The relativistic interaction of charged particle beams with a circularly polarized electromagnetic wave propagating along a uniform guiding magnetic field in the tunneling of a dielectric medium is analyzed. The accel...The relativistic interaction of charged particle beams with a circularly polarized electromagnetic wave propagating along a uniform guiding magnetic field in the tunneling of a dielectric medium is analyzed. The acceleration mechanism and a self-consistent nonlinear theory are presented for the interaction of relativistic charged particle beams with electromagnetic waves. Numerical results show that the beam particle can be efficiently accelerated in the interaction process.展开更多
China’s downstream rare earth companies have slowed production and operation activities this year due to COVID-19,said the Ministry of Commerce on Thursday,when commenting on the drop in the country’s rare earth exp...China’s downstream rare earth companies have slowed production and operation activities this year due to COVID-19,said the Ministry of Commerce on Thursday,when commenting on the drop in the country’s rare earth exports in the first seven months."Chinese companies carry out global trade business based on changes in the international market demand and risk conditions,"ministry spokesman Gao Feng said.展开更多
The prompt export leap following the phase out of quotas has past, while the quota restriction came back again, so that the exportation of home textiles began to slow down in the first half of 2006.
Off-axis aspherical mirrors are widely used in optical systems and precision measuring instruments,whereas off-axis aspherical mirrors with large sizes and off-axis are used in large optical systems such as astronomic...Off-axis aspherical mirrors are widely used in optical systems and precision measuring instruments,whereas off-axis aspherical mirrors with large sizes and off-axis are used in large optical systems such as astronomical telescopes and radio telescopes.However,if the off-axis amount of an off-axis aspherical mirror exceeds the capability of the machine tool,traditional rotary-turning machining methods are not applicable,and advanced computerized numerical control(CNC)machining methods,such as the slow-tool-servo method,must be im-plemented.This article proposes a non-conventional offset(NCO)fabrication method based on slow-tool-servo single-point diamond turning for machining off-axis aspherical surfaces with large off-axis amounts.This method is theoretically applicable to the machining of off-axis aspherical surfaces with any off-axis amount.NCO fab-rication is a simpler and more efficient path-planning solution for machining individual off-axis parabolic sur-faces.In addition,corresponding solutions for other types of aspherical surfaces are proposed using the NCO method.The turning depths of workpieces with different off-axis amounts at the same machining position are analyzed and compared.A specific measurement scheme for the NCO method is presented,and the experimental results indicate that the PV and RMS form errors are 0.658μm and 60 nm,respectively.This work demonstrates that the NCO method can effectively deal with the machining challenges of off-axis aspherical structures with large off-axis amounts.展开更多
The Fast Sweeping Method based on equivalent slowness is an improved algorithm for solving seismic wave traveltime,aiming to address the significant errors caused by the large wavefront curvature near the source point...The Fast Sweeping Method based on equivalent slowness is an improved algorithm for solving seismic wave traveltime,aiming to address the significant errors caused by the large wavefront curvature near the source point in traditional methods.The core of this method lies in transferring part of the complex curvature information of the traveltime eld to the distance term of the analytical solution,thereby simplifying the calculation process of the traveltime eld.Specically,by dening the equivalent slowness as the ratio of traveltime to the straight-line distance from a point to the source point,using a nite dierence scheme to discretely solve the equivalent slowness,and then converting it into traveltime values,this approach can signicantly enhance computational accuracy and efciency.In this study,numerical examples are employed to verify the effectiveness and superiority of the Fast Sweeping Method based on equivalent slowness in handling complex seismic wave traveltime calculations.展开更多
Efficient solar light harvesting is essential for high-performance photocatalysts.Here,Rigorous CoupledWave Analysis(RCWA)computational method is used to investigate and optimize the optical absorption of TiO_(2)-BiVO...Efficient solar light harvesting is essential for high-performance photocatalysts.Here,Rigorous CoupledWave Analysis(RCWA)computational method is used to investigate and optimize the optical absorption of TiO_(2)-BiVO_(4) inverse opal(IO)structures under varying light incidence angles and pore-filling medium(air or water).Simulations were validated against experimental reflectance data.They revealed that small-pore IOs strongly absorb in the UV-C and UV-B regions due to the slow photon effect,making them ideal for sterilization and water disinfection.Medium-and large-pore IOs benefit from additional slow photon effect at the 2nd order photonic band gap,enhancing absorption across both UV and visible regions.Medium-pore IOs are suited for indoor air treatment and water purification,while large-pore IOs with the highest photon flux enhancement enable solar-driven photocatalysis such as outdoor pollutant removal and hydrogen production.For all tested IO designs,the absorbed photon flux exceeds that of equivalent planar slabs,highlighting the advantage of photonic structuring for sustainable photocatalytic applications.展开更多
