The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifact...The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifactorial”with systemic metabolic alterations.Even so,treatments for neurological disorders have remained unchanged for the past decades.Recently,metabolic drugs such as metformin and glucagon-like peptide 1 agonists have demonstrated promising health outcomes for neurodegeneration.展开更多
Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetland...Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.展开更多
Human-modified landscapes serve as ecological filters,determining species distributions and persistence.Energy-efficient technologies,while crucial for climate change mitigation,represent novel filters whose impacts o...Human-modified landscapes serve as ecological filters,determining species distributions and persistence.Energy-efficient technologies,while crucial for climate change mitigation,represent novel filters whose impacts on synanthropic biodiversity are poorly understood.We investigated how attached sunspaces,a widely adopted energy-saving technology in rural China,filter the distribution of two ecologically important aerial insectivores,the Barn Swallow(Hirundo rustica)and Red-rumped Swallow(Cecropis daurica).We surveyed 106 villages during the 2024 and 2025 breeding seasons and recorded a total of 2323 nests(612 Barn Swallow,1711 Red-rumped Swallow).Using Generalized Linear Models,we assessed their responses to building characteristics,landscape composition and the prevalence of sunspaces.Barn Swallow nests preferred perches at the base and single attachment faces,while Red-rumped Swallow nests favored multiple attachment faces and avoided long shelters.The proportion of buildings with sunspaces acted as a strong positive filter for Barn Swallow nest abundance(+24%)but as a significant negative filter for Red-rumped Swallow(-51%).Other landscape variables(e.g.,human population density,NDVI,Human Footprint Index)were not significant.This study demonstrates that specific architectural innovations can act as powerful ecological filters,leading to divergent distributional outcomes for sympatric species reliant on anthropogenic structures.Our findings reveal a critical trade-off in sustainable development:energy efficiency gains may inadvertently reduce habitat suitability for certain species.To reconcile climate and biodiversity goals in rural landscapes,we advocate integrating species-specific habitat requirements into building design.We propose actionable modifications to sunspaces to support swallows without compromising energy savings.These principles provide a template for mitigating the distributional impacts of green infrastructure globally.展开更多
The intrinsic pressure framework,which treats self-propelling force as an external force,provides a convenient and consistent description of mechanical equilibrium in active matter.However,direct experimental evidence...The intrinsic pressure framework,which treats self-propelling force as an external force,provides a convenient and consistent description of mechanical equilibrium in active matter.However,direct experimental evidence is still lacking.To validate this framework,here we employ a programmable robotic platform,where a single light-controlled wheeled robot travels in an activity landscape.Our experiments quantitatively demonstrate that the intrinsic pressure difference across the activity interface is balanced by the emerged polarization force.This result unambiguously confirms the theoretical predictions,thus validating the intrinsic pressure framework and laying the experimental foundation for the intrinsic pressure-based mechanical description of dry active matter.展开更多
Oral squamous cell carcinoma(OSCC)is the most common manifestation of oral cancer.It has been proposed that periodontal pathogens contribute to OSCC progression,mainly by their virulence factors.However,the main perio...Oral squamous cell carcinoma(OSCC)is the most common manifestation of oral cancer.It has been proposed that periodontal pathogens contribute to OSCC progression,mainly by their virulence factors.However,the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood.In this study we investigate the main host-pathogen pathways in OSCC by computational proteomics and the mechanism behind cancer progression by the oral microbiome.The main hostpathogen pathways were analyzed in the secretome of biopsies from patients with OSCC and healthy controls by mass spectrometry.Then,functional assays were performed to evaluate the host-pathogen pathways highlighted in oral cancer.Host proteins associated with LPS response,cell migration/adhesion,and metabolism of amino acids were significantly upregulated in the human cancer proteome,whereas the complement cascade was downregulated in malignant samples.Then,the microbiome analysis revealed large number and variety of peptides from Fusobacterium nucleatum(F.nucleatum)in OSCC samples,from which several enzymes from the L-glutamate degradation pathway were found,indicating that L-glutamate from cancer cells is used as an energy source,and catabolized into butyrate by the bacteria.In fact,we observed that F.nucleatum modulates the cystine/glutamate antiporter in an OSCC cell line by increasing SLC7A11 expression,promoting L-glutamate efflux and favoring bacterial infection.Finally,our results showed that F.nucleatum and its metabolic derivates promote tumor spheroids growth,spheroidsderived cell detachment,epithelial-mesenchymal transition and Galectin-9 upregulation.Altogether,F.nucleatum promotes protumoral mechanism in oral cancer.展开更多
