Injectable filling material is a simple and efficient method for soft tissues reconstruction and is extremely popular in not only plastic surgery but also cosmetic industry.However,there is a lack of soft tissue fille...Injectable filling material is a simple and efficient method for soft tissues reconstruction and is extremely popular in not only plastic surgery but also cosmetic industry.However,there is a lack of soft tissue fillers with perfect performance on the market currently.Here,we constructed a new microsphere/hydrogel composite and evaluated its potential as a candidate for soft tissue augmentation.mPEG-PDLLA micro-spheres were prepared by utilizing a SPG membrane emulsifier which endowed microspheres with good sphericity and particle size uniformity.PDLLA-PEG-PDLLA hydrogel which shared the same component with the mPEG-PDLLA copolymer acted as a carrier and fixed the microspheres at the injected sites.The mPEG-PDLLA microsphere/PDLLA-PEG-PDLLA hydrogel composite was flowable in room temperature and transformed into gel after being heated to body temperature.This feature is convenient for subcutaneous filling.In vivo assessment on mice showed good safety profile of the composite.Moreover,the density of collagen fibers increased over 13 weeks.Overall,this biocompatible microsphere/hydrogel composite involves simple component and no extra crosslinking agents,and has the ability to stimulate collagen production,thus,may be a candidate for soft tissue augmentation.展开更多
Soft tissue augmentation at the implant site is one of several techniques suggested in the case of soft and hard tissue deficiency after implant rehabilitation.The gold standard in this procedure is connective tissue ...Soft tissue augmentation at the implant site is one of several techniques suggested in the case of soft and hard tissue deficiency after implant rehabilitation.The gold standard in this procedure is connective tissue graft(CTG),which is considered an autologous material with a high proliferative pattern.Today,several collagen matrices(VCMXs)are on the market as CTG substitutes and are recommended for this type of procedure.The aim of this case report is to compare the resorption process and the volume gain of two potential collagen matrices(VCMXA and VCMXB)of porcine origin for soft tissue augmentation around single implants.3D analysis with dedicated software(GOM inspect®Braunschweig,Germany)was performed to understand the volumetric and surface changes on the vestibular aspect and the amount of resorbed biomaterial at 7 days from the surgery and at 3 months of follow up.Considering the limitation of the four included patients and the different surgical sites(13 and 17 for VCMXA and 26 and 25 for VCMXB),both VCMXs showed interesting results with respect to the baseline at 7 days(VCMXA gain,+2.93±1.65 mm;VCMXB,+2.58±1.11 mm);however,after 3 months of follow up,an important remodelling process was present in both treated sites(VCMXA,+2.00±0.99 mm;VCMXB,+0.41±0.73 mm).Soft tissue augmentation at the implant site resulted in a similar increase in volume for both the matrices.On the other hand,VCMXA seemed to preserve more volume at 3 months.Future randomised clinical trials are needed to confirm these results.展开更多
基金supported by the National Natural Science Foundation of China(Nos.NSFC31930067,NSFC31771096,and NSFC31525009)the National Key Research and Development Pro-gram of China(No.2017YFC1103502)the 1·3·5 Project for Disci-plines of Excellence,West China Hospital,Sichuan University(No.ZYGD18002)。
文摘Injectable filling material is a simple and efficient method for soft tissues reconstruction and is extremely popular in not only plastic surgery but also cosmetic industry.However,there is a lack of soft tissue fillers with perfect performance on the market currently.Here,we constructed a new microsphere/hydrogel composite and evaluated its potential as a candidate for soft tissue augmentation.mPEG-PDLLA micro-spheres were prepared by utilizing a SPG membrane emulsifier which endowed microspheres with good sphericity and particle size uniformity.PDLLA-PEG-PDLLA hydrogel which shared the same component with the mPEG-PDLLA copolymer acted as a carrier and fixed the microspheres at the injected sites.The mPEG-PDLLA microsphere/PDLLA-PEG-PDLLA hydrogel composite was flowable in room temperature and transformed into gel after being heated to body temperature.This feature is convenient for subcutaneous filling.In vivo assessment on mice showed good safety profile of the composite.Moreover,the density of collagen fibers increased over 13 weeks.Overall,this biocompatible microsphere/hydrogel composite involves simple component and no extra crosslinking agents,and has the ability to stimulate collagen production,thus,may be a candidate for soft tissue augmentation.
文摘Soft tissue augmentation at the implant site is one of several techniques suggested in the case of soft and hard tissue deficiency after implant rehabilitation.The gold standard in this procedure is connective tissue graft(CTG),which is considered an autologous material with a high proliferative pattern.Today,several collagen matrices(VCMXs)are on the market as CTG substitutes and are recommended for this type of procedure.The aim of this case report is to compare the resorption process and the volume gain of two potential collagen matrices(VCMXA and VCMXB)of porcine origin for soft tissue augmentation around single implants.3D analysis with dedicated software(GOM inspect®Braunschweig,Germany)was performed to understand the volumetric and surface changes on the vestibular aspect and the amount of resorbed biomaterial at 7 days from the surgery and at 3 months of follow up.Considering the limitation of the four included patients and the different surgical sites(13 and 17 for VCMXA and 26 and 25 for VCMXB),both VCMXs showed interesting results with respect to the baseline at 7 days(VCMXA gain,+2.93±1.65 mm;VCMXB,+2.58±1.11 mm);however,after 3 months of follow up,an important remodelling process was present in both treated sites(VCMXA,+2.00±0.99 mm;VCMXB,+0.41±0.73 mm).Soft tissue augmentation at the implant site resulted in a similar increase in volume for both the matrices.On the other hand,VCMXA seemed to preserve more volume at 3 months.Future randomised clinical trials are needed to confirm these results.
