template for enhancing both linguistic proficiency and cultural confidence in EFL contexts.展开更多
This study investigated the influence of the production-oriented approach on English speaking anxiety among non-English major college students.A quasi-experimental design was implemented over one semester with two par...This study investigated the influence of the production-oriented approach on English speaking anxiety among non-English major college students.A quasi-experimental design was implemented over one semester with two parallel classes of junior students at a university in northwestern China.Data collected before and after the intervention using a validated Foreign Language Classroom Anxiety Scale indicated that students experiencing POA instruction showed a discernible decrease in overall speaking anxiety,particularly concerning communication apprehension and fear of negative evaluation,relative to peers instructed via the audio-lingual method.Analysis highlighted task-driven learning,scaffolded input facilitation,and formative process evaluation within the POA framework as contributing factors.Findings imply POA represents a potential pedagogical framework for addressing affective challenges in the development of EFL oral skills.展开更多
The theory of new quality productive forces provides a foundational framework for cultivating pre-service English teachers.There is a high degree of consistency between the development of new quality productive forces...The theory of new quality productive forces provides a foundational framework for cultivating pre-service English teachers.There is a high degree of consistency between the development of new quality productive forces and the cultivation of pre-service English teachers.The development of new quality productive forces has put forward new requirements for the cultivation of pre-service English teachers,while the cultivation of pre-service English teachers will also promote the development of new quality productive forces and provide talent support for it.Currently,the cultivation of pre-service English teachers faces numerous challenges,which requires strengthening top-level program design,reconstructing the curriculum system,expanding cultivation fields for pre-service English teachers,improving the digital literacy of pre-service English teachers,deepening international exchanges and cooperation,and building an evidence-based evaluation system as a guarantee to achieve new breakthroughs in the cultivation of pre-service English teachers and promote the development of new quality productive forces.展开更多
We propose an eigen microstate approach(EMA)for analyzing quantum phase transitions in quantum many-body systems,introducing a novel framework that does not require prior knowledge of an order parameter.Using the tran...We propose an eigen microstate approach(EMA)for analyzing quantum phase transitions in quantum many-body systems,introducing a novel framework that does not require prior knowledge of an order parameter.Using the transversefield Ising model(TFIM)as a case study,we demonstrate the effectiveness of EMA by identifying key features of the phase transition through the scaling behavior of eigenvalues and the structure of associated eigen microstates.Our results reveal substantial changes in the ground state of the TFIM as it undergoes a phase transition,as reflected in the behavior of specific componentsξ_(i)^((k))within the eigen microstates.This method is expected to be applicable to other quantum systems where predefining an order parameter is challenging.展开更多
文摘Objective:To analyze the effect of solution-focused approach on advanced schistosomiasis(AS).Methods:10 cases of patients with AS that were treated with a solution-focused approach were included in our study.The indicators before and after the intervention were measured(knowledge mastery,prevention and treatment compliance,personal behavior,self-care ability,management satisfaction,complication rate).Results:After analyzing pre-and post-intervention indicators,statistical significance was found(P<0.05).The intervention received a satisfaction rate of 80.00%,with a complication rate of 10.00%.Conclusion:Using a solution-focused approach for ankylosing spondylitis(AS)patients can enhance their understanding and attitude toward disease prevention and treatment,improve their behaviors and self-care ability,resulting in high satisfaction and reduced complications.
文摘BACKGROUND Improving mental health is crucial for patients who require wound treatment.AIM To analyze the effects of solution-focused brief therapy(SFBT)combined with vacuum sealing drainage on the psychological health of patients undergoing wound treatment,providing a basis for selecting wound treatment protocols.METHODS A total of 102 patients undergoing wound treatment were included,with the study period from March 2020 to March 2024.Sex was not a factor,and patients were randomly assigned to two groups of 51 cases each.The control group received negative pressure wound therapy(NPWT),while the experimental group received NPWT plus SFBT.The recovery of wounds,granulation tissue scores,and psychological health levels were compared between the two groups.Statistical analysis was conducted using SPSS Windows software version 26.0 and GraphPad Prism 8.0.RESULTS Post-treatment,the levels of high-sensitivity C-reactive protein,white blood cell count,and lactate dehydrogenase in the experimental group were significantly lower than those in the control group(P<0.05).The two groups had no significant difference in granulation tissue scores(P<0.05).The psychological health level in the experimental group was significantly higher than in the control group(P<0.05).CONCLUSION The combination of SFBT and NPWT accelerates wound healing,promotes granulation tissue growth,and improves psychological well-being,making it a valuable approach for clinical application.