With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urb...With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urban environment and enhancing the city image.Modern art enriches the expression forms of urban landscape design,and its integration with urban landscape design can greatly improve the urban landscape.This article elaborated on the connotations of modern art and urban landscape design and analyzed the application of modern art in urban landscape design.The application of modern art can help to achieve the goal of urban landscape design to the maximum extent.展开更多
Since the reform and opening up,the development approach targeting urban economic growth has led to a sharp increase in the proportion of impervious hardened surfaces in cities and significant waste of natural resourc...Since the reform and opening up,the development approach targeting urban economic growth has led to a sharp increase in the proportion of impervious hardened surfaces in cities and significant waste of natural resources.The urgent need for water ecological civilization construction is of great significance to the continuation of human civilization in the long run.This paper focuses on the urban waterfront landscape design of the Chongqing Institute of Engineering section of the Huaxi River in Banan District,emphasizing the concept of“symbiosis”.Using site cultural symbols as a medium to connect the campus and the city on both sides of the river,returning the riverbank to the people,restoring the ecological space of the riverfront,enriching the landscape belt,promoting the protection of bird and fish habitats,and stimulating the vitality of the riverbank space;it aims to pave the way for ecological restoration,functional expansion,landscape renewal,and riverfront space activation at the study site.展开更多
In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional c...In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.展开更多
In recent years,rapid urbanization has had a profound impact on landscape stability.As a typical example of China's rapid urbanization,Hangzhou has also experienced significant landscape changes,which have profoun...In recent years,rapid urbanization has had a profound impact on landscape stability.As a typical example of China's rapid urbanization,Hangzhou has also experienced significant landscape changes,which have profoundly affected its ecological stability.Taking Hangzhou as an example,this study integrates land use change data from 1980 to 2020,combines dynamic simulation and ecological modeling techniques,and carries out a comprehensive analysis of historical trends and future predictions,to provide valuable insights into the complex interactions between urban expansion and landscape stability.The results indicate that:1)between 1980 and2020,Hangzhou experienced a significant increase in construction land at the expense of arable land,leading to a gradual decline in landscape stability,though the downward trend has slowed in recent years.2)The spatial distribution of landscape stability shows clear aggregation patterns,with lower stability concentrated in economically active flatlands and higher stability in the mountainous western regions.3)By 2040,further urban expansion is predicted to occur alongside increased landscape integration,reflecting the positive effects of ecological protection strategies.This study highlights the universal challenges of balancing economic growth with ecological stability in rapidly urbanizing regions.The combination of advanced simulation models and spatiotemporal analysis demonstrates a replicable framework for assessing urban expansion's ecological impacts.These findings underscore the importance of tailoring urban planning and ecological policies to address regional disparities,providing valuable insights for sustainable urban development and landscape management globally.展开更多
近15年来,语言景观已成为国际社会语言学研究的重要领域,学科体系日趋成熟。相比之下,中国语言景观研究虽发展迅速,但现有研究的学科意识和问题意识明显不足。本研究从国际语言景观学科的问题导向、研究方法及社会应用价值三个维度对Lin...近15年来,语言景观已成为国际社会语言学研究的重要领域,学科体系日趋成熟。相比之下,中国语言景观研究虽发展迅速,但现有研究的学科意识和问题意识明显不足。本研究从国际语言景观学科的问题导向、研究方法及社会应用价值三个维度对Linguistic Landscape:An International Journal这一国际学术期刊自创刊10年来的143篇文献进行计量分析,探究国际语言景观学科发展的新动态及创新路径。本研究对中国语言景观研究聚焦社会现实,开展学科建设,构建具有中国本土特色的语言景观研究的理论体系与方法体系具有启示作用。展开更多