In the field of rock engineering,the influence of water is a dynamic process that exhibits varying effects over time and across different locations.To further understand how water influences the mechanical properties ...In the field of rock engineering,the influence of water is a dynamic process that exhibits varying effects over time and across different locations.To further understand how water influences the mechanical properties and acoustic emission(AE)behavior of rocks,this study conducted uniaxial compression experiments on sandstones with varying degrees of wetting under both natural conditions and water-chemical environments.In addition,the study combined AE equipment with digital image correlation(DIC)to monitor the entire failure process.Using the sliding window algorithm,the variation in the variance of AE characteristic parameters during the process of sandstone loading to failure is analyzed from the perspective of critical slowing down.This analysis enables the effective identification of the early warning signal before failure.The experimental findings suggest that an increase in wetting height results in a gradual decrease in peak stress,accompanied by a concomitant increase in the percentage of shear cracks.The characteristic parameters,including energy,amplitude,and ringing count,all exhibit critical slowing phenomena.The waveform of AE characteristic parameters of the same sample is similar,and the mutation time of the precursor signal is roughly the same.All signals appear in the irreversible plastic deformation stage of microcrack initiation.The integration of critical slowing down theory and the b-value early warning method facilitates a more comprehensive evaluation of the stability of rock mass,thereby significantly enhancing the efficiency and safety of disaster prevention measures.展开更多
The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the...The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the stability of underground mining engineering,this paper simulates the generation of different degrees of initial defects inside the CTB by adding different contents of air-entraining agent(AEA),investigates the acoustic emission RA/AF eigenvalues of CTB with different contents of AEA under uniaxial compression,and adopts various denoising algorithms(e.g.,moving average smoothing,median filtering,and outlier detection)to improve the accuracy of the data.The variance and autocorrelation coefficients of RA/AF parameters were analyzed in conjunction with the critical slowing down(CSD)theory.The results show that the acoustic emission RA/AF values can be used to characterize the progressive damage evolution of CTB.The denoising algorithm processed the AE signals to reduce the effects of extraneous noise and anomalous spikes.Changes in the variance curves provide clear precursor information,while abrupt changes in the autocorrelation coefficient can be used as an auxiliary localization warning signal.The phenomenon of dramatic increase in the variance and autocorrelation coefficient curves during the compression-tightening stage,which is influenced by the initial defects,can lead to false warnings.As the initial defects of the CTB increase,its instability precursor time and instability time are prolonged,the peak stress decreases,and the time difference between the CTB and the instability damage is smaller.The results provide a new method for real-time monitoring and early warning of CTB instability damage.展开更多
Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neur...Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neurofibrillary tangle hypotheses[1],two FDA-approved antiamyloid monoclonal antibodies(Aβ-mAbs),Kisunla and Lecanemab,have demonstrated efficacy in removing cerebral amyloid buildup,thereby modestly slowing cognitive decline in AD patients[2,3].A 2023 meta-analysis in Neurology demonstrated that anti-amyloid therapies significantly accelerated brain volume loss compared to placebo,with Lecanemab demonstrating 36.4%greater volume reduction and Donanemab 23%.展开更多