文摘Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponin,and natriuretic peptides play crucial roles in CVD management,yet they are often limited by sensitivity and specificity constraints.This narrative review critically examines the emerging landscape of cardiac biomarkers and advocates for a multiple-marker approach to enhance early detection,prognosis,and risk stratification of CVD.In recent years,several novel biomarkers have shown promise in revolutionizing CVD diagnostics.Gamma-glutamyltransferase,microRNAs,endothelial microparticles,placental growth factor,trimethylamine N-oxide,retinol-binding protein 4,copeptin,heart-type fatty acid-binding protein,galectin-3,growth differentiation factor-15,soluble suppression of tumorigenicity 2,fibroblast growth factor 23,and adrenomedullin have emerged as significant indicators of CV health.These biomarkers provide insights into various pathophysiological processes,such as oxidative stress,endothelial dysfunction,inflammation,metabolic disturbances,and myocardial injury.The integration of these novel biomarkers with traditional ones offers a more comprehensive understanding of CVD mechanisms.This multiple-marker approach can improve diagnostic accuracy,allowing for better risk stratification and more personalized treatment strategies.This review underscores the need for continued research to validate the clinical utility of these biomarkers and their potential incorporation into routine clinical practice.By leveraging the strengths of both traditional and novel biomarkers,precise therapeutic plans can be developed,thereby improving the management and prognosis of patients with CVDs.The ongoing exploration and validation of these biomarkers are crucial for advancing CV care and addressing the limitations of current diagnostic tools.
基金supported by Singapore National Medical Research Council(NMRC)grants,including CS-IRG,HLCA2022(to ZDZ),STaR,OF LCG 000207(to EKT)a Clinical Translational Research Programme in Parkinson's DiseaseDuke-Duke-NUS collaboration pilot grant(to ZDZ)。
文摘The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.
基金Supported by National Research Foundation of Korea,No.NRF-2021S1A5A8062526.
文摘This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.
文摘Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermatology department of a top-three hospital in Jingzhou City from November 2022 to July 2023 were selected and divided into control group and test group with 33 cases in each group by random number table method. The control group received routine health education, and the experimental group received health education based on the HAPA theory. Chronic disease self-efficacy scale, hospital anxiety and depression scale and skin disease quality of life scale were used to evaluate the effect of intervention. Results: After 3 months of intervention, the scores of self-efficacy in experimental group were higher than those in control group (P P Conclusion: Health education based on the theory of HAPA can enhance the self-efficacy of patients with type D personality psoriasis, relieve negative emotions and improve their quality of life.
文摘BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head cancer.Intra-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic resections.Globally recognized superior mesenteric artery(SMA)first approaches are invariably performed.The mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this study.AIM To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment modalities.METHODS This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and General Surgery of Kathmandu Medical College and Teaching Hospital from January 1,2021 to February 28,2024.Intraop-erative findings and postoperative outcomes were analyzed.RESULTS In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach pancreatoduodenectomy.The mean age was 67.6 years with a male-to-female ratio of 4:5.CL was seen in four patients.With virtue of CL,Clavien-Dindo grade Ⅱ or higher morbidity was observed in four patients.Two patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition requirement.The mean operative time was 330 minutes.Curative resection was achieved in 100%of the patients.The mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,respectively.CONCLUSION Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of CL.After complete curative resection,these were managed with total parenteral nutrition without adversely impacting outcome.