Ecological security patterns are paramount to the advancement of an ecological civilization in China,aiming to enhance the stability and service functions of ecosystems to achieve sustainable regional development.Howe...Ecological security patterns are paramount to the advancement of an ecological civilization in China,aiming to enhance the stability and service functions of ecosystems to achieve sustainable regional development.However,current regional ecological protection efforts have not been effectively integrated into the regional development planning of ecological security pattern.This study systematically assessed the effectiveness of ecological protection projects in Yanchi County,Ningxia Hui Autonomous Region,China,through the evaluation of landscape ecological quality.Based on the evaluation results of landscape ecological quality,this study used morphological pattern analysis(MSPA),minimum cumulative resistance(MCR)model,and gravity model together to construct the ecological security pattern of Yanchi County.The findings revealed that from 1990 to 2020,with the implementation of ecological protection projects started from 2000,the landscape stability of Yanchi County first decreased and then increased,and the intensity of landscape disturbance first intensified but then decreased,indicating an improvement in the landscape ecological quality and a significant enhancement of the ecological environment in Yanchi County.The ecological security pattern of Yanchi County consisted of 10 ecological sources,10 ecological source points,23 ecological corridors,and 27 ecological nodes.The ecological security pattern of Yanchi County exhibited distinct spatial variations,with stronger ecological security observed in the southern part than in northern part of the county.The ecological sources were denser in the southern part than in the northern part of the county,and accordingly,the length of ecological corridors was shorter and denser in the southern than that in the northern part of the county.Based on the spatial distribution of landscape ecological quality and the characteristics of ecological security pattern of Yanchi County in 2020,we suggested Yanchi County to build four zones to optimize the ecological security pattern construction:the Haba Lake ecological conservation zone,the urban ecological planning zone,the ecological environment restoration zone,and the ecological security improvement zone.This study can provide essential guidance for the construction of ecological security pattern in farming-pastoral areas both in China and worldwide.展开更多
The internal road landscapes of Xizang Cultural Tourism and Creative Park at an altitude of 3,650 m were taken as the research object,and focusing on the restrictive effect of the high-altitude extreme environment on ...The internal road landscapes of Xizang Cultural Tourism and Creative Park at an altitude of 3,650 m were taken as the research object,and focusing on the restrictive effect of the high-altitude extreme environment on the road landscapes,data were collected through data crawling and survey questionnaires.Post occupancy evaluation(POE)was used to establish an evaluation system containing five dimensions and 24 indicators(including five high-altitude specific indicators),and statistical analysis was conducted by using multiple methods such as the analytic hierarchy process(AHP),SD semantic difference method,and IPA image analysis method.The results show that the respondents are generally satisfied with the overall evaluation of road landscapes in Xizang Cultural Tourism and Creative Park.However,the performance of high-altitude associated indicators is worrying.That is,anti-glare safety requirements are not met,and the survival rate of plateau plants is lower than the requirements of landscape effect;the integration of cultural landscapes fails to reflect regional culture.Based on this,high-altitude adaptive design strategies of three-dimensional synergy of“culture,ecology and security”were proposed to provide a certain paradigm reference for the evaluation and design of road landscapes in high-altitude areas.展开更多
In the process of promoting the rural revitalization strategy,paddy filed landscapes,as the most representative form of productive landscape in rural areas,not only serve the function of grain production,but also hold...In the process of promoting the rural revitalization strategy,paddy filed landscapes,as the most representative form of productive landscape in rural areas,not only serve the function of grain production,but also hold significant value in ecological protection,cultural inheritance,and industrial integration.Taking Xiangling Village in Huizhou,Guangdong Province as the research object,this study analyzes the current status and existing problems of the paddy field landscapes through field research.Combining with the overall requirements of rural revitalization of“vibrant local industries,pleasant living environments,social etiquette and civility,sound governance,and affluent living”,this study proposes paddy field landscape design strategies from four dimensions:industrial integration,ecological optimization,cultural empowerment,and spatial reconstruction,and constructs specific design plans to provide practical reference for the landscape improvement of similar rural areas.展开更多