Background:Drug-coated balloons(DCBs)are receiving increasing attention in interventional therapy for coronary artery disease.However,evidence regarding their application in acute myocardial infarction(AMI),particular...Background:Drug-coated balloons(DCBs)are receiving increasing attention in interventional therapy for coronary artery disease.However,evidence regarding their application in acute myocardial infarction(AMI),particularly in high-risk AMI patients,is limited,leading to significant clinical concerns.This study aims to compare the efficacy and safety of DCBs versus standard drug-eluting stents(DESs)in AMI patients and explore their efficacy differences in patients with ST-segment elevation myocardial infarction(STEMI),non-ST-segment elevation myocardial infarction(NSTEMI),and different risk stratifications.Methods:A single-center,retrospective cohort study was conducted,involving 86 patients who underwent percutaneous coronary intervention(PCI)for AMI between January 2023 and July 2025.Patients were divided into a DCB group(n=26)and a DES group(n=60)based on the treatment modality.According to the Killip classification of myocardial infarction at admission,patients were categorized into a low-risk group(Killip Class I,n=68)and a high-risk group(Killip Classes II-IV,n=18).The primary efficacy endpoint was targeting lesion restenosis as shown by coronary angiography follow-up(6-12 months).Safety endpoints included acute in-stent thrombosis during hospitalization(ARC criteria)and long-term coronary slow flow.A multivariate logistic regression model was used to evaluate the associations between intervention modality,risk stratification,infarction type,and endpoint events,and to test for interactions.Results:The DCB and DES groups were generally balanced in terms of baseline traditional risk factors.During hospitalization,three cases(5.0%)of acute in-stent thrombosis occurred in the DES group,all requiring urgent re-intervention,while no such events occurred in the DCB group(0%).Acute in-stent thrombosis formation was significantly associated with high-risk stratification(χ2 test,p=0.047).The overall restenosis rate was 22.1%(19/86).Multivariate analysis showed no statistically significant difference in restenosis risk between the intervention modalities(DCB vs.DES)(adjusted odds ratio[OR]=1.07,95%confidence interval[CI]0.27-4.21,p=0.920),and no statistical differences were found in subgroups based on risk stratification(p=0.382)or infarction type(p=0.484).There was a trend toward increased restenosis risk in high-risk patients(OR=12.34),but the difference was not statistically significant(95%CI 0.28-542.75,p=0.193).The incidence of long-term coronary slow flow was significantly higher in the DES group than in the DCB group(16.7%vs.3.8%,Fisher’s exact test,p=0.048),with a statistically significant difference.Conclusion:For AMI patients,DCBs demonstrate similar efficacy to DESs in preventing restenosis.However,DESs are associated with a higher risk of acute thrombosis during hospitalization,especially in high-risk patients,and a higher risk of long-term slow coronary flow.DCBs exhibit superior perioperative and long-term safety compared to DESs.Given the limited sample size,particularly the small number of high-risk patients and those treated with DCBs,the conclusions require validation through larger-scale prospective studies.展开更多
The first half of 2010 is showing that the impacts of the financial crisis are still lingering.Zhao Jinping,a researcher at the Development Research Center of the State Council,says that the possible implementation of...The first half of 2010 is showing that the impacts of the financial crisis are still lingering.Zhao Jinping,a researcher at the Development Research Center of the State Council,says that the possible implementation of exit strategies in developed countries may deal a heavy blow to a global rally,and it will certainly result in slowed exports growth for China.Zhao published his opinion in the China Economic Times.The first part was published in issue No.33.Edited excerpts of the second part follow:展开更多
China in the rst two months of2013-Apparel retail sales value in50major retailenterprises only increased by6.4%y/y,growthrate slowed down0.6%than the same periodof last year according to Nation Commer-cial Information...China in the rst two months of2013-Apparel retail sales value in50major retailenterprises only increased by6.4%y/y,growthrate slowed down0.6%than the same periodof last year according to Nation Commer-cial Information Center of China.Growthrate slowed down6.1%than in December2012.Men s suitIn February2013,Comprehensive marketshare of the top ten men's suit brands was30.1percent in the national key major retailenterprises,increased by1.6percentage pointscompared to last month.Among them,Youn-gor and ShanShan still occupied the top twoplaces;Goldlion raised to the third;Playboyand Satchi entered the top ten.Men s shirtIn February2013,Comprehensive marketshare of the top ten men's展开更多
According to the statistics of China National Commercial Information Center in April,2013, retail clothing prices rose 6.5% in the national large-scale retail enterprises,the highest growth rate since the beginning of...According to the statistics of China National Commercial Information Center in April,2013, retail clothing prices rose 6.5% in the national large-scale retail enterprises,the highest growth rate since the beginning of the year.展开更多
