BACKGROUND:The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication,and the most common cause of death from paraquat poisoning is multiple organ failure(MOF).This s...BACKGROUND:The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication,and the most common cause of death from paraquat poisoning is multiple organ failure(MOF).This study aimed to evaluate therapeutic effect of smecta on the plasma concentrations of paraquat and multi-organ injury induced by paraquat intoxication in rats.METHODS:A total of 76 healthy adult SD rats were randomly divided into group A(control group,/7=6),group B(poisoned group,n=30) and group C(smecta-treated group,n=30).Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg,and rats in group A was treated intragastrically with saline(1 ml_).Rats in group C were given intragastrically smecta at 400 mg/kg 10 minutes after administration of PQ,while rats in other two groups were treated intragastrically with 1ml_ saline at the same time.Live rats in groups B and C were sacrificed at 2,6,24,48,72 hours after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of the lung,stomach and jejunum.The rats were executed at the end of trial by the same way in group A.RESULTS:The plasma concentration of paraquat(ng/mL) ranged from 440.314±49.776 to4320.6150±413.947.Distinctive pathological changes were seen in the lung,stomach and jejunum in group B.Lung injuries deteriorated gradually,edema,leukocyte infiltration,pneumorrhagia,incrassated septa and lung consolidation were observed.Abruption of mucosa,hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach.The hemorrhage of jejunum mucosa,the abruption of villus,the gland damage with the addition of inflammatory cell infiltration were found.Compared to group B,the plasma concentration of paraquat reduced(P<0.01) and the pathological changes mentioned above were obviously alleviated in group C(P<0.05,P<0.01).CONCLUSION:Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.展开更多
Objective: to analyze the nursing and therapeutic effect of smecta retention enema in the treatment of chronic diarrhea. Methods: 80 cases of children with chronic diarrhea admitted to our hospital from November 2018 ...Objective: to analyze the nursing and therapeutic effect of smecta retention enema in the treatment of chronic diarrhea. Methods: 80 cases of children with chronic diarrhea admitted to our hospital from November 2018 to November 2019 were randomly divided into the experimental group and the control group with 40 cases in each group. Among them, the children in the control group only took smecta, while the patients in the experimental group implemented enema on this basis. The therapeutic effects of the two groups were recorded. Results: the total effective rate of the experimental group was 92.5% and that of the control group was 72.5%. The treatment effect of the experimental group was significantly better than that of the control group (P < 0.05). Conclusion: smecta retention enema for the care and treatment of chronic diarrhea, the patient's clinical treatment time is significantly shortened, pain relief, while the treatment of safety is relatively high, it is worth in clinical large-scale promotion and application of a nursing treatment model.展开更多
文摘BACKGROUND:The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication,and the most common cause of death from paraquat poisoning is multiple organ failure(MOF).This study aimed to evaluate therapeutic effect of smecta on the plasma concentrations of paraquat and multi-organ injury induced by paraquat intoxication in rats.METHODS:A total of 76 healthy adult SD rats were randomly divided into group A(control group,/7=6),group B(poisoned group,n=30) and group C(smecta-treated group,n=30).Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg,and rats in group A was treated intragastrically with saline(1 ml_).Rats in group C were given intragastrically smecta at 400 mg/kg 10 minutes after administration of PQ,while rats in other two groups were treated intragastrically with 1ml_ saline at the same time.Live rats in groups B and C were sacrificed at 2,6,24,48,72 hours after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of the lung,stomach and jejunum.The rats were executed at the end of trial by the same way in group A.RESULTS:The plasma concentration of paraquat(ng/mL) ranged from 440.314±49.776 to4320.6150±413.947.Distinctive pathological changes were seen in the lung,stomach and jejunum in group B.Lung injuries deteriorated gradually,edema,leukocyte infiltration,pneumorrhagia,incrassated septa and lung consolidation were observed.Abruption of mucosa,hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach.The hemorrhage of jejunum mucosa,the abruption of villus,the gland damage with the addition of inflammatory cell infiltration were found.Compared to group B,the plasma concentration of paraquat reduced(P<0.01) and the pathological changes mentioned above were obviously alleviated in group C(P<0.05,P<0.01).CONCLUSION:Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.
文摘Objective: to analyze the nursing and therapeutic effect of smecta retention enema in the treatment of chronic diarrhea. Methods: 80 cases of children with chronic diarrhea admitted to our hospital from November 2018 to November 2019 were randomly divided into the experimental group and the control group with 40 cases in each group. Among them, the children in the control group only took smecta, while the patients in the experimental group implemented enema on this basis. The therapeutic effects of the two groups were recorded. Results: the total effective rate of the experimental group was 92.5% and that of the control group was 72.5%. The treatment effect of the experimental group was significantly better than that of the control group (P < 0.05). Conclusion: smecta retention enema for the care and treatment of chronic diarrhea, the patient's clinical treatment time is significantly shortened, pain relief, while the treatment of safety is relatively high, it is worth in clinical large-scale promotion and application of a nursing treatment model.