To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current...To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current status and existing chal-lenges of virtual digital technology in landscape engineering design.Additionally,the study provided a detailed description and explanation of the integration between virtual digital technology and landscape engineering design,while exploring its charac-teristics and application prospects.The findings revealed:(1)In the early design stage,technological integration enhanced design efficiency.The collaborative use of BIM,GIS,and parametric tools enabled a fully digital workflow from conceptual design to construction drawings,reducing design errors and shortening project timelines.(2)After implementation,interactive experiences revolutionized public engagement.AR/VR technologies introduced dynamic interactivity to landscapes,while metaverse plat-forms expanded the presentation dimensions of virtual landscapes.(3)Smart maintenance promoted sustainability.IoT sensors and AI analytics facilitated real-time plant health monitoring and precise resource management,demonstrating significant advan-tages.The study identified existing limitations and proposed future directions,aiming to provide new theoretical and practical insights for the research and application of digital technology in landscape engineering design.展开更多
In the wave of urbanization,waterfront landscape optimization is very important,but it is faced with ecological deterioration and other problems.By combing the relevant theories and practices at home and abroad and ma...In the wave of urbanization,waterfront landscape optimization is very important,but it is faced with ecological deterioration and other problems.By combing the relevant theories and practices at home and abroad and making a comparison and summary,the future direction of waterfront research was analyzed.In theory,foreign research has experienced multi-stage development,covering definition classification,design methods,etc.China started late,and is mainly in the exploration stage of learning from foreign experience and combining with local characteristics.The current research and practice have shortcomings such as ignoring users’needs and lacking quantitative evaluation.In the future,the construction of waterfront should focus on the needs of users,use scientific methods to build an evaluation system,integrate multi-disciplines,excavate regional culture,and establish a monitoring mechanism to achieve sustainable and coordinated development of the ecology,society and economy of waterfront.展开更多
Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked...Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked lack of progress in pharmacological treatment.The challenges to developing AD therapeutics are rooted in the disease being ill-defined in terms of diagnosis,progression,and etiology.The neuropathological hallmarks of AD are extracellular amyloid-β (Aβ)plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau.Generally,Aβ plaques disrupt neuronal connectivity,while neurofibrillary tangles interfere with intracellular function (Zhang et al.,2023).展开更多
In recent years,the scale of sports consumption in China has continued to expand,demonstrating a vigorous development momentum.According to the "2025-2031 In-depth Research on China's Sports Industry and Futu...In recent years,the scale of sports consumption in China has continued to expand,demonstrating a vigorous development momentum.According to the "2025-2031 In-depth Research on China's Sports Industry and Future Development Trends Report." the total scale of the national sports industry reached RMB 3,117.5 billion in2024.with an added value of RMB 1,224.5 billion.Compared with 2023,the total output increased by 13.9%,and the added value grew by 14.1%.Behind these series of numbers lies the rapid development of China's sports industry and the continuous growth of market demand.展开更多
The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensify...The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensifying global challenges in the security,political,economic,technological and other fields,the international community has a pressing need to reshape the international landscape at this critical moment of change.展开更多
文摘The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifactorial”with systemic metabolic alterations.Even so,treatments for neurological disorders have remained unchanged for the past decades.Recently,metabolic drugs such as metformin and glucagon-like peptide 1 agonists have demonstrated promising health outcomes for neurodegeneration.
