Dear Editor,Chronic hepatitis B virus(HBV)is a global health problem closely associated with a spectrum of liver diseases.Current clinical treatment options for HBV infection are generally not curative,highlighting th...Dear Editor,Chronic hepatitis B virus(HBV)is a global health problem closely associated with a spectrum of liver diseases.Current clinical treatment options for HBV infection are generally not curative,highlighting the need for the development of novel therapeutics.Sodium taurocholate cotransporting polypeptide(NTCP)was identified as a functional receptor for HBV entry,making it a promising therapeutic target for developing novel anti-HBV agents.展开更多
BACKGROUND Sodium taurocholate cotransport polypeptide(NTCP)deficiency disease is a genetic metabolic disorder due to mutations in the SLC10A1 gene and impaired bile acid salt uptake by the basolateral membrane transp...BACKGROUND Sodium taurocholate cotransport polypeptide(NTCP)deficiency disease is a genetic metabolic disorder due to mutations in the SLC10A1 gene and impaired bile acid salt uptake by the basolateral membrane transport protein NTCP in hepatocytes.A variety of clinical manifestations and genetic mutation loci have been reported for this disease.However,specific therapeutic measures are lacking,and the long-term effects are unknown.CASE SUMMARY An infant with elevated bile acids and behavioral neurodevelopmental delay failed to respond to bile acid-lowering therapy.Genetic testing for metabolic liver disease revealed that the child had NTCP deficiency due to the SLC10A1 mutation:c.422dupA(p.Y141X),which is a novel mutation site.The current followup revealed a gradual decrease in bile acid levels after 1 year of age,but the child still had behavioral neurodevelopmental delays.CONCLUSION The clinical manifestations,genetic characteristics,treatment and long-term prognosis due to NTCP deficiency remain poorly defined and need to be further confirmed by more studies and reports.展开更多
Hepatitis B virus(HBV)is a pathogen that infects humans and can lead to the development of liver disease and hepatocellular carcinoma.Currently,however,animal models of HBV infection remain lacking.Similar to humans,t...Hepatitis B virus(HBV)is a pathogen that infects humans and can lead to the development of liver disease and hepatocellular carcinoma.Currently,however,animal models of HBV infection remain lacking.Similar to humans,tree shrews(Tupaia belangeri)can be infected with HBV1,2 and exhibit similar hepatic histopathological changes and hepatocellular carcinoma features as those found in HBV-infected humans.2,3 Sodium taurocholate cotransporting polypeptide is a functional HBV receptor that was recently identified in tree shrews.4 However,the infection rate is usually low in adult animals under natural conditions,and the virus can be eliminated spontaneously over a short period of time.1 Thus,the mechanism related to the weak HBV replication in tree shrews needs to be further explored,although host factors are hypothesized to be major factors affecting HBV infection and persistence.展开更多
基金supported by the National Key R&D Program of China(2022YFA1303600)National Natural Science Foundation of China[No.22137002 to Y.D.,No.92353303,22277010 and 22477013 to Z.G.,No.U23A20472 and 82273423 to J.C.,No.82302507 to H.Y.]+5 种基金Ministry of Human Resources and Social Security Funding Scheme for High-Level Overseas Chinese Students’Return of China[to Z.G.]China Postdoctoral Science Foundation[No.2021T140784 and 2020M683638XB to J.H.]Natural Science Foundation of Chongqing[No.CSTB2022NSCQ-MSX1061 to Z.G.]Chongqing Postdoctoral Science Foundation[No.CSTB2022NSCQ-BHX0616 to J.H.]CQMU Program for Youth Innovation in Future Medicine[No.W0074 to Z.G.]Joint Project of Pinnacle Disciplinary Group of the Second Affiliated Hospital of Chongqing Medical University.
文摘Dear Editor,Chronic hepatitis B virus(HBV)is a global health problem closely associated with a spectrum of liver diseases.Current clinical treatment options for HBV infection are generally not curative,highlighting the need for the development of novel therapeutics.Sodium taurocholate cotransporting polypeptide(NTCP)was identified as a functional receptor for HBV entry,making it a promising therapeutic target for developing novel anti-HBV agents.
基金Yunnan Science Foundation Project,No.2019-81960102.
文摘BACKGROUND Sodium taurocholate cotransport polypeptide(NTCP)deficiency disease is a genetic metabolic disorder due to mutations in the SLC10A1 gene and impaired bile acid salt uptake by the basolateral membrane transport protein NTCP in hepatocytes.A variety of clinical manifestations and genetic mutation loci have been reported for this disease.However,specific therapeutic measures are lacking,and the long-term effects are unknown.CASE SUMMARY An infant with elevated bile acids and behavioral neurodevelopmental delay failed to respond to bile acid-lowering therapy.Genetic testing for metabolic liver disease revealed that the child had NTCP deficiency due to the SLC10A1 mutation:c.422dupA(p.Y141X),which is a novel mutation site.The current followup revealed a gradual decrease in bile acid levels after 1 year of age,but the child still had behavioral neurodevelopmental delays.CONCLUSION The clinical manifestations,genetic characteristics,treatment and long-term prognosis due to NTCP deficiency remain poorly defined and need to be further confirmed by more studies and reports.
文摘Hepatitis B virus(HBV)is a pathogen that infects humans and can lead to the development of liver disease and hepatocellular carcinoma.Currently,however,animal models of HBV infection remain lacking.Similar to humans,tree shrews(Tupaia belangeri)can be infected with HBV1,2 and exhibit similar hepatic histopathological changes and hepatocellular carcinoma features as those found in HBV-infected humans.2,3 Sodium taurocholate cotransporting polypeptide is a functional HBV receptor that was recently identified in tree shrews.4 However,the infection rate is usually low in adult animals under natural conditions,and the virus can be eliminated spontaneously over a short period of time.1 Thus,the mechanism related to the weak HBV replication in tree shrews needs to be further explored,although host factors are hypothesized to be major factors affecting HBV infection and persistence.