文摘In response to the common problems in college English writing teaching,such as the separation of learning and application,students’low interest in writing,and difficulties in expression,this paper,based on the theoretical framework of the production-oriented approach(POA)proposed by Professor Wen Qiufang,designed and implemented a set of IELTS writing teaching plan.This plan takes“motivating,enabling,and assessing”as the core teaching process,and selects typical IELTS argumentative essay topics(such as food diversity)to create real communication scenarios.In the motivating stage,diverse inputs are used to stimulate students’interest and expose their language weaknesses;in the enabling stage,language knowledge,viewpoint generation,and text structure are focused on for targeted input and training;in the assessing stage,a combination of teacher-student cooperation and peer evaluation is adopted to guide students to identify and correct deficiencies in language use.The research results show that the POA model can effectively enhance students’writing interest,active learning awareness,and writing ability,particularly in overcoming vocabulary poverty and material shortages,as well as improving language accuracy and expression richness.This provides an operational theoretical basis and practical path for improving the teaching effect of IELTS writing.
基金supported by grants from the National Nat-ural Science Foundation of China(82173129)the Innova-tive and Entrepreneurial Talent Doctor of Jiangsu Province,China(JSSCBS20221872)。
文摘Background:Dorsal approach is the potentially effective strategy for minimally invasive liver resection.This study aimed to compare the outcomes between robot-assisted and laparoscopic hemihepatectomy through dorsal approach.Methods:We compared the patients who underwent robot-assisted hemihepatectomy(Rob-HH)and who had laparoscopic hemihepatectomy(Lap-HH)through dorsal approach between January 2020 and December 2022.A 1:1 propensity score-matching(PSM)analysis was performed to minimize bias and confounding factors.Results:Ninety-six patients were included,41 with Rob-HH and 55 with Lap-HH.Among them,58 underwent left hemihepatectomy(LHH)and 38 underwent right hemihepatectomy(RHH).Compared with LapHH group,patients with Rob-HH had less estimated blood loss(median:100.0 vs.300.0 m L,P=0.016),lower blood transfusion rates(4.9%vs.29.1%,P=0.003)and postoperative complication rates(26.8%vs.54.5%,P=0.016).These significant differences consistently existed after PSM and in the LHH subgroups.Furthermore,robot-assisted LHH was associated with decreased Pringle duration(45 vs.60 min,P=0.047).RHH subgroup analysis showed that compared with Lap-RHH,Rob-RHH was associated with less estimated blood loss(200.0 vs.400.0 m L,P=0.013).No significant differences were found in other perioperative outcomes among pre-and post-PSM cohorts,such as Pringle duration,operative time,and hospital stay.Conclusions:The dorsal approach was a safe and feasible strategy for hemi-hepatectomy with favorable outcomes under robot-assisted system in reducing intraoperative blood loss,transfusion,and postoperative complications.
基金supported by the National Key R&D Program of China(No.2022YFB3707302)the National Natural Science Foundation of China(Nos.52394271 , 52394270).
文摘Enhancing the mechanical properties is crucial for polyimide films,but the mechanical properties(Young's modulus,tensile strength,and elongation at break)mutually constrain each other,complicating simultaneous enhancement via traditional trial-and-error methods.In this work,we proposed a materials genome approach to design and screen phenylethynyl-terminated polyimides for films with enhanced mechani-cal properties.We first established machine learning models to predict Young's modulus,tensile strength,and elongation at break to explore the chemical space containing thousands of candidate structures.The accuracies of the machine learning models were verified by molecular dynamics simulations on screened polyimides and experimental testing on three representative polyimide films.The performance advantages of the best-selected polyimides were analyzed by comparing well-known polyimides based on molecular dynamics simulations,and the structural rationale was revealed by"gene"analysis and feature importance evaluation.This work provides a cost-effective strategy for designing polyimide films withenhancedmechanical properties.