基金support through the“Trans-Disciplinary Research”Grant(No.R/Dev/IoE/TDRProjects/2023-24/61658),which played a crucial role in enabling this research endeavor.
文摘Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.
基金funded by the National Natural Science Foundation of China(No.32201304)the Fundamental Research Funds for the Central Universities(2412022QD026)。
文摘Human-modified landscapes serve as ecological filters,determining species distributions and persistence.Energy-efficient technologies,while crucial for climate change mitigation,represent novel filters whose impacts on synanthropic biodiversity are poorly understood.We investigated how attached sunspaces,a widely adopted energy-saving technology in rural China,filter the distribution of two ecologically important aerial insectivores,the Barn Swallow(Hirundo rustica)and Red-rumped Swallow(Cecropis daurica).We surveyed 106 villages during the 2024 and 2025 breeding seasons and recorded a total of 2323 nests(612 Barn Swallow,1711 Red-rumped Swallow).Using Generalized Linear Models,we assessed their responses to building characteristics,landscape composition and the prevalence of sunspaces.Barn Swallow nests preferred perches at the base and single attachment faces,while Red-rumped Swallow nests favored multiple attachment faces and avoided long shelters.The proportion of buildings with sunspaces acted as a strong positive filter for Barn Swallow nest abundance(+24%)but as a significant negative filter for Red-rumped Swallow(-51%).Other landscape variables(e.g.,human population density,NDVI,Human Footprint Index)were not significant.This study demonstrates that specific architectural innovations can act as powerful ecological filters,leading to divergent distributional outcomes for sympatric species reliant on anthropogenic structures.Our findings reveal a critical trade-off in sustainable development:energy efficiency gains may inadvertently reduce habitat suitability for certain species.To reconcile climate and biodiversity goals in rural landscapes,we advocate integrating species-specific habitat requirements into building design.We propose actionable modifications to sunspaces to support swallows without compromising energy savings.These principles provide a template for mitigating the distributional impacts of green infrastructure globally.
基金supported by the National Natural Science Foundation of China (Grant Nos.T2325027,12274448,T2350007,12404239,12174041,12325405,12090054,and T2221001)the National Key R&D Program of China (Grant No.2022YFF0503504)。
文摘The intrinsic pressure framework,which treats self-propelling force as an external force,provides a convenient and consistent description of mechanical equilibrium in active matter.However,direct experimental evidence is still lacking.To validate this framework,here we employ a programmable robotic platform,where a single light-controlled wheeled robot travels in an activity landscape.Our experiments quantitatively demonstrate that the intrinsic pressure difference across the activity interface is balanced by the emerged polarization force.This result unambiguously confirms the theoretical predictions,thus validating the intrinsic pressure framework and laying the experimental foundation for the intrinsic pressure-based mechanical description of dry active matter.
基金supported by Agencia Nacional de Investigación y Desarrollo(ANID),Chilean Government Fondecyt Regular 1211480supported by a Master ANID Scholarship+1 种基金funded by ANID/Fondecyt Regular 1211480funded by EQM150061(FONDEQUIP-ANID)。
文摘Oral squamous cell carcinoma(OSCC)is the most common manifestation of oral cancer.It has been proposed that periodontal pathogens contribute to OSCC progression,mainly by their virulence factors.However,the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood.In this study we investigate the main host-pathogen pathways in OSCC by computational proteomics and the mechanism behind cancer progression by the oral microbiome.The main hostpathogen pathways were analyzed in the secretome of biopsies from patients with OSCC and healthy controls by mass spectrometry.Then,functional assays were performed to evaluate the host-pathogen pathways highlighted in oral cancer.Host proteins associated with LPS response,cell migration/adhesion,and metabolism of amino acids were significantly upregulated in the human cancer proteome,whereas the complement cascade was downregulated in malignant samples.Then,the microbiome analysis revealed large number and variety of peptides from Fusobacterium nucleatum(F.nucleatum)in OSCC samples,from which several enzymes from the L-glutamate degradation pathway were found,indicating that L-glutamate from cancer cells is used as an energy source,and catabolized into butyrate by the bacteria.In fact,we observed that F.nucleatum modulates the cystine/glutamate antiporter in an OSCC cell line by increasing SLC7A11 expression,promoting L-glutamate efflux and favoring bacterial infection.Finally,our results showed that F.nucleatum and its metabolic derivates promote tumor spheroids growth,spheroidsderived cell detachment,epithelial-mesenchymal transition and Galectin-9 upregulation.Altogether,F.nucleatum promotes protumoral mechanism in oral cancer.