BACKGROUND Xuanshen decoction(XSD)is a traditional Chinese medicine formulation that is often applied in treating slow transit constipation(STC).However,its specific therapeutic mechanism remains to be characterized.A...BACKGROUND Xuanshen decoction(XSD)is a traditional Chinese medicine formulation that is often applied in treating slow transit constipation(STC).However,its specific therapeutic mechanism remains to be characterized.AIM To investigate the mechanism of XSD for STC,we combined network pharmacology prediction,molecular docking analysis,and in vivo studies.METHODS The therapeutic effects of XSD on loperamide-induced STC in rats were assessed through 24-hour fecal number,fecal moisture content,and intestinal propelling rate.Hematoxylin–eosin and Alcian blue/periodic acid-Schiff staining were applied to analyze colonic mucosa for histopathological presentation and mucin production.Next,the mechanism of action of XSD for STC was elucidated through network pharmacology and molecular docking analyses,and the findings were validated by the animal experiments.RESULTS XSD significantly alleviated the symptoms of STC in rats.Relative to the STC rats,in the medium-dose XSD and high-dose XSD rats,stem cell factor,C-kit,phosphophosphoinositide 3-kinase/phosphoinositide 3-kinase,phospho-protein kinase B/protein kinase B,catalase,and superoxide dismutase were substantially upregulated(P<0.01);nuclear factor erythroid 2-related factor 2(nuclear/cytoplasmic)and B-cell lymphoma 2(Bcl-2)were increased(P<0.05),while cleaved caspase-3,Bcl-2-associated X protein(Bax)/Bcl-2,and malondialdehyde were significantly reduced(P<0.01).Heme oxygenase-1 and glutathione peroxidase in the high-dose XSD group were significantly increased(P<0.01),and Bax was statistically lowered(P<0.01);glutathione peroxidase in the medium-dose XSD group was increased(P<0.05),while Bax was reduced(P<0.05).CONCLUSION XSD may inhibit oxidative-stress-induced apoptosis in interstitial cells of Cajal by stimulating the phosphoinositide 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 pathway,thereby effectively treating STC.展开更多
Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination envir...Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination environment with the[Co(dps)_(4)(N_(3))_(2)]unit.Although the differences in crystal parameters are nearly negligible,their magnetic properties are very different.AC susceptibility data show that 1 behaves as a typical field-induced single-ion magnet(SIM)with the out-of-phase(χ_(M)”)signals,while 2 shows ac signals ofχ_(M)”without peaks even under applied dc filed within our measurement window.Far-IR magneto-spectra(FIRMS)show strong spin-phonon couplings at 0 T in 2,likely making the magnetic relaxation in 2 fast,while the couplings are negligible in 1.Small spin-phonon coupling in 1 likely leads to slower magnetic relaxation,making 1 a SIM.The difference in the properties is due to the structural rigidity of 2 in its 3D network,leading to stronger spin-phonon coupling.Combined high-field EPR(HF-EPR)and FIRMS studies give spin-Hamiltonian parameters,including D=64.0(9)cm^(-1),|E|=15.7(2)cm^(-1)for 1 and D=80.0(2)cm^(-1),|E|=19.0(1)cm^(-1)for 2.展开更多
BACKGROUND The development of slow transit constipation(STC)is associated with intestinal barrier damage.Huangqi decoction(HQD)is effective in treating STC,but me-chanisms are unclear.AIM To investigate whether HQD al...BACKGROUND The development of slow transit constipation(STC)is associated with intestinal barrier damage.Huangqi decoction(HQD)is effective in treating STC,but me-chanisms are unclear.AIM To investigate whether HQD alleviates STC by downregulating the nuclear factorκB(NF-κB)signaling pathway and restoring intestinal barrier function.METHODS KM mice were divided into control,model,and HQD treatment groups.Fresh colonic tissues were collected for single-cell RNA sequencing and spatial tra-nscriptome sequencing.The expressions of claudin-1,mucin 2,and NF-κB P65 proteins were detected by immunohistochemistry.In vitro experiments evaluated the effects of HQD on the LS174T cell line.RESULTS HQD improved intestinal motility,restored mucosal epithelium function and morphology.Single-cell RNA sequencing and spatial transcriptome sequencing data showed a reduction in goblet cells,decreased mucin 2 secretion,and activated apoptotic pathways in STC mice.The population of intestinal stem cells was reduced,and proliferation along with Wnt/β-catenin pathways were inhibited.STC also altered the distribution of intestinal cell states,increasing immune-associated Enterocyte_C3.Aberrant NF-κB pathway activation was noted across various cell types.After HQD treatment,NF-κB pathway activity was down-regulated,while cell proliferation pathways were up-regulated,alongside an increase in Enterocyte_C1 related to material transport.Immunocytochemical,Western blot,and immunohistochemistry analyses confirmed NF-κB pathway activation in goblet cells of STC mice,with HQD inhibiting this aberrant activation.CONCLUSION STC involves intestinal mucosal barrier damage.HQD may treat STC by suppressing NF-κB signaling in epithelial cells,restoring intestinal epithelial cell function,and promoting mucosal barrier repair.展开更多
基金supported by National Natural Science Foundation of China(Nos.51275029,51102007 and 11275007)
文摘The relativistic interaction of charged particle beams with a circularly polarized electromagnetic wave propagating along a uniform guiding magnetic field in the tunneling of a dielectric medium is analyzed. The acceleration mechanism and a self-consistent nonlinear theory are presented for the interaction of relativistic charged particle beams with electromagnetic waves. Numerical results show that the beam particle can be efficiently accelerated in the interaction process.