文摘In recent years,the production-oriented approach has been applied in the field of teaching Chinese as a foreign language,providing a new perspective for language and cultural instruction.Currently,several issues exist in cultural teaching,such as the lack of in-depth cultural input,insufficient training in cross-cultural communication skills,and the over-stylization of cultural teaching in the classroom.The production-oriented approach offers a solution to these challenges.This paper seeks to introduce the production-oriented method into the teaching of Chinese culture as a foreign language,using silk culture as a case study for teaching design.The aim is to implement cultural teaching through a new instructional model and to promote the spread of Chinese silk culture.
文摘Pelvic fractures are rare but severe injuries that severely affect patients’quality of life.Treatment of these fractures often involves invasive approaches with high risk of injuries to nervous structures,particularly lumbosacral plexus.The introduction of minimally invasive surgical approaches,such as the lateral rectus approach,not only contributes to preserving lumbar plexus integrity in operated patients but also positively impacts their psychological well-being.Patients treated by surgical reduction of pelvic fractures with lumbosacral plexus injury often experience states of anxiety and depression.The lateral rectus approach is associated with lower levels of anxiety and depression compared to more invasive surgical techniques used for similar fractures.
文摘This study explores the application of Production-Oriented Approach(POA)in teaching German to nursing students in colleges and universities.Focusing on the requirements of the German B1 exam,the study takes the thematic unit of“Movement”as an example,and designs the teaching through the links of“drive-enable-evaluate”.The results show that POA effectively improves students’speaking and writing output,but there are still deficiencies in reading and listening.Accordingly,this study has proposed the strategies of“vocabulary in-depth facilitation”and“accurate matching of listening and writing”to optimize the input materials and skills training,achieve the goal of“learning and using”,and provide a practical path for teaching German for Special Purposes.This provides a practical path for the teaching of German for special purposes.
基金National Natural Science Foundation of China(Project No.:12371428)Projects of the Provincial College Students’Innovation and Training Program in 2024(Project No.:S202413023106,S202413023110)。
文摘This paper focuses on the numerical solution of a tumor growth model under a data-driven approach.Based on the inherent laws of the data and reasonable assumptions,an ordinary differential equation model for tumor growth is established.Nonlinear fitting is employed to obtain the optimal parameter estimation of the mathematical model,and the numerical solution is carried out using the Matlab software.By comparing the clinical data with the simulation results,a good agreement is achieved,which verifies the rationality and feasibility of the model.
基金co-supported by the Chongqing Natural Science Foundation General Project,China(No.CSTB2022NSCQ-MSX1115)。
文摘A structured method to generate conformal finite element(FE)mesh for realistic 3D woven textile reinforced composite is proposed.It is based on a voxel structure mesh reconstruction framework and aims to provide accurate composite model at yarn level with material properties ready for use in commercial FE software.The textile representative volume element(RVE)is generated at filament level implementing the digital element method.Yarn structure is determined by filament bundle with variant cross-section shapes along its path.Yarn surface is then extracted using the Delaunay triangulation algorithm and a surface mesh is initiated.Then,the mesh domain is defined and constructed by voxel structure.Periodic boundary conditions,inter-yarn,and yarnmatrix interfaces are eliminated by re-mesh and mesh optimization.An element splitting rule is established to split the voxel unit into sub-elements to create smooth interface.A 3D orthogonal weave fabric reinforced composite is generated and simulated under compressive load.The composite structure and damage morphology are in good agreement with those of the experiment.
文摘Objective:To investigate the therapeutic effect of trans-tarsal sinus approach surgery combined with dalteparin sodium and furosemide in the treatment of heel bone fracture.Methods:A hundred patients with heel bone fracture who were hospitalized from August 2023 to January 2025 were selected and randomly divided into two groups of 50 cases each.The control group was operated by purely trans-tarsal sinus approach,and the observation group added dalteparin sodium and furosemide on this basis.Postoperative limb swelling,pain,coagulation and inflammation indexes,fracture healing time,foot function and complications were compared between the two groups.Results:In the observation group,postoperative limb swelling subsided faster,pain score was lower,coagulation and inflammation indexes improved more significantly,fracture healing time was shorter,foot function recovery was better,and complication rate was lower,P<0.05.Conclusion:The treatment of heel fracture by trans-tarsal sinus approach combined with sodium heparin and furosemide can significantly accelerate the patient’s recovery and reduce the occurrence of complications,which has high clinical application value.