文摘With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urban environment and enhancing the city image.Modern art enriches the expression forms of urban landscape design,and its integration with urban landscape design can greatly improve the urban landscape.This article elaborated on the connotations of modern art and urban landscape design and analyzed the application of modern art in urban landscape design.The application of modern art can help to achieve the goal of urban landscape design to the maximum extent.
基金Chongqing Institute of Engineering School-level Project:Research on Urban Waterfront Landscape Design Based on the Concept of River Ecological Restoration-Taking the Section of Chongqing Institute of Engineering on Huaxi River as an Example(Project No.:2022xskz02)。
文摘Since the reform and opening up,the development approach targeting urban economic growth has led to a sharp increase in the proportion of impervious hardened surfaces in cities and significant waste of natural resources.The urgent need for water ecological civilization construction is of great significance to the continuation of human civilization in the long run.This paper focuses on the urban waterfront landscape design of the Chongqing Institute of Engineering section of the Huaxi River in Banan District,emphasizing the concept of“symbiosis”.Using site cultural symbols as a medium to connect the campus and the city on both sides of the river,returning the riverbank to the people,restoring the ecological space of the riverfront,enriching the landscape belt,promoting the protection of bird and fish habitats,and stimulating the vitality of the riverbank space;it aims to pave the way for ecological restoration,functional expansion,landscape renewal,and riverfront space activation at the study site.
文摘In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.
基金Under the auspices of Zhejiang Provincial Natural Science Foundation of China(No.LY19C160007)。
文摘In recent years,rapid urbanization has had a profound impact on landscape stability.As a typical example of China's rapid urbanization,Hangzhou has also experienced significant landscape changes,which have profoundly affected its ecological stability.Taking Hangzhou as an example,this study integrates land use change data from 1980 to 2020,combines dynamic simulation and ecological modeling techniques,and carries out a comprehensive analysis of historical trends and future predictions,to provide valuable insights into the complex interactions between urban expansion and landscape stability.The results indicate that:1)between 1980 and2020,Hangzhou experienced a significant increase in construction land at the expense of arable land,leading to a gradual decline in landscape stability,though the downward trend has slowed in recent years.2)The spatial distribution of landscape stability shows clear aggregation patterns,with lower stability concentrated in economically active flatlands and higher stability in the mountainous western regions.3)By 2040,further urban expansion is predicted to occur alongside increased landscape integration,reflecting the positive effects of ecological protection strategies.This study highlights the universal challenges of balancing economic growth with ecological stability in rapidly urbanizing regions.The combination of advanced simulation models and spatiotemporal analysis demonstrates a replicable framework for assessing urban expansion's ecological impacts.These findings underscore the importance of tailoring urban planning and ecological policies to address regional disparities,providing valuable insights for sustainable urban development and landscape management globally.