文摘China’s downstream rare earth companies have slowed production and operation activities this year due to COVID-19,said the Ministry of Commerce on Thursday,when commenting on the drop in the country’s rare earth exports in the first seven months."Chinese companies carry out global trade business based on changes in the international market demand and risk conditions,"ministry spokesman Gao Feng said.
文摘The prompt export leap following the phase out of quotas has past, while the quota restriction came back again, so that the exportation of home textiles began to slow down in the first half of 2006.
基金Supported by National Key R&D Program of China(Grant No.2023YFE0203800)the National Natural Science Foundation of China(Grant No.52105482).
文摘Off-axis aspherical mirrors are widely used in optical systems and precision measuring instruments,whereas off-axis aspherical mirrors with large sizes and off-axis are used in large optical systems such as astronomical telescopes and radio telescopes.However,if the off-axis amount of an off-axis aspherical mirror exceeds the capability of the machine tool,traditional rotary-turning machining methods are not applicable,and advanced computerized numerical control(CNC)machining methods,such as the slow-tool-servo method,must be im-plemented.This article proposes a non-conventional offset(NCO)fabrication method based on slow-tool-servo single-point diamond turning for machining off-axis aspherical surfaces with large off-axis amounts.This method is theoretically applicable to the machining of off-axis aspherical surfaces with any off-axis amount.NCO fab-rication is a simpler and more efficient path-planning solution for machining individual off-axis parabolic sur-faces.In addition,corresponding solutions for other types of aspherical surfaces are proposed using the NCO method.The turning depths of workpieces with different off-axis amounts at the same machining position are analyzed and compared.A specific measurement scheme for the NCO method is presented,and the experimental results indicate that the PV and RMS form errors are 0.658μm and 60 nm,respectively.This work demonstrates that the NCO method can effectively deal with the machining challenges of off-axis aspherical structures with large off-axis amounts.
基金supported by the Key Project of the Spark Program of Earthquake Science and Technology in Hebei Province(DZ2025091100001 and DZ2025081200001)University Stability Support Program of Shenzhen-General Project(20231128113233002).
文摘The Fast Sweeping Method based on equivalent slowness is an improved algorithm for solving seismic wave traveltime,aiming to address the significant errors caused by the large wavefront curvature near the source point in traditional methods.The core of this method lies in transferring part of the complex curvature information of the traveltime eld to the distance term of the analytical solution,thereby simplifying the calculation process of the traveltime eld.Specically,by dening the equivalent slowness as the ratio of traveltime to the straight-line distance from a point to the source point,using a nite dierence scheme to discretely solve the equivalent slowness,and then converting it into traveltime values,this approach can signicantly enhance computational accuracy and efciency.In this study,numerical examples are employed to verify the effectiveness and superiority of the Fast Sweeping Method based on equivalent slowness in handling complex seismic wave traveltime calculations.
基金supported by the FNRS-FRFC,the Walloon Region,and the University of Namur(Conventions No.2.5020.11,GEQ U.G006.15,1610468,RW/GEQ2016 et U.G011.22)funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska Curie grant agreement n°101034383。
文摘Efficient solar light harvesting is essential for high-performance photocatalysts.Here,Rigorous CoupledWave Analysis(RCWA)computational method is used to investigate and optimize the optical absorption of TiO_(2)-BiVO_(4) inverse opal(IO)structures under varying light incidence angles and pore-filling medium(air or water).Simulations were validated against experimental reflectance data.They revealed that small-pore IOs strongly absorb in the UV-C and UV-B regions due to the slow photon effect,making them ideal for sterilization and water disinfection.Medium-and large-pore IOs benefit from additional slow photon effect at the 2nd order photonic band gap,enhancing absorption across both UV and visible regions.Medium-pore IOs are suited for indoor air treatment and water purification,while large-pore IOs with the highest photon flux enhancement enable solar-driven photocatalysis such as outdoor pollutant removal and hydrogen production.For all tested IO designs,the absorbed photon flux exceeds that of equivalent planar slabs,highlighting the advantage of photonic structuring for sustainable photocatalytic applications.
基金support from the National Natural Science Foundation of China(Grant Nos.52104207 and 52374214)the Shandong Provincial Youth Innovation Team Development Program for Higher Education Institutions(Grant No.2023KJ305).