基金The 2024 Ministry of Education Industry-University Cooperation Collaborative Education Project:“Intelligent-Driven Innovation in College English Intercultural Talent Cultivation Models from a New Liberal Arts Perspective”(2412112116)The 2025 Ministry of Education Supply-Demand Matching Employment Education Program(Phase IV):“Research on the Cultivation Model of‘English+Artificial Intelligence’Interdisciplinary Talents Based on Industry Demand”(2025032560246)The 2025 Ministry of Education Industry-University Cooperation Collaborative Education Project:“Research on the Cultivation Path of Craftsmanship Spirit among University Teachers in the Context of Industry-University Collaboration”(2505164755)。
文摘Social development puts forward higher requirements for students’English application ability and cultural literacy.This study proposes an innovative“3+2+1”blended teaching model integrating the production-oriented approach(POA)to address key challenges in college English cultural courses at application-oriented universities.The model combines three phases(pre-class,in-class,and post-class),two dimensions(online resources and offline interaction),and one overarching goal(all-round education).Through experimental implementation at three universities,results demonstrated significant improvements in student satisfaction,autonomous learning engagement,and crosscultural competence.This research provides a replicable template for enhancing both linguistic proficiency and cultural confidence in EFL contexts.
文摘This study investigated the influence of the production-oriented approach on English speaking anxiety among non-English major college students.A quasi-experimental design was implemented over one semester with two parallel classes of junior students at a university in northwestern China.Data collected before and after the intervention using a validated Foreign Language Classroom Anxiety Scale indicated that students experiencing POA instruction showed a discernible decrease in overall speaking anxiety,particularly concerning communication apprehension and fear of negative evaluation,relative to peers instructed via the audio-lingual method.Analysis highlighted task-driven learning,scaffolded input facilitation,and formative process evaluation within the POA framework as contributing factors.Findings imply POA represents a potential pedagogical framework for addressing affective challenges in the development of EFL oral skills.
基金supported by the National Education Sciences Planning Program of China through the National Office for Education Sciences Planning(Grant No.DIA220376).
文摘The theory of new quality productive forces provides a foundational framework for cultivating pre-service English teachers.There is a high degree of consistency between the development of new quality productive forces and the cultivation of pre-service English teachers.The development of new quality productive forces has put forward new requirements for the cultivation of pre-service English teachers,while the cultivation of pre-service English teachers will also promote the development of new quality productive forces and provide talent support for it.Currently,the cultivation of pre-service English teachers faces numerous challenges,which requires strengthening top-level program design,reconstructing the curriculum system,expanding cultivation fields for pre-service English teachers,improving the digital literacy of pre-service English teachers,deepening international exchanges and cooperation,and building an evidence-based evaluation system as a guarantee to achieve new breakthroughs in the cultivation of pre-service English teachers and promote the development of new quality productive forces.
基金supported by the National Natural Science Foundation of China(Grant Nos.12475033,12135003,12174194,and 12405032)the National Key Research and Development Program of China(Grant No.2023YFE0109000)+1 种基金supported by the Fundamental Research Funds for the Central Universitiessupport from the China Postdoctoral Science Foundation(Grant No.2023M730299).
文摘We propose an eigen microstate approach(EMA)for analyzing quantum phase transitions in quantum many-body systems,introducing a novel framework that does not require prior knowledge of an order parameter.Using the transversefield Ising model(TFIM)as a case study,we demonstrate the effectiveness of EMA by identifying key features of the phase transition through the scaling behavior of eigenvalues and the structure of associated eigen microstates.Our results reveal substantial changes in the ground state of the TFIM as it undergoes a phase transition,as reflected in the behavior of specific componentsξ_(i)^((k))within the eigen microstates.This method is expected to be applicable to other quantum systems where predefining an order parameter is challenging.