文摘近15年来,语言景观已成为国际社会语言学研究的重要领域,学科体系日趋成熟。相比之下,中国语言景观研究虽发展迅速,但现有研究的学科意识和问题意识明显不足。本研究从国际语言景观学科的问题导向、研究方法及社会应用价值三个维度对Linguistic Landscape:An International Journal这一国际学术期刊自创刊10年来的143篇文献进行计量分析,探究国际语言景观学科发展的新动态及创新路径。本研究对中国语言景观研究聚焦社会现实,开展学科建设,构建具有中国本土特色的语言景观研究的理论体系与方法体系具有启示作用。
基金funded by the National Natural Science Foundation of China(41807519)the Open Fund Project of Key Laboratory of Deserts and Desertification,Chinese Academy of Sciences(KLDD-2018-002).
文摘Ecological security patterns are paramount to the advancement of an ecological civilization in China,aiming to enhance the stability and service functions of ecosystems to achieve sustainable regional development.However,current regional ecological protection efforts have not been effectively integrated into the regional development planning of ecological security pattern.This study systematically assessed the effectiveness of ecological protection projects in Yanchi County,Ningxia Hui Autonomous Region,China,through the evaluation of landscape ecological quality.Based on the evaluation results of landscape ecological quality,this study used morphological pattern analysis(MSPA),minimum cumulative resistance(MCR)model,and gravity model together to construct the ecological security pattern of Yanchi County.The findings revealed that from 1990 to 2020,with the implementation of ecological protection projects started from 2000,the landscape stability of Yanchi County first decreased and then increased,and the intensity of landscape disturbance first intensified but then decreased,indicating an improvement in the landscape ecological quality and a significant enhancement of the ecological environment in Yanchi County.The ecological security pattern of Yanchi County consisted of 10 ecological sources,10 ecological source points,23 ecological corridors,and 27 ecological nodes.The ecological security pattern of Yanchi County exhibited distinct spatial variations,with stronger ecological security observed in the southern part than in northern part of the county.The ecological sources were denser in the southern part than in the northern part of the county,and accordingly,the length of ecological corridors was shorter and denser in the southern than that in the northern part of the county.Based on the spatial distribution of landscape ecological quality and the characteristics of ecological security pattern of Yanchi County in 2020,we suggested Yanchi County to build four zones to optimize the ecological security pattern construction:the Haba Lake ecological conservation zone,the urban ecological planning zone,the ecological environment restoration zone,and the ecological security improvement zone.This study can provide essential guidance for the construction of ecological security pattern in farming-pastoral areas both in China and worldwide.
基金Sponsored by the Joint Training Base Project for Master’s Degree Students in Landscape Architecture of Chongqing Jiaotong University and China Merchants Ecological and Environmental Protection Technology Co.,Ltd.(JDLHPY.JD2019003)General Project of Chongqing Natural Science Foundation of China in 2024(CSTB2024NSCQ-MSX1067)Key Project of Humanities and Social Sciences of Chongqing City in 2024(24SKGH346).
文摘The internal road landscapes of Xizang Cultural Tourism and Creative Park at an altitude of 3,650 m were taken as the research object,and focusing on the restrictive effect of the high-altitude extreme environment on the road landscapes,data were collected through data crawling and survey questionnaires.Post occupancy evaluation(POE)was used to establish an evaluation system containing five dimensions and 24 indicators(including five high-altitude specific indicators),and statistical analysis was conducted by using multiple methods such as the analytic hierarchy process(AHP),SD semantic difference method,and IPA image analysis method.The results show that the respondents are generally satisfied with the overall evaluation of road landscapes in Xizang Cultural Tourism and Creative Park.However,the performance of high-altitude associated indicators is worrying.That is,anti-glare safety requirements are not met,and the survival rate of plateau plants is lower than the requirements of landscape effect;the integration of cultural landscapes fails to reflect regional culture.Based on this,high-altitude adaptive design strategies of three-dimensional synergy of“culture,ecology and security”were proposed to provide a certain paradigm reference for the evaluation and design of road landscapes in high-altitude areas.
基金Sponsored by Huizhou City Science and Technology Project for the Social Development Sector(2023CQ010009).