文摘In the field of rock engineering,the influence of water is a dynamic process that exhibits varying effects over time and across different locations.To further understand how water influences the mechanical properties and acoustic emission(AE)behavior of rocks,this study conducted uniaxial compression experiments on sandstones with varying degrees of wetting under both natural conditions and water-chemical environments.In addition,the study combined AE equipment with digital image correlation(DIC)to monitor the entire failure process.Using the sliding window algorithm,the variation in the variance of AE characteristic parameters during the process of sandstone loading to failure is analyzed from the perspective of critical slowing down.This analysis enables the effective identification of the early warning signal before failure.The experimental findings suggest that an increase in wetting height results in a gradual decrease in peak stress,accompanied by a concomitant increase in the percentage of shear cracks.The characteristic parameters,including energy,amplitude,and ringing count,all exhibit critical slowing phenomena.The waveform of AE characteristic parameters of the same sample is similar,and the mutation time of the precursor signal is roughly the same.All signals appear in the irreversible plastic deformation stage of microcrack initiation.The integration of critical slowing down theory and the b-value early warning method facilitates a more comprehensive evaluation of the stability of rock mass,thereby significantly enhancing the efficiency and safety of disaster prevention measures.
基金Projects(52374138,51764013)supported by the National Natural Science Foundation of ChinaProject(20204BCJ22005)supported by the Training Plan for Academic and Technical Leaders of Major Disciplines of Jiangxi Province,China+1 种基金Project(2019M652277)supported by the China Postdoctoral Science FoundationProject(20192ACBL21014)supported by the Natural Science Youth Foundation Key Projects of Jiangxi Province,China。
文摘The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the stability of underground mining engineering,this paper simulates the generation of different degrees of initial defects inside the CTB by adding different contents of air-entraining agent(AEA),investigates the acoustic emission RA/AF eigenvalues of CTB with different contents of AEA under uniaxial compression,and adopts various denoising algorithms(e.g.,moving average smoothing,median filtering,and outlier detection)to improve the accuracy of the data.The variance and autocorrelation coefficients of RA/AF parameters were analyzed in conjunction with the critical slowing down(CSD)theory.The results show that the acoustic emission RA/AF values can be used to characterize the progressive damage evolution of CTB.The denoising algorithm processed the AE signals to reduce the effects of extraneous noise and anomalous spikes.Changes in the variance curves provide clear precursor information,while abrupt changes in the autocorrelation coefficient can be used as an auxiliary localization warning signal.The phenomenon of dramatic increase in the variance and autocorrelation coefficient curves during the compression-tightening stage,which is influenced by the initial defects,can lead to false warnings.As the initial defects of the CTB increase,its instability precursor time and instability time are prolonged,the peak stress decreases,and the time difference between the CTB and the instability damage is smaller.The results provide a new method for real-time monitoring and early warning of CTB instability damage.
基金supported by the Research Personnel Cultivation Programme of Zhongda Hospital Southeast(CZXM-GSP-RC172)the Science and Technology Innovation 2030 Major Projects(2022ZD0211600)the National Natural Science Foundation of China(82271574 and 82502335).
文摘Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neurofibrillary tangle hypotheses[1],two FDA-approved antiamyloid monoclonal antibodies(Aβ-mAbs),Kisunla and Lecanemab,have demonstrated efficacy in removing cerebral amyloid buildup,thereby modestly slowing cognitive decline in AD patients[2,3].A 2023 meta-analysis in Neurology demonstrated that anti-amyloid therapies significantly accelerated brain volume loss compared to placebo,with Lecanemab demonstrating 36.4%greater volume reduction and Donanemab 23%.
基金Social Development Science and Technology Project of Dongguan Science and Technology Bureau(Project No.:20221800905302)。
文摘Background:Drug-coated balloons(DCBs)are receiving increasing attention in interventional therapy for coronary artery disease.However,evidence regarding their application in acute myocardial infarction(AMI),particularly in high-risk AMI patients,is limited,leading to significant clinical concerns.This study aims to compare the efficacy and safety of DCBs versus standard drug-eluting stents(DESs)in AMI patients and explore their efficacy differences in patients with ST-segment elevation myocardial infarction(STEMI),non-ST-segment elevation myocardial infarction(NSTEMI),and different risk stratifications.Methods:A single-center,retrospective cohort study was conducted,involving 86 patients who underwent percutaneous coronary intervention(PCI)for AMI between January 2023 and July 2025.Patients were divided into a DCB group(n=26)and a DES group(n=60)based on the treatment modality.According to the Killip classification of myocardial infarction at admission,patients were categorized into a low-risk group(Killip Class I,n=68)and a high-risk group(Killip Classes II-IV,n=18).The primary efficacy endpoint was targeting lesion restenosis as shown by coronary angiography follow-up(6-12 months).Safety endpoints included acute in-stent thrombosis during hospitalization(ARC criteria)and long-term coronary slow flow.A multivariate logistic regression model was used to evaluate the associations between intervention modality,risk stratification,infarction type,and endpoint events,and to test for interactions.Results:The DCB and DES groups were generally balanced in terms of baseline traditional risk factors.During hospitalization,three cases(5.0%)of acute in-stent thrombosis occurred in the DES group,all requiring urgent re-intervention,while no such events occurred in the DCB group(0%).Acute in-stent thrombosis formation was significantly associated with high-risk stratification(χ2 test,p=0.047).The overall restenosis rate was 22.1%(19/86).Multivariate analysis showed no statistically significant difference in restenosis risk between the intervention modalities(DCB vs.DES)(adjusted odds ratio[OR]=1.07,95%confidence interval[CI]0.27-4.21,p=0.920),and no statistical differences were found in subgroups based on risk stratification(p=0.382)or infarction type(p=0.484).There was a trend toward increased restenosis risk in high-risk patients(OR=12.34),but the difference was not statistically significant(95%CI 0.28-542.75,p=0.193).The incidence of long-term coronary slow flow was significantly higher in the DES group than in the DCB group(16.7%vs.3.8%,Fisher’s exact test,p=0.048),with a statistically significant difference.Conclusion:For AMI patients,DCBs demonstrate similar efficacy to DESs in preventing restenosis.However,DESs are associated with a higher risk of acute thrombosis during hospitalization,especially in high-risk patients,and a higher risk of long-term slow coronary flow.DCBs exhibit superior perioperative and long-term safety compared to DESs.Given the limited sample size,particularly the small number of high-risk patients and those treated with DCBs,the conclusions require validation through larger-scale prospective studies.
文摘The first half of 2010 is showing that the impacts of the financial crisis are still lingering.Zhao Jinping,a researcher at the Development Research Center of the State Council,says that the possible implementation of exit strategies in developed countries may deal a heavy blow to a global rally,and it will certainly result in slowed exports growth for China.Zhao published his opinion in the China Economic Times.The first part was published in issue No.33.Edited excerpts of the second part follow:
文摘China in the rst two months of2013-Apparel retail sales value in50major retailenterprises only increased by6.4%y/y,growthrate slowed down0.6%than the same periodof last year according to Nation Commer-cial Information Center of China.Growthrate slowed down6.1%than in December2012.Men s suitIn February2013,Comprehensive marketshare of the top ten men's suit brands was30.1percent in the national key major retailenterprises,increased by1.6percentage pointscompared to last month.Among them,Youn-gor and ShanShan still occupied the top twoplaces;Goldlion raised to the third;Playboyand Satchi entered the top ten.Men s shirtIn February2013,Comprehensive marketshare of the top ten men's
文摘According to the statistics of China National Commercial Information Center in April,2013, retail clothing prices rose 6.5% in the national large-scale retail enterprises,the highest growth rate since the beginning of the year.
基金Supported by the 2024 Hospital Innovation Talent Cultivation Fund Project,No.2024YGKT12.
文摘BACKGROUND Xuanshen decoction(XSD)is a traditional Chinese medicine formulation that is often applied in treating slow transit constipation(STC).However,its specific therapeutic mechanism remains to be characterized.AIM To investigate the mechanism of XSD for STC,we combined network pharmacology prediction,molecular docking analysis,and in vivo studies.METHODS The therapeutic effects of XSD on loperamide-induced STC in rats were assessed through 24-hour fecal number,fecal moisture content,and intestinal propelling rate.Hematoxylin–eosin and Alcian blue/periodic acid-Schiff staining were applied to analyze colonic mucosa for histopathological presentation and mucin production.Next,the mechanism of action of XSD for STC was elucidated through network pharmacology and molecular docking analyses,and the findings were validated by the animal experiments.RESULTS XSD significantly alleviated the symptoms of STC in rats.Relative to the STC rats,in the medium-dose XSD and high-dose XSD rats,stem cell factor,C-kit,phosphophosphoinositide 3-kinase/phosphoinositide 3-kinase,phospho-protein kinase B/protein kinase B,catalase,and superoxide dismutase were substantially upregulated(P<0.01);nuclear factor erythroid 2-related factor 2(nuclear/cytoplasmic)and B-cell lymphoma 2(Bcl-2)were increased(P<0.05),while cleaved caspase-3,Bcl-2-associated X protein(Bax)/Bcl-2,and malondialdehyde were significantly reduced(P<0.01).Heme oxygenase-1 and glutathione peroxidase in the high-dose XSD group were significantly increased(P<0.01),and Bax was statistically lowered(P<0.01);glutathione peroxidase in the medium-dose XSD group was increased(P<0.05),while Bax was reduced(P<0.05).CONCLUSION XSD may inhibit oxidative-stress-induced apoptosis in interstitial cells of Cajal by stimulating the phosphoinositide 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 pathway,thereby effectively treating STC.