文摘In the process of promoting the rural revitalization strategy,paddy filed landscapes,as the most representative form of productive landscape in rural areas,not only serve the function of grain production,but also hold significant value in ecological protection,cultural inheritance,and industrial integration.Taking Xiangling Village in Huizhou,Guangdong Province as the research object,this study analyzes the current status and existing problems of the paddy field landscapes through field research.Combining with the overall requirements of rural revitalization of“vibrant local industries,pleasant living environments,social etiquette and civility,sound governance,and affluent living”,this study proposes paddy field landscape design strategies from four dimensions:industrial integration,ecological optimization,cultural empowerment,and spatial reconstruction,and constructs specific design plans to provide practical reference for the landscape improvement of similar rural areas.
基金Basic scientific research business expenses of universities directly under Inner Mongolia Autonomous Region,Key project of Philosophy and Social Science Foundation of Inner Mongolia Agricultural University(BR220603)Special project for improving scientific research ability of young teachers of Inner Mongolia Agricultural University(BR230218).
文摘To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current status and existing chal-lenges of virtual digital technology in landscape engineering design.Additionally,the study provided a detailed description and explanation of the integration between virtual digital technology and landscape engineering design,while exploring its charac-teristics and application prospects.The findings revealed:(1)In the early design stage,technological integration enhanced design efficiency.The collaborative use of BIM,GIS,and parametric tools enabled a fully digital workflow from conceptual design to construction drawings,reducing design errors and shortening project timelines.(2)After implementation,interactive experiences revolutionized public engagement.AR/VR technologies introduced dynamic interactivity to landscapes,while metaverse plat-forms expanded the presentation dimensions of virtual landscapes.(3)Smart maintenance promoted sustainability.IoT sensors and AI analytics facilitated real-time plant health monitoring and precise resource management,demonstrating significant advan-tages.The study identified existing limitations and proposed future directions,aiming to provide new theoretical and practical insights for the research and application of digital technology in landscape engineering design.
文摘In the wave of urbanization,waterfront landscape optimization is very important,but it is faced with ecological deterioration and other problems.By combing the relevant theories and practices at home and abroad and making a comparison and summary,the future direction of waterfront research was analyzed.In theory,foreign research has experienced multi-stage development,covering definition classification,design methods,etc.China started late,and is mainly in the exploration stage of learning from foreign experience and combining with local characteristics.The current research and practice have shortcomings such as ignoring users’needs and lacking quantitative evaluation.In the future,the construction of waterfront should focus on the needs of users,use scientific methods to build an evaluation system,integrate multi-disciplines,excavate regional culture,and establish a monitoring mechanism to achieve sustainable and coordinated development of the ecology,society and economy of waterfront.
基金supported by a New Investigator grant from the Alzheimer’s Society of Canadaresearch grant from Djavad Mowafaghian Centre for Brain Health to KSAE。
文摘Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked lack of progress in pharmacological treatment.The challenges to developing AD therapeutics are rooted in the disease being ill-defined in terms of diagnosis,progression,and etiology.The neuropathological hallmarks of AD are extracellular amyloid-β (Aβ)plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau.Generally,Aβ plaques disrupt neuronal connectivity,while neurofibrillary tangles interfere with intracellular function (Zhang et al.,2023).
文摘In recent years,the scale of sports consumption in China has continued to expand,demonstrating a vigorous development momentum.According to the "2025-2031 In-depth Research on China's Sports Industry and Future Development Trends Report." the total scale of the national sports industry reached RMB 3,117.5 billion in2024.with an added value of RMB 1,224.5 billion.Compared with 2023,the total output increased by 13.9%,and the added value grew by 14.1%.Behind these series of numbers lies the rapid development of China's sports industry and the continuous growth of market demand.
文摘The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensifying global challenges in the security,political,economic,technological and other fields,the international community has a pressing need to reshape the international landscape at this critical moment of change.