基金supported by the National Key Research and Development Program of China(No.2021YFA1600304)Joint Fund for Regional Innovation and Development(No.U20A2073)+4 种基金National Natural Science Foundation of China(Nos.22373048,21973038,61904119 and 22105089)Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry(No.20212BCD42018)US National Science Foundation(NSF,No.CHE-2055499)the Interdisciplinary program of Wuhan National High Magnetic Field Center(No.WHMFC202133)the support of the NSF Research Traineeship Program(No.DGE-2152168)。
文摘Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination environment with the[Co(dps)_(4)(N_(3))_(2)]unit.Although the differences in crystal parameters are nearly negligible,their magnetic properties are very different.AC susceptibility data show that 1 behaves as a typical field-induced single-ion magnet(SIM)with the out-of-phase(χ_(M)”)signals,while 2 shows ac signals ofχ_(M)”without peaks even under applied dc filed within our measurement window.Far-IR magneto-spectra(FIRMS)show strong spin-phonon couplings at 0 T in 2,likely making the magnetic relaxation in 2 fast,while the couplings are negligible in 1.Small spin-phonon coupling in 1 likely leads to slower magnetic relaxation,making 1 a SIM.The difference in the properties is due to the structural rigidity of 2 in its 3D network,leading to stronger spin-phonon coupling.Combined high-field EPR(HF-EPR)and FIRMS studies give spin-Hamiltonian parameters,including D=64.0(9)cm^(-1),|E|=15.7(2)cm^(-1)for 1 and D=80.0(2)cm^(-1),|E|=19.0(1)cm^(-1)for 2.
基金Supported by the Natural Science Foundation of Guangdong Province for Distinguished Young Scholars,No.2022B1515020003the National Natural Science Foundation of China,No.82174369,No.82405397,No.82374442,and No.81973847+2 种基金Postdoctoral Fellowship Program of CPSF No.GZC20233247National Key Clinical Disciplineand the Program of Guangdong Provincial Clinical Research Center for Digestive Diseases,No.2020B1111170004.
文摘BACKGROUND The development of slow transit constipation(STC)is associated with intestinal barrier damage.Huangqi decoction(HQD)is effective in treating STC,but me-chanisms are unclear.AIM To investigate whether HQD alleviates STC by downregulating the nuclear factorκB(NF-κB)signaling pathway and restoring intestinal barrier function.METHODS KM mice were divided into control,model,and HQD treatment groups.Fresh colonic tissues were collected for single-cell RNA sequencing and spatial tra-nscriptome sequencing.The expressions of claudin-1,mucin 2,and NF-κB P65 proteins were detected by immunohistochemistry.In vitro experiments evaluated the effects of HQD on the LS174T cell line.RESULTS HQD improved intestinal motility,restored mucosal epithelium function and morphology.Single-cell RNA sequencing and spatial transcriptome sequencing data showed a reduction in goblet cells,decreased mucin 2 secretion,and activated apoptotic pathways in STC mice.The population of intestinal stem cells was reduced,and proliferation along with Wnt/β-catenin pathways were inhibited.STC also altered the distribution of intestinal cell states,increasing immune-associated Enterocyte_C3.Aberrant NF-κB pathway activation was noted across various cell types.After HQD treatment,NF-κB pathway activity was down-regulated,while cell proliferation pathways were up-regulated,alongside an increase in Enterocyte_C1 related to material transport.Immunocytochemical,Western blot,and immunohistochemistry analyses confirmed NF-κB pathway activation in goblet cells of STC mice,with HQD inhibiting this aberrant activation.CONCLUSION STC involves intestinal mucosal barrier damage.HQD may treat STC by suppressing NF-κB signaling in epithelial cells,restoring intestinal epithelial cell function,and promoting mucosal barrier repair.
